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Items: 32

1.

Astrocyte Unfolded Protein Response Induces a Specific Reactivity State that Causes Non-Cell-Autonomous Neuronal Degeneration.

Smith HL, Freeman OJ, Butcher AJ, Holmqvist S, Humoud I, Schätzl T, Hughes DT, Verity NC, Swinden DP, Hayes J, de Weerd L, Rowitch DH, Franklin RJM, Mallucci GR.

Neuron. 2020 Jan 2. pii: S0896-6273(19)31056-6. doi: 10.1016/j.neuron.2019.12.014. [Epub ahead of print]

2.

Chemogenetics defines receptor-mediated functions of short chain free fatty acids.

Bolognini D, Barki N, Butcher AJ, Hudson BD, Sergeev E, Molloy C, Moss CE, Bradley SJ, Le Gouill C, Bouvier M, Tobin AB, Milligan G.

Nat Chem Biol. 2019 May;15(5):489-498. doi: 10.1038/s41589-019-0270-1. Epub 2019 Apr 15.

PMID:
30992568
3.

M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss.

Bradley SJ, Bourgognon JM, Sanger HE, Verity N, Mogg AJ, White DJ, Butcher AJ, Moreno JA, Molloy C, Macedo-Hatch T, Edwards JM, Wess J, Pawlak R, Read DJ, Sexton PM, Broad LM, Steinert JR, Mallucci GR, Christopoulos A, Felder CC, Tobin AB.

J Clin Invest. 2017 Feb 1;127(2):487-499. doi: 10.1172/JCI87526. Epub 2016 Dec 19.

4.

Identification of key phosphorylation sites in PTH1R that determine arrestin3 binding and fine-tune receptor signaling.

Zindel D, Engel S, Bottrill AR, Pin JP, Prézeau L, Tobin AB, Bünemann M, Krasel C, Butcher AJ.

Biochem J. 2016 Nov 15;473(22):4173-4192. Epub 2016 Sep 13.

5.

Mapping physiological G protein-coupled receptor signaling pathways reveals a role for receptor phosphorylation in airway contraction.

Bradley SJ, Wiegman CH, Iglesias MM, Kong KC, Butcher AJ, Plouffe B, Goupil E, Bourgognon JM, Macedo-Hatch T, LeGouill C, Russell K, Laporte SA, König GM, Kostenis E, Bouvier M, Chung KF, Amrani Y, Tobin AB.

Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):4524-9. doi: 10.1073/pnas.1521706113. Epub 2016 Apr 8.

6.

Distinct phosphorylation sites on the ghrelin receptor, GHSR1a, establish a code that determines the functions of ß-arrestins.

Bouzo-Lorenzo M, Santo-Zas I, Lodeiro M, Nogueiras R, Casanueva FF, Castro M, Pazos Y, Tobin AB, Butcher AJ, Camiña JP.

Sci Rep. 2016 Mar 3;6:22495. doi: 10.1038/srep22495.

7.

Distinct Phosphorylation Clusters Determine the Signaling Outcome of Free Fatty Acid Receptor 4/G Protein-Coupled Receptor 120.

Prihandoko R, Alvarez-Curto E, Hudson BD, Butcher AJ, Ulven T, Miller AM, Tobin AB, Milligan G.

Mol Pharmacol. 2016 May;89(5):505-20. doi: 10.1124/mol.115.101949. Epub 2016 Feb 12.

PMID:
26873857
8.

An Antibody Biosensor Establishes the Activation of the M1 Muscarinic Acetylcholine Receptor during Learning and Memory.

Butcher AJ, Bradley SJ, Prihandoko R, Brooke SM, Mogg A, Bourgognon JM, Macedo-Hatch T, Edwards JM, Bottrill AR, Challiss RA, Broad LM, Felder CC, Tobin AB.

J Biol Chem. 2016 Apr 22;291(17):8862-75. doi: 10.1074/jbc.M115.681726. Epub 2016 Jan 29.

9.

The experimental power of FR900359 to study Gq-regulated biological processes.

Schrage R, Schmitz AL, Gaffal E, Annala S, Kehraus S, Wenzel D, Büllesbach KM, Bald T, Inoue A, Shinjo Y, Galandrin S, Shridhar N, Hesse M, Grundmann M, Merten N, Charpentier TH, Martz M, Butcher AJ, Slodczyk T, Armando S, Effern M, Namkung Y, Jenkins L, Horn V, Stößel A, Dargatz H, Tietze D, Imhof D, Galés C, Drewke C, Müller CE, Hölzel M, Milligan G, Tobin AB, Gomeza J, Dohlman HG, Sondek J, Harden TK, Bouvier M, Laporte SA, Aoki J, Fleischmann BK, Mohr K, König GM, Tüting T, Kostenis E.

