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Items: 50

1.

Novel influenza inhibitors designed to target PB1 interactions with host importin RanBP5.

Mohl G, Liddle N, Nygaard J, Dorius A, Lyons N, Hodek J, Weber J, Michaelis DJ, Busath DD.

Antiviral Res. 2019 Apr;164:81-90. doi: 10.1016/j.antiviral.2019.02.003. Epub 2019 Feb 8.

PMID:
30742842
2.

Unraveling the Binding, Proton Blockage, and Inhibition of Influenza M2 WT and S31N by Rimantadine Variants.

Drakopoulos A, Tzitzoglaki C, McGuire K, Hoffmann A, Konstantinidi A, Kolokouris D, Ma C, Freudenberger K, Hutterer J, Gauglitz G, Wang J, Schmidtke M, Busath DD, Kolocouris A.

ACS Med Chem Lett. 2018 Jan 29;9(3):198-203. doi: 10.1021/acsmedchemlett.7b00458. eCollection 2018 Mar 8.

3.

Divalent copper complexes as influenza A M2 inhibitors.

Gordon NA, McGuire KL, Wallentine SK, Mohl GA, Lynch JD, Harrison RG, Busath DD.

Antiviral Res. 2017 Nov;147:100-106. doi: 10.1016/j.antiviral.2017.10.009. Epub 2017 Oct 12.

PMID:
29032206
4.

Resistance-Mutation (N31) Effects on Drug Orientation and Channel Hydration in Amantadine-Bound Influenza A M2.

Gleed ML, Ioannidis H, Kolocouris A, Busath DD.

J Phys Chem B. 2015 Sep 3;119(35):11548-59. doi: 10.1021/acs.jpcb.5b05808. Epub 2015 Aug 20.

PMID:
26268449
5.

Investigation of a recent rise of dual amantadine-resistance mutations in the influenza A M2 sequence.

Durrant MG, Eggett DL, Busath DD.

BMC Genet. 2015;16 Suppl 2:S3. doi: 10.1186/1471-2156-16-S2-S3. Epub 2015 Apr 23.

6.

Why bound amantadine fails to inhibit proton conductance according to simulations of the drug-resistant influenza A M2 (S31N).

Gleed ML, Busath DD.

J Phys Chem B. 2015 Jan 22;119(3):1225-31. doi: 10.1021/jp508545d. Epub 2014 Nov 26.

7.

Aminoadamantanes with persistent in vitro efficacy against H1N1 (2009) influenza A.

Kolocouris A, Tzitzoglaki C, Johnson FB, Zell R, Wright AK, Cross TA, Tietjen I, Fedida D, Busath DD.

J Med Chem. 2014 Jun 12;57(11):4629-39. doi: 10.1021/jm500598u. Epub 2014 May 15.

8.

Endosis and exosis: new names for fusion and budding.

Busath DD, Woodbury DJ, Frost A.

J Membr Biol. 2012 Nov;245(11):759-60. doi: 10.1007/s00232-012-9439-1. Epub 2012 Jun 1. No abstract available.

PMID:
22653449
9.

M2 protein from influenza A: from multiple structures to biophysical and functional insights.

Cross TA, Dong H, Sharma M, Busath DD, Zhou HX.

Curr Opin Virol. 2012 Apr;2(2):128-33. doi: 10.1016/j.coviro.2012.01.005. Epub 2012 Feb 16. Review.

10.
11.

Influence of pK(a) shifts on the calculated dipole moments of proteins.

Mellor BL, Khadka S, Busath DD, Mazzeo BA.

Protein J. 2011 Oct;30(7):490-8. doi: 10.1007/s10930-011-9355-8.

PMID:
21927900
12.

Modeling the membrane environment for membrane proteins.

Separovic F, Killian JA, Cotten M, Busath DD, Cross TA.

Biophys J. 2011 Apr 20;100(8):2073-4; author reply 2075. doi: 10.1016/j.bpj.2011.02.058. No abstract available.

13.

Method for estimating the internal permittivity of proteins using dielectric spectroscopy.

Mellor BL, Cort├ęs EC, Busath DD, Mazzeo BA.

