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Items: 46


Natural products as chemical tools to dissect complex biology in C. elegans.

Butcher RA.

Curr Opin Chem Biol. 2019 May 15;50:138-144. doi: 10.1016/j.cbpa.2019.03.005. [Epub ahead of print] Review.


Tryptophan Metabolism in Caenorhabditis elegans Links Aggregation Behavior to Nutritional Status.

Zhou Y, Zhang X, Butcher RA.

ACS Chem Biol. 2019 Jan 18;14(1):50-57. doi: 10.1021/acschembio.8b00872. Epub 2018 Dec 26.


Neuropeptide Signaling Regulates Pheromone-Mediated Gene Expression of a Chemoreceptor Gene in C. elegans.

Park J, Choi W, Dar AR, Butcher RA, Kim K.

Mol Cells. 2019 Jan 31;42(1):28-35. doi: 10.14348/molcells.2018.0380. Epub 2018 Nov 14.


Feeding state regulates pheromone-mediated avoidance behavior via the insulin signaling pathway in Caenorhabditis elegans.

Ryu L, Cheon Y, Huh YH, Pyo S, Chinta S, Choi H, Butcher RA, Kim K.

EMBO J. 2018 Aug 1;37(15). pii: e98402. doi: 10.15252/embj.201798402. Epub 2018 Jun 19.


Biosynthetic tailoring of existing ascaroside pheromones alters their biological function in C. elegans.

Zhou Y, Wang Y, Zhang X, Bhar S, Jones Lipinski RA, Han J, Feng L, Butcher RA.

Elife. 2018 Jun 4;7. pii: e33286. doi: 10.7554/eLife.33286.


Acyl-CoA Oxidases Fine-Tune the Production of Ascaroside Pheromones with Specific Side Chain Lengths.

Zhang X, Wang Y, Perez DH, Jones Lipinski RA, Butcher RA.

ACS Chem Biol. 2018 Apr 20;13(4):1048-1056. doi: 10.1021/acschembio.7b01021. Epub 2018 Mar 14.


Early Pheromone Experience Modifies a Synaptic Activity to Influence Adult Pheromone Responses of C. elegans.

Hong M, Ryu L, Ow MC, Kim J, Je AR, Chinta S, Huh YH, Lee KJ, Butcher RA, Choi H, Sengupta P, Hall SE, Kim K.

Curr Biol. 2017 Oct 23;27(20):3168-3177.e3. doi: 10.1016/j.cub.2017.08.068. Epub 2017 Oct 5.


Small-molecule pheromones and hormones controlling nematode development.

Butcher RA.

Nat Chem Biol. 2017 May 17;13(6):577-586. doi: 10.1038/nchembio.2356.


Potential Nematode Alarm Pheromone Induces Acute Avoidance in Caenorhabditis elegans.

Zhou Y, Loeza-Cabrera M, Liu Z, Aleman-Meza B, Nguyen JK, Jung SK, Choi Y, Shou Q, Butcher RA, Zhong W.

Genetics. 2017 Jul;206(3):1469-1478. doi: 10.1534/genetics.116.197293. Epub 2017 May 11.


Decoding chemical communication in nematodes.

Butcher RA.

Nat Prod Rep. 2017 May 10;34(5):472-477. doi: 10.1039/c7np00007c. Review.


IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses.

Chen C, Itakura E, Nelson GM, Sheng M, Laurent P, Fenk LA, Butcher RA, Hegde RS, de Bono M.

Nature. 2017 Feb 2;542(7639):43-48. doi: 10.1038/nature20818. Epub 2017 Jan 18.


Regulatory changes in two chemoreceptor genes contribute to a Caenorhabditis elegans QTL for foraging behavior.

Greene JS, Dobosiewicz M, Butcher RA, McGrath PT, Bargmann CI.

Elife. 2016 Nov 28;5. pii: e21454. doi: 10.7554/eLife.21454.


Balancing selection shapes density-dependent foraging behaviour.

Greene JS, Brown M, Dobosiewicz M, Ishida IG, Macosko EZ, Zhang X, Butcher RA, Cline DJ, McGrath PT, Bargmann CI.

Nature. 2016 Nov 10;539(7628):254-258. doi: 10.1038/nature19848. Epub 2016 Oct 31.


Structural characterization of acyl-CoA oxidases reveals a direct link between pheromone biosynthesis and metabolic state in Caenorhabditis elegans.

Zhang X, Li K, Jones RA, Bruner SD, Butcher RA.

Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):10055-60. doi: 10.1073/pnas.1608262113. Epub 2016 Aug 22.


A hybrid polyketide-nonribosomal peptide in nematodes that promotes larval survival.

