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Items: 1 to 50 of 142

1.

Historical reconstruction unveils the risk of mass mortality and ecosystem collapse during pancontinental megadrought.

Godfree RC, Knerr N, Godfree D, Busby J, Robertson B, Encinas-Viso F.

Proc Natl Acad Sci U S A. 2019 Jul 30;116(31):15580-15589. doi: 10.1073/pnas.1902046116. Epub 2019 Jul 15.

2.

Cryo-EM structures of the pore-forming A subunit from the Yersinia entomophaga ABC toxin.

Piper SJ, Brillault L, Rothnagel R, Croll TI, Box JK, Chassagnon I, Scherer S, Goldie KN, Jones SA, Schepers F, Hartley-Tassell L, Ve T, Busby JN, Dalziel JE, Lott JS, Hankamer B, Stahlberg H, Hurst MRH, Landsberg MJ.

Nat Commun. 2019 Apr 26;10(1):1952. doi: 10.1038/s41467-019-09890-8.

3.

Change in type-2 biomarkers and related cytokines with prednisolone in uncontrolled severe oral corticosteroid dependent asthmatics: an interventional open-label study.

Busby J, Holweg CTJ, Chai A, Bradding P, Cai F, Chaudhuri R, Mansur AH, Lordan JL, Matthews JG, Menzies-Gow A, Niven R, Staton T, Heaney LG.

Thorax. 2019 Aug;74(8):806-809. doi: 10.1136/thoraxjnl-2018-212709. Epub 2019 Apr 2.

PMID:
30940770
4.

Teneurin Structures Are Composed of Ancient Bacterial Protein Domains.

Jackson VA, Busby JN, Janssen BJC, Lott JS, Seiradake E.

Front Neurosci. 2019 Mar 13;13:183. doi: 10.3389/fnins.2019.00183. eCollection 2019. Review.

5.

Deep learning using tumor HLA peptide mass spectrometry datasets improves neoantigen identification.

Bulik-Sullivan B, Busby J, Palmer CD, Davis MJ, Murphy T, Clark A, Busby M, Duke F, Yang A, Young L, Ojo NC, Caldwell K, Abhyankar J, Boucher T, Hart MG, Makarov V, Montpreville VT, Mercier O, Chan TA, Scagliotti G, Bironzo P, Novello S, Karachaliou N, Rosell R, Anderson I, Gabrail N, Hrom J, Limvarapuss C, Choquette K, Spira A, Rousseau R, Voong C, Rizvi NA, Fadel E, Frattini M, Jooss K, Skoberne M, Francis J, Yelensky R.

Nat Biotechnol. 2018 Dec 17. doi: 10.1038/nbt.4313. [Epub ahead of print]

PMID:
30556813
6.

Statin use and survival in patients with gastric cancer in two independent population-based cohorts.

Spence AD, Busby J, Hughes CM, Johnston BT, Coleman HG, Cardwell CR.

Pharmacoepidemiol Drug Saf. 2019 Apr;28(4):460-470. doi: 10.1002/pds.4688. Epub 2018 Nov 20.

PMID:
30456916
7.

Remotely Monitored Therapy and Nitric Oxide Suppression Identifies Nonadherence in Severe Asthma.

Heaney LG, Busby J, Bradding P, Chaudhuri R, Mansur AH, Niven R, Pavord ID, Lindsay JT, Costello RW; Medical Research Council UK Refractory Asthma Stratification Programme (RASP-UK).

Am J Respir Crit Care Med. 2019 Feb 15;199(4):454-464. doi: 10.1164/rccm.201806-1182OC.

PMID:
30339770
8.

Postdiagnostic Calcium Channel Blocker Use and Breast Cancer Mortality: A Population-based Cohort Study.

Busby J, Mills K, Zhang SD, Liberante FG, Cardwell CR.

Epidemiology. 2018 May;29(3):407-413. doi: 10.1097/EDE.0000000000000814.

PMID:
29608546
9.

Model for Identifying Individuals at Risk for Esophageal Adenocarcinoma.

Kunzmann AT, Thrift AP, Cardwell CR, Lagergren J, Xie S, Johnston BT, Anderson LA, Busby J, McMenamin ÚC, Spence AD, Coleman HG.

Clin Gastroenterol Hepatol. 2018 Aug;16(8):1229-1236.e4. doi: 10.1016/j.cgh.2018.03.014. Epub 2018 Mar 17.

