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Items: 50

1.

Deficiency and haploinsufficiency of histone macroH2A1.1 in mice recapitulate hematopoietic defects of human myelodysplastic syndrome.

Bereshchenko O, Lo Re O, Nikulenkov F, Flamini S, Kotaskova J, Mazza T, Le Pannérer MM, Buschbeck M, Giallongo C, Palumbo G, Li Volti G, Pazienza V, Cervinek L, Riccardi C, Krejci L, Pospisilova S, Stewart AF, Vinciguerra M.

Clin Epigenetics. 2019 Aug 22;11(1):121. doi: 10.1186/s13148-019-0724-z.

2.

Histone variant MacroH2A1 is downregulated in prostate cancer and influences malignant cell phenotype.

Vieira-Silva TS, Monteiro-Reis S, Barros-Silva D, Ramalho-Carvalho J, Graça I, Carneiro I, Martins AT, Oliveira J, Antunes L, Hurtado-Bagès S, Buschbeck M, Henrique R, Jerónimo C.

Cancer Cell Int. 2019 Apr 29;19:112. doi: 10.1186/s12935-019-0835-9. eCollection 2019.

3.

Direct modulation of the bone marrow mesenchymal stromal cell compartment by azacitidine enhances healthy hematopoiesis.

Wenk C, Garz AK, Grath S, Huberle C, Witham D, Weickert M, Malinverni R, Niggemeyer J, Kyncl M, Hecker J, Pagel C, Mulholland CB, Müller-Thomas C, Leonhardt H, Bassermann F, Oostendorp RAJ, Metzeler KH, Buschbeck M, Götze KS.

Blood Adv. 2018 Dec 11;2(23):3447-3461. doi: 10.1182/bloodadvances.2018022053.

4.

The MacroH2A1.1 - PARP1 Axis at the Intersection Between Stress Response and Metabolism.

Hurtado-Bagès S, Guberovic I, Buschbeck M.

Front Genet. 2018 Oct 9;9:417. doi: 10.3389/fgene.2018.00417. eCollection 2018.

5.

Epigenetic-Transcriptional Regulation of Fatty Acid Metabolism and Its Alterations in Leukaemia.

Maher M, Diesch J, Casquero R, Buschbeck M.

Front Genet. 2018 Sep 24;9:405. doi: 10.3389/fgene.2018.00405. eCollection 2018. Review.

6.

MacroH2A histone variants limit chromatin plasticity through two distinct mechanisms.

Kozlowski M, Corujo D, Hothorn M, Guberovic I, Mandemaker IK, Blessing C, Sporn J, Gutierrez-Triana A, Smith R, Portmann T, Treier M, Scheffzek K, Huet S, Timinszky G, Buschbeck M, Ladurner AG.

EMBO Rep. 2018 Oct;19(10). pii: e44445. doi: 10.15252/embr.201744445. Epub 2018 Sep 3.

7.

Histone variant macroH2A1 rewires carbohydrate and lipid metabolism of hepatocellular carcinoma cells towards cancer stem cells.

Lo Re O, Douet J, Buschbeck M, Fusilli C, Pazienza V, Panebianco C, Castracani CC, Mazza T, Li Volti G, Vinciguerra M.

Epigenetics. 2018;13(8):829-845. doi: 10.1080/15592294.2018.1514239. Epub 2018 Sep 29.

8.

A novel long non-coding RNA from NBL2 pericentromeric macrosatellite forms a perinucleolar aggregate structure in colon cancer.

Dumbovic G, Biayna J, Banús J, Samuelsson J, Roth A, Diederichs S, Alonso S, Buschbeck M, Perucho M, Forcales SV.

Nucleic Acids Res. 2018 Jun 20;46(11):5504-5524. doi: 10.1093/nar/gky263.

9.

Post-Translational Modifications of H2A Histone Variants and Their Role in Cancer.

Corujo D, Buschbeck M.

Cancers (Basel). 2018 Feb 27;10(3). pii: E59. doi: 10.3390/cancers10030059. Review.

10.

Polycomb protein RING1A limits hematopoietic differentiation in myelodysplastic syndromes.

Palau A, Garz AK, Diesch J, Zwick A, Malinverni R, Valero V, Lappin K, Casquero R, Lennartsson A, Zuber J, Navarro T, Mills KI, Götze KS, Buschbeck M.

Oncotarget. 2017 Dec 1;8(70):115002-115017. doi: 10.18632/oncotarget.22839. eCollection 2017 Dec 29.

11.

DNA methylation profile in chronic myelomonocytic leukemia associates with distinct clinical, biological and genetic features.

