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The triacylglycerol, hydroxytriolein, inhibits triple negative mammary breast cancer cell proliferation through a mechanism dependent on dihydroceramide and Akt.

Guardiola-Serrano F, Beteta-Göbel R, Rodríguez-Lorca R, Ibarguren M, López DJ, Terés S, Alonso-Sande M, Higuera M, Torres M, Busquets X, Escribá PV.

Oncotarget. 2019 Apr 2;10(26):2486-2507. doi: 10.18632/oncotarget.26824. eCollection 2019 Apr 2.


The Opposing Contribution of SMS1 and SMS2 to Glioma Progression and Their Value in the Therapeutic Response to 2OHOA.

Fernández-García P, Rosselló CA, Rodríguez-Lorca R, Beteta-Göbel R, Fernández-Díaz J, Lladó V, Busquets X, Escribá PV.

Cancers (Basel). 2019 Jan 14;11(1). pii: E88. doi: 10.3390/cancers11010088.


Treatment with albumin-hydroxyoleic acid complex restores sensorimotor function in rats with spinal cord injury: Efficacy and gene expression regulation.

Avila-Martin G, Mata-Roig M, Galán-Arriero I, Taylor JS, Busquets X, Escribá PV.

PLoS One. 2017 Dec 15;12(12):e0189151. doi: 10.1371/journal.pone.0189151. eCollection 2017.


Triacylglycerol mimetics regulate membrane interactions of glycogen branching enzyme: implications for therapy.

Alvarez R, Casas J, López DJ, Ibarguren M, Suari-Rivera A, Terés S, Guardiola-Serrano F, Lossos A, Busquets X, Kakhlon O, Escribá PV.

J Lipid Res. 2017 Aug;58(8):1598-1612. doi: 10.1194/jlr.M075531. Epub 2017 Jun 19.


G protein-membrane interactions II: Effect of G protein-linked lipids on membrane structure and G protein-membrane interactions.

Casas J, Ibarguren M, Álvarez R, Terés S, Lladó V, Piotto SP, Concilio S, Busquets X, López DJ, Escribá PV.

Biochim Biophys Acta Biomembr. 2017 Sep;1859(9 Pt B):1526-1535. doi: 10.1016/j.bbamem.2017.04.005. Epub 2017 Apr 11.


Neuroprotective effect of 2-hydroxy arachidonic acid in a rat model of transient middle cerebral artery occlusion.

Ugidos IF, Santos-Galdiano M, Pérez-Rodríguez D, Anuncibay-Soto B, Font-Belmonte E, López DJ, Ibarguren M, Busquets X, Fernández-López A.

Biochim Biophys Acta Biomembr. 2017 Sep;1859(9 Pt B):1648-1656. doi: 10.1016/j.bbamem.2017.03.009. Epub 2017 Mar 14.


The hydroxylated form of docosahexaenoic acid (DHA-H) modifies the brain lipid composition in a model of Alzheimer's disease, improving behavioral motor function and survival.

Mohaibes RJ, Fiol-deRoque MA, Torres M, Ordinas M, López DJ, Castro JA, Escribá PV, Busquets X.

Biochim Biophys Acta Biomembr. 2017 Sep;1859(9 Pt B):1596-1603. doi: 10.1016/j.bbamem.2017.02.020. Epub 2017 Mar 9.


Role of the C-terminal basic amino acids and the lipid anchor of the Gγ2 protein in membrane interactions and cell localization.

Noguera-Salvà MA, Guardiola-Serrano F, Martin ML, Marcilla-Etxenike A, Bergo MO, Busquets X, Escribá PV.

Biochim Biophys Acta Biomembr. 2017 Sep;1859(9 Pt B):1536-1547. doi: 10.1016/j.bbamem.2017.02.012. Epub 2017 Feb 21.


Corrigendum to "G protein-membrane interactions I: Gαi1 myristoyl and palmitoyl modifications in protein-lipid interactions and its implications in membrane microdomain localization" [Biochim. Biophys. Acta 1851/11 (2015) 1511-1520].

Alvarez R, López DJ, Casas J, Lladó V, Higuera M, Nagy T, Barceló M, Busquets X, Escribá PV.

Biochim Biophys Acta. 2016 Jan;1861(1):68. doi: 10.1016/j.bbalip.2015.10.006. Epub 2015 Nov 10. No abstract available.


Haemophilus influenzae induces steroid-resistant inflammatory responses in COPD.

Cosío BG, Jahn A, Iglesias A, Shafiek H, Busquets X, Agustí A.

BMC Pulm Med. 2015 Dec 7;15:157. doi: 10.1186/s12890-015-0155-3.


G protein-membrane interactions I: Gαi1 myristoyl and palmitoyl modifications in protein-lipid interactions and its implications in membrane microdomain localization.