Shou Q, Feng L, Long Y, Han J, Nunnery JK, Powell DH, Butcher RA.

Nat Chem Biol. 2016 Oct;12(10):770-2. doi: 10.1038/nchembio.2144. Epub 2016 Aug 8.


Ascarosides coordinate the dispersal of a plant-parasitic nematode with the metamorphosis of its vector beetle.

Zhao L, Zhang X, Wei Y, Zhou J, Zhang W, Qin P, Chinta S, Kong X, Liu Y, Yu H, Hu S, Zou Z, Butcher RA, Sun J.

Nat Commun. 2016 Aug 1;7:12341. doi: 10.1038/ncomms12341.


Selection on a Subunit of the NURF Chromatin Remodeler Modifies Life History Traits in a Domesticated Strain of Caenorhabditis elegans.

Large EE, Xu W, Zhao Y, Brady SC, Long L, Butcher RA, Andersen EC, McGrath PT.

PLoS Genet. 2016 Jul 28;12(7):e1006219. doi: 10.1371/journal.pgen.1006219. eCollection 2016 Jul.


Identification of a dTDP-rhamnose biosynthetic pathway that oscillates with the molting cycle in Caenorhabditis elegans.

Feng L, Shou Q, Butcher RA.

Biochem J. 2016 Jun 1;473(11):1507-21. doi: 10.1042/BCJ20160142. Epub 2016 Mar 23.


A Forward Genetic Screen for Molecules Involved in Pheromone-Induced Dauer Formation in Caenorhabditis elegans.

Neal SJ, Park J, DiTirro D, Yoon J, Shibuya M, Choi W, Schroeder FC, Butcher RA, Kim K, Sengupta P.

G3 (Bethesda). 2016 May 3;6(5):1475-87. doi: 10.1534/g3.115.026450.


Correction: Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling.

Neal SJ, Takeishi A, O'Donnell MP, Park J, Hong M, Butcher RA, Kim K, Sengupta P.

Elife. 2015 Sep 22;4:e11547. doi: 10.7554/eLife.11547. No abstract available.


Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling.

Neal SJ, Takeishi A, O'Donnell MP, Park J, Hong M, Butcher RA, Kim K, Sengupta P.

Elife. 2015 Sep 3;4. pii: e10110. doi: 10.7554/eLife.10110. Erratum in: Elife. 2015;4:e11547.


Acyl-CoA oxidase complexes control the chemical message produced by Caenorhabditis elegans.

Zhang X, Feng L, Chinta S, Singh P, Wang Y, Nunnery JK, Butcher RA.

Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):3955-60. doi: 10.1073/pnas.1423951112. Epub 2015 Mar 16.


Interspecific communication between pinewood nematode, its insect vector, and associated microbes.

Zhao L, Mota M, Vieira P, Butcher RA, Sun J.

Trends Parasitol. 2014 Jun;30(6):299-308. doi: 10.1016/ Epub 2014 May 5. Review.


Chemical signals synchronize the life cycles of a plant-parasitic nematode and its vector beetle.

Zhao L, Zhang S, Wei W, Hao H, Zhang B, Butcher RA, Sun J.

Curr Biol. 2013 Oct 21;23(20):2038-43. doi: 10.1016/j.cub.2013.08.041. Epub 2013 Oct 10.


Analysis of ascarosides from Caenorhabditis elegans using mass spectrometry and NMR spectroscopy.

Zhang X, Noguez JH, Zhou Y, Butcher RA.

Methods Mol Biol. 2013;1068:71-92. doi: 10.1007/978-1-62703-619-1_6.


Ascaroside activity in Caenorhabditis elegans is highly dependent on chemical structure.

Hollister KA, Conner ES, Zhang X, Spell M, Bernard GM, Patel P, de Carvalho AC, Butcher RA, Ragains JR.

Bioorg Med Chem. 2013 Sep 15;21(18):5754-69. doi: 10.1016/j.bmc.2013.07.018. Epub 2013 Jul 18.


A sexually conditioned switch of chemosensory behavior in C. elegans.

Sakai N, Iwata R, Yokoi S, Butcher RA, Clardy J, Tomioka M, Iino Y.

PLoS One. 2013 Jul 4;8(7):e68676. doi: 10.1371/journal.pone.0068676. Print 2013.


Neuromodulatory state and sex specify alternative behaviors through antagonistic synaptic pathways in C. elegans.

Jang H, Kim K, Neal SJ, Macosko E, Kim D, Butcher RA, Zeiger DM, Bargmann CI, Sengupta P.

Neuron. 2012 Aug 23;75(4):585-92. doi: 10.1016/j.neuron.2012.06.034.


