Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 51


Moonlighting matrix metalloproteinase substrates: Enhancement of proinflammatory functions of extracellular tyrosyl-tRNA synthetase upon cleavage.

Jobin PG, Solis N, Machado Y, Bell PA, Rai SK, Kwon NH, Kim S, Overall CM, Butler GS.

J Biol Chem. 2019 Nov 26. pii: jbc.RA119.010486. doi: 10.1074/jbc.RA119.010486. [Epub ahead of print]


The Role of MMP8 in Cancer: A Systematic Review.

Juurikka K, Butler GS, Salo T, Nyberg P, Åström P.

Int J Mol Sci. 2019 Sep 11;20(18). pii: E4506. doi: 10.3390/ijms20184506.


Matrix metalloproteinases inactivate the proinflammatory functions of secreted moonlighting tryptophanyl-tRNA synthetase.

Jobin PG, Solis N, Machado Y, Bell PA, Kwon NH, Kim S, Overall CM, Butler GS.

J Biol Chem. 2019 Aug 30;294(35):12866-12879. doi: 10.1074/jbc.RA119.009584. Epub 2019 Jul 19.


Novel Human Aminopeptidase N Inhibitors: Discovery and Optimization of Subsite Binding Interactions.

Lee J, Vinh NB, Drinkwater N, Yang W, Kannan Sivaraman K, Schembri LS, Gazdik M, Grin PM, Butler GS, Overall CM, Charman SA, McGowan S, Scammells PJ.

J Med Chem. 2019 Aug 8;62(15):7185-7209. doi: 10.1021/acs.jmedchem.9b00757. Epub 2019 Jul 18.


Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases.

Vinh NB, Drinkwater N, Malcolm TR, Kassiou M, Lucantoni L, Grin PM, Butler GS, Duffy S, Overall CM, Avery VM, Scammells PJ, McGowan S.

J Med Chem. 2019 Jan 24;62(2):622-640. doi: 10.1021/acs.jmedchem.8b01310. Epub 2019 Jan 4.


Aging-associated modifications of collagen affect its degradation by matrix metalloproteinases.

Panwar P, Butler GS, Jamroz A, Azizi P, Overall CM, Brömme D.

Matrix Biol. 2018 Jan;65:30-44. doi: 10.1016/j.matbio.2017.06.004. Epub 2017 Jun 17.


New intracellular activities of matrix metalloproteinases shine in the moonlight.

Jobin PG, Butler GS, Overall CM.

Biochim Biophys Acta Mol Cell Res. 2017 Nov;1864(11 Pt A):2043-2055. doi: 10.1016/j.bbamcr.2017.05.013. Epub 2017 May 16. Review.


Protease-Inhibitor Interaction Predictions: Lessons on the Complexity of Protein-Protein Interactions.

Fortelny N, Butler GS, Overall CM, Pavlidis P.

Mol Cell Proteomics. 2017 Jun;16(6):1038-1051. doi: 10.1074/mcp.M116.065706. Epub 2017 Apr 6.


TAILS N-Terminomics and Proteomics Show Protein Degradation Dominates over Proteolytic Processing by Cathepsins in Pancreatic Tumors.

Prudova A, Gocheva V, Auf dem Keller U, Eckhard U, Olson OC, Akkari L, Butler GS, Fortelny N, Lange PF, Mark JC, Joyce JA, Overall CM.

Cell Rep. 2016 Aug 9;16(6):1762-1773. doi: 10.1016/j.celrep.2016.06.086. Epub 2016 Jul 28.


Degradomic and yeast 2-hybrid inactive catalytic domain substrate trapping identifies new membrane-type 1 matrix metalloproteinase (MMP14) substrates: CCN3 (Nov) and CCN5 (WISP2).

Butler GS, Connor AR, Sounni NE, Eckhard U, Morrison CJ, Noël A, Overall CM.

Matrix Biol. 2017 May;59:23-38. doi: 10.1016/j.matbio.2016.07.006. Epub 2016 Jul 26.


Active site specificity profiling datasets of matrix metalloproteinases (MMPs) 1, 2, 3, 7, 8, 9, 12, 13 and 14.

Eckhard U, Huesgen PF, Schilling O, Bellac CL, Butler GS, Cox JH, Dufour A, Goebeler V, Kappelhoff R, Auf dem Keller U, Klein T, Lange PF, Marino G, Morrison CJ, Prudova A, Rodriguez D, Starr AE, Wang Y, Overall CM.

Data Brief. 2016 Feb 22;7:299-310. doi: 10.1016/j.dib.2016.02.036. eCollection 2016 Jun.


