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Surveillance or no surveillance for deep venous thrombosis and outcomes of critically ill patients: A study protocol and statistical analysis plan.

Arabi YM, Burns KEA, Al-Hameed F, Alsolamy S, Almaani M, Mandourah Y, Almekhlafi GA, Al Bshabshe A, Alshahrani M, Khalid I, Hawa H, Arshad Z, Lababidi H, Al Aithan A, Jose J, Abdukahil SAI, Afesh LY, Al-Dawood A; and the PREVENT trial Group.

Medicine (Baltimore). 2018 Sep;97(36):e12258. doi: 10.1097/MD.0000000000012258.


Canadian Critical Care Society revised process for guideline development and endorsement.

Lamontagne F, D'Aragon F, Burns KEA, Belley-Côté É, Kho M, Menon K, Duan E, Masse MH, Archambault P, Hrymak C, Rochwerg B.

Can J Anaesth. 2018 Oct;65(10):1163-1164. doi: 10.1007/s12630-018-1182-3. Epub 2018 Jul 30. No abstract available.


Hamilton-DONATE: a city-wide pilot observational study of the ICU management of deceased organ donors.

D'Aragon F, Cook D, Dhanani S, Ribic C, Burns KEA, Akhtar A, Hand L, Arseneau E, Cupido C, Whittigham H, Healey A, Frenette AJ, Lamontagne F, Meade MO; Canadian Critical Care Trials Group and the Canadian National Transplant Research Program.

Can J Anaesth. 2018 Jul 9. doi: 10.1007/s12630-018-1179-y. [Epub ahead of print]


Intensity of care and withdrawal of life-sustaining therapies in severe traumatic brain injury patients: a post-hoc analysis of a multicentre retrospective cohort study.

Gerges PRA, Moore L, Léger C, Lauzier F, Shemilt M, Zarychanski R, Scales DC, Burns KEA, Bernard F, Zygun D, Neveu X, Turgeon AF; Canadian Critical Care Trials Group.

Can J Anaesth. 2018 Sep;65(9):996-1003. doi: 10.1007/s12630-018-1171-6. Epub 2018 Jun 14.


The role of nanoparticles in the improvement of systemic anticancer drug delivery.

Field LD, Nag OK, Sangtani A, Burns KE, Delehanty JB.

Ther Deliv. 2018 Jul;9(7):527-545. doi: 10.4155/tde-2018-0015.


Evidence Supporting Clinical Use of Proportional Assist Ventilation: A Systematic Review and Meta-Analysis of Clinical Trials.

Tirupakuzhi Vijayaraghavan BK, Hamed S, Jain A, Chimunda T, Telias I, Friedrich JO, Burns KEA.

J Intensive Care Med. 2018 Jan 1:885066618769021. doi: 10.1177/0885066618769021. [Epub ahead of print]


Cellular delivery of doxorubicin mediated by disulfide reduction of a peptide-dendrimer bioconjugate.

Burns KE, Delehanty JB.

Int J Pharm. 2018 Jul 10;545(1-2):64-73. doi: 10.1016/j.ijpharm.2018.04.027. Epub 2018 Apr 27.


A time-driven, activity-based costing methodology for determining the costs of red blood cell transfusion in patients with beta thalassaemia major.

Burns KE, Haysom HE, Higgins AM, Waters N, Tahiri R, Rushford K, Dunstan T, Saxby K, Kaplan Z, Chunilal S, McQuilten ZK, Wood EM.

Transfus Med. 2018 Apr 10. doi: 10.1111/tme.12523. [Epub ahead of print]


Patient and Family Engagement in the ICU. Untapped Opportunities and Underrecognized Challenges.

Burns KEA, Misak C, Herridge M, Meade MO, Oczkowski S; Patient and Family Partnership Committee of the Canadian Critical Care Trials Group.

Am J Respir Crit Care Med. 2018 Aug 1;198(3):310-319. doi: 10.1164/rccm.201710-2032CI.


Implementation of physiological fluids to provide insight into the characterization, fate, and biological interactions of silver nanoparticles.

Breitner EK, Burns KE, Hussain SM, Comfort KK.

