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Items: 1 to 50 of 384

1.

Correction to: Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity.

Cimdins K, Waugh HS, Chrysostomou V, Lopez Sanchez MIG, Johanssen VA, Cook MJ, Crowston JG, Hill AF, Duce JA, Bush AI, Trounce IA.

Mol Neurobiol. 2019 Aug 13. doi: 10.1007/s12035-019-01726-2. [Epub ahead of print]

PMID:
31410736
2.

The Down Syndrome-Associated Protein, Regulator of Calcineurin-1, is Altered in Alzheimer's Disease and Dementia with Lewy Bodies.

N M; AIBL Research Group, C F, I V, Ca M, Rc K, Ai B, A R, Ma P, DI F, Pa A.

J Alzheimers Dis Parkinsonism. 2019;9(2). pii: 462. doi: 10.4172/2161-0460.1000462. Epub 2019 Mar 6.

3.

Cellular Senescence and Iron Dyshomeostasis in Alzheimer's Disease.

Masaldan S, Belaidi AA, Ayton S, Bush AI.

Pharmaceuticals (Basel). 2019 Jun 19;12(2). pii: E93. doi: 10.3390/ph12020093. Review.

4.

Decreasing iron neurotoxicity in pantothenate kinase-associated neurodegeneration.

Ayton S, Bush AI.

Lancet Neurol. 2019 Jul;18(7):616-617. doi: 10.1016/S1474-4422(19)30193-0. No abstract available.

PMID:
31202464
5.

Extracellular Zn2+-independently attenuated LTP by human amyloid β1-40 and rat amyloid β1-42.

Tamano H, Takiguchi M, Shimaya R, Adlard PA, Bush AI, Takeda A.

Biochem Biophys Res Commun. 2019 Jun 30;514(3):888-892. doi: 10.1016/j.bbrc.2019.05.037. Epub 2019 May 10.

PMID:
31084925
6.

In vivo synaptic activity-independent co-uptakes of amyloid β1-42 and Zn2+ into dentate granule cells in the normal brain.

Tamano H, Oneta N, Shioya A, Adlard PA, Bush AI, Takeda A.

Sci Rep. 2019 Apr 24;9(1):6498. doi: 10.1038/s41598-019-43012-0.

7.

Blood and brain protein levels of ubiquitin-conjugating enzyme E2K (UBE2K) are elevated in individuals with schizophrenia.

Meiklejohn H, Mostaid MS, Luza S, Mancuso SG, Kang D, Atherton S, Rothmond DA, Weickert CS, Opazo CM, Pantelis C, Bush AI, Everall IP, Bousman CA.

J Psychiatr Res. 2019 Jun;113:51-57. doi: 10.1016/j.jpsychires.2019.03.005. Epub 2019 Mar 8.

PMID:
30901725
8.

Elevated ubiquitinated proteins in brain and blood of individuals with schizophrenia.

Bousman CA, Luza S, Mancuso SG, Kang D, Opazo CM, Mostaid MS, Cropley V, McGorry P, Shannon Weickert C, Pantelis C, Bush AI, Everall IP.

Sci Rep. 2019 Feb 19;9(1):2307. doi: 10.1038/s41598-019-38490-1.

9.

Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology.

Ayton S, Wang Y, Diouf I, Schneider JA, Brockman J, Morris MC, Bush AI.

Mol Psychiatry. 2019 Feb 18. doi: 10.1038/s41380-019-0375-7. [Epub ahead of print]

PMID:
30778133
10.

A plasma protein classifier for predicting amyloid burden for preclinical Alzheimer's disease.

Ashton NJ, Nevado-Holgado AJ, Barber IS, Lynham S, Gupta V, Chatterjee P, Goozee K, Hone E, Pedrini S, Blennow K, Schöll M, Zetterberg H, Ellis KA, Bush AI, Rowe CC, Villemagne VL, Ames D, Masters CL, Aarsland D, Powell J, Lovestone S, Martins R, Hye A.

Sci Adv. 2019 Feb 6;5(2):eaau7220. doi: 10.1126/sciadv.aau7220. eCollection 2019 Feb.

11.

The Effects of Clioquinol on P-glycoprotein Expression and Biometal Distribution in the Mouse Brain Microvasculature.

McInerney MP, Pan Y, Volitakis I, Bush AI, Short JL, Nicolazzo JA.

