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Items: 32


Interleukin-16 inhibits sodium channel function and GluA1 phosphorylation via CD4- and CD9-independent mechanisms to reduce hippocampal neuronal excitability and synaptic activity.

Hridi SU, Franssen AJPM, Jiang HR, Bushell TJ.

Mol Cell Neurosci. 2019 Mar;95:71-78. doi: 10.1016/j.mcn.2019.01.002. Epub 2019 Feb 7.


Fast Optical Sectioning for Widefield Fluorescence Mesoscopy with the Mesolens based on HiLo Microscopy.

Schniete J, Franssen A, Dempster J, Bushell TJ, Amos WB, McConnell G.

Sci Rep. 2018 Nov 2;8(1):16259. doi: 10.1038/s41598-018-34516-2.


The therapeutic effect of anti-CD52 treatment in murine experimental autoimmune encephalomyelitis is associated with altered IL-33 and ST2 expression levels.

Barbour M, Wood R, Hridi SU, Wilson C, McKay G, Bushell TJ, Jiang HR.

J Neuroimmunol. 2018 May 15;318:87-96. doi: 10.1016/j.jneuroim.2018.02.012. Epub 2018 Feb 24.


Toll-like receptor 3 activation impairs excitability and synaptic activity via TRIF signalling in immature rat and human neurons.

Ritchie L, Tate R, Chamberlain LH, Robertson G, Zagnoni M, Sposito T, Wray S, Wright JA, Bryant CE, Gay NJ, Bushell TJ.

Neuropharmacology. 2018 Jun;135:1-10. doi: 10.1016/j.neuropharm.2018.02.025. Epub 2018 Mar 2.


A Microfluidic Platform for the Characterisation of CNS Active Compounds.

MacKerron C, Robertson G, Zagnoni M, Bushell TJ.

Sci Rep. 2017 Nov 16;7(1):15692. doi: 10.1038/s41598-017-15950-0.


A 340/380 nm light-emitting diode illuminator for Fura-2 AM ratiometric Ca2+ imaging of live cells with better than 5 nM precision.

Tinning PW, Franssen AJPM, Hridi SU, Bushell TJ, McConnell G.

J Microsc. 2018 Mar;269(3):212-220. doi: 10.1111/jmi.12616. Epub 2017 Aug 24.


The C-terminal domain of zDHHC2 contains distinct sorting signals that regulate intracellular localisation in neurons and neuroendocrine cells.

Salaun C, Ritchie L, Greaves J, Bushell TJ, Chamberlain LH.

Mol Cell Neurosci. 2017 Dec;85:235-246. doi: 10.1016/j.mcn.2017.07.007. Epub 2017 Jul 30.


GABAB receptors suppress burst-firing in reticular thalamic neurons.

Cain SM, Garcia E, Waheed Z, Jones KL, Bushell TJ, Snutch TP.

Channels (Austin). 2017 Nov 2;11(6):574-586. doi: 10.1080/19336950.2017.1358836. Epub 2017 Aug 22.


Proteinase-activated receptor 2 is involved in the behavioural changes associated with sickness behaviour.

Abulkassim R, Brett R, MacKenzie SM, Bushell TJ.

J Neuroimmunol. 2016 Jun 15;295-296:139-47. doi: 10.1016/j.jneuroim.2016.04.016. Epub 2016 Apr 27.


Mitogen-Activated Protein Kinase Phosphatase-2 Deletion Impairs Synaptic Plasticity and Hippocampal-Dependent Memory.

Abdul Rahman NZ, Greenwood SM, Brett RR, Tossell K, Ungless MA, Plevin R, Bushell TJ.

J Neurosci. 2016 Feb 24;36(8):2348-54. doi: 10.1523/JNEUROSCI.3825-15.2016.


Widefield Two-Photon Excitation without Scanning: Live Cell Microscopy with High Time Resolution and Low Photo-Bleaching.

Amor R, McDonald A, Trägårdh J, Robb G, Wilson L, Abdul Rahman NZ, Dempster J, Amos WB, Bushell TJ, McConnell G.

PLoS One. 2016 Jan 29;11(1):e0147115. doi: 10.1371/journal.pone.0147115. eCollection 2016.


Protease-Activated Receptor 2: Are Common Functions in Glial and Immune Cells Linked to Inflammation-Related CNS Disorders?

Bushell TJ, Cunningham MR, McIntosh KA, Moudio S, Plevin R.

Curr Drug Targets. 2016;17(16):1861-1870. Review.


Developmental regulation of tau splicing is disrupted in stem cell-derived neurons from frontotemporal dementia patients with the 10 + 16 splice-site mutation in MAPT.

Sposito T, Preza E, Mahoney CJ, Setó-Salvia N, Ryan NS, Morris HR, Arber C, Devine MJ, Houlden H, Warner TT, Bushell TJ, Zagnoni M, Kunath T, Livesey FJ, Fox NC, Rossor MN, Hardy J, Wray S.

Hum Mol Genet. 2015 Sep 15;24(18):5260-9. doi: 10.1093/hmg/ddv246. Epub 2015 Jul 1.


Chemically induced synaptic activity between mixed primary hippocampal co-cultures in a microfluidic system.

Robertson G, Bushell TJ, Zagnoni M.

Integr Biol (Camb). 2014 Jun;6(6):636-44. doi: 10.1039/c3ib40221e.


Lymphocyte-mediated neuroprotection in in vitro models of excitotoxicity involves astrocytic activation and the inhibition of MAP kinase signalling pathways.

Shrestha R, Millington O, Brewer J, Dev KK, Bushell TJ.

