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Forging new antibiotic combinations under iron-limiting conditions.

Chan DCK, Guo I, Burrows LL.

Antimicrob Agents Chemother. 2020 Jan 6. pii: AAC.01909-19. doi: 10.1128/AAC.01909-19. [Epub ahead of print]


Multiple conformations facilitate PilT function in the type IV pilus.

McCallum M, Benlekbir S, Nguyen S, Tammam S, Rubinstein JL, Burrows LL, Howell PL.

Nat Commun. 2019 Nov 15;10(1):5198. doi: 10.1038/s41467-019-13070-z.


Thiostrepton Hijacks Pyoverdine Receptors To Inhibit Growth of Pseudomonas aeruginosa.

Ranieri MRM, Chan DCK, Yaeger LN, Rudolph M, Karabelas-Pittman S, Abdo H, Chee J, Harvey H, Nguyen U, Burrows LL.

Antimicrob Agents Chemother. 2019 Aug 23;63(9). pii: e00472-19. doi: 10.1128/AAC.00472-19. Print 2019 Sep.


The Dynamic Structures of the Type IV Pilus.

McCallum M, Burrows LL, Howell PL.

Microbiol Spectr. 2019 Mar;7(2). doi: 10.1128/microbiolspec.PSIB-0006-2018. Review.


Diversity and Evolution of Myxobacterial Type IV Pilus Systems.

Sharma G, Burrows LL, Singer M.

Front Microbiol. 2018 Jul 19;9:1630. doi: 10.3389/fmicb.2018.01630. eCollection 2018.


Mechanisms of biofilm stimulation by subinhibitory concentrations of antimicrobials.

Ranieri MR, Whitchurch CB, Burrows LL.

Curr Opin Microbiol. 2018 Oct;45:164-169. doi: 10.1016/j.mib.2018.07.006. Epub 2018 Jul 24. Review.


The Pseudomonas aeruginosa PilSR Two-Component System Regulates Both Twitching and Swimming Motilities.

Kilmury SLN, Burrows LL.

mBio. 2018 Jul 24;9(4). pii: e01310-18. doi: 10.1128/mBio.01310-18.


Pseudomonas aeruginosa type IV minor pilins and PilY1 regulate virulence by modulating FimS-AlgR activity.

Marko VA, Kilmury SLN, MacNeil LT, Burrows LL.

PLoS Pathog. 2018 May 18;14(5):e1007074. doi: 10.1371/journal.ppat.1007074. eCollection 2018 May.


The Therapeutic Pipeline for Pseudomonas aeruginosa Infections.

Burrows LL.

ACS Infect Dis. 2018 Jul 13;4(7):1041-1047. doi: 10.1021/acsinfecdis.8b00112. Epub 2018 May 17. Review.


Conserved, unstructured regions in Pseudomonas aeruginosa PilO are important for type IVa pilus function.

Leighton TL, Mok MC, Junop MS, Howell PL, Burrows LL.

Sci Rep. 2018 Feb 8;8(1):2600. doi: 10.1038/s41598-018-20925-w.


A Highly Dynamic Loop of the Pseudomonas aeruginosa PA14 Type IV Pilin Is Essential for Pilus Assembly.

Nguyen Y, Boulton S, McNicholl ET, Akimoto M, Harvey H, Aidoo F, Melacini G, Burrows LL.

ACS Infect Dis. 2018 Jun 8;4(6):936-943. doi: 10.1021/acsinfecdis.7b00229. Epub 2018 Jan 24.


Pseudomonas aeruginosa defends against phages through type IV pilus glycosylation.

Harvey H, Bondy-Denomy J, Marquis H, Sztanko KM, Davidson AR, Burrows LL.

Nat Microbiol. 2018 Jan;3(1):47-52. doi: 10.1038/s41564-017-0061-y. Epub 2017 Nov 13.


Cyclic AMP-Independent Control of Twitching Motility in Pseudomonas aeruginosa.

Buensuceso RNC, Daniel-Ivad M, Kilmury SLN, Leighton TL, Harvey H, Howell PL, Burrows LL.

