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Endothelial cell α-globin and its molecular chaperone α-hemoglobin-stabilizing protein regulate arteriolar contractility.

Lechauve C, Butcher JT, Freiwan A, Biwer LA, Keith JM, Good ME, Ackerman H, Tillman HS, Kiger L, Isakson BE, Weiss MJ.

J Clin Invest. 2018 Aug 28. pii: 99933. doi: 10.1172/JCI99933. [Epub ahead of print]


Monocytes and Macrophages in Heart Valves: Uninvited Guests or Critical Performers?

Sraeyes S, Pham DH, Gee TW, Hua J, Butcher JT.

Curr Opin Biomed Eng. 2018 Mar;5:82-89. doi: 10.1016/j.cobme.2018.02.003. Epub 2018 Mar 5.


The root problem of heart valve engineering.

Butcher JT.

Sci Transl Med. 2018 May 9;10(440). pii: eaat5850. doi: 10.1126/scitranslmed.aat5850. Review.


Endothelial cell Pannexin1 modulates severity of ischemic stroke by regulating cerebral inflammation and myogenic tone.

Good ME, Eucker SA, Li J, Bacon HM, Lang SM, Butcher JT, Johnson TJ, Gaykema RP, Patel MK, Zuo Z, Isakson BE.

JCI Insight. 2018 Mar 22;3(6). pii: 96272. doi: 10.1172/jci.insight.96272. [Epub ahead of print]


Crystallinity of hydroxyapatite drives myofibroblastic activation and calcification in aortic valves.

Richards JM, Kunitake JAMR, Hunt HB, Wnorowski AN, Lin DW, Boskey AL, Donnelly E, Estroff LA, Butcher JT.

Acta Biomater. 2018 Apr 15;71:24-36. doi: 10.1016/j.actbio.2018.02.024. Epub 2018 Mar 2.


Mechanotransduction Mechanisms in Mitral Valve Physiology and Disease Pathogenesis.

Pagnozzi LA, Butcher JT.

Front Cardiovasc Med. 2017 Dec 22;4:83. doi: 10.3389/fcvm.2017.00083. eCollection 2017. Review.


Pannexin 1 Channels as an Unexpected New Target of the Anti-Hypertensive Drug Spironolactone.

Good ME, Chiu YH, Poon IKH, Medina CB, Butcher JT, Mendu SK, DeLalio LJ, Lohman AW, Leitinger N, Barrett E, Lorenz UM, Desai BN, Jaffe IZ, Bayliss DA, Isakson BE, Ravichandran KS.

Circ Res. 2018 Feb 16;122(4):606-615. doi: 10.1161/CIRCRESAHA.117.312380. Epub 2017 Dec 13.


Effect of myostatin deletion on cardiac and microvascular function.

Butcher JT, Ali MI, Ma MW, McCarthy CG, Islam BN, Fox LG, Mintz JD, Larion S, Fulton DJ, Stepp DW.

Physiol Rep. 2017 Dec;5(23). doi: 10.14814/phy2.13525.


Nanofiber-structured hydrogel yarns with pH-response capacity and cardiomyocyte-drivability for bio-microactuator application.

Wu S, Duan B, Qin X, Butcher JT.

Acta Biomater. 2017 Sep 15;60:144-153. doi: 10.1016/j.actbio.2017.07.023. Epub 2017 Jul 18.


Yellow Perch (Perca flavescens) Mercury Unaffected by Wildland Fires in Northern Minnesota.

Riggs CE, Kolka RK, Nater EA, Witt EL, Wickman TR, Woodruff LG, Butcher JT.

J Environ Qual. 2017 May;46(3):623-631. doi: 10.2134/jeq2016.10.0418.


Smooth muscle cell-specific deletion of Col15a1 unexpectedly leads to impaired development of advanced atherosclerotic lesions.

Durgin BG, Cherepanova OA, Gomez D, Karaoli T, Alencar GF, Butcher JT, Zhou YQ, Bendeck MP, Isakson BE, Owens GK, Connelly JJ.

Am J Physiol Heart Circ Physiol. 2017 May 1;312(5):H943-H958. doi: 10.1152/ajpheart.00029.2017. Epub 2017 Mar 10.


Heart function and hemodynamic analysis for zebrafish embryos.

Yalcin HC, Amindari A, Butcher JT, Althani A, Yacoub M.

Dev Dyn. 2017 Nov;246(11):868-880. doi: 10.1002/dvdy.24497. Epub 2017 Apr 11. Review.


JuPOETs: a constrained multiobjective optimization approach to estimate biochemical model ensembles in the Julia programming language.

Bassen DM, Vilkhovoy M, Minot M, Butcher JT, Varner JD.