Nanotechnology. 2018 Jun 22;29(25):254001. doi: 10.1088/1361-6528/aabb9d. Epub 2018 Apr 4.


Statistical analysis plan for the Pneumatic CompREssion for PreVENting Venous Thromboembolism (PREVENT) trial: a study protocol for a randomized controlled trial.

Arabi Y, Al-Hameed F, Burns KEA, Mehta S, Alsolamy S, Almaani M, Mandourah Y, Almekhlafi GA, Al Bshabshe A, Finfer S, Alshahrani M, Khalid I, Mehta Y, Gaur A, Hawa H, Buscher H, Arshad Z, Lababidi H, Al Aithan A, Jose J, Abdukahil SAI, Afesh LY, Dbsawy M, Al-Dawood A; PREVENT trial Group.

Trials. 2018 Mar 15;19(1):182. doi: 10.1186/s13063-018-2534-6.


International Practice Variation in Weaning Critically Ill Adults from Invasive Mechanical Ventilation.

Burns KEA, Raptis S, Nisenbaum R, Rizvi L, Jones A, Bakshi J, Tan W, Meret A, Cook DJ, Lellouche F, Epstein SK, Gattas D, Kapadia FN, Villar J, Brochard L, Lessard MR, Meade MO.

Ann Am Thorac Soc. 2018 Apr;15(4):494-502. doi: 10.1513/AnnalsATS.201705-410OC.


Characterizing Citizens' Preferences for Engagement in Patient Care and Research in Adult and Pediatric Intensive Care Units.

Burns KEA, Rizvi L, Charteris A, Laskey S, Bhatti SB, Chokar K, Choong KLM.

J Intensive Care Med. 2017 Jan 1:885066617729127. doi: 10.1177/0885066617729127. [Epub ahead of print]


Indirect regulation of CYP2C19 gene expression via DNA methylation.

Burns KE, Shepherd P, Finlay G, Tingle MD, Helsby NA.

Xenobiotica. 2018 Aug;48(8):781-792. doi: 10.1080/00498254.2017.1372648. Epub 2017 Sep 19.


Protocol adherence for continuously titrated interventions in randomized trials: an overview of the current methodology and case study.

Lauzier F, Adhikari NK, Seely A, Koo KKY, Belley-Côté EP, Burns KEA, Cook DJ, D'Aragon F, Rochwerg B, Kho ME, Oczkowksi SJW, Duan EH, Meade MO, Day AG, Lamontagne F; for ACCADEMY (Academy of Critical Care – Development, Evaluation, and Methodology).

BMC Med Res Methodol. 2017 Jul 17;17(1):106. doi: 10.1186/s12874-017-0388-3.


Patient and Family Engagement in Designing and Implementing a Weaning Trial: A Novel Research Paradigm in Critical Care.

Burns KEA, Devlin JW, Hill NS.

Chest. 2017 Oct;152(4):707-711. doi: 10.1016/j.chest.2017.06.028. Epub 2017 Jul 4. Review.


Variation in Definition of Prolonged Mechanical Ventilation.

Rose L, McGinlay M, Amin R, Burns KE, Connolly B, Hart N, Jouvet P, Katz S, Leasa D, Mawdsley C, McAuley DF, Schultz MJ, Blackwood B.

Respir Care. 2017 Oct;62(10):1324-1332. doi: 10.4187/respcare.05485. Epub 2017 Jun 13. Review.


Characteristics, clinical course, and outcomes of homeless and non-homeless patients admitted to ICU: A retrospective cohort study.

Smith OM, Chant C, Burns KEA, Kaur M, Ashraf S, DosSantos CC, Hwang SW, Friedrich JO.

PLoS One. 2017 Jun 12;12(6):e0179207. doi: 10.1371/journal.pone.0179207. eCollection 2017.


Trials directly comparing alternative spontaneous breathing trial techniques: a systematic review and meta-analysis.

Burns KEA, Soliman I, Adhikari NKJ, Zwein A, Wong JTY, Gomez-Builes C, Pellegrini JA, Chen L, Rittayamai N, Sklar M, Brochard LJ, Friedrich JO.