J Bacteriol. 2017 Jul 25;199(16). pii: e00188-17. doi: 10.1128/JB.00188-17. Print 2017 Aug 15.


The molecular mechanism of the type IVa pilus motors.

McCallum M, Tammam S, Khan A, Burrows LL, Howell PL.

Nat Commun. 2017 May 5;8:15091. doi: 10.1038/ncomms15091.


The Type IVa Pilus Machinery Is Recruited to Sites of Future Cell Division.

Carter T, Buensuceso RN, Tammam S, Lamers RP, Harvey H, Howell PL, Burrows LL.

mBio. 2017 Jan 31;8(1). pii: e02103-16. doi: 10.1128/mBio.02103-16.


Structure of the Pseudomonas aeruginosa Type IVa Pilus Secretin at 7.4 Å.

Koo J, Lamers RP, Rubinstein JL, Burrows LL, Howell PL.

Structure. 2016 Oct 4;24(10):1778-1787. doi: 10.1016/j.str.2016.08.007.


Type IV Pilus Alignment Subcomplex Proteins PilN and PilO Form Homo- and Heterodimers in Vivo.

Leighton TL, Yong DH, Howell PL, Burrows LL.

J Biol Chem. 2016 Sep 16;291(38):19923-38. doi: 10.1074/jbc.M116.738377. Epub 2016 Jul 29.


The Conserved Tetratricopeptide Repeat-Containing C-Terminal Domain of Pseudomonas aeruginosa FimV Is Required for Its Cyclic AMP-Dependent and -Independent Functions.

Buensuceso RN, Nguyen Y, Zhang K, Daniel-Ivad M, Sugiman-Marangos SN, Fleetwood AD, Zhulin IB, Junop MS, Howell PL, Burrows LL.

J Bacteriol. 2016 Jul 28;198(16):2263-74. doi: 10.1128/JB.00322-16. Print 2016 Aug 15.


Pseudomonas aeruginosa: targeting cell-wall metabolism for new antibacterial discovery and development.

Lamers RP, Burrows LL.

Future Med Chem. 2016 Jun;8(9):975-92. doi: 10.4155/fmc-2016-0017. Epub 2016 May 26. Review.


Type IV pilins regulate their own expression via direct intramembrane interactions with the sensor kinase PilS.

Kilmury SL, Burrows LL.

Proc Natl Acad Sci U S A. 2016 May 24;113(21):6017-22. doi: 10.1073/pnas.1512947113. Epub 2016 May 9.


PilN Binding Modulates the Structure and Binding Partners of the Pseudomonas aeruginosa Type IVa Pilus Protein PilM.

McCallum M, Tammam S, Little DJ, Robinson H, Koo J, Shah M, Calmettes C, Moraes TF, Burrows LL, Howell PL.

J Biol Chem. 2016 May 20;291(21):11003-15. doi: 10.1074/jbc.M116.718353. Epub 2016 Mar 28.


Syndecan-1 (CD138) deficiency increases Staphylococcus aureus infection but has no effect on pathology in a mouse model of peritoneal dialysis.

Kowalewska PM, Nguyen UT, Burrows LL, Fox-Robichaud AE.

J Biomed Sci. 2016 Feb 1;23:20. doi: 10.1186/s12929-016-0232-9.


Loss of membrane-bound lytic transglycosylases increases outer membrane permeability and β-lactam sensitivity in Pseudomonas aeruginosa.

Lamers RP, Nguyen UT, Nguyen Y, Buensuceso RN, Burrows LL.

Microbiologyopen. 2015 Dec;4(6):879-95. doi: 10.1002/mbo3.286. Epub 2015 Sep 15.


Structural and functional studies of the Pseudomonas aeruginosa minor pilin, PilE.

Nguyen Y, Harvey H, Sugiman-Marangos S, Bell SD, Buensuceso RN, Junop MS, Burrows LL.

J Biol Chem. 2015 Oct 30;290(44):26856-65. doi: 10.1074/jbc.M115.683334. Epub 2015 Sep 10.


Nanoscale Pulling of Type IV Pili Reveals Their Flexibility and Adhesion to Surfaces over Extended Lengths of the Pili.