BMC Syst Biol. 2017 Jan 25;11(1):10. doi: 10.1186/s12918-016-0380-2.


Living nano-micro fibrous woven fabric/hydrogel composite scaffolds for heart valve engineering.

Wu S, Duan B, Qin X, Butcher JT.

Acta Biomater. 2017 Mar 15;51:89-100. doi: 10.1016/j.actbio.2017.01.051. Epub 2017 Jan 18.


Matrix stiffening promotes a tumor vasculature phenotype.

Bordeleau F, Mason BN, Lollis EM, Mazzola M, Zanotelli MR, Somasegar S, Califano JP, Montague C, LaValley DJ, Huynh J, Mencia-Trinchant N, Negrón Abril YL, Hassane DC, Bonassar LJ, Butcher JT, Weiss RS, Reinhart-King CA.

Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):492-497. doi: 10.1073/pnas.1613855114. Epub 2016 Dec 29.


Developmental Mechanisms of Aortic Valve Malformation and Disease.

Wu B, Wang Y, Xiao F, Butcher JT, Yutzey KE, Zhou B.

Annu Rev Physiol. 2017 Feb 10;79:21-41. doi: 10.1146/annurev-physiol-022516-034001. Epub 2016 Dec 9. Review.


Modulating Vascular Hemodynamics With an Alpha Globin Mimetic Peptide (HbαX).

Keller TC 4th, Butcher JT, Broseghini-Filho GB, Marziano C, DeLalio LJ, Rogers S, Ning B, Martin JN, Chechova S, Cabot M, Shu X, Best AK, Good ME, Simão Padilha A, Purdy M, Yeager M, Peirce SM, Hu S, Doctor A, Barrett E, Le TH, Columbus L, Isakson BE.

Hypertension. 2016 Dec;68(6):1494-1503. Epub 2016 Oct 31.


Cardiovascular magnetic resonance detects the progression of impaired myocardial perfusion reserve and increased left-ventricular mass in mice fed a high-fat diet.

Naresh NK, Butcher JT, Lye RJ, Chen X, Isakson BE, Gan LM, Kramer CM, Annex BH, Epstein FH.

J Cardiovasc Magn Reson. 2016 Sep 9;18(1):53. doi: 10.1186/s12968-016-0273-y.


Valve interstitial cell tensional homeostasis directs calcification and extracellular matrix remodeling processes via RhoA signaling.

Farrar EJ, Pramil V, Richards JM, Mosher CZ, Butcher JT.

Biomaterials. 2016 Oct;105:25-37. doi: 10.1016/j.biomaterials.2016.07.034. Epub 2016 Jul 29.


Cadherin-11 Overexpression Induces Extracellular Matrix Remodeling and Calcification in Mature Aortic Valves.

Sung DC, Bowen CJ, Vaidya KA, Zhou J, Chapurin N, Recknagel A, Zhou B, Chen J, Kotlikoff M, Butcher JT.

Arterioscler Thromb Vasc Biol. 2016 Aug;36(8):1627-37. doi: 10.1161/ATVBAHA.116.307812. Epub 2016 Jun 16.


Fabrication of Aligned Nanofiber Polymer Yarn Networks for Anisotropic Soft Tissue Scaffolds.

Wu S, Duan B, Liu P, Zhang C, Qin X, Butcher JT.

ACS Appl Mater Interfaces. 2016 Jul 6;8(26):16950-60. doi: 10.1021/acsami.6b05199. Epub 2016 Jun 23.


Optimizing Photo-Encapsulation Viability of Heart Valve Cell Types in 3D Printable Composite Hydrogels.

Kang LH, Armstrong PA, Lee LJ, Duan B, Kang KH, Butcher JT.

Ann Biomed Eng. 2017 Feb;45(2):360-377. doi: 10.1007/s10439-016-1619-1. Epub 2016 Apr 22.


Active tissue stiffness modulation controls valve interstitial cell phenotype and osteogenic potential in 3D culture.

Duan B, Yin Z, Hockaday Kang L, Magin RL, Butcher JT.

Acta Biomater. 2016 May;36:42-54. doi: 10.1016/j.actbio.2016.03.007. Epub 2016 Mar 3.


Targeted Mybpc3 Knock-Out Mice with Cardiac Hypertrophy Exhibit Structural Mitral Valve Abnormalities.

Judge DP, Neamatalla H, Norris RA, Levine RA, Butcher JT, Vignier N, Kang KH, Nguyen Q, Bruneval P, Perier MC, Messas E, Jeunemaitre X, de Vlaming A, Markwald R, Carrier L, Hagège AA.

J Cardiovasc Dev Dis. 2015;2(2):48-65. Epub 2015 Apr 21.