PMID:
29559360
10.

Medications that relax the lower oesophageal sphincter and risk of oesophageal cancer: An analysis of two independent population-based databases.

Spence AD, Busby J, Murchie P, Kunzmann AT, McMenamin ÚC, Coleman HG, Johnston BT, O'Rorke MA, Murray LJ, Iversen L, Lee AJ, Cardwell CR.

Int J Cancer. 2018 Jul 1;143(1):22-31. doi: 10.1002/ijc.31293. Epub 2018 Mar 8.

11.

Post-diagnostic calcium channel blocker use and breast cancer mortality: a population-based cohort study.

Busby J, Mills K, Zhang SD, Liberante FG, Cardwell C.

Epidemiology. 2018 Feb 1. doi: 10.1097/EDE.0000000000000814. [Epub ahead of print]

PMID:
29394190
12.

Selective serotonin reuptake inhibitor use and breast cancer survival: a population-based cohort study.

Busby J, Mills K, Zhang SD, Liberante FG, Cardwell CR.

Breast Cancer Res. 2018 Jan 19;20(1):4. doi: 10.1186/s13058-017-0928-0.

13.

A combined connectivity mapping and pharmacoepidemiology approach to identify existing medications with breast cancer causing or preventing properties.

Busby J, Murray L, Mills K, Zhang SD, Liberante F, Cardwell CR.

Pharmacoepidemiol Drug Saf. 2018 Jan;27(1):78-86. doi: 10.1002/pds.4345. Epub 2017 Dec 4.

PMID:
29205633
14.

Low-Dose Aspirin Use Does Not Increase Survival in 2 Independent Population-Based Cohorts of Patients With Esophageal or Gastric Cancer.

Spence AD, Busby J, Johnston BT, Baron JA, Hughes CM, Coleman HG, Cardwell CR.

Gastroenterology. 2018 Mar;154(4):849-860.e1. doi: 10.1053/j.gastro.2017.10.044. Epub 2017 Nov 6.

PMID:
29122547
15.

Angiotensin receptor blocker use and gastro-oesophageal cancer survival: a population-based cohort study.

Busby J, McMenamin Ú, Spence A, Johnston BT, Hughes C, Cardwell CR.

Aliment Pharmacol Ther. 2018 Jan;47(2):279-288. doi: 10.1111/apt.14388. Epub 2017 Nov 3.

16.

How do population, general practice and hospital factors influence ambulatory care sensitive admissions: a cross sectional study.

Busby J, Purdy S, Hollingworth W.

BMC Fam Pract. 2017 May 25;18(1):67. doi: 10.1186/s12875-017-0638-9.

17.

Calculating hospital length of stay using the Hospital Episode Statistics; a comparison of methodologies.

Busby J, Purdy S, Hollingworth W.

BMC Health Serv Res. 2017 May 12;17(1):347. doi: 10.1186/s12913-017-2295-z.

18.

Patient flow within UK emergency departments: a systematic review of the use of computer simulation modelling methods.

Mohiuddin S, Busby J, Savović J, Richards A, Northstone K, Hollingworth W, Donovan JL, Vasilakis C.

BMJ Open. 2017 May 9;7(5):e015007. doi: 10.1136/bmjopen-2016-015007. Review.

19.

The Diagnosis of Urinary Tract Infection in Young Children (DUTY) Study Clinical Rule: Economic Evaluation.

Hollingworth W, Busby J, Butler CC, O'Brien K, Sterne JA, Hood K, Little P, Lawton M, Birnie K, Thomas-Jones E, Harman K, Hay AD; DUTY Study Team.

Value Health. 2017 Apr;20(4):556-566. doi: 10.1016/j.jval.2017.01.003. Epub 2017 Feb 22.

20.

The role of general practice in reducing unplanned hospital admissions.

Busby J, Hollingworth W, Purdy S.

Br J Hosp Med (Lond). 2017 Apr 2;78(4):186-187. doi: 10.12968/hmed.2017.78.4.186. No abstract available.

PMID:
28398883
21.

The effect of medications which cause inflammation of the gastro-oesophageal tract on cancer risk: a nested case-control study of routine Scottish data.

Busby J, Murchie P, Murray L, Iversen L, Lee AJ, Spence A, Watson MC, Cardwell CR.

