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Items: 24

1.

Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-Mediated Targeted Protein Degradation.

Burslem GM, Schultz AR, Bondeson DP, Eide CA, Savage Stevens SL, Druker BJ, Crews CM.

Cancer Res. 2019 Sep 15;79(18):4744-4753. doi: 10.1158/0008-5472.CAN-19-1236. Epub 2019 Jul 16.

PMID:
31311809
2.

Protein folding state-dependent sorting at the Golgi apparatus.

Hellerschmied D, Serebrenik YV, Shao L, Burslem GM, Crews CM.

Mol Biol Cell. 2019 Aug 1;30(17):2296-2308. doi: 10.1091/mbc.E19-01-0069. Epub 2019 Jun 5.

PMID:
31166830
3.

Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion.

Burslem GM, Song J, Chen X, Hines J, Crews CM.

J Am Chem Soc. 2018 Dec 5;140(48):16428-16432. doi: 10.1021/jacs.8b10320. Epub 2018 Nov 19.

PMID:
30427680
4.

Correction: Correction: Hypoxia inducible factor (HIF) as a model for studying inhibition of protein-protein interactions.

Burslem GM, Kyle HF, Nelson A, Edwards TA, Wilson AJ.

Chem Sci. 2018 Feb 2;9(7):2010-2011. doi: 10.1039/c8sc90024h. eCollection 2018 Feb 21.

5.

Erratum: Further Correction: Hypoxia inducible factor (HIF) as a model for studying inhibition of protein-protein interactions.

Burslem GM, Kyle HF, Nelson A, Edwards TA, Wilson AJ.

Chem Sci. 2018 Feb 1;9(7):2008-2009. doi: 10.1039/c8sc90023j. eCollection 2018 Feb 21.

6.

Efficient Synthesis of Immunomodulatory Drug Analogues Enables Exploration of Structure-Degradation Relationships.

Burslem GM, Ottis P, Jaime-Figueroa S, Morgan A, Cromm PM, Toure M, Crews CM.

ChemMedChem. 2018 Aug 10;13(15):1508-1512. doi: 10.1002/cmdc.201800271. Epub 2018 Jul 4.

7.

Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead.

Bondeson DP, Smith BE, Burslem GM, Buhimschi AD, Hines J, Jaime-Figueroa S, Wang J, Hamman BD, Ishchenko A, Crews CM.

Cell Chem Biol. 2018 Jan 18;25(1):78-87.e5. doi: 10.1016/j.chembiol.2017.09.010. Epub 2017 Nov 9.

8.

The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study.

Burslem GM, Smith BE, Lai AC, Jaime-Figueroa S, McQuaid DC, Bondeson DP, Toure M, Dong H, Qian Y, Wang J, Crew AP, Hines J, Crews CM.

Cell Chem Biol. 2018 Jan 18;25(1):67-77.e3. doi: 10.1016/j.chembiol.2017.09.009. Epub 2017 Nov 9.

9.

Double quick, double click reversible peptide "stapling".

Grison CM, Burslem GM, Miles JA, Pilsl LKA, Yeo DJ, Imani Z, Warriner SL, Webb ME, Wilson AJ.

Chem Sci. 2017 Jul 1;8(7):5166-5171. doi: 10.1039/c7sc01342f. Epub 2017 May 31.

10.

Hypoxia inducible factor (HIF) as a model for studying inhibition of protein-protein interactions.

Burslem GM, Kyle HF, Nelson A, Edwards TA, Wilson AJ.

Chem Sci. 2017 Jun 1;8(6):4188-4202. doi: 10.1039/c7sc00388a. Epub 2017 Apr 26. Erratum in: Chem Sci. 2018 Feb 1;9(7):2008-2009. Chem Sci. 2017 Jul 1;8(7):5214-5215.

11.

Expeditious Synthesis of Isoquinolones and Isocoumarins with a Vinyl Borane as an Acetylene Equivalent.

Toure M, Jaime-Figueroa S, Burslem GM, Crews CM.

European J Org Chem. 2016 Aug;2016(24):4171-4175. doi: 10.1002/ejoc.201600575. Epub 2016 Jul 26.

12.

Small-Molecule Modulation of Protein Homeostasis.

Burslem GM, Crews CM.

Chem Rev. 2017 Sep 13;117(17):11269-11301. doi: 10.1021/acs.chemrev.7b00077. Epub 2017 Aug 4. Review.

PMID:
28777566
13.

