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Items: 1 to 50 of 137

1.

YES1 Drives Lung Cancer Growth and Progression and Predicts Sensitivity to Dasatinib.

Garmendia I, Pajares MJ, Hermida-Prado F, Ajona D, Bértolo C, Sainz C, Lavín A, Remírez AB, Valencia K, Moreno H, Ferrer I, Behrens C, Cuadrado M, Paz-Ares L, Bustelo XR, Gil-Bazo I, Alameda D, Lecanda F, Calvo A, Felip E, Sánchez-Céspedes M, Wistuba II, Granda-Diaz R, Rodrigo JP, García-Pedrero JM, Pio R, Montuenga LM, Agorreta J.

Am J Respir Crit Care Med. 2019 Oct 1;200(7):888-899. doi: 10.1164/rccm.201807-1292OC.

PMID:
31166114
2.

The Vav GEF Family: An Evolutionary and Functional Perspective.

Rodríguez-Fdez S, Bustelo XR.

Cells. 2019 May 16;8(5). pii: E465. doi: 10.3390/cells8050465. Review.

3.

Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1.

Caloca MJ, Zugaza JL, Matallanas D, Crespo P, Bustelo XR.

EMBO J. 2019 Mar 1;38(5). pii: e101432. doi: 10.15252/embj.2018101432. No abstract available.

4.

Vagal afferents contribute to sympathoexcitation-driven metabolic dysfunctions.

Lorenzo-Martín LF, Menacho-Márquez M, Fabbiano S, Al-Massadi O, Abad A, Rodríguez-Fdez S, Sevilla MA, Montero MJ, Diéguez C, Nogueiras R, Bustelo XR.

J Endocrinol. 2019 Mar 1;240(3):483-496. doi: 10.1530/JOE-18-0623.

5.

Editorial overview: New concepts and experimental approaches to understand development, tissue regeneration, and human disease.

Röper K, Bustelo XR.

Curr Opin Cell Biol. 2018 Dec;55:iii-v. doi: 10.1016/j.ceb.2018.09.006. Epub 2018 Oct 1. No abstract available.

PMID:
30287131
6.

An unexpected tumor suppressor role for VAV1a.

Bustelo XR, Lorenzo-Martín LF, Cuadrado M, Fernández-Pisonero I, Robles-Valero J.

Mol Cell Oncol. 2018 Feb 23;5(3):e1432257. doi: 10.1080/23723556.2018.1432257. eCollection 2018.

7.

CANCERTOOL: A Visualization and Representation Interface to Exploit Cancer Datasets.

Cortazar AR, Torrano V, Martín-Martín N, Caro-Maldonado A, Camacho L, Hermanova I, Guruceaga E, Lorenzo-Martín LF, Caloto R, Gomis RR, Apaolaza I, Quesada V, Trka J, Gomez-Muñoz A, Vincent S, Bustelo XR, Planes FJ, Aransay AM, Carracedo A.

Cancer Res. 2018 Nov 1;78(21):6320-6328. doi: 10.1158/0008-5472.CAN-18-1669. Epub 2018 Sep 19.

PMID:
30232219
8.

RAS at the Golgi antagonizes malignant transformation through PTPRκ-mediated inhibition of ERK activation.

Casar B, Badrock AP, Jiménez I, Arozarena I, Colón-Bolea P, Lorenzo-Martín LF, Barinaga-Rementería I, Barriuso J, Cappitelli V, Donoghue DJ, Bustelo XR, Hurlstone A, Crespo P.

Nat Commun. 2018 Sep 5;9(1):3595. doi: 10.1038/s41467-018-05941-8.

9.

Protein-Protein Interactions: Emerging Oncotargets in the RAS-ERK Pathway.

García-Gómez R, Bustelo XR, Crespo P.

Trends Cancer. 2018 Sep;4(9):616-633. doi: 10.1016/j.trecan.2018.07.002. Epub 2018 Aug 9. Review.

PMID:
30149880
10.

Vav proteins maintain epithelial traits in breast cancer cells using miR-200c-dependent and independent mechanisms.

Lorenzo-Martín LF, Citterio C, Menacho-Márquez M, Conde J, Larive RM, Rodríguez-Fdez S, García-Escudero R, Robles-Valero J, Cuadrado M, Fernández-Pisonero I, Dosil M, Sevilla MA, Montero MJ, Fernández-Salguero PM, Paramio JM, Bustelo XR.

