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Items: 34

1.

Author Correction: Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex.

Bussiere DE, Xie L, Srinivas H, Shu W, Burke A, Be C, Zhao J, Godbole A, King D, Karki RG, Hornak V, Xu F, Cobb J, Carte N, Frank AO, Frommlet A, Graff P, Knapp M, Fazal A, Okram B, Jiang S, Michellys PY, Beckwith R, Voshol H, Wiesmann C, Solomon JM, Paulk J.

Nat Chem Biol. 2020 Jan 15. doi: 10.1038/s41589-020-0471-7. [Epub ahead of print]

PMID:
31942047
2.

Discovery and optimization of novel pyridines as highly potent and selective glycogen synthase kinase 3 inhibitors.

Ramurthy S, Pfister KB, Boyce RS, Brown SP, Costales AQ, Desai MC, Fang E, Levine BH, Ng SC, Nuss JM, Ring DB, Shafer CM, Shu W, Subramanian S, Wagman AS, Wang H, Bussiere DE.

Bioorg Med Chem Lett. 2019 Dec 23:126930. doi: 10.1016/j.bmcl.2019.126930. [Epub ahead of print]

PMID:
31926786
3.

Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex.

Bussiere DE, Xie L, Srinivas H, Shu W, Burke A, Be C, Zhao J, Godbole A, King D, Karki RG, Hornak V, Xu F, Cobb J, Carte N, Frank AO, Frommlet A, Graff P, Knapp M, Fazal A, Okram B, Jiang S, Michellys PY, Beckwith R, Voshol H, Wiesmann C, Solomon JM, Paulk J.

Nat Chem Biol. 2020 Jan;16(1):15-23. doi: 10.1038/s41589-019-0411-6. Epub 2019 Dec 9. Erratum in: Nat Chem Biol. 2020 Jan 15;:.

PMID:
31819272
4.

Harnessing the anti-cancer natural product nimbolide for targeted protein degradation.

Spradlin JN, Hu X, Ward CC, Brittain SM, Jones MD, Ou L, To M, Proudfoot A, Ornelas E, Woldegiorgis M, Olzmann JA, Bussiere DE, Thomas JR, Tallarico JA, McKenna JM, Schirle M, Maimone TJ, Nomura DK.

Nat Chem Biol. 2019 Jul;15(7):747-755. doi: 10.1038/s41589-019-0304-8. Epub 2019 Jun 17.

5.

High-Confidence Protein-Ligand Complex Modeling by NMR-Guided Docking Enables Early Hit Optimization.

Proudfoot A, Bussiere DE, Lingel A.

J Am Chem Soc. 2017 Dec 13;139(49):17824-17833. doi: 10.1021/jacs.7b07171. Epub 2017 Nov 30.

PMID:
29190085
6.

Synthesis, Binding Mode, and Antihyperglycemic Activity of Potent and Selective (5-Imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine Inhibitors of Glycogen Synthase Kinase 3.

Wagman AS, Boyce RS, Brown SP, Fang E, Goff D, Jansen JM, Le VP, Levine BH, Ng SC, Ni ZJ, Nuss JM, Pfister KB, Ramurthy S, Renhowe PA, Ring DB, Shu W, Subramanian S, Zhou XA, Shafer CM, Harrison SD, Johnson KW, Bussiere DE.

J Med Chem. 2017 Oct 26;60(20):8482-8514. doi: 10.1021/acs.jmedchem.7b00922. Epub 2017 Oct 10.

PMID:
29016121
7.

Structural basis for therapeutic inhibition of influenza A polymerase PB2 subunit.

Ma X, Xie L, Wartchow C, Warne R, Xu Y, Rivkin A, Tully D, Shia S, Uehara K, Baldwin DM, Muiru G, Zhong W, Zaror I, Bussiere DE, Leonard VHJ.

Sci Rep. 2017 Aug 24;7(1):9385. doi: 10.1038/s41598-017-09538-x.

8.

Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED.

Li L, Zhang H, Zhang M, Zhao M, Feng L, Luo X, Gao Z, Huang Y, Ardayfio O, Zhang JH, Lin Y, Fan H, Mi Y, Li G, Liu L, Feng L, Luo F, Teng L, Qi W, Ottl J, Lingel A, Bussiere DE, Yu Z, Atadja P, Lu C, Li E, Gu J, Zhao K.

