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Infusions of Large Synthetic HDL Containing Trimeric apoA-I Stabilize Atherosclerotic Plaques in Hypercholesterolemic Rabbits.

Parolini C, Adorni MP, Busnelli M, Manzini S, Cipollari E, Favari E, Lorenzon P, Ganzetti GS, Fingerle J, Bernini F, Chiesa G.

Can J Cardiol. 2019 May 30. pii: S0828-282X(19)30379-4. doi: 10.1016/j.cjca.2019.05.033. [Epub ahead of print]


Impact of PPAR-Alpha Polymorphisms-The Case of Metabolic Disorders and Atherosclerosis.

Ruscica M, Busnelli M, Runfola E, Corsini A, Sirtori CR.

Int J Mol Sci. 2019 Sep 6;20(18). pii: E4378. doi: 10.3390/ijms20184378. Review.


Impaired approach to novelty and striatal alterations in the oxytocin receptor deficient mouse model of autism.

Leonzino M, Ponzoni L, Braida D, Gigliucci V, Busnelli M, Ceresini I, Duque-Wilckens N, Nishimori K, Trainor BC, Sala M, Chini B.

Horm Behav. 2019 Aug;114:104543. doi: 10.1016/j.yhbeh.2019.06.007. Epub 2019 Jul 19.


Topiramate protects apoE-deficient mice from kidney damage without affecting plasma lipids.

Manzini S, Busnelli M, Parolini C, Minoli L, Ossoli A, Brambilla E, Simonelli S, Lekka E, Persidis A, Scanziani E, Chiesa G.

Pharmacol Res. 2019 Mar;141:189-200. doi: 10.1016/j.phrs.2018.12.022. Epub 2018 Dec 26.


Effects of Vegetable Proteins on Hypercholesterolemia and Gut Microbiota Modulation.

Busnelli M, Manzini S, Sirtori CR, Chiesa G, Parolini C.

Nutrients. 2018 Sep 6;10(9). pii: E1249. doi: 10.3390/nu10091249. Review.


Lipid phosphate phosphatase 3 in vascular pathophysiology.

Busnelli M, Manzini S, Parolini C, Escalante-Alcalde D, Chiesa G.

Atherosclerosis. 2018 Apr;271:156-165. doi: 10.1016/j.atherosclerosis.2018.02.025. Epub 2018 Mar 2. Review.


Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species.

Muttenthaler M, Andersson Å, Vetter I, Menon R, Busnelli M, Ragnarsson L, Bergmayr C, Arrowsmith S, Deuis JR, Chiu HS, Palpant NJ, O'Brien M, Smith TJ, Wray S, Neumann ID, Gruber CW, Lewis RJ, Alewood PF.

Sci Signal. 2017 Dec 5;10(508). pii: eaan3398. doi: 10.1126/scisignal.aan3398.


Oxytocin Receptors in the Anteromedial Bed Nucleus of the Stria Terminalis Promote Stress-Induced Social Avoidance in Female California Mice.

Duque-Wilckens N, Steinman MQ, Busnelli M, Chini B, Yokoyama S, Pham M, Laredo SA, Hao R, Perkeybile AM, Minie VA, Tan PB, Bales KL, Trainor BC.

Biol Psychiatry. 2018 Feb 1;83(3):203-213. doi: 10.1016/j.biopsych.2017.08.024. Epub 2017 Sep 14. Erratum in: Biol Psychiatry. 2018 Feb 1;83(3):296.


Effect of Dietary Components from Antarctic Krill on Atherosclerosis in apoE-Deficient Mice.

Parolini C, Bjorndal B, Busnelli M, Manzini S, Ganzetti GS, Dellera F, Ramsvik M, Bruheim I, Berge RK, Chiesa G.

Mol Nutr Food Res. 2017 Dec;61(12). doi: 10.1002/mnfr.201700098. Epub 2017 Nov 7.


Molecular Basis of Oxytocin Receptor Signalling in the Brain: What We Know and What We Need to Know.

Busnelli M, Chini B.

Curr Top Behav Neurosci. 2018;35:3-29. doi: 10.1007/7854_2017_6. Review.


Liver-specific deletion of the Plpp3 gene alters plasma lipid composition and worsens atherosclerosis in apoE-/- mice.