Oncogene. 2019 Jan;38(2):209-227. doi: 10.1038/s41388-018-0433-7. Epub 2018 Aug 7.

11.

RAS GTPase-dependent pathways in developmental diseases: old guys, new lads, and current challenges.

Bustelo XR, Crespo P, Fernández-Pisonero I, Rodríguez-Fdez S.

Curr Opin Cell Biol. 2018 Dec;55:42-51. doi: 10.1016/j.ceb.2018.06.007. Epub 2018 Jul 11. Review.

PMID:
30007125
12.

RHO GTPases in cancer: known facts, open questions, and therapeutic challenges.

Bustelo XR.

Biochem Soc Trans. 2018 Jun 19;46(3):741-760. doi: 10.1042/BST20170531. Epub 2018 Jun 5. Review.

PMID:
29871878
13.

Vav3-induced cytoskeletal dynamics contribute to heterotypic properties of endothelial barriers.

Hilfenhaus G, Nguyen DP, Freshman J, Prajapati D, Ma F, Song D, Ziyad S, Cuadrado M, Pellegrini M, Bustelo XR, Iruela-Arispe ML.

J Cell Biol. 2018 Aug 6;217(8):2813-2830. doi: 10.1083/jcb.201706041. Epub 2018 Jun 1.

14.

Differential Role of the RasGEFs Sos1 and Sos2 in Mouse Skin Homeostasis and Carcinogenesis.

Liceras-Boillos P, Jimeno D, García-Navas R, Lorenzo-Martín LF, Menacho-Marquez M, Segrelles C, Gómez C, Calzada N, Fuentes-Mateos R, Paramio JM, Bustelo XR, Baltanás FC, Santos E.

Mol Cell Biol. 2018 Jul 30;38(16). pii: e00049-18. doi: 10.1128/MCB.00049-18. Print 2018 Aug 15.

15.

R-Ras2 is required for germinal center formation to aid B cells during energetically demanding processes.

Mendoza P, Martínez-Martín N, Bovolenta ER, Reyes-Garau D, Hernansanz-Agustín P, Delgado P, Diaz-Muñoz MD, Oeste CL, Fernández-Pisonero I, Castellano E, Martínez-Ruiz A, Alonso-Lopez D, Santos E, Bustelo XR, Kurosaki T, Alarcón B.

Sci Signal. 2018 May 29;11(532). pii: eaal1506. doi: 10.1126/scisignal.aal1506.

PMID:
29844052
16.

New insights into the Vav1 activation cycle in lymphocytes.

Barreira M, Rodríguez-Fdez S, Bustelo XR.

Cell Signal. 2018 May;45:132-144. doi: 10.1016/j.cellsig.2018.01.026. Epub 2018 Feb 2.

PMID:
29410283
17.

Rho guanosine nucleotide exchange factors are not such bad guys after all in cancera.

Robles-Valero J, Lorenzo-Martín LF, Fernández-Pisonero I, Bustelo XR.

Small GTPases. 2018 Jan 24:1-7. doi: 10.1080/21541248.2018.1423851. [Epub ahead of print]

PMID:
29313423
18.

A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia.

Robles-Valero J, Lorenzo-Martín LF, Menacho-Márquez M, Fernández-Pisonero I, Abad A, Camós M, Toribio ML, Espinosa L, Bigas A, Bustelo XR.

Cancer Cell. 2017 Nov 13;32(5):608-623.e9. doi: 10.1016/j.ccell.2017.10.004.

19.

Lung regeneration after toxic injury is improved in absence of dioxin receptor.

Morales-Hernández A, Nacarino-Palma A, Moreno-Marín N, Barrasa E, Paniagua-Quiñones B, Catalina-Fernández I, Alvarez-Barrientos A, Bustelo XR, Merino JM, Fernández-Salguero PM.

Stem Cell Res. 2017 Dec;25:61-71. doi: 10.1016/j.scr.2017.10.009. Epub 2017 Oct 12.

20.

Ribosome biogenesis and cancer: basic and translational challenges.

Bustelo XR, Dosil M.

Curr Opin Genet Dev. 2018 Feb;48:22-29. doi: 10.1016/j.gde.2017.10.003. Epub 2017 Nov 5. Review.

PMID:
29100209
21.

Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis.

de Cárcer G, Wachowicz P, Martínez-Martínez S, Oller J, Méndez-Barbero N, Escobar B, González-Loyola A, Takaki T, El Bakkali A, Cámara JA, Jiménez-Borreguero LJ, Bustelo XR, Cañamero M, Mulero F, de Los Ángeles Sevilla M, Montero MJ, Redondo JM, Malumbres M.

Nat Med. 2017 Aug;23(8):964-974. doi: 10.1038/nm.4364. Epub 2017 Jul 10.

PMID:
28692064
22.

Focal accumulation of preribosomes outside the nucleolus during metaphase-anaphase in budding yeast.

Moriggi G, Gaspar SG, Nieto B, Bustelo XR, Dosil M.

RNA. 2017 Sep;23(9):1432-1443. doi: 10.1261/rna.061259.117. Epub 2017 Jun 6.

23.

Activating mutations and translocations in the guanine exchange factor VAV1 in peripheral T-cell lymphomas.

Abate F, da Silva-Almeida AC, Zairis S, Robles-Valero J, Couronne L, Khiabanian H, Quinn SA, Kim MY, Laginestra MA, Kim C, Fiore D, Bhagat G, Piris MA, Campo E, Lossos IS, Bernard OA, Inghirami G, Pileri S, Bustelo XR, Rabadan R, Ferrando AA, Palomero T.

Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):764-769. doi: 10.1073/pnas.1608839114. Epub 2017 Jan 6.

24.

Vav Proteins Are Key Regulators of Card9 Signaling for Innate Antifungal Immunity.

Roth S, Bergmann H, Jaeger M, Yeroslaviz A, Neumann K, Koenig PA, Prazeres da Costa C, Vanes L, Kumar V, Johnson M, Menacho-Márquez M, Habermann B, Tybulewicz VL, Netea M, Bustelo XR, Ruland J.

Cell Rep. 2016 Dec 6;17(10):2572-2583. doi: 10.1016/j.celrep.2016.11.018.

25.

H-Ras and K-Ras Oncoproteins Induce Different Tumor Spectra When Driven by the Same Regulatory Sequences.

Drosten M, Simón-Carrasco L, Hernández-Porras I, Lechuga CG, Blasco MT, Jacob HK, Fabbiano S, Potenza N, Bustelo XR, Guerra C, Barbacid M.

Cancer Res. 2017 Feb 1;77(3):707-718. doi: 10.1158/0008-5472.CAN-16-2925. Epub 2016 Nov 21.

26.

Characterization of Novel Molecular Mechanisms Favoring Rac1 Membrane Translocation.

Castro-Castro A, Muriel O, Del Pozo MA, Bustelo XR.

PLoS One. 2016 Nov 11;11(11):e0166715. doi: 10.1371/journal.pone.0166715. eCollection 2016.

27.

Immunosuppression-Independent Role of Regulatory T Cells against Hypertension-Driven Renal Dysfunctions.

Fabbiano S, Menacho-Márquez M, Robles-Valero J, Pericacho M, Matesanz-Marín A, García-Macías C, Sevilla MA, Montero MJ, Alarcón B, López-Novoa JM, Martín P, Bustelo XR.

Mol Cell Biol. 2015 Oct;35(20):3528-46. doi: 10.1128/MCB.00518-15. Epub 2015 Aug 3.

28.

Identification of a Vav2-dependent mechanism for GDNF/Ret control of mesolimbic DAT trafficking.

Zhu S, Zhao C, Wu Y, Yang Q, Shao A, Wang T, Wu J, Yin Y, Li Y, Hou J, Zhang X, Zhou G, Gu X, Wang X, Bustelo XR, Zhou J.

Nat Neurosci. 2015 Aug;18(8):1084-93. doi: 10.1038/nn.4060. Epub 2015 Jul 6.

PMID:
26147533
29.

The disease-linked Glu-26-Lys mutant version of Coronin 1A exhibits pleiotropic and pathway-specific signaling defects.

Ojeda V, Robles-Valero J, Barreira M, Bustelo XR.

Mol Biol Cell. 2015 Aug 15;26(16):2895-912. doi: 10.1091/mbc.E15-01-0052. Epub 2015 Jun 24.

30.

New avenue to inhibit Ras signaling.

Bustelo XR.

Chem Biol. 2014 Dec 18;21(12):1599-600. doi: 10.1016/j.chembiol.2014.12.001.

