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Items: 22


RAD18, WRNIP1 and ATMIN promote ATM signalling in response to replication stress.

Kanu N, Zhang T, Burrell RA, Chakraborty A, Cronshaw J, DaCosta C, Grönroos E, Pemberton HN, Anderton E, Gonzalez L, Sabbioneda S, Ulrich HD, Swanton C, Behrens A.

Oncogene. 2016 Jul 28;35(30):4020. doi: 10.1038/onc.2015.500. Epub 2016 Jun 27. No abstract available.


Re-Evaluating Clonal Dominance in Cancer Evolution.

Burrell RA, Swanton C.

Trends Cancer. 2016 May;2(5):263-276. doi: 10.1016/j.trecan.2016.04.002. Epub 2016 Apr 27. Review.


RAD18, WRNIP1 and ATMIN promote ATM signalling in response to replication stress.

Kanu N, Zhang T, Burrell RA, Chakraborty A, Cronshaw J, DaCosta C, Grönroos E, Pemberton HN, Anderton E, Gonzalez L, Sabbioneda S, Ulrich HD, Swanton C, Behrens A.

Oncogene. 2016 Jul 28;35(30):4009-19. doi: 10.1038/onc.2015.427. Epub 2015 Nov 9. Erratum in: Oncogene. 2016 Jul 28;35(30):4020.


SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair.

Kanu N, Grönroos E, Martinez P, Burrell RA, Yi Goh X, Bartkova J, Maya-Mendoza A, Mistrík M, Rowan AJ, Patel H, Rabinowitz A, East P, Wilson G, Santos CR, McGranahan N, Gulati S, Gerlinger M, Birkbak NJ, Joshi T, Alexandrov LB, Stratton MR, Powles T, Matthews N, Bates PA, Stewart A, Szallasi Z, Larkin J, Bartek J, Swanton C.

Oncogene. 2015 Nov 12;34(46):5699-708. doi: 10.1038/onc.2015.24. Epub 2015 Mar 2.


Cancer: evolution within a lifetime.

Gerlinger M, McGranahan N, Dewhurst SM, Burrell RA, Tomlinson I, Swanton C.

Annu Rev Genet. 2014;48:215-36. doi: 10.1146/annurev-genet-120213-092314. Epub 2014 Oct 1. Review.


Expression of regulators of mitotic fidelity are associated with intercellular heterogeneity and chromosomal instability in primary breast cancer.

Roylance R, Endesfelder D, Jamal-Hanjani M, Burrell RA, Gorman P, Sander J, Murphy N, Birkbak NJ, Hanby AM, Speirs V, Johnston SR, Kschischo M, Swanton C.

Breast Cancer Res Treat. 2014 Nov;148(1):221-9. doi: 10.1007/s10549-014-3153-x. Epub 2014 Oct 7.


Tumour heterogeneity and the evolution of polyclonal drug resistance.

Burrell RA, Swanton C.

Mol Oncol. 2014 Sep 12;8(6):1095-111. doi: 10.1016/j.molonc.2014.06.005. Epub 2014 Jul 10. Review.


The evolution of the unstable cancer genome.

Burrell RA, Swanton C.

Curr Opin Genet Dev. 2014 Feb;24:61-7. doi: 10.1016/j.gde.2013.11.011. Epub 2013 Dec 31. Review.


Response to Bakhoum et al.

Burrell RA, McClelland SE, Bartek J, Swanton C.

Curr Biol. 2014 Feb 17;24(4):R150. doi: 10.1016/j.cub.2014.01.021. No abstract available.


Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution.

Dewhurst SM, McGranahan N, Burrell RA, Rowan AJ, Grönroos E, Endesfelder D, Joshi T, Mouradov D, Gibbs P, Ward RL, Hawkins NJ, Szallasi Z, Sieber OM, Swanton C.

Cancer Discov. 2014 Feb;4(2):175-185. doi: 10.1158/2159-8290.CD-13-0285. Epub 2014 Jan 19.


The causes and consequences of genetic heterogeneity in cancer evolution.

Burrell RA, McGranahan N, Bartek J, Swanton C.

