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Items: 16


Hsc70 Ameliorates the Vesicle Recycling Defects Caused by Excess α-Synuclein at Synapses.

Banks SML, Medeiros AT, McQuillan M, Busch DJ, Ibarraran-Viniegra AS, Sousa R, Lafer EM, Morgan JR.

eNeuro. 2020 Jan 31;7(1). pii: ENEURO.0448-19.2020. doi: 10.1523/ENEURO.0448-19.2020. Print 2020 Jan/Feb.


Entropic Control of Receptor Recycling Using Engineered Ligands.

DeGroot ACM, Busch DJ, Hayden CC, Mihelic SA, Alpar AT, Behar M, Stachowiak JC.

Biophys J. 2018 Mar 27;114(6):1377-1388. doi: 10.1016/j.bpj.2018.01.036.


Connectosomes for Direct Molecular Delivery to the Cellular Cytoplasm.

Gadok AK, Busch DJ, Ferrati S, Li B, Smyth HD, Stachowiak JC.

J Am Chem Soc. 2016 Oct 5;138(39):12833-12840. Epub 2016 Sep 26.


Multifunctional Transmembrane Protein Ligands for Cell-Specific Targeting of Plasma Membrane-Derived Vesicles.

Zhao C, Busch DJ, Vershel CP, Stachowiak JC.

Small. 2016 Jul;12(28):3837-48. doi: 10.1002/smll.201600493. Epub 2016 Jun 13.


Reducing synuclein accumulation improves neuronal survival after spinal cord injury.

Fogerson SM, van Brummen AJ, Busch DJ, Allen SR, Roychaudhuri R, Banks SM, Klärner FG, Schrader T, Bitan G, Morgan JR.

Exp Neurol. 2016 Apr;278:105-15. doi: 10.1016/j.expneurol.2016.02.004. Epub 2016 Feb 13.


The impact of physiological crowding on the diffusivity of membrane bound proteins.

Houser JR, Busch DJ, Bell DR, Li B, Ren P, Stachowiak JC.

Soft Matter. 2016 Feb 21;12(7):2127-34. doi: 10.1039/c5sm02572a. Epub 2016 Jan 11.


Intrinsically disordered proteins drive membrane curvature.

Busch DJ, Houser JR, Hayden CC, Sherman MB, Lafer EM, Stachowiak JC.

Nat Commun. 2015 Jul 24;6:7875. doi: 10.1038/ncomms8875.


Designing lipids for selective partitioning into liquid ordered membrane domains.

Momin N, Lee S, Gadok AK, Busch DJ, Bachand GD, Hayden CC, Stachowiak JC, Sasaki DY.

Soft Matter. 2015 Apr 28;11(16):3241-50. doi: 10.1039/c4sm02856b.


Acute increase of α-synuclein inhibits synaptic vesicle recycling evoked during intense stimulation.

Busch DJ, Oliphint PA, Walsh RB, Banks SM, Woods WS, George JM, Morgan JR.

Mol Biol Cell. 2014 Dec 1;25(24):3926-41. doi: 10.1091/mbc.E14-02-0708. Epub 2014 Oct 1.


A role for an Hsp70 nucleotide exchange factor in the regulation of synaptic vesicle endocytosis.

Morgan JR, Jiang J, Oliphint PA, Jin S, Gimenez LE, Busch DJ, Foldes AE, Zhuo Y, Sousa R, Lafer EM.

J Neurosci. 2013 May 1;33(18):8009-21. doi: 10.1523/JNEUROSCI.4505-12.2013.


Synuclein accumulation is associated with cell-specific neuronal death after spinal cord injury.

Busch DJ, Morgan JR.

J Comp Neurol. 2012 Jun 1;520(8):1751-71. doi: 10.1002/cne.23011.


Increased synapsin expression and neurite sprouting in lamprey brain after spinal cord injury.

Lau BY, Foldes AE, Alieva NO, Oliphint PA, Busch DJ, Morgan JR.

Exp Neurol. 2011 Apr;228(2):283-93. doi: 10.1016/j.expneurol.2011.02.003. Epub 2011 Feb 18.


BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90.

Lundgren K, Zhang H, Brekken J, Huser N, Powell RE, Timple N, Busch DJ, Neely L, Sensintaffar JL, Yang YC, McKenzie A, Friedman J, Scannevin R, Kamal A, Hong K, Kasibhatla SR, Boehm MF, Burrows FJ.

Mol Cancer Ther. 2009 Apr;8(4):921-9. doi: 10.1158/1535-7163.MCT-08-0758.


Rationally designed high-affinity 2-amino-6-halopurine heat shock protein 90 inhibitors that exhibit potent antitumor activity.

Kasibhatla SR, Hong K, Biamonte MA, Busch DJ, Karjian PL, Sensintaffar JL, Kamal A, Lough RE, Brekken J, Lundgren K, Grecko R, Timony GA, Ran Y, Mansfield R, Fritz LC, Ulm E, Burrows FJ, Boehm MF.

J Med Chem. 2007 Jun 14;50(12):2767-78. Epub 2007 May 8.


7'-substituted benzothiazolothio- and pyridinothiazolothio-purines as potent heat shock protein 90 inhibitors.

Zhang L, Fan J, Vu K, Hong K, Le Brazidec JY, Shi J, Biamonte M, Busch DJ, Lough RE, Grecko R, Ran Y, Sensintaffar JL, Kamal A, Lundgren K, Burrows FJ, Mansfield R, Timony GA, Ulm EH, Kasibhatla SR, Boehm MF.

J Med Chem. 2006 Aug 24;49(17):5352-62.


Orally active purine-based inhibitors of the heat shock protein 90.

Biamonte MA, Shi J, Hong K, Hurst DC, Zhang L, Fan J, Busch DJ, Karjian PL, Maldonado AA, Sensintaffar JL, Yang YC, Kamal A, Lough RE, Lundgren K, Burrows FJ, Timony GA, Boehm MF, Kasibhatla SR.

J Med Chem. 2006 Jan 26;49(2):817-28.


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