Busnelli M, Manzini S, Hilvo M, Parolini C, Ganzetti GS, Dellera F, Ekroos K, Jänis M, Escalante-Alcalde D, Sirtori CR, Laaksonen R, Chiesa G.

Sci Rep. 2017 Mar 14;7:44503. doi: 10.1038/srep44503.


Impaired thromboxane receptor dimerization reduces signaling efficiency: A potential mechanism for reduced platelet function in vivo.

Capra V, Mauri M, Guzzi F, Busnelli M, Accomazzo MR, Gaussem P, Nisar SP, Mundell SJ, Parenti M, Rovati GE.

Biochem Pharmacol. 2017 Jan 15;124:43-56. doi: 10.1016/j.bcp.2016.11.010. Epub 2016 Nov 11.


Design and Characterization of Superpotent Bivalent Ligands Targeting Oxytocin Receptor Dimers via a Channel-Like Structure.

Busnelli M, Kleinau G, Muttenthaler M, Stoev S, Manning M, Bibic L, Howell LA, McCormick PJ, Di Lascio S, Braida D, Sala M, Rovati GE, Bellini T, Chini B.

J Med Chem. 2016 Aug 11;59(15):7152-66. doi: 10.1021/acs.jmedchem.6b00564. Epub 2016 Jul 28.


Nutraceuticals and Bioactive Components from Fish for Dyslipidemia and Cardiovascular Risk Reduction.

Chiesa G, Busnelli M, Manzini S, Parolini C.

Mar Drugs. 2016 Jun 8;14(6). pii: E113. doi: 10.3390/md14060113. Review.


L-homoarginine administration reduces neointimal hyperplasia in balloon-injured rat carotids.

Dellera F, Ganzetti GS, Froio A, Manzini S, Busnelli M, Meinitzer A, Sirtori CR, Chiesa G, Parolini C.

Thromb Haemost. 2016 Aug 1;116(2):400-2. doi: 10.1160/TH15-10-0831. Epub 2016 Jun 9. No abstract available.


The Timing of the Excitatory-to-Inhibitory GABA Switch Is Regulated by the Oxytocin Receptor via KCC2.

Leonzino M, Busnelli M, Antonucci F, Verderio C, Mazzanti M, Chini B.

Cell Rep. 2016 Apr 5;15(1):96-103. doi: 10.1016/j.celrep.2016.03.013. Epub 2016 Mar 24.


A New Population of Parvocellular Oxytocin Neurons Controlling Magnocellular Neuron Activity and Inflammatory Pain Processing.

Eliava M, Melchior M, Knobloch-Bollmann HS, Wahis J, da Silva Gouveia M, Tang Y, Ciobanu AC, Triana Del Rio R, Roth LC, Althammer F, Chavant V, Goumon Y, Gruber T, Petit-Demoulière N, Busnelli M, Chini B, Tan LL, Mitre M, Froemke RC, Chao MV, Giese G, Sprengel R, Kuner R, Poisbeau P, Seeburg PH, Stoop R, Charlet A, Grinevich V.

Neuron. 2016 Mar 16;89(6):1291-1304. doi: 10.1016/j.neuron.2016.01.041. Epub 2016 Mar 3.


Analysis of G Protein and β-Arrestin Activation in Chemokine Receptors Signaling.

Vacchini A, Busnelli M, Chini B, Locati M, Borroni EM.

Methods Enzymol. 2016;570:421-40. doi: 10.1016/bs.mie.2015.09.016. Epub 2015 Nov 14.


Carbetocin is a Functional Selective Gq Agonist That Does Not Promote Oxytocin Receptor Recycling After Inducing β-Arrestin-Independent Internalisation.

Passoni I, Leonzino M, Gigliucci V, Chini B, Busnelli M.

J Neuroendocrinol. 2016 Apr;28(4). doi: 10.1111/jne.12363.


Unaltered Oxytocin and Vasopressin Plasma Levels in Patients with Schizophrenia After 4 Months of Daily Treatment with Intranasal Oxytocin.

Busnelli M, Dagani J, de Girolamo G, Balestrieri M, Pini S, Saviotti FM, Scocco P, Sisti D, Rocchi M, Chini B.

J Neuroendocrinol. 2016 Apr;28(4). doi: 10.1111/jne.12359.