Nat Commun. 2015 Dec 14;6:10156. doi: 10.1038/ncomms10156.

10.

CK2 acts as a potent negative regulator of receptor-mediated insulin release in vitro and in vivo.

Rossi M, Ruiz de Azua I, Barella LF, Sakamoto W, Zhu L, Cui Y, Lu H, Rebholz H, Matschinsky FM, Doliba NM, Butcher AJ, Tobin AB, Wess J.

Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):E6818-24. doi: 10.1073/pnas.1519430112. Epub 2015 Nov 23.

11.

Determination of GPCR Phosphorylation Status: Establishing a Phosphorylation Barcode.

Prihandoko R, Bradley SJ, Tobin AB, Butcher AJ.

Curr Protoc Pharmacol. 2015 Jun 1;69:2.13.1-2.13.26. doi: 10.1002/0471141755.ph0213s69. Review.

PMID:
26344213
12.

Engineered hyperphosphorylation of the β2-adrenoceptor prolongs arrestin-3 binding and induces arrestin internalization.

Zindel D, Butcher AJ, Al-Sabah S, Lanzerstorfer P, Weghuber J, Tobin AB, Bünemann M, Krasel C.

Mol Pharmacol. 2015 Feb;87(2):349-62. doi: 10.1124/mol.114.095422. Epub 2014 Nov 25.

13.

Concomitant action of structural elements and receptor phosphorylation determines arrestin-3 interaction with the free fatty acid receptor FFA4.

Butcher AJ, Hudson BD, Shimpukade B, Alvarez-Curto E, Prihandoko R, Ulven T, Milligan G, Tobin AB.

J Biol Chem. 2014 Jun 27;289(26):18451-65. doi: 10.1074/jbc.M114.568816. Epub 2014 May 9.

14.

The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism.

Hudson BD, Shimpukade B, Mackenzie AE, Butcher AJ, Pediani JD, Christiansen E, Heathcote H, Tobin AB, Ulven T, Milligan G.

Mol Pharmacol. 2013 Nov;84(5):710-25. doi: 10.1124/mol.113.087783. Epub 2013 Aug 26.

15.

Identification of phosphorylation sites in the COOH-terminal tail of the μ-opioid receptor.

Chen YJ, Oldfield S, Butcher AJ, Tobin AB, Saxena K, Gurevich VV, Benovic JL, Henderson G, Kelly E.

J Neurochem. 2013 Jan;124(2):189-99. doi: 10.1111/jnc.12071. Epub 2012 Nov 30.

16.

Physiological role of G-protein coupled receptor phosphorylation.

Butcher AJ, Kong KC, Prihandoko R, Tobin AB.

Handb Exp Pharmacol. 2012;(208):79-94. doi: 10.1007/978-3-642-23274-9_5. Review.

PMID:
22222696
17.

Examining site-specific GPCR phosphorylation.

Butcher AJ, Tobin AB, Kong KC.

Methods Mol Biol. 2011;746:237-49. doi: 10.1007/978-1-61779-126-0_12.

PMID:
21607860
18.

Differential G-protein-coupled receptor phosphorylation provides evidence for a signaling bar code.

Butcher AJ, Prihandoko R, Kong KC, McWilliams P, Edwards JM, Bottrill A, Mistry S, Tobin AB.

J Biol Chem. 2011 Apr 1;286(13):11506-18. doi: 10.1074/jbc.M110.154526. Epub 2010 Dec 21.

19.

M3-muscarinic receptor promotes insulin release via receptor phosphorylation/arrestin-dependent activation of protein kinase D1.

Kong KC, Butcher AJ, McWilliams P, Jones D, Wess J, Hamdan FF, Werry T, Rosethorne EM, Charlton SJ, Munson SE, Cragg HA, Smart AD, Tobin AB.

Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21181-6. doi: 10.1073/pnas.1011651107. Epub 2010 Nov 15.

20.

Three-dimensional structure of CaV3.1: comparison with the cardiac L-type voltage-gated calcium channel monomer architecture.

Walsh CP, Davies A, Butcher AJ, Dolphin AC, Kitmitto A.