J Pharm Sci. 2019 Jul;108(7):2247-2255. doi: 10.1016/j.xphs.2019.01.030. Epub 2019 Feb 7.

PMID:
30738852
12.

l-3,4-dihydroxyphenylalanine (l-DOPA) modulates brain iron, dopaminergic neurodegeneration and motor dysfunction in iron overload and mutant alpha-synuclein mouse models of Parkinson's disease.

Billings JL, Gordon SL, Rawling T, Doble PA, Bush AI, Adlard PA, Finkelstein DI, Hare DJ.

J Neurochem. 2019 Jul;150(1):88-106. doi: 10.1111/jnc.14676. Epub 2019 Mar 28.

PMID:
30716176
13.

Zn-DTSM, A Zinc Ionophore with Therapeutic Potential for Acrodermatitis Enteropathica?

Bray L, Volitakis I, Ayton S, Bush AI, Adlard PA.

Nutrients. 2019 Jan 21;11(1). pii: E206. doi: 10.3390/nu11010206.

14.

Difference in ability for extracellular Zn2+ influx between human and rat amyloid β1-42 and its significance.

Tamano H, Suzuki H, Kobuchi S, Adlard PA, Bush AI, Takeda A.

Neurotoxicology. 2019 May;72:1-5. doi: 10.1016/j.neuro.2019.01.005. Epub 2019 Jan 18.

PMID:
30664975
15.

Treating Alzheimer's disease by targeting iron.

Nikseresht S, Bush AI, Ayton S.

Br J Pharmacol. 2019 Jan 10. doi: 10.1111/bph.14567. [Epub ahead of print] Review.

PMID:
30632143
16.

Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity.

Cimdins K, Waugh HS, Chrysostomou V, Lopez Sanchez MIG, Johannsen VA, Cook MJ, Crowston JG, Hill AF, Duce JA, Bush AI, Trounce IA.

Mol Neurobiol. 2019 Aug;56(8):5471-5482. doi: 10.1007/s12035-018-1460-7. Epub 2019 Jan 5. Erratum in: Mol Neurobiol. 2019 Aug 13;:.

17.

Cerebrospinal fluid ferritin levels predict brain hypometabolism in people with underlying β-amyloid pathology.

Diouf I, Fazlollahi A, Bush AI, Ayton S; Alzheimer's disease Neuroimaging Initiative.

Neurobiol Dis. 2019 Apr;124:335-339. doi: 10.1016/j.nbd.2018.12.010. Epub 2018 Dec 14.

PMID:
30557658
18.

Molecular Mechanisms of Glutaredoxin Enzymes: Versatile Hubs for Thiol-Disulfide Exchange between Protein Thiols and Glutathione.

Xiao Z, La Fontaine S, Bush AI, Wedd AG.

J Mol Biol. 2019 Jan 18;431(2):158-177. doi: 10.1016/j.jmb.2018.12.006. Epub 2018 Dec 12. Review.

PMID:
30552876
19.

Amyloid β1-42-Induced Rapid Zn2+ Influx into Dentate Granule Cells Attenuates Maintained LTP Followed by Retrograde Amnesia.

Tamano H, Suzuki H, Murakami T, Fujii H, Adlard PA, Bush AI, Takeda A.

Mol Neurobiol. 2019 Jul;56(7):5041-5050. doi: 10.1007/s12035-018-1429-6. Epub 2018 Nov 20.

PMID:
30460616
20.

Parkinson's disease prevalence and the association with rurality and agricultural determinants.

Ayton D, Ayton S, Barker AL, Bush AI, Warren N.

Parkinsonism Relat Disord. 2019 Apr;61:198-202. doi: 10.1016/j.parkreldis.2018.10.026. Epub 2018 Oct 23.

PMID:
30377035
21.

Striking while the iron is hot: Iron metabolism and ferroptosis in neurodegeneration.

Masaldan S, Bush AI, Devos D, Rolland AS, Moreau C.

Free Radic Biol Med. 2019 Mar;133:221-233. doi: 10.1016/j.freeradbiomed.2018.09.033. Epub 2018 Sep 25. Review.

PMID:
30266679
22.

Supranutritional Sodium Selenate Supplementation Delivers Selenium to the Central Nervous System: Results from a Randomized Controlled Pilot Trial in Alzheimer's Disease.

