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Items: 33


Structure based design of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors from a phenotypic screen.

Palacios DS, Meredith E, Kawanami T, Adams C, Chen X, Darsigny V, Geno E, Palermo M, Baird D, Boynton G, Busby SA, George EL, Guy C, Hewett J, Tierney L, Thigale S, Weihofen W, Wang L, White N, Yin M, Argikar UA.

Bioorg Med Chem Lett. 2018 Feb 1;28(3):365-370. doi: 10.1016/j.bmcl.2017.12.037. Epub 2017 Dec 18.


Identifying initiation and elongation inhibitors of dengue virus RNA polymerase in a high-throughput lead-finding campaign.

Smith TM, Lim SP, Yue K, Busby SA, Arora R, Seh CC, Wright SK, Nutiu R, Niyomrattanakit P, Wan KF, Beer D, Shi PY, Benson TE.

J Biomol Screen. 2015 Jan;20(1):153-63. doi: 10.1177/1087057114551141. Epub 2014 Sep 24.


Activation of AMP-activated protein kinase revealed by hydrogen/deuterium exchange mass spectrometry.

Landgraf RR, Goswami D, Rajamohan F, Harris MS, Calabrese MF, Hoth LR, Magyar R, Pascal BD, Chalmers MJ, Busby SA, Kurumbail RG, Griffin PR.

Structure. 2013 Nov 5;21(11):1942-53. doi: 10.1016/j.str.2013.08.023. Epub 2013 Sep 26.


Antibiotic susceptibility and resistance of Staphylococcus aureus isolated from fresh porcine skin xenografts: risk to recipients with thermal injury.

Busby SA, Robb A, Lang S, Takeuchi Y, Vesely P, Scobie L.

Burns. 2014 Mar;40(2):288-94. doi: 10.1016/j.burns.2013.06.006. Epub 2013 Jul 10.


Identification of a novel selective inverse agonist probe and analogs for the Retinoic acid receptor-related Orphan Receptor Alpha (RORα).

Kumar N, Nuhant P, Solt LA, Conkright JJ, Wang Y, Istrate MA, Busby SA, Ruben DGO, Burris TP, Cameron M, Mercer BA, Hodder P, Roush WR, Rosen H, Griffin PR.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2010 Sep 1 [updated 2013 Mar 14].


Potent Anti-Diabetic Actions of a Novel Non-Agonist PPARγ Ligand that Blocks Cdk5-Mediated Phosphorylation.

Kamenecka TM, Busby SA, Kumar N, Choi JH, Banks AS, Vidovic D, Cameron MD, Schurer SC, Mercer BA, Hodder P, Spiegelman BM, Griffin PR.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2011 Jul 5 [updated 2013 Mar 7].


Suggestions for the diagnosis and elimination of hepatitis E virus in pigs used for xenotransplantation.

Busby SA, Crossan C, Godwin J, Petersen B, Galli C, Cozzi E, Takeuchi Y, Scobie L.

Xenotransplantation. 2013 May-Jun;20(3):188-92. doi: 10.1111/xen.12038. Epub 2013 May 7.


Targeting orphan nuclear receptors for treatment of metabolic diseases and autoimmunity.

Burris TP, Busby SA, Griffin PR.

Chem Biol. 2012 Jan 27;19(1):51-9. doi: 10.1016/j.chembiol.2011.12.011. Review.


Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation.

Choi JH, Banks AS, Kamenecka TM, Busby SA, Chalmers MJ, Kumar N, Kuruvilla DS, Shin Y, He Y, Bruning JB, Marciano DP, Cameron MD, Laznik D, Jurczak MJ, Schürer SC, Vidović D, Shulman GI, Spiegelman BM, Griffin PR.

Nature. 2011 Sep 4;477(7365):477-81. doi: 10.1038/nature10383.


Campaign to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR).

Kumar N, Solt LA, Conkright J, Wang Y, Istrate MA, Busby SA, Garcia-Ordonez RD, Nuhant P, Burris T, Mercer BA, Hodder P, Roush WR, Rosen H, Griffin PR.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2009 Jan 3 [updated 2011 Mar 11].


A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects.

Lee JM, Lee YK, Mamrosh JL, Busby SA, Griffin PR, Pathak MC, Ortlund EA, Moore DD.

Nature. 2011 May 25;474(7352):506-10. doi: 10.1038/nature10111.


DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex.

Zhang J, Chalmers MJ, Stayrook KR, Burris LL, Wang Y, Busby SA, Pascal BD, Garcia-Ordonez RD, Bruning JB, Istrate MA, Kojetin DJ, Dodge JA, Burris TP, Griffin PR.

Nat Struct Mol Biol. 2011 May;18(5):556-63. doi: 10.1038/nsmb.2046. Epub 2011 Apr 10.


Identification of a novel non-retinoid pan inverse agonist of the retinoic acid receptors.

Busby SA, Kumar N, Kuruvilla DS, Istrate MA, Conkright JJ, Wang Y, Kamenecka TM, Cameron MD, Roush WR, Burris TP, Griffin PR.

ACS Chem Biol. 2011 Jun 17;6(6):618-27. doi: 10.1021/cb100396s. Epub 2011 Mar 17.


Differential hydrogen/deuterium exchange mass spectrometry analysis of protein-ligand interactions.

Chalmers MJ, Busby SA, Pascal BD, West GM, Griffin PR.

Expert Rev Proteomics. 2011 Feb;8(1):43-59. doi: 10.1586/epr.10.109. Review.


Helix 11 dynamics is critical for constitutive androstane receptor activity.

Wright E, Busby SA, Wisecarver S, Vincent J, Griffin PR, Fernandez EJ.

