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A simple ex vivo bioassay for 5-FU transport into healthy buccal mucosal cells.

Burns KE, Allright D, Porter D, Findlay MP, Helsby NA.

Cancer Chemother Pharmacol. 2019 Jul 19. doi: 10.1007/s00280-019-03904-4. [Epub ahead of print]


Pneumatic Compression in Venous Thromboprophylaxis. Reply.

Arabi YM, Burns KEA, Finfer S.

N Engl J Med. 2019 Jul 4;381(1):95. doi: 10.1056/NEJMc1905933. No abstract available.


High-flow nasal cannula compared with conventional oxygen therapy for acute hypoxemic respiratory failure: author's reply.

Rochwerg B, Granton D, Wang DX, Einav S, Burns KEA.

Intensive Care Med. 2019 Jun 24. doi: 10.1007/s00134-019-05658-2. [Epub ahead of print] No abstract available.


The importance of both CYP2C19 and CYP2B6 germline variations in cyclophosphamide pharmacokinetics and clinical outcomes.

Helsby NA, Yong M, van Kan M, de Zoysa JR, Burns KE.

Br J Clin Pharmacol. 2019 Jun 19. doi: 10.1111/bcp.14031. [Epub ahead of print] Review.


Factors influencing decisions by critical care physicians to withdraw life-sustaining treatments in critically ill adult patients with severe traumatic brain injury.

Turgeon AF, Dorrance K, Archambault P, Lauzier F, Lamontagne F, Zarychanski R, Fowler R, Moore L, Lacroix J, English S, Boutin A, Muscedere J, Burns KEA, Griesdale D, McIntyre LA, Scales D, Bernard F, Yamada J, Squires JE; Canadian Traumatic Brain Injury Research Consortium and the Canadian Critical Care Trials Group.

CMAJ. 2019 Jun 17;191(24):E652-E663. doi: 10.1503/cmaj.190154.


Revisiting, Reframing, and Casting a New Light on Liberation From Mechanical Ventilation.

Girard TD, Burns KEA.

JAMA. 2019 Jun 11;321(22):2167-2169. doi: 10.1001/jama.2019.7364. No abstract available.


Practice Patterns in the Treatment of Patients With Severe Alcohol Withdrawal: A Multidisciplinary, Cross-Sectional Survey.

Buell D, Filewod N, Ailon J, Burns KEA.

J Intensive Care Med. 2019 May 23:885066619847119. doi: 10.1177/0885066619847119. [Epub ahead of print]


Multicentre pilot randomised clinical trial of early in-bed cycle ergometry with ventilated patients.

Kho ME, Molloy AJ, Clarke FJ, Reid JC, Herridge MS, Karachi T, Rochwerg B, Fox-Robichaud AE, Seely AJ, Mathur S, Lo V, Burns KE, Ball IM, Pellizzari JR, Tarride JE, Rudkowski JC, Koo K, Heels-Ansdell D, Cook DJ.

BMJ Open Respir Res. 2019 Feb 18;6(1):e000383. doi: 10.1136/bmjresp-2018-000383. eCollection 2019.


Frequency of Screening for Weaning From Mechanical Ventilation: Two Contemporaneous Proof-of-Principle Randomized Controlled Trials.

Burns KEA, Wong JTY, Dodek P, Cook DJ, Lamontagne F, Cohen A, Mehta S, Kho ME, Hebert PC, Aslanian P, Friedrich JO, Brochard L, Rizvi L, Hand L, Meade MO, Amaral AC, Seely AJ; Canadian Critical Care Trials Group.

Crit Care Med. 2019 Jun;47(6):817-825. doi: 10.1097/CCM.0000000000003722.


Selection and Receipt of Kidney Replacement in Critically Ill Older Patients with AKI.

Bagshaw SM, Adhikari NKJ, Burns KEA, Friedrich JO, Bouchard J, Lamontagne F, McIntrye LA, Cailhier JF, Dodek P, Stelfox HT, Herridge M, Lapinsky S, Muscedere J, Barton J, Griesdale D, Soth M, Ambosta A, Lebovic G, Wald R; Canadian Critical Care Trials Group.

Clin J Am Soc Nephrol. 2019 Apr 5;14(4):496-505. doi: 10.2215/CJN.05530518. Epub 2019 Mar 21.


Noninvasive Ventilation: Education and Training. A Narrative Analysis and an International Consensus Document.