Int J Cancer. 2017 Apr 15;140(8):1828-1835. doi: 10.1002/ijc.30612. Epub 2017 Feb 6.

22.

Analysis of Affordance, Time, and Adaptation in the Assessment of Industrial Control System Cybersecurity Risk.

Busby JS, Green B, Hutchison D.

Risk Anal. 2017 Jul;37(7):1298-1314. doi: 10.1111/risa.12681. Epub 2017 Jan 17.

PMID:
28095596
23.

An Alternative Approach to ChIP-Seq Normalization Enables Detection of Genome-Wide Changes in Histone H3 Lysine 27 Trimethylation upon EZH2 Inhibition.

Egan B, Yuan CC, Craske ML, Labhart P, Guler GD, Arnott D, Maile TM, Busby J, Henry C, Kelly TK, Tindell CA, Jhunjhunwala S, Zhao F, Hatton C, Bryant BM, Classon M, Trojer P.

PLoS One. 2016 Nov 22;11(11):e0166438. doi: 10.1371/journal.pone.0166438. eCollection 2016.

24.

Using geographic variation in unplanned ambulatory care sensitive condition admission rates to identify commissioning priorities: an analysis of routine data from England.

Busby J, Purdy S, Hollingworth W.

J Health Serv Res Policy. 2017 Jan;22(1):20-27. doi: 10.1177/1355819616666397. Epub 2016 Nov 30.

PMID:
27827306
25.

Opportunities for primary care to reduce hospital admissions: a cross-sectional study of geographical variation.

Busby J, Purdy S, Hollingworth W.

Br J Gen Pract. 2017 Jan;67(654):e20-e28. doi: 10.3399/bjgp16X687949. Epub 2016 Oct 24.

26.

The Diagnosis of Urinary Tract infection in Young children (DUTY): a diagnostic prospective observational study to derive and validate a clinical algorithm for the diagnosis of urinary tract infection in children presenting to primary care with an acute illness.

Hay AD, Birnie K, Busby J, Delaney B, Downing H, Dudley J, Durbaba S, Fletcher M, Harman K, Hollingworth W, Hood K, Howe R, Lawton M, Lisles C, Little P, MacGowan A, O'Brien K, Pickles T, Rumsby K, Sterne JA, Thomas-Jones E, van der Voort J, Waldron CA, Whiting P, Wootton M, Butler CC.

Health Technol Assess. 2016 Jul;20(51):1-294. doi: 10.3310/hta20510.

27.

Improving the Diagnosis and Treatment of Urinary Tract Infection in Young Children in Primary Care: Results from the DUTY Prospective Diagnostic Cohort Study.

Hay AD, Sterne JA, Hood K, Little P, Delaney B, Hollingworth W, Wootton M, Howe R, MacGowan A, Lawton M, Busby J, Pickles T, Birnie K, O'Brien K, Waldron CA, Dudley J, Van Der Voort J, Downing H, Thomas-Jones E, Harman K, Lisles C, Rumsby K, Durbaba S, Whiting P, Butler CC.

Ann Fam Med. 2016 Jul;14(4):325-36. doi: 10.1370/afm.1954.

28.

An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells.

Vinogradova M, Gehling VS, Gustafson A, Arora S, Tindell CA, Wilson C, Williamson KE, Guler GD, Gangurde P, Manieri W, Busby J, Flynn EM, Lan F, Kim HJ, Odate S, Cochran AG, Liu Y, Wongchenko M, Yang Y, Cheung TK, Maile TM, Lau T, Costa M, Hegde GV, Jackson E, Pitti R, Arnott D, Bailey C, Bellon S, Cummings RT, Albrecht BK, Harmange JC, Kiefer JR, Trojer P, Classon M.

Nat Chem Biol. 2016 Jul;12(7):531-8. doi: 10.1038/nchembio.2085. Epub 2016 May 23.

PMID:
27214401
29.

Combining cross-crystal averaging and MRSAD to phase a 4354-amino-acid structure.

Busby JN, Lott JS, Panjikar S.

Acta Crystallogr D Struct Biol. 2016 Feb;72(Pt 2):182-91. doi: 10.1107/S2059798315023566. Epub 2016 Jan 22.

PMID:
26894666
30.
31.

Using clinical practice variations as a method for commissioners and clinicians to identify and prioritise opportunities for disinvestment in health care: a cross-sectional study, systematic reviews and qualitative study.