Crit Care. 2017 Jun 1;21(1):127. doi: 10.1186/s13054-017-1698-x. Review.


Targeting therapeutics to the plasma membrane: opportunities for nanoparticle-mediated delivery abound.

Burns KE, Delehanty JB.

Ther Deliv. 2017 Mar;8(5):235-237. doi: 10.4155/tde-2016-0091. No abstract available.


Gender Parity in Critical Care Medicine.

Mehta S, Burns KEA, Machado FR, Fox-Robichaud AE, Cook DJ, Calfee CS, Ware LB, Burnham EL, Kissoon N, Marshall JC, Mancebo J, Finfer S, Hartog C, Reinhart K, Maitland K, Stapleton RD, Kwizera A, Amin P, Abroug F, Smith O, Laake JH, Shrestha GS, Herridge MS.

Am J Respir Crit Care Med. 2017 Aug 15;196(4):425-429. doi: 10.1164/rccm.201701-0076CP. Review.


Therapeutic Efficacy of a Family of pHLIP-MMAF Conjugates in Cancer Cells and Mouse Models.

Burns KE, Hensley H, Robinson MK, Thévenin D.

Mol Pharm. 2017 Feb 6;14(2):415-422. doi: 10.1021/acs.molpharmaceut.6b00847. Epub 2017 Jan 13.


Long-Term Outcomes and Health Care Utilization after Prolonged Mechanical Ventilation.

Hill AD, Fowler RA, Burns KE, Rose L, Pinto RL, Scales DC.

Ann Am Thorac Soc. 2017 Mar;14(3):355-362. doi: 10.1513/AnnalsATS.201610-792OC.


Outcomes of elderly critically ill medical and surgical patients: a multicentre cohort study.

Ball IM, Bagshaw SM, Burns KE, Cook DJ, Day AG, Dodek PM, Kutsogiannis DJ, Mehta S, Muscedere JG, Turgeon AF, Stelfox HT, Wells GA, Stiell IG.

Can J Anaesth. 2017 Mar;64(3):260-269. doi: 10.1007/s12630-016-0798-4. Epub 2016 Dec 27.


The Experience of Surrogate Decision Makers on Being Approached for Consent for Patient Participation in Research. A Multicenter Study.

Burns KE, Prats CJ, Maione M, Lanceta M, Zubrinich C, Jeffs L, Smith OM; Canadian Critical Care Trials Group.

Ann Am Thorac Soc. 2017 Feb;14(2):238-245. doi: 10.1513/AnnalsATS.201606-425OC.


Early mobilization of critically ill adults: a survey of knowledge, perceptions and practices of Canadian physicians and physiotherapists.

Koo KK, Choong K, Cook DJ, Herridge M, Newman A, Lo V, Guyatt G, Priestap F, Campbell E, Burns KE, Lamontagne F, Meade MO; Canadian Critical Care Trials Group.

CMAJ Open. 2016 Aug 18;4(3):E448-E454. eCollection 2016 Jul-Sep.


Spontaneous Breathing Trials With T-Piece or Pressure Support Ventilation.

Pellegrini JA, Moraes RB, Maccari JG, de Oliveira RP, Savi A, Ribeiro RA, Burns KE, Teixeira C.

Respir Care. 2016 Dec;61(12):1693-1703. Epub 2016 Sep 6. Review.


Erratum to: Thromboprophylaxis using combined intermittent pneumatic compression and pharmacologic prophylaxis versus pharmacologic prophylaxis alone in critically ill patients: study protocol for a randomized controlled trial.

Arabi YM, Alsolamy S, Al-Dawood A, Al-Omari A, Al-Hameed F, Burns KE, Almaani M, Lababidi H, Al Bshabshe A, Mehta S, Al-Aithan AM, Mandourah Y, Almekhlafi G, Finfer S, Abdukahil SA, Afesh LY, Dbsawy M, Sadat M.

Trials. 2016 Aug 23;17(1):420. No abstract available.