Karim HMR, Burns KEA, Ciobanu LD, El-Khatib M, Nicolini A, Vargas N, Hernández-Gilsoul T, Skoczyński S, Falcone VA, Arnal JM, Bach J, De Santo LS, Lucchini A, Steier J, Purro A, Petroianni A, Sassoon CS, Bambi S, Aguiar M, Soubani AO, Taniguchi C, Mollica C, Berlin DA, Piervincenzi E, Rao F, Luigi FS, Ferrari R, Garuti G, Laier-Groeneveld G, Fiorentino G, Ho KM, Alqahtani JS, Luján M, Moerer O, Resta O, Pierucci P, Papadakos P, Steiner S, Stieglitz S, Dikmen Y, Duan J, Bhakta P, Iglesias AU, Corcione N, Caldeira V, Karakurt Z, Valli G, Kondili E, Ruggieri MP, Raposo MS, Bottino F, Soler-González R, Gurjar M, Sandoval-Gutierrez JL, Jafari B, Arroyo-Cozar M, Noval AR, Esquinas AM, Sarc I.

Adv Respir Med. 2019 Mar 4. doi: 10.5603/ARM.a2019.0006. [Epub ahead of print]


Gender differences in career satisfaction, moral distress, and incivility: a national, cross-sectional survey of Canadian critical care physicians.

Burns KEA, Fox-Robichaud A, Lorens E, Martin CM; Canadian Critical Care Society.

Can J Anaesth. 2019 May;66(5):503-511. doi: 10.1007/s12630-019-01321-y. Epub 2019 Feb 20.


Adjunctive Intermittent Pneumatic Compression for Venous Thromboprophylaxis.

Arabi YM, Al-Hameed F, Burns KEA, Mehta S, Alsolamy SJ, Alshahrani MS, Mandourah Y, Almekhlafi GA, Almaani M, Al Bshabshe A, Finfer S, Arshad Z, Khalid I, Mehta Y, Gaur A, Hawa H, Buscher H, Lababidi H, Al Aithan A, Abdukahil SAI, Jose J, Afesh LY, Al-Dawood A; Saudi Critical Care Trials Group.

N Engl J Med. 2019 Apr 4;380(14):1305-1315. doi: 10.1056/NEJMoa1816150. Epub 2019 Feb 18.


Burnout in women intensivists: a hidden epidemic?

Burnham EL, Burns KEA, Moss M, Dodek PM.

Lancet Respir Med. 2019 Apr;7(4):292-294. doi: 10.1016/S2213-2600(19)30029-3. Epub 2019 Feb 8. No abstract available.


Characteristic of Subjects Who Fail a 120-Minute Spontaneous Breathing Trial: When Minutes Are Taken Into Account.

Burns KEA, Karim HMR, Esquinas AM.

Respir Care. 2019 Jan;64(1):114. doi: 10.4187/respcare.06404. No abstract available.


High-flow nasal cannula in adults with acute respiratory failure and after extubation: a systematic review and meta-analysis.

Xu Z, Li Y, Zhou J, Li X, Huang Y, Liu X, Burns KEA, Zhong N, Zhang H.

Respir Res. 2018 Oct 16;19(1):202. doi: 10.1186/s12931-018-0908-7.


Qualitative pilot study of veterinarians' perceptions of and experiences with counseling about dog walking in companion-animal practice in southern Ontario.

Burns KE, Dwyer JJM, Coe JB, Tam GCY, Wong SNR.

J Vet Med Educ. 2018 Oct 4:1-12. doi: 10.3138/jvme.0117-011r1. [Epub ahead of print]


Surveillance or no surveillance for deep venous thrombosis and outcomes of critically ill patients: A study protocol and statistical analysis plan.

Arabi YM, Burns KEA, Al-Hameed F, Alsolamy S, Almaani M, Mandourah Y, Almekhlafi GA, Al Bshabshe A, Alshahrani M, Khalid I, Hawa H, Arshad Z, Lababidi H, Al Aithan A, Jose J, Abdukahil SAI, Afesh LY, Al-Dawood A; and the PREVENT trial Group.

Medicine (Baltimore). 2018 Sep;97(36):e12258. doi: 10.1097/MD.0000000000012258.


Canadian Critical Care Society revised process for guideline development and endorsement.

Lamontagne F, D'Aragon F, Burns KEA, Belley-Côté É, Kho M, Menon K, Duan E, Masse MH, Archambault P, Hrymak C, Rochwerg B.

