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The early proximal αβ TCR signalosome specifies thymic selection outcome through a quantitative protein interaction network.

Neier SC, Ferrer A, Wilton KM, Smith SEP, Kelcher AMH, Pavelko KD, Canfield JM, Davis TR, Stiles RJ, Chen Z, McCluskey J, Burrows SR, Rossjohn J, Hebrink DM, Carmona EM, Limper AH, Kappes DJ, Wettstein PJ, Johnson AJ, Pease LR, Daniels MA, Neuhauser C, Gil D, Schrum AG.

Sci Immunol. 2019 Feb 15;4(32). pii: eaal2201. doi: 10.1126/sciimmunol.aal2201.


Epstein-Barr virus-specific T cell therapy for progressive multiple sclerosis.

Pender MP, Csurhes PA, Smith C, Douglas NL, Neller MA, Matthews KK, Beagley L, Rehan S, Crooks P, Hopkins TJ, Blum S, Green KA, Ioannides ZA, Swayne A, Aftab BT, Hooper KD, Burrows SR, Thompson KM, Coulthard A, Khanna R.

JCI Insight. 2018 Nov 15;3(22). pii: 124714. doi: 10.1172/jci.insight.124714.


Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry.

Miles JJ, Tan MP, Dolton G, Edwards ES, Galloway SA, Laugel B, Clement M, Makinde J, Ladell K, Matthews KK, Watkins TS, Tungatt K, Wong Y, Lee HS, Clark RJ, Pentier JM, Attaf M, Lissina A, Ager A, Gallimore A, Rizkallah PJ, Gras S, Rossjohn J, Burrows SR, Cole DK, Price DA, Sewell AK.

J Clin Invest. 2018 Apr 2;128(4):1569-1580. doi: 10.1172/JCI91512. Epub 2018 Mar 12.


Erratum: Defective T-cell control of Epstein-Barr virus infection in multiple sclerosis.

Pender MP, Csurhes PA, Burrows JM, Burrows SR.

Clin Transl Immunology. 2017 Jun 16;6(6):e147. doi: 10.1038/cti.2017.25. eCollection 2017 Jun.


Defective T-cell control of Epstein-Barr virus infection in multiple sclerosis.

Pender MP, Csurhes PA, Burrows JM, Burrows SR.

Clin Transl Immunology. 2017 Jan 20;6(1):e126. doi: 10.1038/cti.2016.87. eCollection 2017 Jan. Erratum in: Clin Transl Immunology. 2017 Jun 16;6(6):e147.


Targeted suppression of autoreactive CD8+ T-cell activation using blocking anti-CD8 antibodies.

Clement M, Pearson JA, Gras S, van den Berg HA, Lissina A, Llewellyn-Lacey S, Willis MD, Dockree T, McLaren JE, Ekeruche-Makinde J, Gostick E, Robertson NP, Rossjohn J, Burrows SR, Price DA, Wong FS, Peakman M, Skowera A, Wooldridge L.

Sci Rep. 2016 Oct 17;6:35332. doi: 10.1038/srep35332.


CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold.

Dockree T, Holland CJ, Clement M, Ladell K, McLaren JE, van den Berg HA, Gostick E, L Miners K, Llewellyn-Lacey S, Bridgeman JS, Man S, Bailey M, Burrows SR, Price DA, Wooldridge L.

Immunol Cell Biol. 2017 Jan;95(1):68-76. doi: 10.1038/icb.2016.85. Epub 2016 Nov 8.


Engineering of Isogenic Cells Deficient for MR1 with a CRISPR/Cas9 Lentiviral System: Tools To Study Microbial Antigen Processing and Presentation to Human MR1-Restricted T Cells.

Laugel B, Lloyd A, Meermeier EW, Crowther MD, Connor TR, Dolton G, Miles JJ, Burrows SR, Gold MC, Lewinsohn DM, Sewell AK.

J Immunol. 2016 Aug 1;197(3):971-82. doi: 10.4049/jimmunol.1501402. Epub 2016 Jun 15.


Coinfection with Human Cytomegalovirus Genetic Variants in Transplant Recipients and Its Impact on Antiviral T Cell Immune Reconstitution.

Smith C, Brennan RM, Tey SK, Smyth MJ, Burrows SR, Miles JJ, Hill GR, Khanna R.