J Phys Chem B. 2011 Mar 17;115(10):2205-13. doi: 10.1021/jp1111873. Epub 2011 Feb 23.

PMID:
21344910
14.

Functional reconstitution of influenza A M2(22-62).

Peterson E, Ryser T, Funk S, Inouye D, Sharma M, Qin H, Cross TA, Busath DD.

Biochim Biophys Acta. 2011 Feb;1808(2):516-21. doi: 10.1016/j.bbamem.2010.10.010. Epub 2010 Oct 20.

15.

Insight into the mechanism of the influenza A proton channel from a structure in a lipid bilayer.

Sharma M, Yi M, Dong H, Qin H, Peterson E, Busath DD, Zhou HX, Cross TA.

Science. 2010 Oct 22;330(6003):509-12. doi: 10.1126/science.1191750.

16.

Drug sensitivity, drug-resistant mutations, and structures of three conductance domains of viral porins.

Sharma M, Li C, Busath DD, Zhou HX, Cross TA.

Biochim Biophys Acta. 2011 Feb;1808(2):538-46. doi: 10.1016/j.bbamem.2010.07.015. Epub 2010 Jul 23. Review.

17.

Gramicidin channels are internally gated.

Jones TL, Fu R, Nielson F, Cross TA, Busath DD.

Biophys J. 2010 Apr 21;98(8):1486-93. doi: 10.1016/j.bpj.2009.11.055.

18.

The gramicidin channel ion permeation free-energy profile: direct and indirect effects of CHARMM force field improvements.

Mustafa M, Busath DD.

Interdiscip Sci. 2009 Jun;1(2):113-27. doi: 10.1007/s12539-009-0025-3.

19.

Computational studies of gramicidin permeation: an entry way sulfonate enhances cation occupancy at entry sites.

Mustafa M, Henderson DJ, Busath DD.

Biochim Biophys Acta. 2009 Jun;1788(6):1404-12. doi: 10.1016/j.bbamem.2009.03.021. Epub 2009 Apr 8.

20.

Free-energy profiles for ions in the influenza M2-TMD channel.

Mustafa M, Henderson DJ, Busath DD.

Proteins. 2009 Sep;76(4):794-807. doi: 10.1002/prot.22376.

21.

Integration of ganglioside GT1b receptor into DPPE and DPPC phospholipid monolayers: an X-ray reflectivity and grazing-incidence diffraction study.

Miller CE, Busath DD, Strongin B, Majewski J.

Biophys J. 2008 Oct;95(7):3278-86. doi: 10.1529/biophysj.107.128538. Epub 2008 Jul 3.

22.

Proton transport through influenza A virus M2 protein reconstituted in vesicles.

Moffat JC, Vijayvergiya V, Gao PF, Cross TA, Woodbury DJ, Busath DD.

Biophys J. 2008 Jan 15;94(2):434-45. Epub 2007 Sep 7.

23.

Tryptophan contributions to the empirical free-energy profile in gramicidin A/M heterodimer channels.

Durrant JD, Caywood D, Busath DD.

Biophys J. 2006 Nov 1;91(9):3230-41. Epub 2006 Jul 21.

24.

Histidines, heart of the hydrogen ion channel from influenza A virus: toward an understanding of conductance and proton selectivity.

Hu J, Fu R, Nishimura K, Zhang L, Zhou HX, Busath DD, Vijayvergiya V, Cross TA.

Proc Natl Acad Sci U S A. 2006 May 2;103(18):6865-70. Epub 2006 Apr 21.

25.

Proton conductance of influenza virus M2 protein in planar lipid bilayers.

Vijayvergiya V, Wilson R, Chorak A, Gao PF, Cross TA, Busath DD.

Biophys J. 2004 Sep;87(3):1697-704.

26.

AFM visualization of mobile influenza A M2 molecules in planar bilayers.

Hughes T, Strongin B, Gao FP, Vijayvergiya V, Busath DD, Davis RC.

Biophys J. 2004 Jul;87(1):311-22.

27.
28.

Molecular dynamics simulations of Trp side-chain conformational flexibility in the gramicidin A channel.