Cyclic Mechanical Loading Is Essential for Rac1-Mediated Elongation and Remodeling of the Embryonic Mitral Valve.

Gould RA, Yalcin HC, MacKay JL, Sauls K, Norris R, Kumar S, Butcher JT.

Curr Biol. 2016 Jan 11;26(1):27-37. doi: 10.1016/j.cub.2015.11.033. Epub 2015 Dec 24.


Increased peripheral vascular disease risk progressively constrains perfusion adaptability in the skeletal muscle microcirculation.

Frisbee JC, Butcher JT, Frisbee SJ, Olfert IM, Chantler PD, Tabone LE, d'Audiffret AC, Shrader CD, Goodwill AG, Stapleton PA, Brooks SD, Brock RW, Lombard JH.

Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H488-504. doi: 10.1152/ajpheart.00790.2015. Epub 2015 Dec 23.


Notch-Tnf signalling is required for development and homeostasis of arterial valves.

Wang Y, Wu B, Farrar E, Lui W, Lu P, Zhang D, Alfieri CM, Mao K, Chu M, Yang D, Xu D, Rauchman M, Taylor V, Conway SJ, Yutzey KE, Butcher JT, Zhou B.

Eur Heart J. 2017 Mar 1;38(9):675-686. doi: 10.1093/eurheartj/ehv520.


Mitral valve disease--morphology and mechanisms.

Levine RA, Hagége AA, Judge DP, Padala M, Dal-Bianco JP, Aikawa E, Beaudoin J, Bischoff J, Bouatia-Naji N, Bruneval P, Butcher JT, Carpentier A, Chaput M, Chester AH, Clusel C, Delling FN, Dietz HC, Dina C, Durst R, Fernandez-Friera L, Handschumacher MD, Jensen MO, Jeunemaitre XP, Le Marec H, Le Tourneau T, Markwald RR, Mérot J, Messas E, Milan DP, Neri T, Norris RA, Peal D, Perrocheau M, Probst V, Pucéat M, Rosenthal N, Solis J, Schott JJ, Schwammenthal E, Slaugenhaupt SA, Song JK, Yacoub MH; Leducq Mitral Transatlantic Network.

Nat Rev Cardiol. 2015 Dec;12(12):689-710. doi: 10.1038/nrcardio.2015.161. Epub 2015 Oct 20. Review.


Endothelial nitric oxide synthase in the microcirculation.

Shu X, Keller TC 4th, Begandt D, Butcher JT, Biwer L, Keller AS, Columbus L, Isakson BE.

Cell Mol Life Sci. 2015 Dec;72(23):4561-75. doi: 10.1007/s00018-015-2021-0. Epub 2015 Aug 25. Review.


Pannexin 1 channels regulate leukocyte emigration through the venous endothelium during acute inflammation.

Lohman AW, Leskov IL, Butcher JT, Johnstone SR, Stokes TA, Begandt D, DeLalio LJ, Best AK, Penuela S, Leitinger N, Ravichandran KS, Stokes KY, Isakson BE.

Nat Commun. 2015 Aug 5;6:7965. doi: 10.1038/ncomms8965.


Cadherin-11 coordinates cellular migration and extracellular matrix remodeling during aortic valve maturation.

Bowen CJ, Zhou J, Sung DC, Butcher JT.

Dev Biol. 2015 Nov 1;407(1):145-57. doi: 10.1016/j.ydbio.2015.07.012. Epub 2015 Jul 16.


Current progress in tissue engineering of heart valves: multiscale problems, multiscale solutions.

Cheung DY, Duan B, Butcher JT.

Expert Opin Biol Ther. 2015;15(8):1155-72. doi: 10.1517/14712598.2015.1051527. Epub 2015 Jun 1. Review.


Diphenyl phosphine oxide-1-sensitive K(+) channels contribute to the vascular tone and reactivity of resistance arteries from brain and skeletal muscle.

Fancher IS, Butcher JT, Brooks SD, Rottgen TS, Skaff PR, Frisbee JC, Dick GM.

Microcirculation. 2015 May;22(4):315-25. doi: 10.1111/micc.12201.


A molecular signature in the pannexin1 intracellular loop confers channel activation by the α1 adrenoreceptor in smooth muscle cells.

Billaud M, Chiu YH, Lohman AW, Parpaite T, Butcher JT, Mutchler SM, DeLalio LJ, Artamonov MV, Sandilos JK, Best AK, Somlyo AV, Thompson RJ, Le TH, Ravichandran KS, Bayliss DA, Isakson BE.

Sci Signal. 2015 Feb 17;8(364):ra17. doi: 10.1126/scisignal.2005824.