Thromboprophylaxis using combined intermittent pneumatic compression and pharmacologic prophylaxis versus pharmacologic prophylaxis alone in critically ill patients: study protocol for a randomized controlled trial.

Arabi YM, Alsolamy S, Al-Dawood A, Al-Omari A, Al-Hameed F, Burns KE, Almaani M, Lababidi H, Al Bshabshe A, Mehta S, Al-Aithan AM, Mandourah Y, Almekhlafi G, Finfer S, Abdukahil SA, Afesh LY, Dbsawy M, Sadat M.

Trials. 2016 Aug 3;17(1):390. doi: 10.1186/s13063-016-1520-0. Erratum in: Trials. 2016;17(1):420.


A clinical prediction tool for hospital mortality in critically ill elderly patients.

Ball IM, Bagshaw SM, Burns KE, Cook DJ, Day AG, Dodek PM, Kutsogiannis DJ, Mehta S, Muscedere JG, Stelfox HT, Turgeon AF, Wells GA, Stiell IG.

J Crit Care. 2016 Oct;35:206-12. doi: 10.1016/j.jcrc.2016.05.026. Epub 2016 Jun 7.


pH-Selective Cytotoxicity of pHLIP-Antimicrobial Peptide Conjugates.

Burns KE, McCleerey TP, Thévenin D.

Sci Rep. 2016 Jun 23;6:28465. doi: 10.1038/srep28465.


Hypertonic salt solution for peri-operative fluid management.

Shrum B, Church B, McArthur E, Burns KE, Znajda T, McAlister V.

Cochrane Database Syst Rev. 2016 Jun 6;(6):CD005576. doi: 10.1002/14651858.CD005576.pub3. Review.


Emergency Department Length of Stay for Critical Care Admissions. A Population-based Study.

Rose L, Scales DC, Atzema C, Burns KE, Gray S, Doing C, Kiss A, Rubenfeld G, Lee JS.

Ann Am Thorac Soc. 2016 Aug;13(8):1324-32. doi: 10.1513/AnnalsATS.201511-773OC.


The influence of corticosteroid treatment on the outcome of influenza A(H1N1pdm09)-related critical illness.

Delaney JW, Pinto R, Long J, Lamontagne F, Adhikari NK, Kumar A, Marshall JC, Cook DJ, Jouvet P, Ferguson ND, Griesdale D, Burry LD, Burns KE, Hutchison J, Mehta S, Menon K, Fowler RA; Canadian Critical Care Trials Group H1N1 Collaborative.

Crit Care. 2016 Mar 30;20:75. doi: 10.1186/s13054-016-1230-8.


High CYP2C19 phenotypic variability in gastrointestinal cancer patients.

Burns KE, Lo WY, Findlay MP, Sharples K, Laking G, Helsby NA.

Cancer Chemother Pharmacol. 2016 Jan;77(1):195-204. doi: 10.1007/s00280-015-2923-4. Epub 2015 Nov 27.


Determinants of Citation Impact in Large Clinical Trials in Critical Care: The Role of Investigator-Led Clinical Trials Groups.

Marshall JC, Kwong W, Kommaraju K, Burns KE.

Crit Care Med. 2016 Apr;44(4):663-70. doi: 10.1097/CCM.0000000000001466. Review.


Noninvasive ventilation practice patterns for acute respiratory failure in Canadian tertiary care centres: A descriptive analysis.

Digby GC, Keenan SP, Parker CM, Sinuff T, Burns KE, Mehta S, Ronco JJ, Kutsogiannis DJ, Rose L, Ayas NT, Berthiaume LR, D'Arsigny CL, Stollery DE, Muscedere J.

Can Respir J. 2015 Nov-Dec;22(6):331-40. Epub 2015 Oct 15.


Down-regulation of PAR1 activity with a pHLIP-based allosteric antagonist induces cancer cell death.

Burns KE, Thévenin D.

Biochem J. 2015 Dec 15;472(3):287-95. doi: 10.1042/BJ20150876. Epub 2015 Sep 30.


Outcomes of sustained low efficiency dialysis versus continuous renal replacement therapy in critically ill adults with acute kidney injury: a cohort study.