Can J Anaesth. 2018 Oct;65(10):1163-1164. doi: 10.1007/s12630-018-1182-3. Epub 2018 Jul 30. No abstract available.


Hamilton-DONATE: a city-wide pilot observational study of the ICU management of deceased organ donors.

D'Aragon F, Cook D, Dhanani S, Ribic C, Burns KEA, Akhtar A, Hand L, Arseneau E, Cupido C, Whittigham H, Healey A, Frenette AJ, Lamontagne F, Meade MO; Canadian Critical Care Trials Group and the Canadian National Transplant Research Program.

Can J Anaesth. 2018 Oct;65(10):1110-1119. doi: 10.1007/s12630-018-1179-y. Epub 2018 Jul 9.


Intensity of care and withdrawal of life-sustaining therapies in severe traumatic brain injury patients: a post-hoc analysis of a multicentre retrospective cohort study.

Gerges PRA, Moore L, Léger C, Lauzier F, Shemilt M, Zarychanski R, Scales DC, Burns KEA, Bernard F, Zygun D, Neveu X, Turgeon AF; Canadian Critical Care Trials Group.

Can J Anaesth. 2018 Sep;65(9):996-1003. doi: 10.1007/s12630-018-1171-6. Epub 2018 Jun 14.


The role of nanoparticles in the improvement of systemic anticancer drug delivery.

Field LD, Nag OK, Sangtani A, Burns KE, Delehanty JB.

Ther Deliv. 2018 Jul;9(7):527-545. doi: 10.4155/tde-2018-0015. Review.


Evidence Supporting Clinical Use of Proportional Assist Ventilation: A Systematic Review and Meta-Analysis of Clinical Trials.

Tirupakuzhi Vijayaraghavan BK, Hamed S, Jain A, Chimunda T, Telias I, Friedrich JO, Burns KEA.

J Intensive Care Med. 2018 Jan 1:885066618769021. doi: 10.1177/0885066618769021. [Epub ahead of print]


Cellular delivery of doxorubicin mediated by disulfide reduction of a peptide-dendrimer bioconjugate.

Burns KE, Delehanty JB.

Int J Pharm. 2018 Jul 10;545(1-2):64-73. doi: 10.1016/j.ijpharm.2018.04.027. Epub 2018 Apr 27.


A time-driven, activity-based costing methodology for determining the costs of red blood cell transfusion in patients with beta thalassaemia major.

Burns KE, Haysom HE, Higgins AM, Waters N, Tahiri R, Rushford K, Dunstan T, Saxby K, Kaplan Z, Chunilal S, McQuilten ZK, Wood EM.

Transfus Med. 2019 Feb;29(1):33-40. doi: 10.1111/tme.12523. Epub 2018 Apr 10.


Patient and Family Engagement in the ICU. Untapped Opportunities and Underrecognized Challenges.

Burns KEA, Misak C, Herridge M, Meade MO, Oczkowski S; Patient and Family Partnership Committee of the Canadian Critical Care Trials Group.

Am J Respir Crit Care Med. 2018 Aug 1;198(3):310-319. doi: 10.1164/rccm.201710-2032CI.


Implementation of physiological fluids to provide insight into the characterization, fate, and biological interactions of silver nanoparticles.

Breitner EK, Burns KE, Hussain SM, Comfort KK.

Nanotechnology. 2018 Jun 22;29(25):254001. doi: 10.1088/1361-6528/aabb9d. Epub 2018 Apr 4.


Statistical analysis plan for the Pneumatic CompREssion for PreVENting Venous Thromboembolism (PREVENT) trial: a study protocol for a randomized controlled trial.

Arabi Y, Al-Hameed F, Burns KEA, Mehta S, Alsolamy S, Almaani M, Mandourah Y, Almekhlafi GA, Al Bshabshe A, Finfer S, Alshahrani M, Khalid I, Mehta Y, Gaur A, Hawa H, Buscher H, Arshad Z, Lababidi H, Al Aithan A, Jose J, Abdukahil SAI, Afesh LY, Dbsawy M, Al-Dawood A; PREVENT trial Group.

Trials. 2018 Mar 15;19(1):182. doi: 10.1186/s13063-018-2534-6.


International Practice Variation in Weaning Critically Ill Adults from Invasive Mechanical Ventilation.

