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Items: 1 to 50 of 103

1.

Engineered skeletal muscles for disease modeling and drug discovery.

Wang J, Khodabukus A, Rao L, Vandusen K, Abutaleb N, Bursac N.

Biomaterials. 2019 Nov;221:119416. doi: 10.1016/j.biomaterials.2019.119416. Epub 2019 Aug 8.

PMID:
31419653
2.

Altering integrin engagement regulates membrane localization of Kir2.1 channels.

Sengupta S, Rothenberg KE, Li H, Hoffman BD, Bursac N.

J Cell Sci. 2019 Sep 2;132(17). pii: jcs225383. doi: 10.1242/jcs.225383.

PMID:
31391240
3.

Biomaterializing the promise of cardiac tissue engineering.

Pomeroy JE, Helfer A, Bursac N.

Biotechnol Adv. 2019 Feb 20. pii: S0734-9750(19)30028-X. doi: 10.1016/j.biotechadv.2019.02.009. [Epub ahead of print] Review.

PMID:
30794878
4.

Ion channel engineering for modulation and de novo generation of electrical excitability.

Nguyen HX, Bursac N.

Curr Opin Biotechnol. 2019 Aug;58:100-107. doi: 10.1016/j.copbio.2019.01.004. Epub 2019 Feb 16. Review.

PMID:
30776744
5.

Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure.

Berry JL, Zhu W, Tang YL, Krishnamurthy P, Ge Y, Cooke JP, Chen Y, Garry DJ, Yang HT, Rajasekaran NS, Koch WJ, Li S, Domae K, Qin G, Cheng K, Kamp TJ, Ye L, Hu S, Ogle BM, Rogers JM, Abel ED, Davis ME, Prabhu SD, Liao R, Pu WT, Wang Y, Ping P, Bursac N, Vunjak-Novakovic G, Wu JC, Bolli R, Menasché P, Zhang J.

Circ Res. 2019 Jan 4;124(1):161-169. doi: 10.1161/CIRCRESAHA.118.314216.

PMID:
30605412
6.

Incorporation of macrophages into engineered skeletal muscle enables enhanced muscle regeneration.

Juhas M, Abutaleb N, Wang JT, Ye J, Shaikh Z, Sriworarat C, Qian Y, Bursac N.

Nat Biomed Eng. 2018 Dec;2(12):942-954. doi: 10.1038/s41551-018-0290-2. Epub 2018 Oct 1.

7.

Electrical stimulation increases hypertrophy and metabolic flux in tissue-engineered human skeletal muscle.

Khodabukus A, Madden L, Prabhu NK, Koves TR, Jackman CP, Muoio DM, Bursac N.

Biomaterials. 2019 Apr;198:259-269. doi: 10.1016/j.biomaterials.2018.08.058. Epub 2018 Aug 31.

PMID:
30180985
8.

Long-term contractile activity and thyroid hormone supplementation produce engineered rat myocardium with adult-like structure and function.

Jackman C, Li H, Bursac N.

Acta Biomater. 2018 Sep 15;78:98-110. doi: 10.1016/j.actbio.2018.08.003. Epub 2018 Aug 4.

9.

Correction of Biochemical Abnormalities and Improved Muscle Function in a Phase I/II Clinical Trial of Clenbuterol in Pompe Disease.

Koeberl DD, Case LE, Smith EC, Walters C, Han SO, Li Y, Chen W, Hornik CP, Huffman KM, Kraus WE, Thurberg BL, Corcoran DL, Bali D, Bursac N, Kishnani PS.

Mol Ther. 2018 Sep 5;26(9):2304-2314. doi: 10.1016/j.ymthe.2018.06.023. Epub 2018 Jul 5.

10.

Microheterogeneity-induced conduction slowing and wavefront collisions govern macroscopic conduction behavior: A computational and experimental study.

Gokhale TA, Asfour H, Verma S, Bursac N, Henriquez CS.

PLoS Comput Biol. 2018 Jul 16;14(7):e1006276. doi: 10.1371/journal.pcbi.1006276. eCollection 2018 Jul.

11.

In Vitro Tissue-Engineered Skeletal Muscle Models for Studying Muscle Physiology and Disease.

Khodabukus A, Prabhu N, Wang J, Bursac N.

Adv Healthc Mater. 2018 Aug;7(15):e1701498. doi: 10.1002/adhm.201701498. Epub 2018 Apr 25. Review.