Álvarez R, López DJ, Casas J, Lladó V, Higuera M, Nagy T, Barceló M, Busquets X, Escribá PV.

Biochim Biophys Acta. 2015 Nov;1851(11):1511-20. doi: 10.1016/j.bbalip.2015.08.001. Epub 2015 Aug 4.


The Novel Anticancer Drug Hydroxytriolein Inhibits Lung Cancer Cell Proliferation via a Protein Kinase Cα- and Extracellular Signal-Regulated Kinase 1/2-Dependent Mechanism.

Guardiola-Serrano F, Beteta-Göbel R, Rodríguez-Lorca R, Ibarguren M, López DJ, Terés S, Alvarez R, Alonso-Sande M, Busquets X, Escribá PV.

J Pharmacol Exp Ther. 2015 Aug;354(2):213-24. doi: 10.1124/jpet.114.222281. Epub 2015 Jun 11.


Membrane lipid therapy: Modulation of the cell membrane composition and structure as a molecular base for drug discovery and new disease treatment.

Escribá PV, Busquets X, Inokuchi J, Balogh G, Török Z, Horváth I, Harwood JL, Vígh L.

Prog Lipid Res. 2015 Jul;59:38-53. doi: 10.1016/j.plipres.2015.04.003. Epub 2015 May 9. Review.


The unfolded protein response in the therapeutic effect of hydroxy-DHA against Alzheimer's disease.

Torres M, Marcilla-Etxenike A, Fiol-deRoque MA, Escribá PV, Busquets X.

Apoptosis. 2015 May;20(5):712-24. doi: 10.1007/s10495-015-1099-z.


Oral 2-hydroxyoleic acid inhibits reflex hypersensitivity and open-field-induced anxiety after spared nerve injury.

Avila-Martin G, Galan-Arriero I, Ferrer-Donato A, Busquets X, Gomez-Soriano J, Escribá PV, Taylor J.

Eur J Pain. 2015 Jan;19(1):111-22. doi: 10.1002/ejp.528. Epub 2014 May 13.


Regulation of the cancer cell membrane lipid composition by NaCHOleate: effects on cell signaling and therapeutical relevance in glioma.

Lladó V, López DJ, Ibarguren M, Alonso M, Soriano JB, Escribá PV, Busquets X.

Biochim Biophys Acta. 2014 Jun;1838(6):1619-27. doi: 10.1016/j.bbamem.2014.01.027. Epub 2014 Feb 10. Review.


The effect of hydroxylated fatty acid-containing phospholipids in the remodeling of lipid membranes.

Piotto S, Trapani A, Bianchino E, Ibarguren M, López DJ, Busquets X, Concilio S.

Biochim Biophys Acta. 2014 Jun;1838(6):1509-17. doi: 10.1016/j.bbamem.2014.01.014. Epub 2014 Jan 24. Review.


Differential effect of 2-hydroxyoleic acid enantiomers on protein (sphingomyelin synthase) and lipid (membrane) targets.

Piotto S, Concilio S, Bianchino E, Iannelli P, López DJ, Terés S, Ibarguren M, Barceló-Coblijn G, Martin ML, Guardiola-Serrano F, Alonso-Sande M, Funari SS, Busquets X, Escribá PV.

Biochim Biophys Acta. 2014 Jun;1838(6):1628-37. doi: 10.1016/j.bbamem.2013.12.023. Epub 2014 Jan 9.


Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer's disease.

Torres M, Price SL, Fiol-Deroque MA, Marcilla-Etxenike A, Ahyayauch H, Barceló-Coblijn G, Terés S, Katsouri L, Ordinas M, López DJ, Ibarguren M, Goñi FM, Busquets X, Vitorica J, Sastre M, Escribá PV.

Biochim Biophys Acta. 2014 Jun;1838(6):1680-92. doi: 10.1016/j.bbamem.2013.12.016. Epub 2013 Dec 27.


Cognitive recovery and restoration of cell proliferation in the dentate gyrus in the 5XFAD transgenic mice model of Alzheimer's disease following 2-hydroxy-DHA treatment.

Fiol-deRoque MA, Gutierrez-Lanza R, Terés S, Torres M, Barceló P, Rial RV, Verkhratsky A, Escribá PV, Busquets X, Rodríguez JJ.

Biogerontology. 2013 Dec;14(6):763-75. doi: 10.1007/s10522-013-9461-4. Epub 2013 Oct 10.


Description of extreme longevity in the Balearic Islands: Exploring a potential Blue Zone in Menorca, Spain.

Soriano JB, Fernández Vázquez S, Carretero S, Puga González MD, Soriano C, Romaguera D, Alonso-Fernández A, Busquets X, Balcells S, Grinberg D, Poulain M.

Geriatr Gerontol Int. 2014 Jul;14(3):620-7. doi: 10.1111/ggi.12148. Epub 2013 Sep 30.