Lu S, Giuliani M, Harvey H, Burrows LL, Wickham RA, Dutcher JR.

Biophys J. 2015 Jun 16;108(12):2865-75. doi: 10.1016/j.bpj.2015.05.016.


Novel Role for PilNO in Type IV Pilus Retraction Revealed by Alignment Subcomplex Mutations.

Leighton TL, Dayalani N, Sampaleanu LM, Howell PL, Burrows LL.

J Bacteriol. 2015 Jul;197(13):2229-2238. doi: 10.1128/JB.00220-15. Epub 2015 Apr 27.


Biogenesis of Pseudomonas aeruginosa type IV pili and regulation of their function.

Leighton TL, Buensuceso RN, Howell PL, Burrows LL.

Environ Microbiol. 2015 Nov;17(11):4148-63. doi: 10.1111/1462-2920.12849. Epub 2015 Jun 25. Review.


Pseudomonas aeruginosa minor pilins prime type IVa pilus assembly and promote surface display of the PilY1 adhesin.

Nguyen Y, Sugiman-Marangos S, Harvey H, Bell SD, Charlton CL, Junop MS, Burrows LL.

J Biol Chem. 2015 Jan 2;290(1):601-11. doi: 10.1074/jbc.M114.616904. Epub 2014 Nov 11.


Role of PBPD1 in stimulation of Listeria monocytogenes biofilm formation by subminimal inhibitory β-lactam concentrations.

Nguyen UT, Harvey H, Hogan AJ, Afonso AC, Wright GD, Burrows LL.

Antimicrob Agents Chemother. 2014 Nov;58(11):6508-17. doi: 10.1128/AAC.03671-14. Epub 2014 Aug 18.


DNase I and proteinase K impair Listeria monocytogenes biofilm formation and induce dispersal of pre-existing biofilms.

Nguyen UT, Burrows LL.

Int J Food Microbiol. 2014 Sep 18;187:26-32. doi: 10.1016/j.ijfoodmicro.2014.06.025. Epub 2014 Jul 4.


A new twist in the assembly of type IV pilus-like fibers.

Burrows LL.

Structure. 2014 May 6;22(5):659-61. doi: 10.1016/j.str.2014.04.009.


The dynamics of peptidoglycan structure and function: conference report on the 3rd Great Wall Symposium.

Williams AH, Boneca IG, Burrows LL, Bugg TD.

Res Microbiol. 2014 Jan;165(1):60-7. doi: 10.1016/j.resmic.2013.11.002. Epub 2013 Nov 15. No abstract available.


A new route for polar navigation.

Burrows LL.

Mol Microbiol. 2013 Dec;90(5):919-22. doi: 10.1111/mmi.12433. Epub 2013 Oct 30.


Changes to its peptidoglycan-remodeling enzyme repertoire modulate β-lactam resistance in Pseudomonas aeruginosa.

Cavallari JF, Lamers RP, Scheurwater EM, Matos AL, Burrows LL.

Antimicrob Agents Chemother. 2013 Jul;57(7):3078-84. doi: 10.1128/AAC.00268-13. Epub 2013 Apr 22.


Functional mapping of PilF and PilQ in the Pseudomonas aeruginosa type IV pilus system.

Koo J, Tang T, Harvey H, Tammam S, Sampaleanu L, Burrows LL, Howell PL.

Biochemistry. 2013 Apr 30;52(17):2914-23. doi: 10.1021/bi3015345. Epub 2013 Apr 18.


The efflux inhibitor phenylalanine-arginine beta-naphthylamide (PAβN) permeabilizes the outer membrane of gram-negative bacteria.

Lamers RP, Cavallari JF, Burrows LL.

PLoS One. 2013;8(3):e60666. doi: 10.1371/journal.pone.0060666. Epub 2013 Mar 27.


PilMNOPQ from the Pseudomonas aeruginosa type IV pilus system form a transenvelope protein interaction network that interacts with PilA.

Tammam S, Sampaleanu LM, Koo J, Manoharan K, Daubaras M, Burrows LL, Howell PL.