J Virol. 2016 Jul 27;90(16):7497-507. doi: 10.1128/JVI.00297-16. Print 2016 Aug 15.


Identification of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors.

Szomolay B, Liu J, Brown PE, Miles JJ, Clement M, Llewellyn-Lacey S, Dolton G, Ekeruche-Makinde J, Lissina A, Schauenburg AJ, Sewell AK, Burrows SR, Roederer M, Price DA, Wooldridge L, van den Berg HA.

Immunol Cell Biol. 2016 Jul;94(6):573-82. doi: 10.1038/icb.2016.12. Epub 2016 Feb 5.


The impact of HLA class I and EBV latency-II antigen-specific CD8(+) T cells on the pathogenesis of EBV(+) Hodgkin lymphoma.

Jones K, Wockner L, Brennan RM, Keane C, Chattopadhyay PK, Roederer M, Price DA, Cole DK, Hassan B, Beck K, Gottlieb D, Ritchie DS, Seymour JF, Vari F, Crooks P, Burrows SR, Gandhi MK.

Clin Exp Immunol. 2016 Feb;183(2):206-20. doi: 10.1111/cei.12716. Epub 2015 Nov 13.


A Safeguard System for Induced Pluripotent Stem Cell-Derived Rejuvenated T Cell Therapy.

Ando M, Nishimura T, Yamazaki S, Yamaguchi T, Kawana-Tachikawa A, Hayama T, Nakauchi Y, Ando J, Ota Y, Takahashi S, Nishimura K, Ohtaka M, Nakanishi M, Miles JJ, Burrows SR, Brenner MK, Nakauchi H.

Stem Cell Reports. 2015 Oct 13;5(4):597-608. doi: 10.1016/j.stemcr.2015.07.011. Epub 2015 Aug 28.


T Cell Cross-Reactivity between a Highly Immunogenic EBV Epitope and a Self-Peptide Naturally Presented by HLA-B*18:01+ Cells.

Rist MJ, Hibbert KM, Croft NP, Smith C, Neller MA, Burrows JM, Miles JJ, Purcell AW, Rossjohn J, Gras S, Burrows SR.

J Immunol. 2015 May 15;194(10):4668-75. doi: 10.4049/jimmunol.1500233. Epub 2015 Apr 8.


Naive CD8⁺ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics.

Neller MA, Ladell K, McLaren JE, Matthews KK, Gostick E, Pentier JM, Dolton G, Schauenburg AJ, Koning D, Fontaine Costa AI, Watkins TS, Venturi V, Smith C, Khanna R, Miners K, Clement M, Wooldridge L, Cole DK, van Baarle D, Sewell AK, Burrows SR, Price DA, Miles JJ.

Immunol Cell Biol. 2015 Aug;93(7):625-33. doi: 10.1038/icb.2015.17. Epub 2015 Mar 24.


Epstein-Barr virus and multiple sclerosis: potential opportunities for immunotherapy.

Pender MP, Burrows SR.

Clin Transl Immunology. 2014 Oct 31;3(10):e27. doi: 10.1038/cti.2014.25. eCollection 2014 Oct. Review.


T cell epitope clustering in the highly immunogenic BZLF1 antigen of Epstein-Barr virus.

Rist MJ, Neller MA, Burrows JM, Burrows SR.

J Virol. 2015 Jan;89(1):703-12. doi: 10.1128/JVI.02642-14. Epub 2014 Oct 29.


CD8+ T cells from a novel T cell receptor transgenic mouse induce liver-stage immunity that can be boosted by blood-stage infection in rodent malaria.

Lau LS, Fernandez-Ruiz D, Mollard V, Sturm A, Neller MA, Cozijnsen A, Gregory JL, Davey GM, Jones CM, Lin YH, Haque A, Engwerda CR, Nie CQ, Hansen DS, Murphy KM, Papenfuss AT, Miles JJ, Burrows SR, de Koning-Ward T, McFadden GI, Carbone FR, Crabb BS, Heath WR.

PLoS Pathog. 2014 May 22;10(5):e1004135. doi: 10.1371/journal.ppat.1004135. eCollection 2014 May.


Deficiency of CD8+ effector memory T cells is an early and persistent feature of multiple sclerosis.