Kitchlu A, Adhikari N, Burns KE, Friedrich JO, Garg AX, Klein D, Richardson RM, Wald R.

BMC Nephrol. 2015 Aug 4;16:127. doi: 10.1186/s12882-015-0123-4.


Comparison of standard and accelerated initiation of renal replacement therapy in acute kidney injury.

Wald R, Adhikari NK, Smith OM, Weir MA, Pope K, Cohen A, Thorpe K, McIntyre L, Lamontagne F, Soth M, Herridge M, Lapinsky S, Clark E, Garg AX, Hiremath S, Klein D, Mazer CD, Richardson RM, Wilcox ME, Friedrich JO, Burns KE, Bagshaw SM; Canadian Critical Care Trials Group.

Kidney Int. 2015 Oct;88(4):897-904. doi: 10.1038/ki.2015.184. Epub 2015 Jul 8.


Inhibition of cancer cell proliferation and breast tumor targeting of pHLIP-monomethyl auristatin E conjugates.

Burns KE, Robinson MK, Thévenin D.

Mol Pharm. 2015 Apr 6;12(4):1250-8. doi: 10.1021/mp500779k. Epub 2015 Mar 13.


How to assess a survey report: a guide for readers and peer reviewers.

Burns KE, Kho ME.

CMAJ. 2015 Apr 7;187(6):E198-205. doi: 10.1503/cmaj.140545. Epub 2015 Feb 17. Review. No abstract available.


Changing incidence and outcomes following dialysis-requiring acute kidney injury among critically ill adults: a population-based cohort study.

Wald R, McArthur E, Adhikari NK, Bagshaw SM, Burns KE, Garg AX, Harel Z, Kitchlu A, Mazer CD, Nash DM, Scales DC, Silver SA, Ray JG, Friedrich JO.

Am J Kidney Dis. 2015 Jun;65(6):870-7. doi: 10.1053/j.ajkd.2014.10.017. Epub 2014 Dec 18.


Is there a role for physician involvement in introducing research to surrogate decision makers in the intensive care unit? (The Approach trial: a pilot mixed methods study).

Burns KE, Rizvi L, Smith OM, Lee Y, Lee J, Wang M, Brown M, Parker M, Premji A, Leung D, Hammond Mobilio M, Gotlib-Conn L, Nisenbaum R, Santos M, Li Y, Mehta S.

Intensive Care Med. 2015 Jan;41(1):58-67. doi: 10.1007/s00134-014-3558-3. Epub 2014 Dec 10.


Protocolized versus non-protocolized weaning for reducing the duration of mechanical ventilation in critically ill adult patients.

Blackwood B, Burns KE, Cardwell CR, O'Halloran P.

Cochrane Database Syst Rev. 2014 Nov 6;(11):CD006904. doi: 10.1002/14651858.CD006904.pub3. Review.


Inter-hospital transfers and outcomes of critically ill patients with severe acute kidney injury: a multicenter cohort study.

Kudlow P, Burns KE, Adhikari NK, Bell B, Klein DJ, Xie B, Friedrich JO, Wald R.

Crit Care. 2014 Sep 17;18(5):513. doi: 10.1186/s13054-014-0513-1.


Automated weaning and SBT systems versus non-automated weaning strategies for weaning time in invasively ventilated critically ill adults.

Burns KE, Lellouche F, Nisenbaum R, Lessard MR, Friedrich JO.

Cochrane Database Syst Rev. 2014 Sep 9;(9):CD008638. doi: 10.1002/14651858.CD008638.pub2. Review.


Deferred consent in a minimal-risk study involving critically ill subarachnoid hemorrhage patients.

Topolovec-Vranic J, Santos M, Baker AJ, Smith OM, Burns KE.

Can Respir J. 2014 Sep-Oct;21(5):293-6. Epub 2014 Jun 10.


Evaluation of an internal review process for grants and manuscripts in the Canadian Critical Care Trials Group.

Burns KE, Caon E, Dodek PM; Canadian Critical Care Trials Group.

Can Respir J. 2014 Sep-Oct;21(5):283-6. Epub 2014 Apr 7.

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