Palomo L, Malinverni R, Cabezón M, Xicoy B, Arnan M, Coll R, Pomares H, García O, Fuster-Tormo F, Grau J, Feliu E, Solé F, Buschbeck M, Zamora L.

Epigenetics. 2018;13(1):8-18. doi: 10.1080/15592294.2017.1405199. Epub 2018 Feb 6.

12.

MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD+ consumption.

Posavec Marjanović M, Hurtado-Bagès S, Lassi M, Valero V, Malinverni R, Delage H, Navarro M, Corujo D, Guberovic I, Douet J, Gama-Perez P, Garcia-Roves PM, Ahel I, Ladurner AG, Yanes O, Bouvet P, Suelves M, Teperino R, Pospisilik JA, Buschbeck M.

Nat Struct Mol Biol. 2017 Nov;24(11):902-910. doi: 10.1038/nsmb.3481. Epub 2017 Oct 9.

13.

Induction of cancer cell stemness by depletion of macrohistone H2A1 in hepatocellular carcinoma.

Lo Re O, Fusilli C, Rappa F, Van Haele M, Douet J, Pindjakova J, Rocha SW, Pata I, Valčíková B, Uldrijan S, Yeung RS, Peixoto CA, Roskams T, Buschbeck M, Mazza T, Vinciguerra M.

Hepatology. 2018 Feb;67(2):636-650. doi: 10.1002/hep.29519. Epub 2018 Jan 2.

PMID:
28913935
14.

MacroH2A histone variants maintain nuclear organization and heterochromatin architecture.

Douet J, Corujo D, Malinverni R, Renauld J, Sansoni V, Posavec Marjanović M, Cantariño N, Valero V, Mongelard F, Bouvet P, Imhof A, Thiry M, Buschbeck M.

J Cell Sci. 2017 May 1;130(9):1570-1582. doi: 10.1242/jcs.199216. Epub 2017 Mar 10.

15.

Variants of core histones and their roles in cell fate decisions, development and cancer.

Buschbeck M, Hake SB.

Nat Rev Mol Cell Biol. 2017 May;18(5):299-314. doi: 10.1038/nrm.2016.166. Epub 2017 Feb 1. Review.

PMID:
28144029
16.

Barcelona conference on epigenetics and cancer 2016 - beyond cancer genomes.

Dumbovic G, Biayna J, Font B, Buschbeck M, Forcales SV.

Epigenetics. 2017 Mar 4;12(3):238-245. doi: 10.1080/15592294.2017.1281503. Epub 2017 Jan 25.

17.

Immunophenotypic, cytogenetic, and mutational characterization of cell lines derived from myelodysplastic syndrome patients after progression to acute myeloid leukemia.

Palau A, Mallo M, Palomo L, Rodríguez-Hernández I, Diesch J, Campos D, Granada I, Juncà J, Drexler HG, Solé F, Buschbeck M.

Genes Chromosomes Cancer. 2017 Mar;56(3):243-252. doi: 10.1002/gcc.22430. Epub 2016 Nov 21.

PMID:
27750403
18.

Development Refractoriness of MLL-Rearranged Human B Cell Acute Leukemias to Reprogramming into Pluripotency.

Muñoz-López A, Romero-Moya D, Prieto C, Ramos-Mejía V, Agraz-Doblas A, Varela I, Buschbeck M, Palau A, Carvajal-Vergara X, Giorgetti A, Ford A, Lako M, Granada I, Ruiz-Xivillé N, Rodríguez-Perales S, Torres-Ruíz R, Stam RW, Fuster JL, Fraga MF, Nakanishi M, Cazzaniga G, Bardini M, Cobo I, Bayon GF, Fernandez AF, Bueno C, Menendez P.

Stem Cell Reports. 2016 Oct 11;7(4):602-618. doi: 10.1016/j.stemcr.2016.08.013. Epub 2016 Sep 22.

19.

A clinical-molecular update on azanucleoside-based therapy for the treatment of hematologic cancers.

Diesch J, Zwick A, Garz AK, Palau A, Buschbeck M, Götze KS.

Clin Epigenetics. 2016 Jun 21;8:71. doi: 10.1186/s13148-016-0237-y. eCollection 2016. Review.

20.

Downregulation of the Deiminase PADI2 Is an Early Event in Colorectal Carcinogenesis and Indicates Poor Prognosis.

Cantariño N, Musulén E, Valero V, Peinado MA, Perucho M, Moreno V, Forcales SV, Douet J, Buschbeck M.

Mol Cancer Res. 2016 Sep;14(9):841-8. doi: 10.1158/1541-7786.MCR-16-0034. Epub 2016 Jun 8.

21.

A cellular model reflecting the phenotypic heterogeneity of mutant HRAS driven squamous cell carcinoma.