A novel ascaroside controls the parasitic life cycle of the entomopathogenic nematode Heterorhabditis bacteriophora.

Noguez JH, Conner ES, Zhou Y, Ciche TA, Ragains JR, Butcher RA.

ACS Chem Biol. 2012 Jun 15;7(6):961-6. doi: 10.1021/cb300056q. Epub 2012 Apr 13.


Parallel evolution of domesticated Caenorhabditis species targets pheromone receptor genes.

McGrath PT, Xu Y, Ailion M, Garrison JL, Butcher RA, Bargmann CI.

Nature. 2011 Aug 17;477(7364):321-5. doi: 10.1038/nature10378.


Olfactory plasticity is regulated by pheromonal signaling in Caenorhabditis elegans.

Yamada K, Hirotsu T, Matsuki M, Butcher RA, Tomioka M, Ishihara T, Clardy J, Kunitomo H, Iino Y.

Science. 2010 Sep 24;329(5999):1647-50. doi: 10.1126/science.1192020.


Two chemoreceptors mediate developmental effects of dauer pheromone in C. elegans.

Kim K, Sato K, Shibuya M, Zeiger DM, Butcher RA, Ragains JR, Clardy J, Touhara K, Sengupta P.

Science. 2009 Nov 13;326(5955):994-8. doi: 10.1126/science.1176331. Epub 2009 Oct 1.


An indole-containing dauer pheromone component with unusual dauer inhibitory activity at higher concentrations.

Butcher RA, Ragains JR, Clardy J.

Org Lett. 2009 Jul 16;11(14):3100-3. doi: 10.1021/ol901011c.


A hub-and-spoke circuit drives pheromone attraction and social behaviour in C. elegans.

Macosko EZ, Pokala N, Feinberg EH, Chalasani SH, Butcher RA, Clardy J, Bargmann CI.

Nature. 2009 Apr 30;458(7242):1171-5. doi: 10.1038/nature07886. Epub 2009 Apr 6.


Biosynthesis of the Caenorhabditis elegans dauer pheromone.

Butcher RA, Ragains JR, Li W, Ruvkun G, Clardy J, Mak HY.

Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1875-9. doi: 10.1073/pnas.0810338106. Epub 2009 Jan 27.


A potent dauer pheromone component in Caenorhabditis elegans that acts synergistically with other components.

Butcher RA, Ragains JR, Kim E, Clardy J.

Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14288-92. doi: 10.1073/pnas.0806676105. Epub 2008 Sep 12.


Sporulenes, heptaprenyl metabolites from Bacillus subtilis spores.

Kontnik R, Bosak T, Butcher RA, Brocks JJ, Losick R, Clardy J, Pearson A.

Org Lett. 2008 Aug 21;10(16):3551-4. doi: 10.1021/ol801314k. Epub 2008 Jul 17.


Small-molecule pheromones that control dauer development in Caenorhabditis elegans.

Butcher RA, Fujita M, Schroeder FC, Clardy J.

Nat Chem Biol. 2007 Jul;3(7):420-2. Epub 2007 Jun 10.


A microarray-based protocol for monitoring the growth of yeast overexpression strains.

Butcher RA, Schreiber SL.

Nat Protoc. 2006;1(2):569-76.


The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis.

Butcher RA, Schroeder FC, Fischbach MA, Straight PD, Kolter R, Walsh CT, Clardy J.

Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1506-9. Epub 2007 Jan 18.


Microarray-based method for monitoring yeast overexpression strains reveals small-molecule targets in TOR pathway.

Butcher RA, Bhullar BS, Perlstein EO, Marsischky G, LaBaer J, Schreiber SL.

Nat Chem Biol. 2006 Feb;2(2):103-9. Epub 2006 Jan 15.


Using genome-wide transcriptional profiling to elucidate small-molecule mechanism.

Butcher RA, Schreiber SL.

Curr Opin Chem Biol. 2005 Feb;9(1):25-30. Review.


Identification of Ald6p as the target of a class of small-molecule suppressors of FK506 and their use in network dissection.

Butcher RA, Schreiber SL.

Proc Natl Acad Sci U S A. 2004 May 25;101(21):7868-73. Epub 2004 May 14.


Multidimensional chemical genetic analysis of diversity-oriented synthesis-derived deacetylase inhibitors using cell-based assays.

Haggarty SJ, Koeller KM, Wong JC, Butcher RA, Schreiber SL.

Chem Biol. 2003 May;10(5):383-96.


Minocycline excretion and distribution in relation to renal function in man.

Carney S, Butcher RA, Dawborn JK, Pattison G.

Clin Exp Pharmacol Physiol. 1974 Jul-Aug;1(4):299-308. No abstract available.


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