Positional proteomics in the era of the human proteome project on the doorstep of precision medicine.

Eckhard U, Marino G, Butler GS, Overall CM.

Biochimie. 2016 Mar;122:110-8. doi: 10.1016/j.biochi.2015.10.018. Epub 2015 Nov 14. Review.


Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic peptide cleavage analyses.

Eckhard U, Huesgen PF, Schilling O, Bellac CL, Butler GS, Cox JH, Dufour A, Goebeler V, Kappelhoff R, Keller UAD, Klein T, Lange PF, Marino G, Morrison CJ, Prudova A, Rodriguez D, Starr AE, Wang Y, Overall CM.

Matrix Biol. 2016 Jan;49:37-60. doi: 10.1016/j.matbio.2015.09.003. Epub 2015 Sep 25.


Macrophage matrix metalloproteinase-12 dampens inflammation and neutrophil influx in arthritis.

Bellac CL, Dufour A, Krisinger MJ, Loonchanta A, Starr AE, Auf dem Keller U, Lange PF, Goebeler V, Kappelhoff R, Butler GS, Burtnick LD, Conway EM, Roberts CR, Overall CM.

Cell Rep. 2014 Oct 23;9(2):618-32. doi: 10.1016/j.celrep.2014.09.006. Epub 2014 Oct 9.


A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity.

Marchant DJ, Bellac CL, Moraes TJ, Wadsworth SJ, Dufour A, Butler GS, Bilawchuk LM, Hendry RG, Robertson AG, Cheung CT, Ng J, Ang L, Luo Z, Heilbron K, Norris MJ, Duan W, Bucyk T, Karpov A, Devel L, Georgiadis D, Hegele RG, Luo H, Granville DJ, Dive V, McManus BM, Overall CM.

Nat Med. 2014 May;20(5):493-502. doi: 10.1038/nm.3508. Epub 2014 Apr 28.


Matrix metalloproteinase processing of signaling molecules to regulate inflammation.

Butler GS, Overall CM.

Periodontol 2000. 2013 Oct;63(1):123-48. doi: 10.1111/prd.12035. Review.


School nurses' involvement, attitudes and training needs for mental health work: a UK-wide cross-sectional study.

Haddad M, Butler GS, Tylee A.

J Adv Nurs. 2010 Nov;66(11):2471-80. doi: 10.1111/j.1365-2648.2010.05432.x. Epub 2010 Aug 23.


Multiplex N-terminome analysis of MMP-2 and MMP-9 substrate degradomes by iTRAQ-TAILS quantitative proteomics.

Prudova A, auf dem Keller U, Butler GS, Overall CM.

Mol Cell Proteomics. 2010 May;9(5):894-911. doi: 10.1074/mcp.M000050-MCP201. Epub 2010 Mar 20.


A statistics-based platform for quantitative N-terminome analysis and identification of protease cleavage products.

auf dem Keller U, Prudova A, Gioia M, Butler GS, Overall CM.

Mol Cell Proteomics. 2010 May;9(5):912-27. doi: 10.1074/mcp.M000032-MCP201. Epub 2010 Mar 20.


Identification of cellular MMP substrates using quantitative proteomics: isotope-coded affinity tags (ICAT) and isobaric tags for relative and absolute quantification (iTRAQ).

Butler GS, Dean RA, Morrison CJ, Overall CM.

Methods Mol Biol. 2010;622:451-70. doi: 10.1007/978-1-60327-299-5_26.


Proteomic identification of multitasking proteins in unexpected locations complicates drug targeting.

Butler GS, Overall CM.

Nat Rev Drug Discov. 2009 Dec;8(12):935-48. doi: 10.1038/nrd2945. Review.


Updated biological roles for matrix metalloproteinases and new "intracellular" substrates revealed by degradomics.

Butler GS, Overall CM.

Biochemistry. 2009 Nov 24;48(46):10830-45. doi: 10.1021/bi901656f. Review.


Matrix metalloproteinase proteomics: substrates, targets, and therapy.

Morrison CJ, Butler GS, Rodríguez D, Overall CM.

Curr Opin Cell Biol. 2009 Oct;21(5):645-53. doi: 10.1016/ Epub 2009 Jul 16. Review.


Membrane protease degradomics: proteomic identification and quantification of cell surface protease substrates.

Butler GS, Dean RA, Smith D, Overall CM.

Methods Mol Biol. 2009;528:159-76. doi: 10.1007/978-1-60327-310-7_12.


Metadegradomics: toward in vivo quantitative degradomics of proteolytic post-translational modifications of the cancer proteome.

Doucet A, Butler GS, Rodríguez D, Prudova A, Overall CM.