Hollingworth W, Rooshenas L, Busby J, Hine CE, Badrinath P, Whiting PF, Moore THM, Owen-Smith A, Sterne JAC, Jones HE, Beynon C, Donovan JL.

Southampton (UK): NIHR Journals Library; 2015 Apr.

32.

EZH2 inhibitor efficacy in non-Hodgkin's lymphoma does not require suppression of H3K27 monomethylation.

Bradley WD, Arora S, Busby J, Balasubramanian S, Gehling VS, Nasveschuk CG, Vaswani RG, Yuan CC, Hatton C, Zhao F, Williamson KE, Iyer P, Méndez J, Campbell R, Cantone N, Garapaty-Rao S, Audia JE, Cook AS, Dakin LA, Albrecht BK, Harmange JC, Daniels DL, Cummings RT, Bryant BM, Normant E, Trojer P.

Chem Biol. 2014 Nov 20;21(11):1463-75. doi: 10.1016/j.chembiol.2014.09.017.

33.

Can urinary PCA3 supplement PSA in the early detection of prostate cancer?

Wei JT, Feng Z, Partin AW, Brown E, Thompson I, Sokoll L, Chan DW, Lotan Y, Kibel AS, Busby JE, Bidair M, Lin DW, Taneja SS, Viterbo R, Joon AY, Dahlgren J, Kagan J, Srivastava S, Sanda MG.

J Clin Oncol. 2014 Dec 20;32(36):4066-72. doi: 10.1200/JCO.2013.52.8505. Epub 2014 Nov 10.

34.

A mutation in Ampd2 is associated with nephrotic syndrome and hypercholesterolemia in mice.

Helmering J, Juan T, Li CM, Chhoa M, Baron W, Gyuris T, Richards WG, Turk JR, Lawrence J, Cosgrove PA, Busby J, Kim KW, Kaufman SA, Cummings C, Carlson G, Véniant MM, Lloyd DJ.

Lipids Health Dis. 2014 Oct 31;13:167. doi: 10.1186/1476-511X-13-167.

35.

Crystal structure of PhnF, a GntR-family transcriptional regulator of phosphate transport in Mycobacterium smegmatis.

Gebhard S, Busby JN, Fritz G, Moreland NJ, Cook GM, Lott JS, Baker EN, Money VA.

J Bacteriol. 2014 Oct;196(19):3472-81. doi: 10.1128/JB.01965-14. Epub 2014 Jul 21.

36.

Organizational sensemaking about risk controls: the case of offshore hydrocarbons production.

Busby JS, Collins AM.

Risk Anal. 2014 Sep;34(9):1738-52. doi: 10.1111/risa.12198. Epub 2014 Apr 1.

PMID:
24689551
37.

Piperazine oxadiazole inhibitors of acetyl-CoA carboxylase.

Bourbeau MP, Siegmund A, Allen JG, Shu H, Fotsch C, Bartberger MD, Kim KW, Komorowski R, Graham M, Busby J, Wang M, Meyer J, Xu Y, Salyers K, Fielden M, Véniant MM, Gu W.

J Med Chem. 2013 Dec 27;56(24):10132-41. doi: 10.1021/jm401601s. Epub 2013 Dec 11.

PMID:
24294923
38.

Identification of EZH2 and EZH1 small molecule inhibitors with selective impact on diffuse large B cell lymphoma cell growth.

Garapaty-Rao S, Nasveschuk C, Gagnon A, Chan EY, Sandy P, Busby J, Balasubramanian S, Campbell R, Zhao F, Bergeron L, Audia JE, Albrecht BK, Harmange JC, Cummings R, Trojer P.

Chem Biol. 2013 Nov 21;20(11):1329-39. doi: 10.1016/j.chembiol.2013.09.013. Epub 2013 Oct 31.

39.

Direct interaction between AR and PAK6 in androgen-stimulated PAK6 activation.

Liu X, Busby J, John C, Wei J, Yuan X, Lu ML.

PLoS One. 2013 Oct 10;8(10):e77367. doi: 10.1371/journal.pone.0077367. eCollection 2013.

40.

A pragmatic randomised controlled trial of 'PhysioDirect' telephone assessment and advice services for patients with musculoskeletal problems: economic evaluation.

Hollinghurst S, Coast J, Busby J, Bishop A, Foster NE, Franchini A, Grove S, Hall J, Hopper C, Kaur S, Montgomery AA, Salisbury C.