J Biol Chem. 2009 Aug 14;284(33):22310-21. doi: 10.1074/jbc.M109.017152. Epub 2009 Jun 11.

21.

N-methyl-D-aspartate receptors mediate the phosphorylation and desensitization of muscarinic receptors in cerebellar granule neurons.

Butcher AJ, Torrecilla I, Young KW, Kong KC, Mistry SC, Bottrill AR, Tobin AB.

J Biol Chem. 2009 Jun 19;284(25):17147-56. doi: 10.1074/jbc.M901031200. Epub 2009 Mar 30.

22.

The stargazin-related protein gamma 7 interacts with the mRNA-binding protein heterogeneous nuclear ribonucleoprotein A2 and regulates the stability of specific mRNAs, including CaV2.2.

Ferron L, Davies A, Page KM, Cox DJ, Leroy J, Waithe D, Butcher AJ, Sellaturay P, Bolsover S, Pratt WS, Moss FJ, Dolphin AC.

J Neurosci. 2008 Oct 15;28(42):10604-17. doi: 10.1523/JNEUROSCI.2709-08.2008.

23.

Location, location, location...site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling.

Tobin AB, Butcher AJ, Kong KC.

Trends Pharmacol Sci. 2008 Aug;29(8):413-20. doi: 10.1016/j.tips.2008.05.006. Epub 2008 Jul 6. Review.

24.

The importance of occupancy rather than affinity of CaV(beta) subunits for the calcium channel I-II linker in relation to calcium channel function.

Butcher AJ, Leroy J, Richards MW, Pratt WS, Dolphin AC.

J Physiol. 2006 Jul 15;574(Pt 2):387-98. Epub 2006 Apr 20.

25.

Phosphorylation sites on calcium channel alpha1 and beta subunits regulate ERK-dependent modulation of neuronal N-type calcium channels.

Martin SW, Butcher AJ, Berrow NS, Richards MW, Paddon RE, Turner DJ, Dolphin AC, Sihra TS, Fitzgerald EM.

Cell Calcium. 2006 Mar;39(3):275-92. Epub 2006 Jan 6.

PMID:
16406008
26.

Interaction via a key tryptophan in the I-II linker of N-type calcium channels is required for beta1 but not for palmitoylated beta2, implicating an additional binding site in the regulation of channel voltage-dependent properties.

Leroy J, Richards MW, Butcher AJ, Nieto-Rostro M, Pratt WS, Davies A, Dolphin AC.

J Neurosci. 2005 Jul 27;25(30):6984-96. Erratum in: J Neurosci. 2005 Oct 5;25(40):table of contents. Richards, Mark S [corrected to Richards, Mark W].

27.

Ca2+ channel beta-subunits: structural insights AID our understanding.

Richards MW, Butcher AJ, Dolphin AC.

Trends Pharmacol Sci. 2004 Dec;25(12):626-32. Review.

PMID:
15530640
28.

PI3K promotes voltage-dependent calcium channel trafficking to the plasma membrane.

Viard P, Butcher AJ, Halet G, Davies A, Nürnberg B, Heblich F, Dolphin AC.

Nat Neurosci. 2004 Sep;7(9):939-46. Epub 2004 Aug 15.

PMID:
15311280
29.

Dominant-negative calcium channel suppression by truncated constructs involves a kinase implicated in the unfolded protein response.

Page KM, Heblich F, Davies A, Butcher AJ, Leroy J, Bertaso F, Pratt WS, Dolphin AC.

J Neurosci. 2004 Jun 9;24(23):5400-9.

30.

Purification of the proline-rich homeodomain protein.

Butcher AJ, Gaston K, Jayaraman PS.

J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Mar 25;786(1-2):3-6.

PMID:
12650996
31.

Evidence for two concentration-dependent processes for beta-subunit effects on alpha1B calcium channels.

Cantí C, Davies A, Berrow NS, Butcher AJ, Page KM, Dolphin AC.

Biophys J. 2001 Sep;81(3):1439-51.

32.

Biophysical properties, pharmacology, and modulation of human, neuronal L-type (alpha(1D), Ca(V)1.3) voltage-dependent calcium currents.

Bell DC, Butcher AJ, Berrow NS, Page KM, Brust PF, Nesterova A, Stauderman KA, Seabrook GR, Nürnberg B, Dolphin AC.

J Neurophysiol. 2001 Feb;85(2):816-27.

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