Cardoso BR, Roberts BR, Malpas CB, Vivash L, Genc S, Saling MM, Desmond P, Steward C, Hicks RJ, Callahan J, Brodtmann A, Collins S, Macfarlane S, Corcoran NM, Hovens CM, Velakoulis D, O'Brien TJ, Hare DJ, Bush AI.

Neurotherapeutics. 2019 Jan;16(1):192-202. doi: 10.1007/s13311-018-0662-z.

PMID:
30215171
23.

Targeting metals rescues the phenotype in an animal model of tauopathy.

Sedjahtera A, Gunawan L, Bray L, Hung LW, Parsons J, Okamura N, Villemagne VL, Yanai K, Liu XM, Chan J, Bush AI, Finkelstein DI, Barnham KJ, Cherny RA, Adlard PA.

Metallomics. 2018 Sep 19;10(9):1339-1347. doi: 10.1039/c8mt00153g.

PMID:
30168573
24.

Redox Modulating Factors Affect Longevity Regulation in Rotifers.

Macsai L, Olah Z, Bush AI, Galik B, Onody R, Kalman J, Datki Z.

J Gerontol A Biol Sci Med Sci. 2019 May 16;74(6):811-814. doi: 10.1093/gerona/gly193.

PMID:
30165673
25.

Manganese causes neurotoxic iron accumulation via translational repression of amyloid precursor protein and H-Ferritin.

Venkataramani V, Doeppner TR, Willkommen D, Cahill CM, Xin Y, Ye G, Liu Y, Southon A, Aron A, Au-Yeung HY, Huang X, Lahiri DK, Wang F, Bush AI, Wulf GG, Ströbel P, Michalke B, Rogers JT.

J Neurochem. 2018 Dec;147(6):831-848. doi: 10.1111/jnc.14580. Epub 2018 Nov 19.

PMID:
30152072
26.

Marked Age-Related Changes in Brain Iron Homeostasis in Amyloid Protein Precursor Knockout Mice.

Belaidi AA, Gunn AP, Wong BX, Ayton S, Appukuttan AT, Roberts BR, Duce JA, Bush AI.

Neurotherapeutics. 2018 Oct;15(4):1055-1062. doi: 10.1007/s13311-018-0656-x.

PMID:
30112699
27.

Overcoming the Blood-Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases.

Furtado D, Björnmalm M, Ayton S, Bush AI, Kempe K, Caruso F.

Adv Mater. 2018 Nov;30(46):e1801362. doi: 10.1002/adma.201801362. Epub 2018 Jul 31. Review.

28.

Adrenergic β receptor activation in the basolateral amygdala, which is intracellular Zn2+-dependent, rescues amyloid β1-42-induced attenuation of dentate gyrus LTP.

Tamano H, Kubota M, Fujise Y, Shimaya R, Itoh R, Suzuki M, Adlard PA, Bush AI, Takeda A.

Neurochem Int. 2018 Nov;120:43-48. doi: 10.1016/j.neuint.2018.07.005. Epub 2018 Jul 17.

PMID:
30030113
29.

Mediator effects of parameters of inflammation and neurogenesis from a N-acetyl cysteine clinical-trial for bipolar depression.

Panizzutti B, Bortolasci C, Hasebe K, Kidnapillai S, Gray L, Walder K, Berk M, Mohebbi M, Dodd S, Gama C, Magalhães PV, Cotton SM, Kapczinski F, Bush AI, Malhi GS, Dean OM.

Acta Neuropsychiatr. 2018 Dec;30(6):334-341. doi: 10.1017/neu.2018.13. Epub 2018 Jul 16.

PMID:
30008280
30.

Ablation of tau causes an olfactory deficit in a murine model of Parkinson's disease.

Beauchamp LC, Chan J, Hung LW, Padman BS, Vella LJ, Liu XM, Coleman B, Bush AI, Lazarou M, Hill AF, Jacobson L, Barnham KJ.

Acta Neuropathol Commun. 2018 Jul 5;6(1):57. doi: 10.1186/s40478-018-0560-y.

31.

Association of metals with the risk and clinical characteristics of Parkinson's disease.

Kim MJ, Oh SB, Kim J, Kim K, Ryu HS, Kim MS, Ayton S, Bush AI, Lee JY, Chung SJ.

Parkinsonism Relat Disord. 2018 Oct;55:117-121. doi: 10.1016/j.parkreldis.2018.05.022. Epub 2018 May 28.

