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Items: 1 to 50 of 80

1.

LRRK2 activation in idiopathic Parkinson's disease.

Di Maio R, Hoffman EK, Rocha EM, Keeney MT, Sanders LH, De Miranda BR, Zharikov A, Van Laar A, Stepan AF, Lanz TA, Kofler JK, Burton EA, Alessi DR, Hastings TG, Greenamyre JT.

Sci Transl Med. 2018 Jul 25;10(451). pii: eaar5429. doi: 10.1126/scitranslmed.aar5429.

PMID:
30045977
2.

Astrocyte-specific DJ-1 overexpression protects against rotenone-induced neurotoxicity in a rat model of Parkinson's disease.

De Miranda BR, Rocha EM, Bai Q, El Ayadi A, Hinkle D, Burton EA, Timothy Greenamyre J.

Neurobiol Dis. 2018 Jul;115:101-114. doi: 10.1016/j.nbd.2018.04.008. Epub 2018 Apr 9.

PMID:
29649621
3.

Astroglial DJ-1 over-expression up-regulates proteins involved in redox regulation and is neuroprotective in vivo.

Frøyset AK, Edson AJ, Gharbi N, Khan EA, Dondorp D, Bai Q, Tiraboschi E, Suster ML, Connolly JB, Burton EA, Fladmark KE.

Redox Biol. 2018 Jun;16:237-247. doi: 10.1016/j.redox.2018.02.010. Epub 2018 Feb 17.

4.

Modulation of the zebrafish optokinetic reflex by pharmacologic agents targeting GABAA receptors.

Shao E, Scheetz SD, Xie W, Burton EA.

Neurosci Lett. 2018 Apr 3;671:33-37. doi: 10.1016/j.neulet.2018.01.055. Epub 2018 Feb 2.

PMID:
29410359
5.

An open-source method to analyze optokinetic reflex responses in larval zebrafish.

Scheetz SD, Shao E, Zhou Y, Cario CL, Bai Q, Burton EA.

J Neurosci Methods. 2018 Jan 1;293:329-337. doi: 10.1016/j.jneumeth.2017.10.012. Epub 2017 Oct 16.

PMID:
29042258
6.

Quantitative Responses of Adult Zebrafish to Changes in Ambient Illumination.

Shao E, Bai Q, Zhou Y, Burton EA.

Zebrafish. 2017 Dec;14(6):508-516. doi: 10.1089/zeb.2017.1468. Epub 2017 Sep 14.

PMID:
28910236
7.

Spectral properties of the zebrafish visual motor response.

Burton CE, Zhou Y, Bai Q, Burton EA.

Neurosci Lett. 2017 Apr 12;646:62-67. doi: 10.1016/j.neulet.2017.03.002. Epub 2017 Mar 4.

8.

Live imaging of mitochondrial dynamics in CNS dopaminergic neurons in vivo demonstrates early reversal of mitochondrial transport following MPP(+) exposure.

Dukes AA, Bai Q, Van Laar VS, Zhou Y, Ilin V, David CN, Agim ZS, Bonkowsky JL, Cannon JR, Watkins SC, Croix CM, Burton EA, Berman SB.

Neurobiol Dis. 2016 Nov;95:238-49. doi: 10.1016/j.nbd.2016.07.020. Epub 2016 Jul 22.

9.

α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson's disease.

Di Maio R, Barrett PJ, Hoffman EK, Barrett CW, Zharikov A, Borah A, Hu X, McCoy J, Chu CT, Burton EA, Hastings TG, Greenamyre JT.

Sci Transl Med. 2016 Jun 8;8(342):342ra78. doi: 10.1126/scitranslmed.aaf3634.

10.

The Developmental Toxicity of Complex Silica-Embedded Nickel Nanoparticles Is Determined by Their Physicochemical Properties.

Mahoney S, Najera M, Bai Q, Burton EA, Veser G.

PLoS One. 2016 Mar 31;11(3):e0152010. doi: 10.1371/journal.pone.0152010. eCollection 2016.

11.

The effect of blur on cortical responses to global form and motion.

Burton EA, Wattam-Bell J, Rubin GS, Atkinson J, Braddick O, Nardini M.

J Vis. 2015;15(15):12. doi: 10.1167/15.15.12.

12.

RAF inhibitors that evade paradoxical MAPK pathway activation.