Beta2-adrenergic activity modulates vascular tone regulation in lecithin:cholesterol acyltransferase knockout mice.

Manzini S, Pinna C, Busnelli M, Cinquanta P, Rigamonti E, Ganzetti GS, Dellera F, Sala A, Calabresi L, Franceschini G, Parolini C, Chiesa G.

Vascul Pharmacol. 2015 Nov;74:114-121. doi: 10.1016/j.vph.2015.08.006. Epub 2015 Aug 5.


High-density lipoprotein deficiency in genetically modified mice deeply affects skin morphology: A structural and ultrastructural study.

Arnaboldi F, Busnelli M, Cornaghi L, Manzini S, Parolini C, Dellera F, Ganzetti GS, Sirtori CR, Donetti E, Chiesa G.

Exp Cell Res. 2015 Oct 15;338(1):105-12. doi: 10.1016/j.yexcr.2015.07.032. Epub 2015 Aug 1.


Assembling the Puzzle: Pathways of Oxytocin Signaling in the Brain.

Grinevich V, Knobloch-Bollmann HS, Eliava M, Busnelli M, Chini B.

Biol Psychiatry. 2016 Feb 1;79(3):155-64. doi: 10.1016/j.biopsych.2015.04.013. Epub 2015 Apr 25. Review.


Region specific up-regulation of oxytocin receptors in the opioid oprm1 (-/-) mouse model of autism.

Gigliucci V, Leonzino M, Busnelli M, Luchetti A, Palladino VS, D'Amato FR, Chini B.

Front Pediatr. 2014 Sep 1;2:91. doi: 10.3389/fped.2014.00091. eCollection 2014.


A salmon protein hydrolysate exerts lipid-independent anti-atherosclerotic activity in ApoE-deficient mice.

Parolini C, Vik R, Busnelli M, Bjørndal B, Holm S, Brattelid T, Manzini S, Ganzetti GS, Dellera F, Halvorsen B, Aukrust P, Sirtori CR, Nordrehaug JE, Skorve J, Berge RK, Chiesa G.

PLoS One. 2014 May 19;9(5):e97598. doi: 10.1371/journal.pone.0097598. eCollection 2014.


Magnetic resonance imaging visualization of vulnerable atherosclerotic plaques at the brachiocephalic artery of apolipoprotein E knockout mice by the blood-pool contrast agent B22956/1.

Parolini C, Busnelli M, Ganzetti GS, Dellera F, Manzini S, Scanziani E, Johnson JL, Sirtori CR, Chiesa G.

Mol Imaging. 2014;13. doi: 10.2310/7290.2014.00012.


An immunomodulating fatty acid analogue targeting mitochondria exerts anti-atherosclerotic effect beyond plasma cholesterol-lowering activity in apoe(-/-) mice.

Vik R, Busnelli M, Parolini C, Bjørndal B, Holm S, Bohov P, Halvorsen B, Brattelid T, Manzini S, Ganzetti GS, Dellera F, Nygård OK, Aukrust P, Sirtori CR, Chiesa G, Berge RK.

PLoS One. 2013 Dec 4;8(12):e81963. doi: 10.1371/journal.pone.0081963. eCollection 2013.


Germline prokineticin receptor 2 (PROKR2) variants associated with central hypogonadism cause differental modulation of distinct intracellular pathways.

Libri DV, Kleinau G, Vezzoli V, Busnelli M, Guizzardi F, Sinisi AA, Pincelli AI, Mancini A, Russo G, Beck-Peccoz P, Loche S, Crivellaro C, Maghnie M, Krausz C, Persani L, Bonomi M; Italian Study Group on Idiopathic Central Hypogonadism (ICH).

J Clin Endocrinol Metab. 2014 Mar;99(3):E458-63. doi: 10.1210/jc.2013-2431. Epub 2013 Nov 25.


Diet induced mild hypercholesterolemia in pigs: local and systemic inflammation, effects on vascular injury - rescue by high-dose statin treatment.

Busnelli M, Manzini S, Froio A, Vargiolu A, Cerrito MG, Smolenski RT, Giunti M, Cinti A, Zannoni A, Leone BE, Forni M, Bacci ML, Biasi GM, Giovannoni R, Lavitrano M.

PLoS One. 2013 Nov 15;8(11):e80588. doi: 10.1371/journal.pone.0080588. eCollection 2013.