PLoS One. 2017 Jan 10;12(1):e0169855. doi: 10.1371/journal.pone.0169855. eCollection 2017.

9.

Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase.

Lingel A, Sendzik M, Huang Y, Shultz MD, Cantwell J, Dillon MP, Fu X, Fuller J, Gabriel T, Gu J, Jiang X, Li L, Liang F, McKenna M, Qi W, Rao W, Sheng X, Shu W, Sutton J, Taft B, Wang L, Zeng J, Zhang H, Zhang M, Zhao K, Lindvall M, Bussiere DE.

J Med Chem. 2017 Jan 12;60(1):415-427. doi: 10.1021/acs.jmedchem.6b01473. Epub 2017 Jan 3.

PMID:
27992714
10.

Molecular Basis of mRNA Cap Recognition by Influenza B Polymerase PB2 Subunit.

Xie L, Wartchow C, Shia S, Uehara K, Steffek M, Warne R, Sutton J, Muiru GT, Leonard VH, Bussiere DE, Ma X.

J Biol Chem. 2016 Jan 1;291(1):363-70. doi: 10.1074/jbc.M115.693051. Epub 2015 Nov 11.

11.

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.

Dowdle WE, Nyfeler B, Nagel J, Elling RA, Liu S, Triantafellow E, Menon S, Wang Z, Honda A, Pardee G, Cantwell J, Luu C, Cornella-Taracido I, Harrington E, Fekkes P, Lei H, Fang Q, Digan ME, Burdick D, Powers AF, Helliwell SB, D'Aquin S, Bastien J, Wang H, Wiederschain D, Kuerth J, Bergman P, Schwalb D, Thomas J, Ugwonali S, Harbinski F, Tallarico J, Wilson CJ, Myer VE, Porter JA, Bussiere DE, Finan PM, Labow MA, Mao X, Hamann LG, Manning BD, Valdez RA, Nicholson T, Schirle M, Knapp MS, Keaney EP, Murphy LO.

Nat Cell Biol. 2014 Nov;16(11):1069-79. doi: 10.1038/ncb3053. Epub 2014 Oct 19.

PMID:
25327288
12.

Targeting the purinome.

Murray JM, Bussiere DE.

Methods Mol Biol. 2009;575:47-92. doi: 10.1007/978-1-60761-274-2_3. Review.

PMID:
19727611
13.

Targeting cancer: the challenges and successes of structure-based drug design against the human purinome.

Knapp M, Bellamacina C, Murray JM, Bussiere DE.

Curr Top Med Chem. 2006;6(11):1129-59. Review.

PMID:
16842151
14.

4-(Aminoalkylamino)-3-benzimidazole-quinolinones as potent CHK-1 inhibitors.

Ni ZJ, Barsanti P, Brammeier N, Diebes A, Poon DJ, Ng S, Pecchi S, Pfister K, Renhowe PA, Ramurthy S, Wagman AS, Bussiere DE, Le V, Zhou Y, Jansen JM, Ma S, Gesner TG.

Bioorg Med Chem Lett. 2006 Jun 15;16(12):3121-4. Epub 2006 Apr 5.

PMID:
16603354
15.

Crystal structure of VC0702 at 2.0 A: conserved hypothetical protein from Vibrio cholerae.

Ni S, Forouhar F, Bussiere DE, Robinson H, Kennedy MA.

Proteins. 2006 Jun 1;63(4):733-41.

PMID:
16498616
16.

Structure of 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase from Shewanella oneidensis at 1.6 A: identification of farnesyl pyrophosphate trapped in a hydrophobic cavity.

Ni S, Robinson H, Marsing GC, Bussiere DE, Kennedy MA.

Acta Crystallogr D Biol Crystallogr. 2004 Nov;60(Pt 11):1949-57. Epub 2004 Oct 20.

PMID:
15502301
17.

Crystallization and preliminary crystallographic analysis of an Enterococcus faecalis repressor protein, CylR2, involved in regulating cytolysin production through quorum-sensing.