PMID:
29891430
32.

Iron and Alzheimer's Disease: An Update on Emerging Mechanisms.

Lane DJR, Ayton S, Bush AI.

J Alzheimers Dis. 2018;64(s1):S379-S395. doi: 10.3233/JAD-179944. Review.

PMID:
29865061
33.

Glutaredoxins employ parallel monothiol-dithiol mechanisms to catalyze thiol-disulfide exchanges with protein disulfides.

Ukuwela AA, Bush AI, Wedd AG, Xiao Z.

Chem Sci. 2017 Dec 6;9(5):1173-1183. doi: 10.1039/c7sc04416j. eCollection 2018 Feb 7.

34.

Alzheimer's Disease: A Journey from Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies-Gains from AIBL and DIAN Cohort Studies.

Martins RN, Villemagne V, Sohrabi HR, Chatterjee P, Shah TM, Verdile G, Fraser P, Taddei K, Gupta VB, Rainey-Smith SR, Hone E, Pedrini S, Lim WL, Martins I, Frost S, Gupta S, O'Bryant S, Rembach A, Ames D, Ellis K, Fuller SJ, Brown B, Gardener SL, Fernando B, Bharadwaj P, Burnham S, Laws SM, Barron AM, Goozee K, Wahjoepramono EJ, Asih PR, Doecke JD, Salvado O, Bush AI, Rowe CC, Gandy SE, Masters CL.

J Alzheimers Dis. 2018;62(3):965-992. doi: 10.3233/JAD-171145. Review.

35.

Metals and Alzheimer's Disease: How Far Have We Come in the Clinic?

Adlard PA, Bush AI.

J Alzheimers Dis. 2018;62(3):1369-1379. doi: 10.3233/JAD-170662. Review.

36.

Ionophore and Biometal Modulation of P-glycoprotein Expression and Function in Human Brain Microvascular Endothelial Cells.

McInerney MP, Volitakis I, Bush AI, Banks WA, Short JL, Nicolazzo JA.

Pharm Res. 2018 Mar 5;35(4):83. doi: 10.1007/s11095-018-2377-6.

PMID:
29508078
37.

Novel Defense by Metallothionein Induction Against Cognitive Decline: From Amyloid β1-42-Induced Excess Zn2+ to Functional Zn2+ Deficiency.

Takeda A, Tamano H, Hashimoto W, Kobuchi S, Suzuki H, Murakami T, Tempaku M, Koike Y, Adlard PA, Bush AI.

Mol Neurobiol. 2018 Oct;55(10):7775-7788. doi: 10.1007/s12035-018-0948-5. Epub 2018 Feb 19.

PMID:
29460269
38.

KIBRA is associated with accelerated cognitive decline and hippocampal atrophy in APOE ε4-positive cognitively normal adults with high Aβ-amyloid burden.

Porter T, Burnham SC, Doré V, Savage G, Bourgeat P, Begemann K, Milicic L, Ames D, Bush AI, Maruff P, Masters CL, Rowe CC, Rainey-Smith S, Martins RN, Groth D, Verdile G, Villemagne VL, Laws SM.

Sci Rep. 2018 Feb 1;8(1):2034. doi: 10.1038/s41598-018-20513-y.

39.

Iron as a therapeutic target for Parkinson's disease.

Moreau C, Duce JA, Rascol O, Devedjian JC, Berg D, Dexter D, Cabantchik ZI, Bush AI, Devos D; FAIRPARK-II study group.

Mov Disord. 2018 Apr;33(4):568-574. doi: 10.1002/mds.27275. Epub 2018 Jan 30. Review. No abstract available.

PMID:
29380903
40.

What can predict and prevent the long-term use of benzodiazepines?

Hata T, Kanazawa T, Hamada T, Nishihara M, Bush AI, Yoneda H, Nakajima M, Katsumata T.

J Psychiatr Res. 2018 Feb;97:94-100. doi: 10.1016/j.jpsychires.2017.11.012. Epub 2017 Nov 24.

PMID:
29223863
41.

Concordance Between Cerebrospinal Fluid Biomarkers with Alzheimer's Disease Pathology Between Three Independent Assay Platforms.