BMJ Open. 2013 Oct 3;3(10):e003406. doi: 10.1136/bmjopen-2013-003406.

41.

The BC component of ABC toxins is an RHS-repeat-containing protein encapsulation device.

Busby JN, Panjikar S, Landsberg MJ, Hurst MR, Lott JS.

Nature. 2013 Sep 26;501(7468):547-50. doi: 10.1038/nature12465. Epub 2013 Aug 4.

PMID:
23913273
42.

Uptake of carotid artery stenting in England and subsequent vascular admissions: an appropriate response to emerging evidence?

Lee AH, Busby J, Brooks M, Hollingworth W.

Eur J Vasc Endovasc Surg. 2013 Sep;46(3):282-9. doi: 10.1016/j.ejvs.2013.04.019. Epub 2013 May 20.

43.

Temporal growth and geographic variation in the use of laboratory tests by NHS general practices: using routine data to identify research priorities.

Busby J, Schroeder K, Woltersdorf W, Sterne JA, Ben-Shlomo Y, Hay A, Hollingworth W.

Br J Gen Pract. 2013 Apr;63(609):e256-66. doi: 10.3399/bjgp13X665224.

44.

Trends in procedures for infertility and caesarean sections: was NICE disinvestment guidance implemented? NICE recommendation reminders.

Chamberlain CA, Martin RM, Busby J, Gilbert R, Cahill DJ, Hollingworth W.

BMC Public Health. 2013 Feb 6;13:112. doi: 10.1186/1471-2458-13-112.

45.

A pragmatic randomised controlled trial of the effectiveness and cost-effectiveness of 'PhysioDirect' telephone assessment and advice services for physiotherapy.

Salisbury C, Foster NE, Hopper C, Bishop A, Hollinghurst S, Coast J, Kaur S, Pearson J, Franchini A, Hall J, Grove S, Calnan M, Busby J, Montgomery AA.

Health Technol Assess. 2013 Jan;17(2):1-157, v-vi. doi: 10.3310/hta17020.

46.

Prostate cancer, Version 3.2012: featured updates to the NCCN guidelines.

Mohler JL, Armstrong AJ, Bahnson RR, Boston B, Busby JE, D'Amico AV, Eastham JA, Enke CA, Farrington T, Higano CS, Horwitz EM, Kantoff PW, Kawachi MH, Kuettel M, Lee RJ, MacVicar GR, Malcolm AW, Miller D, Plimack ER, Pow-Sang JM, Roach M 3rd, Rohren E, Rosenfeld S, Srinivas S, Strope SA, Tward J, Twardowski P, Walsh PC, Ho M, Shead DA.

J Natl Compr Canc Netw. 2012 Sep;10(9):1081-7.

PMID:
22956807
47.

FGF21 promotes metabolic homeostasis via white adipose and leptin in mice.

Véniant MM, Hale C, Helmering J, Chen MM, Stanislaus S, Busby J, Vonderfecht S, Xu J, Lloyd DJ.

PLoS One. 2012;7(7):e40164. doi: 10.1371/journal.pone.0040164. Epub 2012 Jul 6.

48.

Robotic versus open radical cystectomy: identification of patients who benefit from the robotic approach.

Knox ML, El-Galley R, Busby JE.

J Endourol. 2013 Jan;27(1):40-4. doi: 10.1089/end.2012.0168. Epub 2012 Oct 11.

PMID:
22788707
49.

A phase 2 cancer chemoprevention biomarker trial of isoflavone G-2535 (genistein) in presurgical bladder cancer patients.

Messing E, Gee JR, Saltzstein DR, Kim K, diSant'Agnese A, Kolesar J, Harris L, Faerber A, Havighurst T, Young JM, Efros M, Getzenberg RH, Wheeler MA, Tangrea J, Parnes H, House M, Busby JE, Hohl R, Bailey H.

Cancer Prev Res (Phila). 2012 Apr;5(4):621-30. doi: 10.1158/1940-6207.CAPR-11-0455. Epub 2012 Jan 31.

50.

3D structure of the Yersinia entomophaga toxin complex and implications for insecticidal activity.

Landsberg MJ, Jones SA, Rothnagel R, Busby JN, Marshall SD, Simpson RM, Lott JS, Hankamer B, Hurst MR.

Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20544-9. doi: 10.1073/pnas.1111155108. Epub 2011 Dec 7.

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