Neuropharmacology. 2014 Jan;76 Pt A:184-93. doi: 10.1016/j.neuropharm.2013.06.025. Epub 2013 Jul 4.


In vivo real-time multiphoton imaging of T lymphocytes in the mouse brain after experimental stroke.

Fumagalli S, Coles JA, Ejlerskov P, Ortolano F, Bushell TJ, Brewer JM, De Simoni MG, Dever G, Garside P, Maffia P, Carswell HV.

Stroke. 2011 May;42(5):1429-36. doi: 10.1161/STROKEAHA.110.603704. Epub 2011 Mar 24.


Indirect modulation of neuronal excitability and synaptic transmission in the hippocampus by activation of proteinase-activated receptor-2.

Gan J, Greenwood SM, Cobb SR, Bushell TJ.

Br J Pharmacol. 2011 Jul;163(5):984-94. doi: 10.1111/j.1476-5381.2011.01293.x.


Cannabidiol inhibits synaptic transmission in rat hippocampal cultures and slices via multiple receptor pathways.

Ledgerwood CJ, Greenwood SM, Brett RR, Pratt JA, Bushell TJ.

Br J Pharmacol. 2011 Jan;162(1):286-94. doi: 10.1111/j.1476-5381.2010.01015.x.


Astrocytic activation and an inhibition of MAP kinases are required for proteinase-activated receptor-2-mediated protection from neurotoxicity.

Greenwood SM, Bushell TJ.

J Neurochem. 2010 Jun;113(6):1471-80. doi: 10.1111/j.1471-4159.2010.06737.x. Epub 2010 Apr 6.


Two-pore potassium ion channels are inhibited by both G(q/11)- and G(i)-coupled P2Y receptors.

Shrestha SS, Parmar M, Kennedy C, Bushell TJ.

Mol Cell Neurosci. 2010 Apr;43(4):363-9. doi: 10.1016/j.mcn.2010.01.003. Epub 2010 Jan 22.


Advances in imaging of new targets for pharmacological intervention in stroke: real-time tracking of T-cells in the ischaemic brain.

Ortolano F, Maffia P, Dever G, Rodolico G, Millington OR, De Simoni MG, Brewer JM, Bushell TJ, Garside P, Carswell HV.

Br J Pharmacol. 2010 Feb;159(4):808-11. doi: 10.1111/j.1476-5381.2009.00527.x. Epub 2009 Dec 10.


Imaging T-cell movement in the brain during experimental cerebral malaria.

Ortolano F, Maffia P, Dever G, Hutchison S, Benson R, Millington OR, De Simoni MG, Bushell TJ, Garside P, Carswell HV, Brewer JM.

Parasite Immunol. 2009 Mar;31(3):147-50. doi: 10.1111/j.1365-3024.2008.01090.x.


mGlu4 potentiation of K(2P)2.1 is dependant on C-terminal dephosphorylation.

Cain SM, Meadows HJ, Dunlop J, Bushell TJ.

Mol Cell Neurosci. 2008 Jan;37(1):32-9. Epub 2007 Aug 23.


Characterization of proteinase-activated receptor 2 signalling and expression in rat hippocampal neurons and astrocytes.

Bushell TJ, Plevin R, Cobb S, Irving AJ.

Neuropharmacology. 2006 May;50(6):714-25. Epub 2006 Jan 20.


Two-pore-domain K+ channels are a novel target for the anesthetic gases xenon, nitrous oxide, and cyclopropane.

Gruss M, Bushell TJ, Bright DP, Lieb WR, Mathie A, Franks NP.

Mol Pharmacol. 2004 Feb;65(2):443-52.


Altered short-term synaptic plasticity in mice lacking the metabotropic glutamate receptor mGlu7.

Bushell TJ, Sansig G, Collett VJ, van der Putten H, Collingridge GL.

ScientificWorldJournal. 2002 Mar 15;2:730-7.


Determinants of the anesthetic sensitivity of neuronal nicotinic acetylcholine receptors.

Downie DL, Vicente-Agullo F, Campos-Caro A, Bushell TJ, Lieb WR, Franks NP.

J Biol Chem. 2002 Mar 22;277(12):10367-73. Epub 2001 Dec 10.


Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7.

Sansig G, Bushell TJ, Clarke VR, Rozov A, Burnashev N, Portet C, Gasparini F, Schmutz M, Klebs K, Shigemoto R, Flor PJ, Kuhn R, Knoepfel T, Schroeder M, Hampson DR, Collett VJ, Zhang C, Duvoisin RM, Collingridge GL, van Der Putten H.

J Neurosci. 2001 Nov 15;21(22):8734-45.


Modulation of synaptic transmission and differential localisation of mGlus in cultured hippocampal autapses.

Bushell TJ, Lee CC, Shigemoto R, Miller RJ.

Neuropharmacology. 1999 Oct;38(10):1553-67.


Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity.

Meucci O, Fatatis A, Simen AA, Bushell TJ, Gray PW, Miller RJ.

Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14500-5.


Pharmacological antagonism of the actions of group II and III mGluR agonists in the lateral perforant path of rat hippocampal slices.

Bushell TJ, Jane DE, Tse HW, Watkins JC, Garthwaite J, Collingridge GL.

Br J Pharmacol. 1996 Apr;117(7):1457-62.


Antagonism of the synaptic depressant actions of L-AP4 in the lateral perforant path by MAP4.

Bushell TJ, Jane DE, Tse HW, Watkins JC, Davies CH, Garthwaite J, Collingridge GL.

Neuropharmacology. 1995 Feb;34(2):239-41.


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