31.

Vav family exchange factors: an integrated regulatory and functional view.

Bustelo XR.

Small GTPases. 2014;5(2):9. doi: 10.4161/21541248.2014.973757. Review.

32.

K-RasV14I recapitulates Noonan syndrome in mice.

Hernández-Porras I, Fabbiano S, Schuhmacher AJ, Aicher A, Cañamero M, Cámara JA, Cussó L, Desco M, Heeschen C, Mulero F, Bustelo XR, Guerra C, Barbacid M.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16395-400. doi: 10.1073/pnas.1418126111. Epub 2014 Oct 30.

33.

Genetic dissection of the vav2-rac1 signaling axis in vascular smooth muscle cells.

Fabbiano S, Menacho-Márquez M, Sevilla MA, Albarrán-Juárez J, Zheng Y, Offermanns S, Montero MJ, Bustelo XR.

Mol Cell Biol. 2014 Dec;34(24):4404-19. doi: 10.1128/MCB.01066-14. Epub 2014 Oct 6.

34.

Coronin1 proteins dictate rac1 intracellular dynamics and cytoskeletal output.

Ojeda V, Castro-Castro A, Bustelo XR.

Mol Cell Biol. 2014 Sep 15;34(18):3388-406. doi: 10.1128/MCB.00347-14. Epub 2014 Jun 30.

35.

VAV3 mediates resistance to breast cancer endocrine therapy.

Aguilar H, Urruticoechea A, Halonen P, Kiyotani K, Mushiroda T, Barril X, Serra-Musach J, Islam A, Caizzi L, Di Croce L, Nevedomskaya E, Zwart W, Bostner J, Karlsson E, Pérez Tenorio G, Fornander T, Sgroi DC, Garcia-Mata R, Jansen MP, García N, Bonifaci N, Climent F, Soler MT, Rodríguez-Vida A, Gil M, Brunet J, Martrat G, Gómez-Baldó L, Extremera AI, Figueras A, Balart J, Clarke R, Burnstein KL, Carlson KE, Katzenellenbogen JA, Vizoso M, Esteller M, Villanueva A, Rodríguez-Peña AB, Bustelo XR, Nakamura Y, Zembutsu H, Stål O, Beijersbergen RL, Pujana MA.

Breast Cancer Res. 2014 May 28;16(3):R53. doi: 10.1186/bcr3664.

36.

Contribution of the R-Ras2 GTP-binding protein to primary breast tumorigenesis and late-stage metastatic disease.

Larive RM, Moriggi G, Menacho-Márquez M, Cañamero M, de Álava E, Alarcón B, Dosil M, Bustelo XR.

Nat Commun. 2014 May 14;5:3881. doi: 10.1038/ncomms4881.

37.

The C-terminal SH3 domain contributes to the intramolecular inhibition of Vav family proteins.

Barreira M, Fabbiano S, Couceiro JR, Torreira E, Martínez-Torrecuadrada JL, Montoya G, Llorca O, Bustelo XR.

Sci Signal. 2014 Apr 15;7(321):ra35. doi: 10.1126/scisignal.2004993.

PMID:
24736456
38.

The Rho exchange factors Vav2 and Vav3 favor skin tumor initiation and promotion by engaging extracellular signaling loops.

Menacho-Márquez M, García-Escudero R, Ojeda V, Abad A, Delgado P, Costa C, Ruiz S, Alarcón B, Paramio JM, Bustelo XR.

PLoS Biol. 2013 Jul;11(7):e1001615. doi: 10.1371/journal.pbio.1001615. Epub 2013 Jul 23.

39.

Chronic sympathoexcitation through loss of Vav3, a Rac1 activator, results in divergent effects on metabolic syndrome and obesity depending on diet.

Menacho-Márquez M, Nogueiras R, Fabbiano S, Sauzeau V, Al-Massadi O, Diéguez C, Bustelo XR.

Cell Metab. 2013 Aug 6;18(2):199-211. doi: 10.1016/j.cmet.2013.07.001.

40.

The dioxin receptor has tumor suppressor activity in melanoma growth and metastasis.

Contador-Troca M, Alvarez-Barrientos A, Barrasa E, Rico-Leo EM, Catalina-Fernández I, Menacho-Márquez M, Bustelo XR, García-Borrón JC, Gómez-Durán A, Sáenz-Santamaría J, Fernández-Salguero PM.