Cantariño N, Fernández-Figueras MT, Valero V, Musulén E, Malinverni R, Granada I, Goldie SJ, Martín-Caballero J, Douet J, Forcales SV, Buschbeck M.

Int J Cancer. 2016 Sep 1;139(5):1106-16. doi: 10.1002/ijc.30139. Epub 2016 May 5.

22.

Barcelona conference on epigenetics and cancer 2015: Coding and non-coding functions of the genome.

Corujo D, Mas G, Malinverni R, Di Croce L, Buschbeck M.

Epigenetics. 2016;11(1):95-100. doi: 10.1080/15592294.2015.1131377.

23.

DNA Hypomethylation and Histone Variant macroH2A1 Synergistically Attenuate Chemotherapy-Induced Senescence to Promote Hepatocellular Carcinoma Progression.

Borghesan M, Fusilli C, Rappa F, Panebianco C, Rizzo G, Oben JA, Mazzoccoli G, Faulkes C, Pata I, Agodi A, Rezaee F, Minogue S, Warren A, Peterson A, Sedivy JM, Douet J, Buschbeck M, Cappello F, Mazza T, Pazienza V, Vinciguerra M.

Cancer Res. 2016 Feb 1;76(3):594-606. doi: 10.1158/0008-5472.CAN-15-1336. Epub 2016 Jan 15.

24.

regioneR: an R/Bioconductor package for the association analysis of genomic regions based on permutation tests.

Gel B, Díez-Villanueva A, Serra E, Buschbeck M, Peinado MA, Malinverni R.

Bioinformatics. 2016 Jan 15;32(2):289-91. doi: 10.1093/bioinformatics/btv562. Epub 2015 Sep 30.

25.

A Cbx8-containing polycomb complex facilitates the transition to gene activation during ES cell differentiation.

Creppe C, Palau A, Malinverni R, Valero V, Buschbeck M.

PLoS Genet. 2014 Dec 11;10(12):e1004851. doi: 10.1371/journal.pgen.1004851. eCollection 2014 Dec.

26.

Epo-induced erythroid maturation is dependent on Plcγ1 signaling.

Schnöder TM, Arreba-Tutusaus P, Griehl I, Bullinger L, Buschbeck M, Lane SW, Döhner K, Plass C, Lipka DB, Heidel FH, Fischer T.

Cell Death Differ. 2015 Jun;22(6):974-85. doi: 10.1038/cdd.2014.186. Epub 2014 Nov 14.

27.

First Barcelona Conference on Epigenetics and Cancer.

Palau A, Perucho M, Esteller M, Buschbeck M.

Epigenetics. 2014 Mar;9(3):468-75. doi: 10.4161/epi.27759. Epub 2014 Jan 10.

28.

macroH2A1 histone variant represses rDNA transcription.

Cong R, Das S, Douet J, Wong J, Buschbeck M, Mongelard F, Bouvet P.

Nucleic Acids Res. 2014 Jan;42(1):181-92. doi: 10.1093/nar/gkt863. Epub 2013 Sep 25.

29.

Murine cell glycolipids customization by modular expression of glycosyltransferases.

Cid E, Yamamoto M, Buschbeck M, Yamamoto F.

PLoS One. 2013 Jun 14;8(6):e64728. doi: 10.1371/journal.pone.0064728. Print 2013.

30.

MacroH2A--an epigenetic regulator of cancer.

Cantariño N, Douet J, Buschbeck M.

Cancer Lett. 2013 Aug 19;336(2):247-52. doi: 10.1016/j.canlet.2013.03.022. Epub 2013 Mar 24. Review.

PMID:
23531411
31.

Macro domains as metabolite sensors on chromatin.

Posavec M, Timinszky G, Buschbeck M.

Cell Mol Life Sci. 2013 May;70(9):1509-24. doi: 10.1007/s00018-013-1294-4. Epub 2013 Mar 3. Review.

PMID:
23455074
32.

MacroH2A in stem cells: a story beyond gene repression.

Creppe C, Posavec M, Douet J, Buschbeck M.

Epigenomics. 2012 Apr;4(2):221-7. doi: 10.2217/epi.12.8.

33.

MacroH2A1 regulates the balance between self-renewal and differentiation commitment in embryonic and adult stem cells.

Creppe C, Janich P, Cantariño N, Noguera M, Valero V, Musulén E, Douet J, Posavec M, Martín-Caballero J, Sumoy L, Di Croce L, Benitah SA, Buschbeck M.

Mol Cell Biol. 2012 Apr;32(8):1442-52. doi: 10.1128/MCB.06323-11. Epub 2012 Feb 13.

34.

E-box-independent regulation of transcription and differentiation by MYC.