Pender MP, Csurhes PA, Pfluger CM, Burrows SR.

Mult Scler. 2014 Dec;20(14):1825-32. doi: 10.1177/1352458514536252. Epub 2014 May 19.


A molecular basis for the interplay between T cells, viral mutants, and human leukocyte antigen micropolymorphism.

Liu YC, Chen Z, Neller MA, Miles JJ, Purcell AW, McCluskey J, Burrows SR, Rossjohn J, Gras S.

J Biol Chem. 2014 Jun 13;289(24):16688-98. doi: 10.1074/jbc.M114.563502. Epub 2014 Apr 23.


Missense single nucleotide polymorphisms in the human T cell receptor loci control variable gene usage in the T cell repertoire.

Brennan RM, Burrows JM, Elliott T, Neller MA, Gras S, Rossjohn J, Miles JJ, Burrows SR.

Br J Haematol. 2014 Jul;166(1):148-52. doi: 10.1111/bjh.12830. Epub 2014 Mar 20. No abstract available.


Multivariate Analysis Using High Definition Flow Cytometry Reveals Distinct T Cell Repertoires between the Fetal-Maternal Interface and the Peripheral Blood.

Neller MA, Santner-Nanan B, Brennan RM, Hsu P, Joung S, Nanan R, Burrows SR, Miles JJ.

Front Immunol. 2014 Feb 5;5:33. doi: 10.3389/fimmu.2014.00033. eCollection 2014.


Molecular imprint of exposure to naturally occurring genetic variants of human cytomegalovirus on the T cell repertoire.

Smith C, Gras S, Brennan RM, Bird NL, Valkenburg SA, Twist KA, Burrows JM, Miles JJ, Chambers D, Bell S, Campbell S, Kedzierska K, Burrows SR, Rossjohn J, Khanna R.

Sci Rep. 2014 Feb 10;4:3993. doi: 10.1038/srep03993.


Epstein-Barr virus-specific adoptive immunotherapy for progressive multiple sclerosis.

Pender MP, Csurhes PA, Smith C, Beagley L, Hooper KD, Raj M, Coulthard A, Burrows SR, Khanna R.

Mult Scler. 2014 Oct;20(11):1541-4. doi: 10.1177/1352458514521888. Epub 2014 Feb 3.


IMGT/HighV QUEST paradigm for T cell receptor IMGT clonotype diversity and next generation repertoire immunoprofiling.

Li S, Lefranc MP, Miles JJ, Alamyar E, Giudicelli V, Duroux P, Freeman JD, Corbin VD, Scheerlinck JP, Frohman MA, Cameron PU, Plebanski M, Loveland B, Burrows SR, Papenfuss AT, Gowans EJ.

Nat Commun. 2013;4:2333. doi: 10.1038/ncomms3333.


Immune parameters to consider when choosing T-cell receptors for therapy.

Burrows SR, Miles JJ.

Front Immunol. 2013 Aug 5;4:229. doi: 10.3389/fimmu.2013.00229. eCollection 2013.


HLA peptide length preferences control CD8+ T cell responses.

Rist MJ, Theodossis A, Croft NP, Neller MA, Welland A, Chen Z, Sullivan LC, Burrows JM, Miles JJ, Brennan RM, Gras S, Khanna R, Brooks AG, McCluskey J, Purcell AW, Rossjohn J, Burrows SR.

J Immunol. 2013 Jul 15;191(2):561-71. doi: 10.4049/jimmunol.1300292. Epub 2013 Jun 7.


Highly divergent T-cell receptor binding modes underlie specific recognition of a bulged viral peptide bound to a human leukocyte antigen class I molecule.

Liu YC, Miles JJ, Neller MA, Gostick E, Price DA, Purcell AW, McCluskey J, Burrows SR, Rossjohn J, Gras S.

J Biol Chem. 2013 May 31;288(22):15442-54. doi: 10.1074/jbc.M112.447185. Epub 2013 Apr 8.


Peptide length determines the outcome of TCR/peptide-MHCI engagement.

Ekeruche-Makinde J, Miles JJ, van den Berg HA, Skowera A, Cole DK, Dolton G, Schauenburg AJ, Tan MP, Pentier JM, Llewellyn-Lacey S, Miles KM, Bulek AM, Clement M, Williams T, Trimby A, Bailey M, Rizkallah P, Rossjohn J, Peakman M, Price DA, Burrows SR, Sewell AK, Wooldridge L.