Burns KEA, Raptis S, Nisenbaum R, Rizvi L, Jones A, Bakshi J, Tan W, Meret A, Cook DJ, Lellouche F, Epstein SK, Gattas D, Kapadia FN, Villar J, Brochard L, Lessard MR, Meade MO.

Ann Am Thorac Soc. 2018 Apr;15(4):494-502. doi: 10.1513/AnnalsATS.201705-410OC. Erratum in: Ann Am Thorac Soc. 2018 Jul;15(7):894.


Characterizing Citizens' Preferences for Engagement in Patient Care and Research in Adult and Pediatric Intensive Care Units.

Burns KEA, Rizvi L, Charteris A, Laskey S, Bhatti SB, Chokar K, Choong KLM.

J Intensive Care Med. 2017 Jan 1:885066617729127. doi: 10.1177/0885066617729127. [Epub ahead of print]


Indirect regulation of CYP2C19 gene expression via DNA methylation.

Burns KE, Shepherd P, Finlay G, Tingle MD, Helsby NA.

Xenobiotica. 2018 Aug;48(8):781-792. doi: 10.1080/00498254.2017.1372648. Epub 2017 Sep 19.


Protocol adherence for continuously titrated interventions in randomized trials: an overview of the current methodology and case study.

Lauzier F, Adhikari NK, Seely A, Koo KKY, Belley-Côté EP, Burns KEA, Cook DJ, D'Aragon F, Rochwerg B, Kho ME, Oczkowksi SJW, Duan EH, Meade MO, Day AG, Lamontagne F; for ACCADEMY (Academy of Critical Care – Development, Evaluation, and Methodology).

BMC Med Res Methodol. 2017 Jul 17;17(1):106. doi: 10.1186/s12874-017-0388-3.


Patient and Family Engagement in Designing and Implementing a Weaning Trial: A Novel Research Paradigm in Critical Care.

Burns KEA, Devlin JW, Hill NS.

Chest. 2017 Oct;152(4):707-711. doi: 10.1016/j.chest.2017.06.028. Epub 2017 Jul 4. Review.


Variation in Definition of Prolonged Mechanical Ventilation.

Rose L, McGinlay M, Amin R, Burns KE, Connolly B, Hart N, Jouvet P, Katz S, Leasa D, Mawdsley C, McAuley DF, Schultz MJ, Blackwood B.

Respir Care. 2017 Oct;62(10):1324-1332. doi: 10.4187/respcare.05485. Epub 2017 Jun 13. Review.


Characteristics, clinical course, and outcomes of homeless and non-homeless patients admitted to ICU: A retrospective cohort study.

Smith OM, Chant C, Burns KEA, Kaur M, Ashraf S, DosSantos CC, Hwang SW, Friedrich JO.

PLoS One. 2017 Jun 12;12(6):e0179207. doi: 10.1371/journal.pone.0179207. eCollection 2017.


Trials directly comparing alternative spontaneous breathing trial techniques: a systematic review and meta-analysis.

Burns KEA, Soliman I, Adhikari NKJ, Zwein A, Wong JTY, Gomez-Builes C, Pellegrini JA, Chen L, Rittayamai N, Sklar M, Brochard LJ, Friedrich JO.

Crit Care. 2017 Jun 1;21(1):127. doi: 10.1186/s13054-017-1698-x. Review.


Targeting therapeutics to the plasma membrane: opportunities for nanoparticle-mediated delivery abound.

Burns KE, Delehanty JB.

Ther Deliv. 2017 Mar;8(5):235-237. doi: 10.4155/tde-2016-0091. No abstract available.


Gender Parity in Critical Care Medicine.

Mehta S, Burns KEA, Machado FR, Fox-Robichaud AE, Cook DJ, Calfee CS, Ware LB, Burnham EL, Kissoon N, Marshall JC, Mancebo J, Finfer S, Hartog C, Reinhart K, Maitland K, Stapleton RD, Kwizera A, Amin P, Abroug F, Smith O, Laake JH, Shrestha GS, Herridge MS.

Am J Respir Crit Care Med. 2017 Aug 15;196(4):425-429. doi: 10.1164/rccm.201701-0076CP. Review.


Therapeutic Efficacy of a Family of pHLIP-MMAF Conjugates in Cancer Cells and Mouse Models.

Burns KE, Hensley H, Robinson MK, Thévenin D.

Mol Pharm. 2017 Feb 6;14(2):415-422. doi: 10.1021/acs.molpharmaceut.6b00847. Epub 2017 Jan 13.