Correction: Hypoxia inducible factor (HIF) as a model for studying inhibition of protein-protein interactions.

Burslem GM, Kyle HF, Nelson A, Edwards TA, Wilson AJ.

Chem Sci. 2017 Jul 1;8(7):5214-5215. doi: 10.1039/c7sc90030a. Epub 2017 Jun 6. Erratum in: Chem Sci. 2018 Feb 2;9(7):2010-2011.

14.

Trivalent Gd-DOTA reagents for modification of proteins.

Fisher MJ, Williamson DJ, Burslem GM, Plante JP, Manfield IW, Tiede C, Ault JR, Stockley PG, Plein S, Maqbool A, Tomlinson DC, Foster R, Warriner SL, Bon RS.

RSC Adv. 2015 Dec 9;5(116):96194-96200. Epub 2015 Nov 11.

15.

Towards "bionic" proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics.

Burslem GM, Kyle HF, Breeze AL, Edwards TA, Nelson A, Warriner SL, Wilson AJ.

Chem Commun (Camb). 2016 Apr 7;52(31):5421-4. doi: 10.1039/c6cc01812b.

16.

Synthesis of highly functionalized oligobenzamide proteomimetic foldamers by late stage introduction of sensitive groups.

Burslem GM, Kyle HF, Prabhakaran P, Breeze AL, Edwards TA, Warriner SL, Nelson A, Wilson AJ.

Org Biomol Chem. 2016 Apr 12;14(15):3782-6. doi: 10.1039/c6ob00078a.

17.

Exploration of the HIF-1α/p300 interface using peptide and Adhiron phage display technologies.

Kyle HF, Wickson KF, Stott J, Burslem GM, Breeze AL, Tiede C, Tomlinson DC, Warriner SL, Nelson A, Wilson AJ, Edwards TA.

Mol Biosyst. 2015 Oct;11(10):2738-49. doi: 10.1039/c5mb00284b.

18.

Development of solvent-free synthesis of hydrogen-bonded supramolecular polyurethanes.

Houton KA, Burslem GM, Wilson AJ.

Chem Sci. 2015 Apr 1;6(4):2382-2388. doi: 10.1039/c4sc03804e. Epub 2015 Feb 3.

19.

Aminomethylhydroxylation of alkenes: Exploitation in the synthesis of scaffolds for small molecule libraries.

Colomer I, Adeniji O, Burslem GM, Craven P, Rasmussen MO, Willaume A, Kalliokoski T, Foster R, Marsden SP, Nelson A.

Bioorg Med Chem. 2015 Jun 1;23(11):2736-40. doi: 10.1016/j.bmc.2015.01.058. Epub 2015 Feb 11.

PMID:
25740633
20.

Multivalent helix mimetics for PPI-inhibition.

Barnard A, Miles JA, Burslem GM, Barker AM, Wilson AJ.

Org Biomol Chem. 2015 Jan 7;13(1):258-64. doi: 10.1039/c4ob02066a.

21.

Orthogonal functionalisation of α-helix mimetics.

Barnard A, Long K, Yeo DJ, Miles JA, Azzarito V, Burslem GM, Prabhakaran P, A Edwards T, Wilson AJ.

Org Biomol Chem. 2014 Sep 21;12(35):6794-9. doi: 10.1039/c4ob00915k.

22.

Small-molecule proteomimetic inhibitors of the HIF-1α-p300 protein-protein interaction.

Burslem GM, Kyle HF, Breeze AL, Edwards TA, Nelson A, Warriner SL, Wilson AJ.

Chembiochem. 2014 May 26;15(8):1083-7. doi: 10.1002/cbic.201400009. Epub 2014 Apr 29.

23.

A modular lead-oriented synthesis of diverse piperazine, 1,4-diazepane and 1,5-diazocane scaffolds.

James T, Maclellan P, Burslem GM, Simpson I, Grant JA, Warriner S, Sridharan V, Nelson A.

Org Biomol Chem. 2014 Apr 28;12(16):2584-91. doi: 10.1039/c3ob42512f.

PMID:
24614952
24.

In-cell click labelling of small molecules to determine subcellular localisation.

Jones LH, Beal D, Selby MD, Everson O, Burslem GM, Dodd P, Millbank J, Tran TD, Wakenhut F, Graham EJ, Targett-Adams P.

J Chem Biol. 2011 Apr;4(2):49-53. doi: 10.1007/s12154-010-0047-1. Epub 2010 Nov 18.

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