Zhang C, Spevak W, Zhang Y, Burton EA, Ma Y, Habets G, Zhang J, Lin J, Ewing T, Matusow B, Tsang G, Marimuthu A, Cho H, Wu G, Wang W, Fong D, Nguyen H, Shi S, Womack P, Nespi M, Shellooe R, Carias H, Powell B, Light E, Sanftner L, Walters J, Tsai J, West BL, Visor G, Rezaei H, Lin PS, Nolop K, Ibrahim PN, Hirth P, Bollag G.

Nature. 2015 Oct 22;526(7574):583-6. doi: 10.1038/nature14982. Epub 2015 Oct 14.

PMID:
26466569
13.

Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death.

Keatinge M, Bui H, Menke A, Chen YC, Sokol AM, Bai Q, Ellett F, Da Costa M, Burke D, Gegg M, Trollope L, Payne T, McTighe A, Mortiboys H, de Jager S, Nuthall H, Kuo MS, Fleming A, Schapira AH, Renshaw SA, Highley JR, Chacinska A, Panula P, Burton EA, O'Neill MJ, Bandmann O.

Hum Mol Genet. 2015 Dec 1;24(23):6640-52. doi: 10.1093/hmg/ddv369. Epub 2015 Sep 16.

14.

Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor.

Tap WD, Wainberg ZA, Anthony SP, Ibrahim PN, Zhang C, Healey JH, Chmielowski B, Staddon AP, Cohn AL, Shapiro GI, Keedy VL, Singh AS, Puzanov I, Kwak EL, Wagner AJ, Von Hoff DD, Weiss GJ, Ramanathan RK, Zhang J, Habets G, Zhang Y, Burton EA, Visor G, Sanftner L, Severson P, Nguyen H, Kim MJ, Marimuthu A, Tsang G, Shellooe R, Gee C, West BL, Hirth P, Nolop K, van de Rijn M, Hsu HH, Peterfy C, Lin PS, Tong-Starksen S, Bollag G.

N Engl J Med. 2015 Jul 30;373(5):428-37. doi: 10.1056/NEJMoa1411366.

15.

shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson's disease model.

Zharikov AD, Cannon JR, Tapias V, Bai Q, Horowitz MP, Shah V, El Ayadi A, Hastings TG, Greenamyre JT, Burton EA.

J Clin Invest. 2015 Jul 1;125(7):2721-35. doi: 10.1172/JCI64502. Epub 2015 Jun 15.

16.

Targeting cells of the myeloid lineage attenuates pain and disease progression in a prostate model of bone cancer.

Thompson ML, Jimenez-Andrade JM, Chartier S, Tsai J, Burton EA, Habets G, Lin PS, West BL, Mantyh PW.

Pain. 2015 Sep;156(9):1692-702. doi: 10.1097/j.pain.0000000000000228.

17.

Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397.

Smith CC, Zhang C, Lin KC, Lasater EA, Zhang Y, Massi E, Damon LE, Pendleton M, Bashir A, Sebra R, Perl A, Kasarskis A, Shellooe R, Tsang G, Carias H, Powell B, Burton EA, Matusow B, Zhang J, Spevak W, Ibrahim PN, Le MH, Hsu HH, Habets G, West BL, Bollag G, Shah NP.

Cancer Discov. 2015 Jun;5(6):668-79. doi: 10.1158/2159-8290.CD-15-0060. Epub 2015 Apr 6.

18.

Different mechanisms regulate expression of zebrafish myelin protein zero (P0) in myelinating oligodendrocytes and its induction following axonal injury.

Bai Q, Parris RS, Burton EA.

J Biol Chem. 2014 Aug 29;289(35):24114-28. doi: 10.1074/jbc.M113.545426. Epub 2014 Jul 15.

19.

Quantification of larval zebrafish motor function in multiwell plates using open-source MATLAB applications.

Zhou Y, Cattley RT, Cario CL, Bai Q, Burton EA.

Nat Protoc. 2014 Jul;9(7):1533-48. doi: 10.1038/nprot.2014.094. Epub 2014 Jun 5.

20.

Research on the premotor symptoms of Parkinson's disease: clinical and etiological implications.