2-hydroxy arachidonic acid: a new non-steroidal anti-inflammatory drug.

Lopez DH, Fiol-deRoque MA, Noguera-Salvà MA, Terés S, Campana F, Piotto S, Castro JA, Mohaibes RJ, Escribá PV, Busquets X.

PLoS One. 2013 Aug 27;8(8):e72052. doi: 10.1371/journal.pone.0072052. eCollection 2013.


Partitioning of liquid-ordered/liquid-disordered membrane microdomains induced by the fluidifying effect of 2-hydroxylated fatty acid derivatives.

Ibarguren M, López DJ, Encinar JA, González-Ros JM, Busquets X, Escribá PV.

Biochim Biophys Acta. 2013 Nov;1828(11):2553-63. doi: 10.1016/j.bbamem.2013.06.014. Epub 2013 Jun 18.


Patients attended by palliative care teams: are they always comparable populations?

Nabal M, Barcons M, Moreno R, Busquets X, Trujillano JJ, Requena A.

Springerplus. 2013 Apr 22;2(1):177. doi: 10.1186/2193-1801-2-177. Print 2013 Dec.


Sustained activation of sphingomyelin synthase by 2-hydroxyoleic acid induces sphingolipidosis in tumor cells.

Martin ML, Liebisch G, Lehneis S, Schmitz G, Alonso-Sande M, Bestard-Escalas J, Lopez DH, García-Verdugo JM, Soriano-Navarro M, Busquets X, Escribá PV, Barceló-Coblijn G.

J Lipid Res. 2013 May;54(5):1457-65. doi: 10.1194/jlr.M036749. Epub 2013 Mar 7.


The role of membrane fatty acid remodeling in the antitumor mechanism of action of 2-hydroxyoleic acid.

Martin ML, Barceló-Coblijn G, de Almeida RF, Noguera-Salvà MA, Terés S, Higuera M, Liebisch G, Schmitz G, Busquets X, Escribá PV.

Biochim Biophys Acta. 2013 May;1828(5):1405-13. doi: 10.1016/j.bbamem.2013.01.013. Epub 2013 Jan 27.


2-Hydroxyoleic acid induces ER stress and autophagy in various human glioma cell lines.

Marcilla-Etxenike A, Martín ML, Noguera-Salvà MA, García-Verdugo JM, Soriano-Navarro M, Dey I, Escribá PV, Busquets X.

PLoS One. 2012;7(10):e48235. doi: 10.1371/journal.pone.0048235. Epub 2012 Oct 25.


Normalization of sphingomyelin levels by 2-hydroxyoleic acid induces autophagic cell death of SF767 cancer cells.

Terés S, Lladó V, Higuera M, Barceló-Coblijn G, Martin ML, Noguera-Salvà MA, Marcilla-Etxenike A, García-Verdugo JM, Soriano-Navarro M, Saus C, Gómez-Pinedo U, Busquets X, Escribá PV.

Autophagy. 2012 Oct;8(10):1542-4. doi: 10.4161/auto.21341. Epub 2012 Aug 15.


2-Hydroxyoleate, a nontoxic membrane binding anticancer drug, induces glioma cell differentiation and autophagy.

Terés S, Lladó V, Higuera M, Barceló-Coblijn G, Martin ML, Noguera-Salvà MA, Marcilla-Etxenike A, García-Verdugo JM, Soriano-Navarro M, Saus C, Gómez-Pinedo U, Busquets X, Escribá PV.

Proc Natl Acad Sci U S A. 2012 May 29;109(22):8489-94. doi: 10.1073/pnas.1118349109. Epub 2012 May 14.


Pivotal role of dihydrofolate reductase knockdown in the anticancer activity of 2-hydroxyoleic acid.

Lladó V, Terés S, Higuera M, Alvarez R, Noguera-Salva MA, Halver JE, Escribá PV, Busquets X.

Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13754-8. doi: 10.1073/pnas.0907300106. Epub 2009 Aug 3.


Minerval induces apoptosis in Jurkat and other cancer cells.

Llado V, Gutierrez A, Martínez J, Casas J, Terés S, Higuera M, Galmés A, Saus C, Besalduch J, Busquets X, Escribá PV.

J Cell Mol Med. 2010 Mar;14(3):659-70. doi: 10.1111/j.1582-4934.2008.00625.x. Epub 2008 Dec 24.


Membranes: a meeting point for lipids, proteins and therapies.

Escribá PV, González-Ros JM, Goñi FM, Kinnunen PK, Vigh L, Sánchez-Magraner L, Fernández AM, Busquets X, Horváth I, Barceló-Coblijn G.

J Cell Mol Med. 2008 Jun;12(3):829-75. doi: 10.1111/j.1582-4934.2008.00281.x. Epub 2008 Feb 8. Review.