Long-Term Outcomes and Health Care Utilization after Prolonged Mechanical Ventilation.

Hill AD, Fowler RA, Burns KE, Rose L, Pinto RL, Scales DC.

Ann Am Thorac Soc. 2017 Mar;14(3):355-362. doi: 10.1513/AnnalsATS.201610-792OC.


Outcomes of elderly critically ill medical and surgical patients: a multicentre cohort study.

Ball IM, Bagshaw SM, Burns KE, Cook DJ, Day AG, Dodek PM, Kutsogiannis DJ, Mehta S, Muscedere JG, Turgeon AF, Stelfox HT, Wells GA, Stiell IG.

Can J Anaesth. 2017 Mar;64(3):260-269. doi: 10.1007/s12630-016-0798-4. Epub 2016 Dec 27.


The Experience of Surrogate Decision Makers on Being Approached for Consent for Patient Participation in Research. A Multicenter Study.

Burns KE, Prats CJ, Maione M, Lanceta M, Zubrinich C, Jeffs L, Smith OM; Canadian Critical Care Trials Group.

Ann Am Thorac Soc. 2017 Feb;14(2):238-245. doi: 10.1513/AnnalsATS.201606-425OC.


Early mobilization of critically ill adults: a survey of knowledge, perceptions and practices of Canadian physicians and physiotherapists.

Koo KK, Choong K, Cook DJ, Herridge M, Newman A, Lo V, Guyatt G, Priestap F, Campbell E, Burns KE, Lamontagne F, Meade MO; Canadian Critical Care Trials Group.

CMAJ Open. 2016 Aug 18;4(3):E448-E454. eCollection 2016 Jul-Sep.


Spontaneous Breathing Trials With T-Piece or Pressure Support Ventilation.

Pellegrini JA, Moraes RB, Maccari JG, de Oliveira RP, Savi A, Ribeiro RA, Burns KE, Teixeira C.

Respir Care. 2016 Dec;61(12):1693-1703. Epub 2016 Sep 6. Review.


Erratum to: Thromboprophylaxis using combined intermittent pneumatic compression and pharmacologic prophylaxis versus pharmacologic prophylaxis alone in critically ill patients: study protocol for a randomized controlled trial.

Arabi YM, Alsolamy S, Al-Dawood A, Al-Omari A, Al-Hameed F, Burns KE, Almaani M, Lababidi H, Al Bshabshe A, Mehta S, Al-Aithan AM, Mandourah Y, Almekhlafi G, Finfer S, Abdukahil SA, Afesh LY, Dbsawy M, Sadat M.

Trials. 2016 Aug 23;17(1):420. No abstract available.


Thromboprophylaxis using combined intermittent pneumatic compression and pharmacologic prophylaxis versus pharmacologic prophylaxis alone in critically ill patients: study protocol for a randomized controlled trial.

Arabi YM, Alsolamy S, Al-Dawood A, Al-Omari A, Al-Hameed F, Burns KE, Almaani M, Lababidi H, Al Bshabshe A, Mehta S, Al-Aithan AM, Mandourah Y, Almekhlafi G, Finfer S, Abdukahil SA, Afesh LY, Dbsawy M, Sadat M.

Trials. 2016 Aug 3;17(1):390. doi: 10.1186/s13063-016-1520-0. Erratum in: Trials. 2016;17(1):420.


A clinical prediction tool for hospital mortality in critically ill elderly patients.

Ball IM, Bagshaw SM, Burns KE, Cook DJ, Day AG, Dodek PM, Kutsogiannis DJ, Mehta S, Muscedere JG, Stelfox HT, Turgeon AF, Wells GA, Stiell IG.

J Crit Care. 2016 Oct;35:206-12. doi: 10.1016/j.jcrc.2016.05.026. Epub 2016 Jun 7.


pH-Selective Cytotoxicity of pHLIP-Antimicrobial Peptide Conjugates.

Burns KE, McCleerey TP, Thévenin D.

Sci Rep. 2016 Jun 23;6:28465. doi: 10.1038/srep28465.


Hypertonic salt solution for peri-operative fluid management.

Shrum B, Church B, McArthur E, Burns KE, Znajda T, McAlister V.

Cochrane Database Syst Rev. 2016 Jun 6;(6):CD005576. doi: 10.1002/14651858.CD005576.pub3. Review.


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