Chen H, Burton EA, Ross GW, Huang X, Savica R, Abbott RD, Ascherio A, Caviness JN, Gao X, Gray KA, Hong JS, Kamel F, Jennings D, Kirshner A, Lawler C, Liu R, Miller GW, Nussbaum R, Peddada SD, Rick AC, Ritz B, Siderowf AD, Tanner CM, Tröster AI, Zhang J.

Environ Health Perspect. 2013 Nov-Dec;121(11-12):1245-52. doi: 10.1289/ehp.1306967. Epub 2013 Aug 9. Review.

21.

Recurrent BRAF kinase fusions in melanocytic tumors offer an opportunity for targeted therapy.

Botton T, Yeh I, Nelson T, Vemula SS, Sparatta A, Garrido MC, Allegra M, Rocchi S, Bahadoran P, McCalmont TH, LeBoit PE, Burton EA, Bollag G, Ballotti R, Bastian BC.

Pigment Cell Melanoma Res. 2013 Nov;26(6):845-51. doi: 10.1111/pcmr.12148. Epub 2013 Aug 19.

22.

Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor.

Zhang C, Ibrahim PN, Zhang J, Burton EA, Habets G, Zhang Y, Powell B, West BL, Matusow B, Tsang G, Shellooe R, Carias H, Nguyen H, Marimuthu A, Zhang KY, Oh A, Bremer R, Hurt CR, Artis DR, Wu G, Nespi M, Spevak W, Lin P, Nolop K, Hirth P, Tesch GH, Bollag G.

Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5689-94. doi: 10.1073/pnas.1219457110. Epub 2013 Mar 14.

23.

The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: the next therapeutic frontier).

Boxer AL, Gold M, Huey E, Hu WT, Rosen H, Kramer J, Gao FB, Burton EA, Chow T, Kao A, Leavitt BR, Lamb B, Grether M, Knopman D, Cairns NJ, Mackenzie IR, Mitic L, Roberson ED, Van Kammen D, Cantillon M, Zahs K, Jackson G, Salloway S, Morris J, Tong G, Feldman H, Fillit H, Dickinson S, Khachaturian ZS, Sutherland M, Abushakra S, Lewcock J, Farese R, Kenet RO, Laferla F, Perrin S, Whitaker S, Honig L, Mesulam MM, Boeve B, Grossman M, Miller BL, Cummings JL.

Alzheimers Dement. 2013 Mar;9(2):189-98. doi: 10.1016/j.jalz.2012.03.003. Epub 2012 Oct 10. Review.

24.

Frontotemporal degeneration, the next therapeutic frontier: molecules and animal models for frontotemporal degeneration drug development.

Boxer AL, Gold M, Huey E, Gao FB, Burton EA, Chow T, Kao A, Leavitt BR, Lamb B, Grether M, Knopman D, Cairns NJ, Mackenzie IR, Mitic L, Roberson ED, Van Kammen D, Cantillon M, Zahs K, Salloway S, Morris J, Tong G, Feldman H, Fillit H, Dickinson S, Khachaturian Z, Sutherland M, Farese R, Miller BL, Cummings J.

Alzheimers Dement. 2013 Mar;9(2):176-88. doi: 10.1016/j.jalz.2012.03.002. Epub 2012 Oct 5. Review.

25.

The zebrafish homologue of the human DYT1 dystonia gene is widely expressed in CNS neurons but non-essential for early motor system development.

Sager JJ, Torres GE, Burton EA.

PLoS One. 2012;7(9):e45175. doi: 10.1371/journal.pone.0045175. Epub 2012 Sep 28.

26.

RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors.

Su F, Viros A, Milagre C, Trunzer K, Bollag G, Spleiss O, Reis-Filho JS, Kong X, Koya RC, Flaherty KT, Chapman PB, Kim MJ, Hayward R, Martin M, Yang H, Wang Q, Hilton H, Hang JS, Noe J, Lambros M, Geyer F, Dhomen N, Niculescu-Duvaz I, Zambon A, Niculescu-Duvaz D, Preece N, Robert L, Otte NJ, Mok S, Kee D, Ma Y, Zhang C, Habets G, Burton EA, Wong B, Nguyen H, Kockx M, Andries L, Lestini B, Nolop KB, Lee RJ, Joe AK, Troy JL, Gonzalez R, Hutson TE, Puzanov I, Chmielowski B, Springer CJ, McArthur GA, Sosman JA, Lo RS, Ribas A, Marais R.