Angiotensin-converting-enzyme gene polymorphisms, smoking and chronic obstructive pulmonary disease.

Busquets X, MacFarlane NG, Heine-Suñer D, Morlá M, Torres-Juan L, Iglesias A, Lladó J, Sauleda J, Agustí AG.

Int J Chron Obstruct Pulmon Dis. 2007;2(3):329-34.


Mutations in TBX1 genocopy the 22q11.2 deletion and duplication syndromes: a new susceptibility factor for mental retardation.

Torres-Juan L, Rosell J, Morla M, Vidal-Pou C, García-Algas F, de la Fuente MA, Juan M, Tubau A, Bachiller D, Bernues M, Perez-Granero A, Govea N, Busquets X, Heine-Suñer D.

Eur J Hum Genet. 2007 Jun;15(6):658-63. Epub 2007 Mar 21.


[Reduced expression of the sarcoplasmic calcium pump SERCA2 in skeletal muscle from patients with chronic obstructive pulmonary disease and low body weight].

Morlà M, Iglesias A, Sauleda J, Cosio B, Agustí A, Busquets X.

Arch Bronconeumol. 2007 Jan;43(1):4-8. Spanish.


Telomere shortening in smokers with and without COPD.

Morlá M, Busquets X, Pons J, Sauleda J, MacNee W, Agustí AG.

Eur Respir J. 2006 Mar;27(3):525-8.


IFN-gamma prevents TNF-alpha-induced apoptosis in C2C12 myotubes through down-regulation of TNF-R2 and increased NF-kappaB activity.

Tolosa L, Morlá M, Iglesias A, Busquets X, Lladó J, Olmos G.

Cell Signal. 2005 Nov;17(11):1333-42. Epub 2005 Mar 29.


Decreased plasma levels of orexin-A in sleep apnea.

Busquets X, Barbé F, Barceló A, de la Peña M, Sigritz N, Mayoralas LR, Ladaria A, Agustí A.

Respiration. 2004 Nov-Dec;71(6):575-9.


NF-kappaB activation and iNOS upregulation in skeletal muscle of patients with COPD and low body weight.

Agustí A, Morlá M, Sauleda J, Saus C, Busquets X.

Thorax. 2004 Jun;59(6):483-7.


Fragile-X syndrome and skewed X-chromosome inactivation within a family: a female member with complete inactivation of the functional X chromosome.

Heine-Suñer D, Torres-Juan L, Morlà M, Busquets X, Barceló F, Picó G, Bonilla L, Govea N, Bernués M, Rosell J.

Am J Med Genet A. 2003 Oct 1;122A(2):108-14.


Systemic effects of chronic obstructive pulmonary disease.

Agustí AG, Noguera A, Sauleda J, Sala E, Pons J, Busquets X.

Eur Respir J. 2003 Feb;21(2):347-60. Review.


Weight loss in chronic obstructive pulmonary disease. Mechanisms and implications.

Agust AG, Gari PG, Sauleda J, Busquets X.

Pulm Pharmacol Ther. 2002;15(5):425-32. Review.


Skeletal muscle apoptosis and weight loss in chronic obstructive pulmonary disease.

Agustí AG, Sauleda J, Miralles C, Gomez C, Togores B, Sala E, Batle S, Busquets X.

Am J Respir Crit Care Med. 2002 Aug 15;166(4):485-9.


[Systemic inflammation during exacerbations of chronic obstructive pulmonary disease].

Malo O, Sauleda J, Busquets X, Miralles C, Agustí AG, Noguera A.

Arch Bronconeumol. 2002 Apr;38(4):172-6. Spanish.


[Gene chip (DNA array): the future is now!].

Busquets X, Agustí A.

Arch Bronconeumol. 2001 Oct;37(9):394-6. Spanish. No abstract available.


[Skeletal muscle dysfunction in COPD. Cell mechanisms. A.G.N].

Agustí A, Sauleda J, Morlá M, Miralles C, Busquets X.

Arch Bronconeumol. 2001 Apr;37(4):197-205. Spanish. No abstract available.


Enhanced neutrophil response in chronic obstructive pulmonary disease.

Noguera A, Batle S, Miralles C, Iglesias J, Busquets X, MacNee W, Agustí AG.

Thorax. 2001 Jun;56(6):432-7.


Changes induced by oxygen in rat liver proteins identified by high-resolution two-dimensional gel electrophoresis.

Miralles C, Agustí AG, Aubry C, Sanchez JC, Walzer C, Hochstrasser D, Busquets X.

Eur J Biochem. 2000 Sep;267(17):5580-4.


Regulation of iNOS expression and glutathione levels in rat liver by oxygen tension.

Miralles C, Busquets X, Santos C, Togores B, Hussain S, Rahman I, MacNee W, Agustí AG.

FEBS Lett. 2000 Jul 7;476(3):253-7.

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