Blood. 2013 Feb 14;121(7):1112-23. doi: 10.1182/blood-2012-06-437202. Epub 2012 Dec 18.


CD8+ T cells far predominate over CD4+ T cells in healthy immune response to Epstein-Barr virus infected lymphoblastoid cell lines.

Pender MP, Csurhes PA, Pfluger CM, Burrows SR.

Blood. 2012 Dec 13;120(25):5085-7. doi: 10.1182/blood-2012-06-437285. No abstract available.


High frequency of herpesvirus-specific clonotypes in the human T cell repertoire can remain stable over decades with minimal turnover.

Neller MA, Burrows JM, Rist MJ, Miles JJ, Burrows SR.

J Virol. 2013 Jan;87(1):697-700. doi: 10.1128/JVI.02180-12. Epub 2012 Oct 17.


A structural voyage toward an understanding of the MHC-I-restricted immune response: lessons learned and much to be learned.

Gras S, Burrows SR, Turner SJ, Sewell AK, McCluskey J, Rossjohn J.

Immunol Rev. 2012 Nov;250(1):61-81. doi: 10.1111/j.1600-065X.2012.01159.x. Review.


Endogenous antigen presentation impacts on T-box transcription factor expression and functional maturation of CD8+ T cells.

Smith C, Elhassen D, Gras S, Wynn KK, Dasari V, Tellam J, Tey SK, Rehan S, Liu YC, Rossjohn J, Burrows SR, Khanna R.

Blood. 2012 Oct 18;120(16):3237-45. doi: 10.1182/blood-2012-03-420182. Epub 2012 Aug 31.


Tracking the repertoire of human adult and neonatal T cells during ex vivo amplification.

Neller MA, Sewell AK, Burrows SR, Miles JJ.

Br J Haematol. 2012 Nov;159(3):370-3. doi: 10.1111/bjh.12022. Epub 2012 Aug 25. No abstract available.


Immune self-reactivity triggered by drug-modified HLA-peptide repertoire.

Illing PT, Vivian JP, Dudek NL, Kostenko L, Chen Z, Bharadwaj M, Miles JJ, Kjer-Nielsen L, Gras S, Williamson NA, Burrows SR, Purcell AW, Rossjohn J, McCluskey J.

Nature. 2012 Jun 28;486(7404):554-8. doi: 10.1038/nature11147.


The energetic basis underpinning T-cell receptor recognition of a super-bulged peptide bound to a major histocompatibility complex class I molecule.

Liu YC, Chen Z, Burrows SR, Purcell AW, McCluskey J, Rossjohn J, Gras S.

J Biol Chem. 2012 Apr 6;287(15):12267-76. doi: 10.1074/jbc.M112.344689. Epub 2012 Feb 16.


The impact of a large and frequent deletion in the human TCR β locus on antiviral immunity.

Brennan RM, Petersen J, Neller MA, Miles JJ, Burrows JM, Smith C, McCluskey J, Khanna R, Rossjohn J, Burrows SR.

J Immunol. 2012 Mar 15;188(6):2742-8. doi: 10.4049/jimmunol.1102675. Epub 2012 Feb 8.


A structural basis for varied αβ TCR usage against an immunodominant EBV antigen restricted to a HLA-B8 molecule.

Gras S, Wilmann PG, Chen Z, Halim H, Liu YC, Kjer-Nielsen L, Purcell AW, Burrows SR, McCluskey J, Rossjohn J.

J Immunol. 2012 Jan 1;188(1):311-21. doi: 10.4049/jimmunol.1102686. Epub 2011 Dec 2.


Epstein-Barr virus isolates retain their capacity to evade T cell immunity through BNLF2a despite extensive sequence variation.

Horst D, Burrows SR, Gatherer D, van Wilgenburg B, Bell MJ, Boer IG, Ressing ME, Wiertz EJ.

J Virol. 2012 Jan;86(1):572-7. doi: 10.1128/JVI.05151-11. Epub 2011 Oct 19.


CD8 T cell deficiency impairs control of Epstein--Barr virus and worsens with age in multiple sclerosis.