N Engl J Med. 2012 Jan 19;366(3):207-15. doi: 10.1056/NEJMoa1105358.

27.

Hypokinesia and reduced dopamine levels in zebrafish lacking β- and γ1-synucleins.

Milanese C, Sager JJ, Bai Q, Farrell TC, Cannon JR, Greenamyre JT, Burton EA.

J Biol Chem. 2012 Jan 27;287(5):2971-83. doi: 10.1074/jbc.M111.308312. Epub 2011 Nov 29.

28.

Claudin k is specifically expressed in cells that form myelin during development of the nervous system and regeneration of the optic nerve in adult zebrafish.

Münzel EJ, Schaefer K, Obirei B, Kremmer E, Burton EA, Kuscha V, Becker CG, Brösamle C, Williams A, Becker T.

Glia. 2012 Feb;60(2):253-70. doi: 10.1002/glia.21260. Epub 2011 Oct 21.

PMID:
22020875
29.

Evaluation of spontaneous propulsive movement as a screening tool to detect rescue of Parkinsonism phenotypes in zebrafish models.

Farrell TC, Cario CL, Milanese C, Vogt A, Jeong JH, Burton EA.

Neurobiol Dis. 2011 Oct;44(1):9-18. doi: 10.1016/j.nbd.2011.05.016. Epub 2011 Jun 6.

30.

Automated measurement of zebrafish larval movement.

Cario CL, Farrell TC, Milanese C, Burton EA.

J Physiol. 2011 Aug 1;589(Pt 15):3703-8. doi: 10.1113/jphysiol.2011.207308. Epub 2011 Jun 6.

31.

Major isoform of zebrafish P0 is a 23.5 kDa myelin glycoprotein expressed in selected white matter tracts of the central nervous system.

Bai Q, Sun M, Stolz DB, Burton EA.

J Comp Neurol. 2011 Jun 1;519(8):1580-96. doi: 10.1002/cne.22587.

32.

Single-cell redox imaging demonstrates a distinctive response of dopaminergic neurons to oxidative insults.

Horowitz MP, Milanese C, Di Maio R, Hu X, Montero LM, Sanders LH, Tapias V, Sepe S, van Cappellen WA, Burton EA, Greenamyre JT, Mastroberardino PG.

Antioxid Redox Signal. 2011 Aug 15;15(4):855-71. doi: 10.1089/ars.2010.3629. Epub 2011 Jun 6.

33.

Bioenergetics of neurons inhibit the translocation response of Parkin following rapid mitochondrial depolarization.

Van Laar VS, Arnold B, Cassady SJ, Chu CT, Burton EA, Berman SB.

Hum Mol Genet. 2011 Mar 1;20(5):927-40. doi: 10.1093/hmg/ddq531. Epub 2010 Dec 7.

34.

Pseudotype-dependent lentiviral transduction of astrocytes or neurons in the rat substantia nigra.

Cannon JR, Sew T, Montero L, Burton EA, Greenamyre JT.

Exp Neurol. 2011 Mar;228(1):41-52. doi: 10.1016/j.expneurol.2010.10.016. Epub 2010 Nov 5.

35.

Zebrafish models of Tauopathy.

Bai Q, Burton EA.

Biochim Biophys Acta. 2011 Mar;1812(3):353-63. doi: 10.1016/j.bbadis.2010.09.004. Epub 2010 Sep 16. Review.

36.

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma.

Bollag G, Hirth P, Tsai J, Zhang J, Ibrahim PN, Cho H, Spevak W, Zhang C, Zhang Y, Habets G, Burton EA, Wong B, Tsang G, West BL, Powell B, Shellooe R, Marimuthu A, Nguyen H, Zhang KY, Artis DR, Schlessinger J, Su F, Higgins B, Iyer R, D'Andrea K, Koehler A, Stumm M, Lin PS, Lee RJ, Grippo J, Puzanov I, Kim KB, Ribas A, McArthur GA, Sosman JA, Chapman PB, Flaherty KT, Xu X, Nathanson KL, Nolop K.

Nature. 2010 Sep 30;467(7315):596-9. doi: 10.1038/nature09454.

37.

Noncovalent polymerization and assembly in water promoted by thermodynamic incompatibility.

Simon KA, Sejwal P, Falcone ER, Burton EA, Yang S, Prashar D, Bandyopadhyay D, Narasimhan SK, Varghese N, Gobalasingham NS, Reese JB, Luk YY.