Ni S, McAteer K, Bussiere DE, Kennedy MA.

Acta Crystallogr D Biol Crystallogr. 2004 Jun;60(Pt 6):1145-8. Epub 2004 May 21.

PMID:
15159583
18.

Discovery and development of GSK3 inhibitors for the treatment of type 2 diabetes.

Wagman AS, Johnson KW, Bussiere DE.

Curr Pharm Des. 2004;10(10):1105-37. Review.

PMID:
15078145
19.

Structural and functional analysis of a bipolar replication terminus. Implications for the origin of polarity of fork arrest.

Mohanty BK, Bussiere DE, Sahoo T, Pai KS, Meijer WJ, Bron S, Bastia D.

J Biol Chem. 2001 Apr 20;276(16):13160-8. Epub 2001 Jan 16.

20.

The role of macromolecular crystallography and structure for drug discovery: advances and caveats.

Shiochet BK, Bussiere DE.

Curr Opin Drug Discov Devel. 2000 Jul;3(4):408-22.

PMID:
19649872
21.

Structural genomics in the post-genomics era - the shapes of things to come.

Peat TS, Newman JM, Bussiere DE.

Curr Opin Drug Discov Devel. 2000 Jul;3(4):399-407.

PMID:
19649871
22.

Termination of DNA replication of bacterial and plasmid chromosomes.

Bussiere DE, Bastia D.

Mol Microbiol. 1999 Mar;31(6):1611-8. Review.

23.

Structure of the E2 DNA-binding domain from human papillomavirus serotype 31 at 2.4 A.

Bussiere DE, Kong X, Egan DA, Walter K, Holzman TF, Lindh F, Robins T, Giranda VL.

Acta Crystallogr D Biol Crystallogr. 1998 Nov 1;54(Pt 6 Pt 2):1367-76.

PMID:
10089498
25.

The structure of VanX reveals a novel amino-dipeptidase involved in mediating transposon-based vancomycin resistance.

Bussiere DE, Pratt SD, Katz L, Severin JM, Holzman T, Park CH.

Mol Cell. 1998 Jul;2(1):75-84.

26.

Ribosomal proteins S5 and L6: high-resolution crystal structures and roles in protein synthesis and antibiotic resistance.

Davies C, Bussiere DE, Golden BL, Porter SJ, Ramakrishnan V, White SW.

J Mol Biol. 1998 Jun 19;279(4):873-88.

PMID:
9642068
27.

Crystal structure of ErmC', an rRNA methyltransferase which mediates antibiotic resistance in bacteria.

Bussiere DE, Muchmore SW, Dealwis CG, Schluckebier G, Nienaber VL, Edalji RP, Walter KA, Ladror US, Holzman TF, Abad-Zapatero C.

Biochemistry. 1998 May 19;37(20):7103-12.

PMID:
9585521
28.

Helicase-contrahelicase interaction and the mechanism of termination of DNA replication.

Manna AC, Pai KS, Bussiere DE, Davies C, White SW, Bastia D.

Cell. 1996 Nov 29;87(5):881-91.

29.

Structure of the replication terminus-terminator protein complex as probed by affinity cleavage.

Pai KS, Bussiere DE, Wang F, White SW, Bastia D.

Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10647-52.

30.
31.

The dimer-dimer interaction surface of the replication terminator protein of Bacillus subtilis and termination of DNA replication.

Manna AC, Pai KS, Bussiere DE, White SW, Bastia D.

Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3253-8.

32.

Crystal structure of the replication terminator protein from B. subtilis at 2.6 A.

Bussiere DE, Bastia D, White SW.

Cell. 1995 Feb 24;80(4):651-60.

33.

Crystallization and preliminary structural analysis of the replication terminator protein of Bacillus subtilis.

Mehta PP, Bussiere DE, Hoffman DW, Bastia D, White SW.

J Biol Chem. 1992 Sep 15;267(26):18885-9.

34.

The biosynthesis of lipoic acid. Cloning of lip, a lipoate biosynthetic locus of Escherichia coli.

Hayden MA, Huang I, Bussiere DE, Ashley GW.

J Biol Chem. 1992 May 15;267(14):9512-5.

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