12.

Generation and customization of biosynthetic excitable tissues for electrophysiological studies and cell-based therapies.

Nguyen HX, Kirkton RD, Bursac N.

Nat Protoc. 2018 May;13(5):927-945. doi: 10.1038/nprot.2018.016. Epub 2018 Apr 5.

13.

Engineering human pluripotent stem cells into a functional skeletal muscle tissue.

Rao L, Qian Y, Khodabukus A, Ribar T, Bursac N.

Nat Commun. 2018 Jan 9;9(1):126. doi: 10.1038/s41467-017-02636-4.

14.

Engineered cardiac tissue patch maintains structural and electrical properties after epicardial implantation.

Jackman CP, Ganapathi AM, Asfour H, Qian Y, Allen BW, Li Y, Bursac N.

Biomaterials. 2018 Mar;159:48-58. doi: 10.1016/j.biomaterials.2018.01.002. Epub 2018 Jan 3.

15.

Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues.

Shadrin IY, Allen BW, Qian Y, Jackman CP, Carlson AL, Juhas ME, Bursac N.

Nat Commun. 2017 Nov 28;8(1):1825. doi: 10.1038/s41467-017-01946-x.

16.

Tension Creates an Endoreplication Wavefront that Leads Regeneration of Epicardial Tissue.

Cao J, Wang J, Jackman CP, Cox AH, Trembley MA, Balowski JJ, Cox BD, De Simone A, Dickson AL, Di Talia S, Small EM, Kiehart DP, Bursac N, Poss KD.

Dev Cell. 2017 Sep 25;42(6):600-615.e4. doi: 10.1016/j.devcel.2017.08.024.

17.

Genetically Encoded Photoactuators and Photosensors for Characterization and Manipulation of Pluripotent Stem Cells.

Pomeroy JE, Nguyen HX, Hoffman BD, Bursac N.

Theranostics. 2017 Aug 18;7(14):3539-3558. doi: 10.7150/thno.20593. eCollection 2017. Review.

18.

An Engineered Optogenetic Switch for Spatiotemporal Control of Gene Expression, Cell Differentiation, and Tissue Morphogenesis.

Polstein LR, Juhas M, Hanna G, Bursac N, Gersbach CA.

ACS Synth Biol. 2017 Nov 17;6(11):2003-2013. doi: 10.1021/acssynbio.7b00147. Epub 2017 Sep 6.

19.

Overcoming the Roadblocks to Cardiac Cell Therapy Using Tissue Engineering.

Yanamandala M, Zhu W, Garry DJ, Kamp TJ, Hare JM, Jun HW, Yoon YS, Bursac N, Prabhu SD, Dorn GW 2nd, Bolli R, Kitsis RN, Zhang J.

J Am Coll Cardiol. 2017 Aug 8;70(6):766-775. doi: 10.1016/j.jacc.2017.06.012. Review.

20.

The extracellular matrix protein agrin promotes heart regeneration in mice.

Bassat E, Mutlak YE, Genzelinakh A, Shadrin IY, Baruch Umansky K, Yifa O, Kain D, Rajchman D, Leach J, Riabov Bassat D, Udi Y, Sarig R, Sagi I, Martin JF, Bursac N, Cohen S, Tzahor E.

Nature. 2017 Jul 13;547(7662):179-184. doi: 10.1038/nature22978. Epub 2017 Jun 5.

21.

Age-dependent functional crosstalk between cardiac fibroblasts and cardiomyocytes in a 3D engineered cardiac tissue.

Li Y, Asfour H, Bursac N.

Acta Biomater. 2017 Jun;55:120-130. doi: 10.1016/j.actbio.2017.04.027. Epub 2017 Apr 25.

22.

Developmental stage-dependent effects of cardiac fibroblasts on function of stem cell-derived engineered cardiac tissues.

Liau B, Jackman CP, Li Y, Bursac N.

Sci Rep. 2017 Feb 9;7:42290. doi: 10.1038/srep42290.

23.

Modeling an Excitable Biosynthetic Tissue with Inherent Variability for Paired Computational-Experimental Studies.

Gokhale TA, Kim JM, Kirkton RD, Bursac N, Henriquez CS.

PLoS Comput Biol. 2017 Jan 20;13(1):e1005342. doi: 10.1371/journal.pcbi.1005342. eCollection 2017 Jan.