J Phys Chem B. 2010 Aug 19;114(32):10357-67. doi: 10.1021/jp103143x.

PMID:
20701370
38.

Of fish, flies, worms and men: powerful approaches to neuropsychiatric disease using genetic models.

Burton EA, Palladino MJ.

Neurobiol Dis. 2010 Oct;40(1):1-3. doi: 10.1016/j.nbd.2010.07.009. Epub 2010 Jul 21. No abstract available.

39.

Genetic zebrafish models of neurodegenerative diseases.

Bandmann O, Burton EA.

Neurobiol Dis. 2010 Oct;40(1):58-65. doi: 10.1016/j.nbd.2010.05.017. Epub 2010 May 20. Review.

PMID:
20493258
40.

Transgenic zebrafish models of neurodegenerative diseases.

Sager JJ, Bai Q, Burton EA.

Brain Struct Funct. 2010 Mar;214(2-3):285-302. doi: 10.1007/s00429-009-0237-1. Epub 2010 Feb 17. Review.

PMID:
20162303
41.

Cis-acting elements responsible for dopaminergic neuron-specific expression of zebrafish slc6a3 (dopamine transporter) in vivo are located remote from the transcriptional start site.

Bai Q, Burton EA.

Neuroscience. 2009 Dec 15;164(3):1138-51. doi: 10.1016/j.neuroscience.2009.09.014. Epub 2009 Sep 12.

PMID:
19755139
42.

Nonamphiphilic assembly in water: polymorphic nature, thread structure, and thermodynamic incompatibility.

Wu L, Lal J, Simon KA, Burton EA, Luk YY.

J Am Chem Soc. 2009 Jun 3;131(21):7430-43. doi: 10.1021/ja9015149.

PMID:
19422237
43.

Prolonged control of patterned biofilm formation by bio-inert surface chemistry.

Hou S, Burton EA, Wu RL, Luk YY, Ren D.

Chem Commun (Camb). 2009 Mar 14;(10):1207-9. doi: 10.1039/b822197a. Epub 2009 Feb 4.

PMID:
19240875
44.

Molecular gradients of bioinertness reveal a mechanistic difference between mammalian cell adhesion and bacterial biofilm formation.

Burton EA, Simon KA, Hou S, Ren D, Luk YY.

Langmuir. 2009 Feb 3;25(3):1547-53. doi: 10.1021/la803261b.

PMID:
19133791
45.

Expression of a 12-kb promoter element derived from the zebrafish enolase-2 gene in the zebrafish visual system.

Bai Q, Wei X, Burton EA.

Neurosci Lett. 2009 Jan 16;449(3):252-7. doi: 10.1016/j.neulet.2008.10.101. Epub 2008 Nov 5.

46.

Generation of a transgenic zebrafish model of Tauopathy using a novel promoter element derived from the zebrafish eno2 gene.

Bai Q, Garver JA, Hukriede NA, Burton EA.

Nucleic Acids Res. 2007;35(19):6501-16. Epub 2007 Sep 25.

47.

Survival of transplanted neural progenitor cells enhanced by brain irradiation.

Niranjan A, Fellows W, Stauffer W, Burton EA, Hong CS, Lunsford LD, Kondziolka D, Glorioso JC, Gobbel GT.

J Neurosurg. 2007 Aug;107(2):383-91.

PMID:
17695394
48.

Inhibition of Escherichia coli biofilm formation by self-assembled monolayers of functional alkanethiols on gold.

Hou S, Burton EA, Simon KA, Blodgett D, Luk YY, Ren D.

Appl Environ Microbiol. 2007 Jul;73(13):4300-7. Epub 2007 May 4.

49.

Enhancing cell adhesion and confinement by gradient nanotopography.

Simon KA, Burton EA, Han Y, Li J, Huang A, Luk YY.

J Am Chem Soc. 2007 Apr 25;129(16):4892-3. Epub 2007 Mar 30. No abstract available.

PMID:
17394313
50.

Zebrafish DJ-1 is evolutionarily conserved and expressed in dopaminergic neurons.

Bai Q, Mullett SJ, Garver JA, Hinkle DA, Burton EA.

Brain Res. 2006 Oct 3;1113(1):33-44. Epub 2006 Aug 30.

PMID:
16942755

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