Chronic and acute intranasal oxytocin produce divergent social effects in mice.

Huang H, Michetti C, Busnelli M, Managò F, Sannino S, Scheggia D, Giancardo L, Sona D, Murino V, Chini B, Scattoni ML, Papaleo F.

Neuropsychopharmacology. 2014 Apr;39(5):1102-14. doi: 10.1038/npp.2013.310. Epub 2013 Nov 4.


Selective and potent agonists and antagonists for investigating the role of mouse oxytocin receptors.

Busnelli M, Bulgheroni E, Manning M, Kleinau G, Chini B.

J Pharmacol Exp Ther. 2013 Aug;346(2):318-27. doi: 10.1124/jpet.113.202994. Epub 2013 May 30.


Full and partial agonists of thromboxane prostanoid receptor unveil fine tuning of receptor superactive conformation and G protein activation.

Capra V, Busnelli M, Perenna A, Ambrosio M, Accomazzo MR, Galés C, Chini B, Rovati GE.

PLoS One. 2013;8(3):e60475. doi: 10.1371/journal.pone.0060475. Epub 2013 Mar 28.


Effect of the combinations between pea proteins and soluble fibres on cholesterolaemia and cholesterol metabolism in rats.

Parolini C, Manzini S, Busnelli M, Rigamonti E, Marchesi M, Diani E, Sirtori CR, Chiesa G.

Br J Nutr. 2013 Oct;110(8):1394-401. doi: 10.1017/S0007114513000639. Epub 2013 Mar 5.


Deciphering the specific role of G(αi/o) isoforms: functional selective oxytocin ligands and somatostatin SST5 receptor mutants.

Busnelli M, Peverelli E, Mantovani G, Spada A, Chini B.

Biochem Soc Trans. 2013 Feb 1;41(1):166-71. doi: 10.1042/BST20120306. Review.


Analysis of GPCR dimerization using acceptor photobleaching resonance energy transfer techniques.

Busnelli M, Mauri M, Parenti M, Chini B.

Methods Enzymol. 2013;521:311-27. doi: 10.1016/B978-0-12-391862-8.00017-X.


Specific roles of G(i) protein family members revealed by dissecting SST5 coupling in human pituitary cells.

Peverelli E, Busnelli M, Vitali E, Giardino E, Galés C, Lania AG, Beck-Peccoz P, Chini B, Mantovani G, Spada A.

J Cell Sci. 2013 Jan 15;126(Pt 2):638-44. doi: 10.1242/jcs.116434. Epub 2012 Nov 23.


Mice heterozygous for the oxytocin receptor gene (Oxtr(+/-)) show impaired social behaviour but not increased aggression or cognitive inflexibility: evidence of a selective haploinsufficiency gene effect.

Sala M, Braida D, Donzelli A, Martucci R, Busnelli M, Bulgheroni E, Rubino T, Parolaro D, Nishimori K, Chini B.

J Neuroendocrinol. 2013 Feb;25(2):107-18. doi: 10.1111/j.1365-2826.2012.02385.x.


Blood cell mitochondrial DNA content and premature ovarian aging.

Bonomi M, Somigliana E, Cacciatore C, Busnelli M, Rossetti R, Bonetti S, Paffoni A, Mari D, Ragni G, Persani L; Italian Network for the study of Ovarian Dysfunctions.

PLoS One. 2012;7(8):e42423. Epub 2012 Aug 3.


Reduced biliary sterol output with no change in total faecal excretion in mice expressing a human apolipoprotein A-I variant.

Parolini C, Caligari S, Gilio D, Manzini S, Busnelli M, Montagnani M, Locatelli M, Diani E, Giavarini F, Caruso D, Roda E, Roda A, Sirtori CR, Chiesa G.

Liver Int. 2012 Oct;32(9):1363-71. doi: 10.1111/j.1478-3231.2012.02855.x. Epub 2012 Jul 29.


Cholesterol-lowering effect of dietary Lupinus angustifolius proteins in adult rats through regulation of genes involved in cholesterol homeostasis.

Parolini C, Rigamonti E, Marchesi M, Busnelli M, Cinquanta P, Manzini S, Sirtori CR, Chiesa G.

Food Chem. 2012 Jun 1;132(3):1475-1479. doi: 10.1016/j.foodchem.2011.12.004. Epub 2011 Dec 11.