Comparison of Mesenchymal Stem Cell Source Differentiation Toward Human Pediatric Aortic Valve Interstitial Cells within 3D Engineered Matrices.

Duan B, Hockaday LA, Das S, Xu C, Butcher JT.

Tissue Eng Part C Methods. 2015 Aug;21(8):795-807. doi: 10.1089/ten.TEC.2014.0589. Epub 2015 Apr 13.


Growth and hemodynamics after early embryonic aortic arch occlusion.

Lindsey SE, Menon PG, Kowalski WJ, Shekhar A, Yalcin HC, Nishimura N, Schaffer CB, Butcher JT, Pekkan K.

Biomech Model Mechanobiol. 2015 Aug;14(4):735-51. doi: 10.1007/s10237-014-0633-1. Epub 2014 Nov 23.


Microvascular perfusion heterogeneity contributes to peripheral vascular disease in metabolic syndrome.

Frisbee JC, Goodwill AG, Frisbee SJ, Butcher JT, Wu F, Chantler PD.

J Physiol. 2016 Apr 15;594(8):2233-43. doi: 10.1113/jphysiol.2014.285247. Epub 2014 Dec 18. Review.


Distinct temporal phases of microvascular rarefaction in skeletal muscle of obese Zucker rats.

Frisbee JC, Goodwill AG, Frisbee SJ, Butcher JT, Brock RW, Olfert IM, DeVallance ER, Chantler PD.

Am J Physiol Heart Circ Physiol. 2014 Dec 15;307(12):H1714-28. doi: 10.1152/ajpheart.00605.2014. Epub 2014 Oct 10.


Hemoglobin α/eNOS coupling at myoendothelial junctions is required for nitric oxide scavenging during vasoconstriction.

Straub AC, Butcher JT, Billaud M, Mutchler SM, Artamonov MV, Nguyen AT, Johnson T, Best AK, Miller MP, Palmer LA, Columbus L, Somlyo AV, Le TH, Isakson BE.

Arterioscler Thromb Vasc Biol. 2014 Dec;34(12):2594-600. doi: 10.1161/ATVBAHA.114.303974. Epub 2014 Oct 2.


Micro/nano-computed tomography technology for quantitative dynamic, multi-scale imaging of morphogenesis.

Gregg CL, Recknagel AK, Butcher JT.

Methods Mol Biol. 2015;1189:47-61. doi: 10.1007/978-1-4939-1164-6_4.


Mechanical regulation of cardiac development.

Lindsey SE, Butcher JT, Yalcin HC.

Front Physiol. 2014 Aug 21;5:318. doi: 10.3389/fphys.2014.00318. eCollection 2014. Review.


Protective effect of sex on chronic stress- and depressive behavior-induced vascular dysfunction in BALB/cJ mice.

Stanley SC, Brooks SD, Butcher JT, d'Audiffret AC, Frisbee SJ, Frisbee JC.

J Appl Physiol (1985). 2014 Nov 1;117(9):959-70. doi: 10.1152/japplphysiol.00537.2014. Epub 2014 Aug 14.


The living aortic valve: From molecules to function.

Chester AH, El-Hamamsy I, Butcher JT, Latif N, Bertazzo S, Yacoub MH.

Glob Cardiol Sci Pract. 2014 Jan 29;2014(1):52-77. doi: 10.5339/gcsp.2014.11. eCollection 2014. Review.


Endothelial retention and phenotype on carbonized cardiovascular implant surfaces.

Frendl CM, Tucker SM, Khan NA, Esch MB, Kanduru S, Cao TM, García AJ, King MR, Butcher JT.

Biomaterials. 2014 Sep;35(27):7714-23. doi: 10.1016/j.biomaterials.2014.05.075. Epub 2014 Jun 20.


Effects of shear stress pattern and magnitude on mesenchymal transformation and invasion of aortic valve endothelial cells.

Mahler GJ, Frendl CM, Cao Q, Butcher JT.

Biotechnol Bioeng. 2014 Nov;111(11):2326-37. doi: 10.1002/bit.25291. Epub 2014 Aug 5.


Hemoglobin α in the blood vessel wall.

Butcher JT, Johnson T, Beers J, Columbus L, Isakson BE.

Free Radic Biol Med. 2014 Aug;73:136-42. doi: 10.1016/j.freeradbiomed.2014.04.019. Epub 2014 May 14. Review.


Impact of increased intramuscular perfusion heterogeneity on skeletal muscle microvascular hematocrit in the metabolic syndrome.

Butcher JT, Stanley SC, Brooks SD, Chantler PD, Wu F, Frisbee JC.

Microcirculation. 2014 Nov;21(8):677-87. doi: 10.1111/micc.12146.

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