Uribesalgo I, Buschbeck M, Gutiérrez A, Teichmann S, Demajo S, Kuebler B, Nomdedéu JF, Martín-Caballero J, Roma G, Benitah SA, Di Croce L.

Nat Cell Biol. 2011 Oct 23;13(12):1443-9. doi: 10.1038/ncb2355.

PMID:
22020439
35.

Elongator: an ancestral complex driving transcription and migration through protein acetylation.

Creppe C, Buschbeck M.

J Biomed Biotechnol. 2011;2011:924898. doi: 10.1155/2011/924898. Epub 2011 Jan 12. Review.

36.

Approaching the molecular and physiological function of macroH2A variants.

Buschbeck M, Di Croce L.

Epigenetics. 2010 Feb 16;5(2):118-23. Epub 2010 Feb 20.

PMID:
20160488
37.

The histone variant macroH2A is an epigenetic regulator of key developmental genes.

Buschbeck M, Uribesalgo I, Wibowo I, Rué P, Martin D, Gutierrez A, Morey L, Guigó R, López-Schier H, Di Croce L.

Nat Struct Mol Biol. 2009 Oct;16(10):1074-9. doi: 10.1038/nsmb.1665. Epub 2009 Sep 6.

PMID:
19734898
38.

MBD3, a component of the NuRD complex, facilitates chromatin alteration and deposition of epigenetic marks.

Morey L, Brenner C, Fazi F, Villa R, Gutierrez A, Buschbeck M, Nervi C, Minucci S, Fuks F, Di Croce L.

Mol Cell Biol. 2008 Oct;28(19):5912-23. doi: 10.1128/MCB.00467-08. Epub 2008 Jul 21.

39.

K313dup is a recurrent CEBPA mutation in de novo acute myeloid leukemia (AML).

Carnicer MJ, Lasa A, Buschbeck M, Serrano E, Carricondo M, Brunet S, Aventin A, Sierra J, Di Croce L, Nomdedeu JF.

Ann Hematol. 2008 Oct;87(10):819-27. doi: 10.1007/s00277-008-0528-2. Epub 2008 Jun 28.

PMID:
18587575
40.

PML4 induces differentiation by Myc destabilization.

Buschbeck M, Uribesalgo I, Ledl A, Gutierrez A, Minucci S, Muller S, Di Croce L.

Oncogene. 2007 May 17;26(23):3415-22. Epub 2006 Dec 4.

PMID:
17146439
41.

Chromatin structure and epigenetics.

Quina AS, Buschbeck M, Di Croce L.

Biochem Pharmacol. 2006 Nov 30;72(11):1563-9. Epub 2006 Jul 11. Review.

PMID:
16836980
42.
43.

The methyl-CpG binding protein MBD1 is required for PML-RARalpha function.

Villa R, Morey L, Raker VA, Buschbeck M, Gutierrez A, De Santis F, Corsaro M, Varas F, Bossi D, Minucci S, Pelicci PG, Di Croce L.

Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1400-5. Epub 2006 Jan 23.

44.

Identification of a transcriptionally active hVH-5 pseudogene on 10q22.2.

Berger IR, Buschbeck M, Bange J, Ullrich A.

Cancer Genet Cytogenet. 2005 Jun;159(2):155-9.

PMID:
15899389
45.

Abl-kinase-sensitive levels of ERK5 and its intrinsic basal activity contribute to leukaemia cell survival.

Buschbeck M, Hofbauer S, Di Croce L, Keri G, Ullrich A.

EMBO Rep. 2005 Jan;6(1):63-9.

46.
47.

Altered epigenetic signals in human disease.

Di Croce L, Buschbeck M, Gutierrez A, Joval I, Morey L, Villa R, Minucci S.

Cancer Biol Ther. 2004 Sep;3(9):831-7. Epub 2004 Sep 23. Review.

PMID:
15467421
48.

Negative regulation of HER2 signaling by the PEST-type protein-tyrosine phosphatase BDP1.

Gensler M, Buschbeck M, Ullrich A.

J Biol Chem. 2004 Mar 26;279(13):12110-6. Epub 2003 Dec 2.

49.

Phosphotyrosine-specific phosphatase PTP-SL regulates the ERK5 signaling pathway.

Buschbeck M, Eickhoff J, Sommer MN, Ullrich A.

J Biol Chem. 2002 Aug 16;277(33):29503-9. Epub 2002 May 31.

50.

Stress stimuli increase calcium-induced arachidonic acid release through phosphorylation of cytosolic phospholipase A2.

Buschbeck M, Ghomashchi F, Gelb MH, Watson SP, Börsch-Haubold AG.

Biochem J. 1999 Dec 1;344 Pt 2:359-66.

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