Structure. 2011 Jan 12;19(1):37-44. doi: 10.1016/j.str.2010.11.008.


A combined ligand- and structure-based virtual screening protocol identifies submicromolar PPARγ partial agonists.

Vidović D, Busby SA, Griffin PR, Schürer SC.

ChemMedChem. 2011 Jan 3;6(1):94-103. doi: 10.1002/cmdc.201000428.


The benzenesulfoamide T0901317 [N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide] is a novel retinoic acid receptor-related orphan receptor-alpha/gamma inverse agonist.

Kumar N, Solt LA, Conkright JJ, Wang Y, Istrate MA, Busby SA, Garcia-Ordonez RD, Burris TP, Griffin PR.

Mol Pharmacol. 2010 Feb;77(2):228-36. doi: 10.1124/mol.109.060905. Epub 2009 Nov 3.


Apo-human carbonic anhydrase II revisited: implications of the loss of a metal in protein structure, stability, and solvent network.

Avvaru BS, Busby SA, Chalmers MJ, Griffin PR, Venkatakrishnan B, Agbandje-McKenna M, Silverman DN, McKenna R.

Biochemistry. 2009 Aug 11;48(31):7365-72. doi: 10.1021/bi9007512.


Identification of specific hemopexin-like domain residues that facilitate matrix metalloproteinase collagenolytic activity.

Lauer-Fields JL, Chalmers MJ, Busby SA, Minond D, Griffin PR, Fields GB.

J Biol Chem. 2009 Sep 4;284(36):24017-24. doi: 10.1074/jbc.M109.016873. Epub 2009 Jul 1.


HD desktop: an integrated platform for the analysis and visualization of H/D exchange data.

Pascal BD, Chalmers MJ, Busby SA, Griffin PR.

J Am Soc Mass Spectrom. 2009 Apr;20(4):601-10. doi: 10.1016/j.jasms.2008.11.019. Epub 2008 Dec 6.


Partial agonists activate PPARgamma using a helix 12 independent mechanism.

Bruning JB, Chalmers MJ, Prasad S, Busby SA, Kamenecka TM, He Y, Nettles KW, Griffin PR.

Structure. 2007 Oct;15(10):1258-71.


A two-stage differential hydrogen deuterium exchange method for the rapid characterization of protein/ligand interactions.

Chalmers MJ, Busby SA, Pascal BD, Southern MR, Griffin PR.

J Biomol Tech. 2007 Sep;18(4):194-204.


The Deuterator: software for the determination of backbone amide deuterium levels from H/D exchange MS data.

Pascal BD, Chalmers MJ, Busby SA, Mader CC, Southern MR, Tsinoremas NF, Griffin PR.

BMC Bioinformatics. 2007 May 16;8:156.


Chemical derivatization of histones for facilitated analysis by mass spectrometry.

Garcia BA, Mollah S, Ueberheide BM, Busby SA, Muratore TL, Shabanowitz J, Hunt DF.

Nat Protoc. 2007;2(4):933-8.


HDM2-binding partners: interaction with translation elongation factor EF1alpha.

Frum R, Busby SA, Ramamoorthy M, Deb S, Shabanowitz J, Hunt DF, Deb SP.

J Proteome Res. 2007 Apr;6(4):1410-7. Epub 2007 Mar 21.


Genomic and functional evolution of the Drosophila melanogaster sperm proteome.

Dorus S, Busby SA, Gerike U, Shabanowitz J, Hunt DF, Karr TL.

Nat Genet. 2006 Dec;38(12):1440-5. Epub 2006 Nov 12.


Comprehensive phosphoprotein analysis of linker histone H1 from Tetrahymena thermophila.

Garcia BA, Joshi S, Thomas CE, Chitta RK, Diaz RL, Busby SA, Andrews PC, Ogorzalek Loo RR, Shabanowitz J, Kelleher NL, Mizzen CA, Allis CD, Hunt DF.

Mol Cell Proteomics. 2006 Sep;5(9):1593-609. Epub 2006 Jul 10.


Structural mobility in human manganese superoxide dismutase.

Quint P, Ayala I, Busby SA, Chalmers MJ, Griffin PR, Rocca J, Nick HS, Silverman DN.

Biochemistry. 2006 Jul 11;45(27):8209-15.


Probing protein ligand interactions by automated hydrogen/deuterium exchange mass spectrometry.

Chalmers MJ, Busby SA, Pascal BD, He Y, Hendrickson CL, Marshall AG, Griffin PR.

Anal Chem. 2006 Feb 15;78(4):1005-14.


Resetting the epigenetic histone code in the MRL-lpr/lpr mouse model of lupus by histone deacetylase inhibition.

Garcia BA, Busby SA, Shabanowitz J, Hunt DF, Mishra N.

J Proteome Res. 2005 Nov-Dec;4(6):2032-42.


Modifications of human histone H3 variants during mitosis.

Garcia BA, Barber CM, Hake SB, Ptak C, Turner FB, Busby SA, Shabanowitz J, Moran RG, Allis CD, Hunt DF.

Biochemistry. 2005 Oct 4;44(39):13202-13.


Simian virus 40 small t antigen mediates conformation-dependent transfer of protein phosphatase 2A onto the androgen receptor.

Yang CS, Vitto MJ, Busby SA, Garcia BA, Kesler CT, Gioeli D, Shabanowitz J, Hunt DF, Rundell K, Brautigan DL, Paschal BM.

Mol Cell Biol. 2005 Feb;25(4):1298-308.


Characterization of phosphorylation sites on histone H1 isoforms by tandem mass spectrometry.

Garcia BA, Busby SA, Barber CM, Shabanowitz J, Allis CD, Hunt DF.

J Proteome Res. 2004 Nov-Dec;3(6):1219-27.


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