Nature. 2013 Sep 19;501(7467):338-45. doi: 10.1038/nature12625. Review.


Parallel evolution of tumour subclones mimics diversity between tumours.

Martinez P, Birkbak NJ, Gerlinger M, McGranahan N, Burrell RA, Rowan AJ, Joshi T, Fisher R, Larkin J, Szallasi Z, Swanton C.

J Pathol. 2013 Aug;230(4):356-64. doi: 10.1002/path.4214.


Replication stress links structural and numerical cancer chromosomal instability.

Burrell RA, McClelland SE, Endesfelder D, Groth P, Weller MC, Shaikh N, Domingo E, Kanu N, Dewhurst SM, Gronroos E, Chew SK, Rowan AJ, Schenk A, Sheffer M, Howell M, Kschischo M, Behrens A, Helleday T, Bartek J, Tomlinson IP, Swanton C.

Nature. 2013 Feb 28;494(7438):492-496. doi: 10.1038/nature11935. Erratum in: Nature. 2013 Aug 22;500(7463):490.


Cancer chromosomal instability: therapeutic and diagnostic challenges.

McGranahan N, Burrell RA, Endesfelder D, Novelli MR, Swanton C.

EMBO Rep. 2012 Jun 1;13(6):528-38. doi: 10.1038/embor.2012.61. Review.


Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target.

Gerlinger M, Santos CR, Spencer-Dene B, Martinez P, Endesfelder D, Burrell RA, Vetter M, Jiang M, Saunders RE, Kelly G, Dykema K, Rioux-Leclercq N, Stamp G, Patard JJ, Larkin J, Howell M, Swanton C.

J Pathol. 2012 Jun;227(2):146-56. doi: 10.1002/path.4006. Epub 2012 Apr 18. Erratum in: J Pathol. 2015 Aug;236(4):531.


Relationship of extreme chromosomal instability with long-term survival in a retrospective analysis of primary breast cancer.

Roylance R, Endesfelder D, Gorman P, Burrell RA, Sander J, Tomlinson I, Hanby AM, Speirs V, Richardson AL, Birkbak NJ, Eklund AC, Downward J, Kschischo M, Szallasi Z, Swanton C.

Cancer Epidemiol Biomarkers Prev. 2011 Oct;20(10):2183-94. doi: 10.1158/1055-9965.EPI-11-0343. Epub 2011 Jul 22.


Breast cancer genome heterogeneity: a challenge to personalised medicine?

Swanton C, Burrell RA, Futreal PA.

Breast Cancer Res. 2011 Feb 1;13(1):104. doi: 10.1186/bcr2807.


Targeting chromosomal instability and tumour heterogeneity in HER2-positive breast cancer.

Burrell RA, Juul N, Johnston SR, Reis-Filho JS, Szallasi Z, Swanton C.

J Cell Biochem. 2010 Nov 1;111(4):782-90. doi: 10.1002/jcb.22781. Review.


Assessment of an RNA interference screen-derived mitotic and ceramide pathway metagene as a predictor of response to neoadjuvant paclitaxel for primary triple-negative breast cancer: a retrospective analysis of five clinical trials.

Juul N, Szallasi Z, Eklund AC, Li Q, Burrell RA, Gerlinger M, Valero V, Andreopoulou E, Esteva FJ, Symmans WF, Desmedt C, Haibe-Kains B, Sotiriou C, Pusztai L, Swanton C.

Lancet Oncol. 2010 Apr;11(4):358-65. doi: 10.1016/S1470-2045(10)70018-8. Epub 2010 Feb 26.


Chromosomal instability: a composite phenotype that influences sensitivity to chemotherapy.

McClelland SE, Burrell RA, Swanton C.

Cell Cycle. 2009 Oct 15;8(20):3262-6. Epub 2009 Oct 31. Review.


Quinoxaline precursors of fungitoxic benzimidazolycarbamates: syntheses and photochemically-induced transformations.

Burrell RA, Cox JM, Savins EG.

J Chem Soc Perkin 1. 1973;22:2707-13. No abstract available.


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