Mol Cell Proteomics. 2008 Oct;7(10):1925-51. doi: 10.1074/mcp.R800012-MCP200. Epub 2008 Jul 2. Review.


Pharmacoproteomics of a metalloproteinase hydroxamate inhibitor in breast cancer cells: dynamics of membrane type 1 matrix metalloproteinase-mediated membrane protein shedding.

Butler GS, Dean RA, Tam EM, Overall CM.

Mol Cell Biol. 2008 Aug;28(15):4896-914. doi: 10.1128/MCB.01775-07. Epub 2008 May 27.


Protease yoga: extreme flexibility of a matrix metalloproteinase.

Overall CM, Butler GS.

Structure. 2007 Oct;15(10):1159-61. No abstract available.


Proteolytic processing of SDF-1alpha reveals a change in receptor specificity mediating HIV-associated neurodegeneration.

Vergote D, Butler GS, Ooms M, Cox JH, Silva C, Hollenberg MD, Jhamandas JH, Overall CM, Power C.

Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19182-7. Epub 2006 Dec 5.


Dissecting the role of matrix metalloproteinases (MMP) and integrin alpha(v)beta3 in angiogenesis in vitro: absence of hemopexin C domain bioactivity, but membrane-Type 1-MMP and alpha(v)beta3 are critical.

Nisato RE, Hosseini G, Sirrenberg C, Butler GS, Crabbe T, Docherty AJ, Wiesner M, Murphy G, Overall CM, Goodman SL, Pepper MS.

Cancer Res. 2005 Oct 15;65(20):9377-87.


HIV-induced metalloproteinase processing of the chemokine stromal cell derived factor-1 causes neurodegeneration.

Zhang K, McQuibban GA, Silva C, Butler GS, Johnston JB, Holden J, Clark-Lewis I, Overall CM, Power C.

Nat Neurosci. 2003 Oct;6(10):1064-71. Epub 2003 Sep 21.


Mannose-binding lectin (MBL) mutants are susceptible to matrix metalloproteinase proteolysis: potential role in human MBL deficiency.

Butler GS, Sim D, Tam E, Devine D, Overall CM.

J Biol Chem. 2002 May 17;277(20):17511-9. Epub 2002 Mar 12.


The role of psychological functioning in morbid obesity and its treatment with gastroplasty.

Vallis TM, Butler GS, Perey B, Veldhuyzen van Zanten SJ, MacDonald AS, Konok G.

Obes Surg. 2001 Dec;11(6):716-25.


Cellular activation of MMP-2 (gelatinase A) by MT2-MMP occurs via a TIMP-2-independent pathway.

Morrison CJ, Butler GS, Bigg HF, Roberts CR, Soloway PD, Overall CM.

J Biol Chem. 2001 Dec 14;276(50):47402-10. Epub 2001 Oct 2.


Matrix metalloproteinase activity inactivates the CXC chemokine stromal cell-derived factor-1.

McQuibban GA, Butler GS, Gong JH, Bendall L, Power C, Clark-Lewis I, Overall CM.

J Biol Chem. 2001 Nov 23;276(47):43503-8. Epub 2001 Sep 24.


Analysis of the interaction of TIMP-2 and MMPs: engineering the changes.

Hutton M, Butler GS, Wattam BA, Willenbrock F, Williamson RA, Murphy G.

Ann N Y Acad Sci. 1999 Jun 30;878:524-7. No abstract available.


The specificity of TIMP-2 for matrix metalloproteinases can be modified by single amino acid mutations.

Butler GS, Hutton M, Wattam BA, Williamson RA, Knäuper V, Willenbrock F, Murphy G.

J Biol Chem. 1999 Jul 16;274(29):20391-6.


The Obesity Adjustment Survey: development of a scale to assess psychological adjustment to morbid obesity.

Butler GS, Vallis TM, Perey B, Veldhuyzen van Zanten SJ, MacDonald AS, Konok G.

Int J Obes Relat Metab Disord. 1999 May;23(5):505-11.


The TIMP2 membrane type 1 metalloproteinase "receptor" regulates the concentration and efficient activation of progelatinase A. A kinetic study.

Butler GS, Butler MJ, Atkinson SJ, Will H, Tamura T, Schade van Westrum S, Crabbe T, Clements J, d'Ortho MP, Murphy G.

J Biol Chem. 1998 Jan 9;273(2):871-80.


Prehospital education: effectiveness with total hip replacement surgery patients.

Butler GS, Hurley CA, Buchanan KL, Smith-VanHorne J.

Patient Educ Couns. 1996 Nov;29(2):189-97.


Supplemental Content

Loading ...
Support Center