Bingham NC, Smith NE, Cross TA, Busath DD.

Biopolymers. 2003;71(5):593-600.

PMID:
14635099
29.

Noncontact dipole effects on channel permeation. VI. 5F- and 6F-Trp gramicidin channel currents.

Cole CD, Frost AS, Thompson N, Cotten M, Cross TA, Busath DD.

Biophys J. 2002 Oct;83(4):1974-86.

31.

The role of Trp side chains in tuning single proton conduction through gramicidin channels.

Gowen JA, Markham JC, Morrison SE, Cross TA, Busath DD, Mapes EJ, Schumaker MF.

Biophys J. 2002 Aug;83(2):880-98.

32.

An inverting basket model for AE1 transport.

Ramakrishnan V, Busath DD.

J Theor Biol. 2002 Mar 21;215(2):215-26.

PMID:
12051975
33.
34.

Noncontact dipole effects on channel permeation. V. Computed potentials for fluorinated gramicidin.

Anderson DG, Shirts RB, Cross TA, Busath DD.

Biophys J. 2001 Sep;81(3):1255-64.

35.

Noncontact dipole effects on channel permeation. IV. Kinetic model of 5F-Trp(13) gramicidin A currents.

Thompson N, Thompson G, Cole CD, Cotten M, Cross TA, Busath DD.

Biophys J. 2001 Sep;81(3):1245-54.

36.

Comparison of gramicidin A and gramicidin M channel conductance dispersities.

Markham JC, Gowen JA, Cross TA, Busath DD.

Biochim Biophys Acta. 2001 Aug 6;1513(2):185-92.

37.

Molecular dynamics simulation of continuous current flow through a model biological membrane channel.

Crozier PS, Rowley RL, Holladay NB, Henderson D, Busath DD.

Phys Rev Lett. 2001 Mar 12;86(11):2467-70.

PMID:
11289956
38.

Noncontact dipole effects on channel permeation. III. Anomalous proton conductance effects in gramicidin.

Phillips LR, Cole CD, Hendershot RJ, Cotten M, Cross TA, Busath DD.

Biophys J. 1999 Nov;77(5):2492-501. doi: 10.1016/S0006-3495(99)77085-2. Epub 2008 Nov 21.

39.

Lorentzian noise in single gramicidin A channel formamidinium currents.

Fairbanks TG, Andrus CL, Busath DD.

Novartis Found Symp. 1999;225:74-87; discussion 87-92.

PMID:
10472049
40.

Modulating dipoles for structure-function correlations in the gramicidin A channel.

Cotten M, Tian C, Busath DD, Shirts RB, Cross TA.

Biochemistry. 1999 Jul 20;38(29):9185-97.

PMID:
10413493
41.

Gramicidin channel controversy--the structure in a lipid environment.

Andersen OS, Apell HJ, Bamberg E, Busath DD, Koeppe RE 2nd, Sigworth FJ, Szabo G, Urry DW, Woolley A.

Nat Struct Biol. 1999 Jul;6(7):609; discussion 611-2. No abstract available.

PMID:
10404209
42.
43.

Noncontact dipole effects on channel permeation. I. Experiments with (5F-indole)Trp13 gramicidin A channels.

Busath DD, Thulin CD, Hendershot RW, Phillips LR, Maughan P, Cole CD, Bingham NC, Morrison S, Baird LC, Hendershot RJ, Cotten M, Cross TA.

Biophys J. 1998 Dec;75(6):2830-44.

44.
46.
47.

An SS1-SS2 beta-barrel structure for the voltage-activated potassium channel.

Bogusz S, Boxer A, Busath DD.

Protein Eng. 1992 Jun;5(4):285-93.

PMID:
1409550
48.

Ultraviolet flash photolysis of gramicidin-doped lipid bilayers.

Busath DD, Hayon E.

Biochim Biophys Acta. 1988 Sep 15;944(1):73-8.

PMID:
2458137
49.
50.

Ion movement through membrane channels.

Szabo G, Busath DD.

Prog Clin Biol Res. 1983;126:297-312. No abstract available.

PMID:
6193536

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