Pender MP, Csurhes PA, Pfluger CM, Burrows SR.

J Neurol Neurosurg Psychiatry. 2012 Mar;83(3):353-4. doi: 10.1136/jnnp-2011-300213. Epub 2011 Jul 26. No abstract available.


Current and past Epstein-Barr virus infection in risk of initial CNS demyelination.

Lucas RM, Ponsonby AL, Dear K, Valery P, Pender MP, Burrows JM, Burrows SR, Chapman C, Coulthard A, Dwyer DE, Dwyer T, Kilpatrick T, Lay ML, McMichael AJ, Taylor BV, van der Mei IA, Williams D.

Neurology. 2011 Jul 26;77(4):371-9. doi: 10.1212/WNL.0b013e318227062a. Epub 2011 Jul 13.


Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining.

Clement M, Ladell K, Ekeruche-Makinde J, Miles JJ, Edwards ES, Dolton G, Williams T, Schauenburg AJ, Cole DK, Lauder SN, Gallimore AM, Godkin AJ, Burrows SR, Price DA, Sewell AK, Wooldridge L.

J Immunol. 2011 Jul 15;187(2):654-63. doi: 10.4049/jimmunol.1003941. Epub 2011 Jun 15.


Human immunology: a case for the ascent of non-furry immunology.

Khanna R, Burrows SR.

Immunol Cell Biol. 2011 Mar;89(3):330-1. doi: 10.1038/icb.2010.173. No abstract available.


EBV: immunobiology and host response.

Moss DJ, Burrows SR, Khanna R.

In: Arvin A, Campadelli-Fiume G, Mocarski E, Moore PS, Roizman B, Whitley R, Yamanishi K, editors. Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis. Cambridge: Cambridge University Press; 2007. Chapter 51.


Understanding human T-cell-mediated immunoregulation through herpesviruses.

Burrows SR, Moss DJ, Khanna R.

Immunol Cell Biol. 2011 Mar;89(3):352-8. doi: 10.1038/icb.2010.136. Epub 2011 Feb 8. Review.


Antigen-driven patterns of TCR bias are shared across diverse outcomes of human hepatitis C virus infection.

Miles JJ, Thammanichanond D, Moneer S, Nivarthi UK, Kjer-Nielsen L, Tracy SL, Aitken CK, Brennan RM, Zeng W, Marquart L, Jackson D, Burrows SR, Bowden DS, Torresi J, Hellard M, Rossjohn J, McCluskey J, Bharadwaj M.

J Immunol. 2011 Jan 15;186(2):901-12. doi: 10.4049/jimmunol.1003167. Epub 2010 Dec 15.


Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection.

Miles JJ, Bulek AM, Cole DK, Gostick E, Schauenburg AJ, Dolton G, Venturi V, Davenport MP, Tan MP, Burrows SR, Wooldridge L, Price DA, Rizkallah PJ, Sewell AK.

PLoS Pathog. 2010 Nov 18;6(11):e1001198. doi: 10.1371/journal.ppat.1001198.


Allelic polymorphism in the T cell receptor and its impact on immune responses.

Gras S, Chen Z, Miles JJ, Liu YC, Bell MJ, Sullivan LC, Kjer-Nielsen L, Brennan RM, Burrows JM, Neller MA, Khanna R, Purcell AW, Brooks AG, McCluskey J, Rossjohn J, Burrows SR.

J Exp Med. 2010 Jul 5;207(7):1555-67. doi: 10.1084/jem.20100603. Epub 2010 Jun 21.


Expansion of EBNA1-specific effector T cells in posttransplantation lymphoproliferative disorders.

Jones K, Nourse JP, Morrison L, Nguyen-Van D, Moss DJ, Burrows SR, Gandhi MK.

Blood. 2010 Sep 30;116(13):2245-52. doi: 10.1182/blood-2010-03-274076. Epub 2010 Jun 18.


Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability.

Burrows SR, Chen Z, Archbold JK, Tynan FE, Beddoe T, Kjer-Nielsen L, Miles JJ, Khanna R, Moss DJ, Liu YC, Gras S, Kostenko L, Brennan RM, Clements CS, Brooks AG, Purcell AW, McCluskey J, Rossjohn J.

Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10608-13. doi: 10.1073/pnas.1004926107. Epub 2010 May 18.

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