Functional selective oxytocin-derived agonists discriminate between individual G protein family subtypes.

Busnelli M, Saulière A, Manning M, Bouvier M, Galés C, Chini B.

J Biol Chem. 2012 Feb 3;287(6):3617-29. doi: 10.1074/jbc.M111.277178. Epub 2011 Nov 8.


Neurohypophyseal hormones manipulation modulate social and anxiety-related behavior in zebrafish.

Braida D, Donzelli A, Martucci R, Capurro V, Busnelli M, Chini B, Sala M.

Psychopharmacology (Berl). 2012 Mar;220(2):319-30. doi: 10.1007/s00213-011-2482-2. Epub 2011 Sep 29.


Heme oxygenase-1 inhibition prevents intimal hyperplasia enhancing nitric oxide-dependent apoptosis of vascular smooth muscle cells.

Cerrito MG, Scagliarini A, Froio A, Liloia A, Busnelli M, Giovannoni R, Otterbein LE, Mainetti L, Villa M, Bach FH, Leone BE, Biasi GM, Lavitrano M.

Biol Pharm Bull. 2011;34(8):1204-14.


Rosuvastatin does not affect human apolipoprotein A-I expression in genetically modified mice: a clue to the disputed effect of statins on HDL.

Marchesi M, Parolini C, Caligari S, Gilio D, Manzini S, Busnelli M, Cinquanta P, Camera M, Brambilla M, Sirtori CR, Chiesa G.

Br J Pharmacol. 2011 Nov;164(5):1460-8. doi: 10.1111/j.1476-5381.2011.01429.x.


Pharmacologic rescue of impaired cognitive flexibility, social deficits, increased aggression, and seizure susceptibility in oxytocin receptor null mice: a neurobehavioral model of autism.

Sala M, Braida D, Lentini D, Busnelli M, Bulgheroni E, Capurro V, Finardi A, Donzelli A, Pattini L, Rubino T, Parolaro D, Nishimori K, Parenti M, Chini B.

Biol Psychiatry. 2011 May 1;69(9):875-82. doi: 10.1016/j.biopsych.2010.12.022. Epub 2011 Feb 21.


In vitro production of multigene transgenic blastocysts via sperm-mediated gene transfer allows rapid screening of constructs to be used in xenotransplantation experiments.

Vargiolu A, Manzini S, de Cecco M, Bacci ML, Forni M, Galeati G, Cerrito MG, Busnelli M, Lavitrano M, Giovannoni R.

Transplant Proc. 2010 Jul-Aug;42(6):2142-5. doi: 10.1016/j.transproceed.2010.05.115.


Dual modulation of inward rectifier potassium currents in olfactory neuronal cells by promiscuous G protein coupling of the oxytocin receptor.

Gravati M, Busnelli M, Bulgheroni E, Reversi A, Spaiardi P, Parenti M, Toselli M, Chini B.

J Neurochem. 2010 Sep 1;114(5):1424-35. doi: 10.1111/j.1471-4159.2010.06861.x. Epub 2010 Jun 14.


Oxytocin-induced cell growth proliferation in human myometrial cells and leiomyomas.

Busnelli M, Rimoldi V, Viganò P, Persani L, Di Blasio AM, Chini B.

Fertil Steril. 2010 Oct;94(5):1869-74. doi: 10.1016/j.fertnstert.2009.10.064. Epub 2010 Jan 8.


Pathogenetic role of hypercholesterolemia in a novel preclinical model of vascular injury in pigs.

Busnelli M, Froio A, Bacci ML, Giunti M, Cerrito MG, Giovannoni R, Forni M, Gentilini F, Scagliarini A, Deleo G, Benatti C, Leone BE, Biasi GM, Lavitrano M.

Atherosclerosis. 2009 Dec;207(2):384-90. doi: 10.1016/j.atherosclerosis.2009.05.022. Epub 2009 May 27.


A family with complete resistance to thyrotropin-releasing hormone.

Bonomi M, Busnelli M, Beck-Peccoz P, Costanzo D, Antonica F, Dolci C, Pilotta A, Buzi F, Persani L.

N Engl J Med. 2009 Feb 12;360(7):731-4. doi: 10.1056/NEJMc0808557. No abstract available.


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