J Bacteriol. 2013 May;195(10):2126-35. doi: 10.1128/JB.00032-13. Epub 2013 Mar 1.


The platform protein is essential for type IV pilus biogenesis.

Takhar HK, Kemp K, Kim M, Howell PL, Burrows LL.

J Biol Chem. 2013 Apr 5;288(14):9721-8. doi: 10.1074/jbc.M113.453506. Epub 2013 Feb 14.


Type IV pilin proteins: versatile molecular modules.

Giltner CL, Nguyen Y, Burrows LL.

Microbiol Mol Biol Rev. 2012 Dec;76(4):740-72. doi: 10.1128/MMBR.00035-12. Review.


Prime time for minor subunits of the type II secretion and type IV pilus systems.

Burrows LL.

Mol Microbiol. 2012 Nov;86(4):765-9. doi: 10.1111/mmi.12034. Epub 2012 Sep 24.


Pseudomonas aeruginosa twitching motility: type IV pili in action.

Burrows LL.

Annu Rev Microbiol. 2012;66:493-520. doi: 10.1146/annurev-micro-092611-150055. Epub 2012 Jul 2. Review.


Small-molecule modulators of Listeria monocytogenes biofilm development.

Nguyen UT, Wenderska IB, Chong MA, Koteva K, Wright GD, Burrows LL.

Appl Environ Microbiol. 2012 Mar;78(5):1454-65. doi: 10.1128/AEM.07227-11. Epub 2011 Dec 22.


Decoding the roles of pilotins and accessory proteins in secretin escort services.

Koo J, Burrows LL, Howell PL.

FEMS Microbiol Lett. 2012 Mar;328(1):1-12. doi: 10.1111/j.1574-6968.2011.02464.x. Epub 2011 Dec 8. Review.


Characterization of the PilN, PilO and PilP type IVa pilus subcomplex.

Tammam S, Sampaleanu LM, Koo J, Sundaram P, Ayers M, Chong PA, Forman-Kay JD, Burrows LL, Howell PL.

Mol Microbiol. 2011 Dec;82(6):1496-514. doi: 10.1111/j.1365-2958.2011.07903.x. Epub 2011 Nov 18.


Palmitoyl-DL-carnitine is a multitarget inhibitor of Pseudomonas aeruginosa biofilm development.

Wenderska IB, Chong M, McNulty J, Wright GD, Burrows LL.

Chembiochem. 2011 Dec 16;12(18):2759-66. doi: 10.1002/cbic.201100500. Epub 2011 Nov 2.


Intravital microscopy of the murine urinary bladder microcirculation.

Kowalewska PM, Burrows LL, Fox-Robichaud AE.

Microcirculation. 2011 Nov;18(8):613-22. doi: 10.1111/j.1549-8719.2011.00123.x.


Pseudomonas aeruginosa D-arabinofuranose biosynthetic pathway and its role in type IV pilus assembly.

Harvey H, Kus JV, Tessier L, Kelly J, Burrows LL.

J Biol Chem. 2011 Aug 12;286(32):28128-37. doi: 10.1074/jbc.M111.255794. Epub 2011 Jun 15.


Maintaining network security: how macromolecular structures cross the peptidoglycan layer.

Scheurwater EM, Burrows LL.

FEMS Microbiol Lett. 2011 May;318(1):1-9. doi: 10.1111/j.1574-6968.2011.02228.x. Epub 2011 Mar 14. Review.


Mass spectrometry unmasks mystery Methanococcus pilin.

Burrows LL.

J Bacteriol. 2011 Feb;193(4):801-3. doi: 10.1128/JB.01406-10. Epub 2010 Dec 10. No abstract available.


The peptidoglycan-binding protein FimV promotes assembly of the Pseudomonas aeruginosa type IV pilus secretin.

Wehbi H, Portillo E, Harvey H, Shimkoff AE, Scheurwater EM, Howell PL, Burrows LL.

J Bacteriol. 2011 Jan;193(2):540-50. doi: 10.1128/JB.01048-10. Epub 2010 Nov 19.

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