Doecke JD, Rembach A, Villemagne VL, Varghese S, Rainey-Smith S, Sarros S, Evered LA, Fowler CJ, Pertile KK, Rumble RL, Trounson B, Taddei K, Laws SM, Macaulay SL, Bush AI, Ellis KA, Martins R, Ames D, Silbert B, Vanderstichele H, Masters CL, Darby DG, Li QX, Collins S; AIBL Research Group.

J Alzheimers Dis. 2018;61(1):169-183. doi: 10.3233/JAD-170128.

PMID:
29171991
42.

S-sulfocysteine/NMDA receptor-dependent signaling underlies neurodegeneration in molybdenum cofactor deficiency.

Kumar A, Dejanovic B, Hetsch F, Semtner M, Fusca D, Arjune S, Santamaria-Araujo JA, Winkelmann A, Ayton S, Bush AI, Kloppenburg P, Meier JC, Schwarz G, Belaidi AA.

J Clin Invest. 2017 Dec 1;127(12):4365-4378. doi: 10.1172/JCI89885. Epub 2017 Nov 6.

43.

A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of β-amyloid load in an AD cohort.

Pedrini S, Gupta VB, Hone E, Doecke J, O'Bryant S, James I, Bush AI, Rowe CC, Villemagne VL, Ames D, Masters CL, Martins RN; AIBL Research Group.

Sci Rep. 2017 Oct 25;7(1):14057. doi: 10.1038/s41598-017-14020-9.

44.

Nanoscale Imaging Reveals Big Role for Iron in Alzheimer's Disease.

Ayton S, James SA, Bush AI.

Cell Chem Biol. 2017 Oct 19;24(10):1192-1194. doi: 10.1016/j.chembiol.2017.10.002.

45.

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease.

Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, Fulda S, Gascón S, Hatzios SK, Kagan VE, Noel K, Jiang X, Linkermann A, Murphy ME, Overholtzer M, Oyagi A, Pagnussat GC, Park J, Ran Q, Rosenfeld CS, Salnikow K, Tang D, Torti FM, Torti SV, Toyokuni S, Woerpel KA, Zhang DD.

Cell. 2017 Oct 5;171(2):273-285. doi: 10.1016/j.cell.2017.09.021. Review.

46.

Reduction potentials of protein disulfides and catalysis of glutathionylation and deglutathionylation by glutaredoxin enzymes.

Ukuwela AA, Bush AI, Wedd AG, Xiao Z.

Biochem J. 2017 Nov 9;474(22):3799-3815. doi: 10.1042/BCJ20170589.

PMID:
28963348
47.

Evidence that iron accelerates Alzheimer's pathology: a CSF biomarker study.

Ayton S, Diouf I, Bush AI; Alzheimer’s disease Neuroimaging Initiative.

J Neurol Neurosurg Psychiatry. 2018 May;89(5):456-460. doi: 10.1136/jnnp-2017-316551. Epub 2017 Sep 22.

PMID:
28939683
48.

Cerebral quantitative susceptibility mapping predicts amyloid-β-related cognitive decline.

Ayton S, Fazlollahi A, Bourgeat P, Raniga P, Ng A, Lim YY, Diouf I, Farquharson S, Fripp J, Ames D, Doecke J, Desmond P, Ordidge R, Masters CL, Rowe CC, Maruff P, Villemagne VL; Australian Imaging Biomarkers and Lifestyle (AIBL) Research Group, Salvado O, Bush AI.

Brain. 2017 Aug 1;140(8):2112-2119. doi: 10.1093/brain/awx137.

PMID:
28899019
49.

Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis.

Masaldan S, Clatworthy SAS, Gamell C, Meggyesy PM, Rigopoulos AT, Haupt S, Haupt Y, Denoyer D, Adlard PA, Bush AI, Cater MA.

Redox Biol. 2018 Apr;14:100-115. doi: 10.1016/j.redox.2017.08.015. Epub 2017 Sep 1.

50.

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke.

Tuo QZ, Lei P, Jackman KA, Li XL, Xiong H, Li XL, Liuyang ZY, Roisman L, Zhang ST, Ayton S, Wang Q, Crouch PJ, Ganio K, Wang XC, Pei L, Adlard PA, Lu YM, Cappai R, Wang JZ, Liu R, Bush AI.

Mol Psychiatry. 2017 Nov;22(11):1520-1530. doi: 10.1038/mp.2017.171. Epub 2017 Sep 8.

PMID:
28886009

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