24.

Tissue-engineered 3-dimensional (3D) microenvironment enhances the direct reprogramming of fibroblasts into cardiomyocytes by microRNAs.

Li Y, Dal-Pra S, Mirotsou M, Jayawardena TM, Hodgkinson CP, Bursac N, Dzau VJ.

Sci Rep. 2016 Dec 12;6:38815. doi: 10.1038/srep38815.

25.

Dynamic culture yields engineered myocardium with near-adult functional output.

Jackman CP, Carlson AL, Bursac N.

Biomaterials. 2016 Dec;111:66-79. doi: 10.1016/j.biomaterials.2016.09.024. Epub 2016 Sep 30.

26.

Engineering prokaryotic channels for control of mammalian tissue excitability.

Nguyen HX, Kirkton RD, Bursac N.

Nat Commun. 2016 Oct 18;7:13132. doi: 10.1038/ncomms13132.

27.

Distilling complexity to advance cardiac tissue engineering.

Ogle BM, Bursac N, Domian I, Huang NF, Menasché P, Murry CE, Pruitt B, Radisic M, Wu JC, Wu SM, Zhang J, Zimmermann WH, Vunjak-Novakovic G.

Sci Transl Med. 2016 Jun 8;8(342):342ps13. doi: 10.1126/scitranslmed.aad2304. Review.

28.

Striated muscle function, regeneration, and repair.

Shadrin IY, Khodabukus A, Bursac N.

Cell Mol Life Sci. 2016 Nov;73(22):4175-4202. Epub 2016 Jun 6. Review.

29.

Cell Density and Joint microRNA-133a and microRNA-696 Inhibition Enhance Differentiation and Contractile Function of Engineered Human Skeletal Muscle Tissues.

Cheng CS, Ran L, Bursac N, Kraus WE, Truskey GA.

Tissue Eng Part A. 2016 Apr;22(7-8):573-83. doi: 10.1089/ten.TEA.2015.0359.

30.

Synergizing Engineering and Biology to Treat and Model Skeletal Muscle Injury and Disease.

Bursac N, Juhas M, Rando TA.

Annu Rev Biomed Eng. 2015;17:217-42. doi: 10.1146/annurev-bioeng-071114-040640. Review.

31.

Design, evaluation, and application of engineered skeletal muscle.

Juhas M, Ye J, Bursac N.

Methods. 2016 Apr 15;99:81-90. doi: 10.1016/j.ymeth.2015.10.002. Epub 2015 Oct 6. Review.

32.

STIM1-Ca2+ signaling modulates automaticity of the mouse sinoatrial node.

Zhang H, Sun AY, Kim JJ, Graham V, Finch EA, Nepliouev I, Zhao G, Li T, Lederer WJ, Stiber JA, Pitt GS, Bursac N, Rosenberg PB.

Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):E5618-27. doi: 10.1073/pnas.1503847112. Epub 2015 Sep 30.

33.

Rapid fusion between mesenchymal stem cells and cardiomyocytes yields electrically active, non-contractile hybrid cells.

Shadrin IY, Yoon W, Li L, Shepherd N, Bursac N.

Sci Rep. 2015 Jul 10;5:12043. doi: 10.1038/srep12043.

34.

Human Cardiac Tissue Engineering: From Pluripotent Stem Cells to Heart Repair.

Jackman CP, Shadrin IY, Carlson AL, Bursac N.

Curr Opin Chem Eng. 2015 Feb;7:57-64.

35.

Bioengineered human myobundles mimic clinical responses of skeletal muscle to drugs.

Madden L, Juhas M, Kraus WE, Truskey GA, Bursac N.

Elife. 2015 Jan 9;4:e04885. doi: 10.7554/eLife.04885.

36.

Stoichiometry of Gata4, Mef2c, and Tbx5 influences the efficiency and quality of induced cardiac myocyte reprogramming.

Wang L, Liu Z, Yin C, Asfour H, Chen O, Li Y, Bursac N, Liu J, Qian L.

Circ Res. 2015 Jan 16;116(2):237-44. doi: 10.1161/CIRCRESAHA.116.305547. Epub 2014 Nov 21.

37.

Roles of adherent myogenic cells and dynamic culture in engineered muscle function and maintenance of satellite cells.

Juhas M, Bursac N.