Carcinogenesis. 2013 Dec;34(12):2683-93. doi: 10.1093/carcin/bgt248. Epub 2013 Jul 10.

41.

Role of Src homology domain binding in signaling complexes assembled by the murid γ-herpesvirus M2 protein.

Pires de Miranda M, Lopes FB, McVey CE, Bustelo XR, Simas JP.

J Biol Chem. 2013 Feb 8;288(6):3858-70. doi: 10.1074/jbc.M112.439810. Epub 2012 Dec 20.

42.

The rho exchange factors vav2 and vav3 control a lung metastasis-specific transcriptional program in breast cancer cells.

Citterio C, Menacho-Márquez M, García-Escudero R, Larive RM, Barreiro O, Sánchez-Madrid F, Paramio JM, Bustelo XR.

Sci Signal. 2012 Oct 2;5(244):ra71. doi: 10.1126/scisignal.2002962.

43.

Expression of VAV1 in the tumour microenvironment of glioblastoma multiforme.

Garcia JL, Couceiro J, Gomez-Moreta JA, Gonzalez Valero JM, Briz AS, Sauzeau V, Lumbreras E, Delgado M, Robledo C, Almunia ML, Bustelo XR, Hernandez JM.

J Neurooncol. 2012 Oct;110(1):69-77. doi: 10.1007/s11060-012-0936-y. Epub 2012 Aug 4.

PMID:
22864683
44.

Rac-ing to the plasma membrane: the long and complex work commute of Rac1 during cell signaling.

Bustelo XR, Ojeda V, Barreira M, Sauzeau V, Castro-Castro A.

Small GTPases. 2012 Jan-Mar;3(1):60-6. doi: 10.4161/sgtp.19111.

45.

Intratumoral stages of metastatic cells: a synthesis of ontogeny, Rho/Rac GTPases, epithelial-mesenchymal transitions, and more.

Bustelo XR.

Bioessays. 2012 Sep;34(9):748-59. doi: 10.1002/bies.201200041. Epub 2012 Jun 18. Review.

46.

Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival.

Chang KH, Sanchez-Aguilera A, Shen S, Sengupta A, Madhu MN, Ficker AM, Dunn SK, Kuenzi AM, Arnett JL, Santho RA, Agirre X, Perentesis JP, Deininger MW, Zheng Y, Bustelo XR, Williams DA, Cancelas JA.

Blood. 2012 Jul 26;120(4):800-11. doi: 10.1182/blood-2011-06-361709. Epub 2012 Jun 12.

47.

The Ras-like protein R-Ras2/TC21 is important for proper mammary gland development.

Larive RM, Abad A, Cardaba CM, Hernández T, Cañamero M, de Álava E, Santos E, Alarcón B, Bustelo XR.

Mol Biol Cell. 2012 Jun;23(12):2373-87. doi: 10.1091/mbc.E12-01-0060. Epub 2012 Apr 25.

48.

Reduction of NADPH-oxidase activity ameliorates the cardiovascular phenotype in a mouse model of Williams-Beuren Syndrome.

Campuzano V, Segura-Puimedon M, Terrado V, Sánchez-Rodríguez C, Coustets M, Menacho-Márquez M, Nevado J, Bustelo XR, Francke U, Pérez-Jurado LA.

PLoS Genet. 2012 Feb;8(2):e1002458. doi: 10.1371/journal.pgen.1002458. Epub 2012 Feb 2.

49.

Coronin 1A promotes a cytoskeletal-based feedback loop that facilitates Rac1 translocation and activation.

Castro-Castro A, Ojeda V, Barreira M, Sauzeau V, Navarro-Lérida I, Muriel O, Couceiro JR, Pimentel-Muíños FX, Del Pozo MA, Bustelo XR.

EMBO J. 2011 Aug 26;30(19):3913-27. doi: 10.1038/emboj.2011.310.

50.

T cell receptor internalization from the immunological synapse is mediated by TC21 and RhoG GTPase-dependent phagocytosis.

Martínez-Martín N, Fernández-Arenas E, Cemerski S, Delgado P, Turner M, Heuser J, Irvine DJ, Huang B, Bustelo XR, Shaw A, Alarcón B.

Immunity. 2011 Aug 26;35(2):208-22. doi: 10.1016/j.immuni.2011.06.003. Epub 2011 Aug 4.

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