Biomaterials. 2014 Nov;35(35):9438-46. doi: 10.1016/j.biomaterials.2014.07.035. Epub 2014 Aug 22.

38.

Quantifying electrical interactions between cardiomyocytes and other cells in micropatterned cell pairs.

Nguyen H, Badie N, McSpadden L, Pedrotty D, Bursac N.

Methods Mol Biol. 2014;1181:249-62. doi: 10.1007/978-1-4939-1047-2_21.

39.

Cardiac fibroblasts in pressure overload hypertrophy: the enemy within?

Bursac N.

J Clin Invest. 2014 Jul;124(7):2850-3. doi: 10.1172/JCI76628. Epub 2014 Jun 17.

40.

Introduction to the special issue on tissue engineering and regenerative medicine.

Hsiai T, Li S, Bursac N.

Ann Biomed Eng. 2014 Jul;42(7):1355-6. doi: 10.1007/s10439-014-1053-1. No abstract available.

41.

Physiology and metabolism of tissue-engineered skeletal muscle.

Cheng CS, Davis BN, Madden L, Bursac N, Truskey GA.

Exp Biol Med (Maywood). 2014 Sep;239(9):1203-14. doi: 10.1177/1535370214538589. Epub 2014 Jun 9. Review.

42.

Controlling the structural and functional anisotropy of engineered cardiac tissues.

Bian W, Jackman CP, Bursac N.

Biofabrication. 2014 Jun;6(2):024109-24109. doi: 10.1088/1758-5082/6/2/024109. Epub 2014 Apr 10.

43.

Biomimetic engineered muscle with capacity for vascular integration and functional maturation in vivo.

Juhas M, Engelmayr GC Jr, Fontanella AN, Palmer GM, Bursac N.

Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5508-13. doi: 10.1073/pnas.1402723111. Epub 2014 Mar 31.

44.

Design considerations for an integrated microphysiological muscle tissue for drug and tissue toxicity testing.

Truskey GA, Achneck HE, Bursac N, Chan H, Cheng CS, Fernandez C, Hong S, Jung Y, Koves T, Kraus WE, Leong K, Madden L, Reichert WM, Zhao X.

Stem Cell Res Ther. 2013;4 Suppl 1:S10. doi: 10.1186/scrt371. Epub 2013 Dec 20. Review.

45.

Robust T-tubulation and maturation of cardiomyocytes using tissue-engineered epicardial mimetics.

Bian W, Badie N, Himel HD 4th, Bursac N.

Biomaterials. 2014 Apr;35(12):3819-28. doi: 10.1016/j.biomaterials.2014.01.045. Epub 2014 Feb 6.

46.

Adjunctive β2-agonist treatment reduces glycogen independently of receptor-mediated acid α-glucosidase uptake in the limb muscles of mice with Pompe disease.

Farah BL, Madden L, Li S, Nance S, Bird A, Bursac N, Yen PM, Young SP, Koeberl DD.

FASEB J. 2014 May;28(5):2272-80. doi: 10.1096/fj.13-244202. Epub 2014 Jan 21.

47.

Use of flow, electrical, and mechanical stimulation to promote engineering of striated muscles.

Rangarajan S, Madden L, Bursac N.

Ann Biomed Eng. 2014 Jul;42(7):1391-405. doi: 10.1007/s10439-013-0966-4. Epub 2013 Dec 24. Review.

48.

Spatial profiles of electrical mismatch determine vulnerability to conduction failure across a host-donor cell interface.

Kirkton RD, Badie N, Bursac N.

Circ Arrhythm Electrophysiol. 2013 Dec;6(6):1200-7. doi: 10.1161/CIRCEP.113.001050. Epub 2013 Nov 14.

49.

WNT3 is a biomarker capable of predicting the definitive endoderm differentiation potential of hESCs.

Jiang W, Zhang D, Bursac N, Zhang Y.

Stem Cell Reports. 2013 Jun 4;1(1):46-52. doi: 10.1016/j.stemcr.2013.03.003. eCollection 2013.

50.

Induced pluripotent stem cell-derived cardiac progenitors differentiate to cardiomyocytes and form biosynthetic tissues.

Christoforou N, Liau B, Chakraborty S, Chellapan M, Bursac N, Leong KW.

PLoS One. 2013 Jun 13;8(6):e65963. doi: 10.1371/journal.pone.0065963. Print 2013.

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