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Items: 1 to 50 of 169

1.

Circulating microRNA as biomarkers of clozapine-induced cardiotoxicity.

Burns KE, Deane-Alder KD, Bellissima BL, Tingle MD.

Biomarkers. 2019 Nov 14:1-32. doi: 10.1080/1354750X.2019.1693631. [Epub ahead of print]

PMID:
31722571
2.

Spontaneous Breathing Trials and Successful Extubation.

Friedrich JO, Burns KEA.

JAMA. 2019 Nov 5;322(17):1716. doi: 10.1001/jama.2019.14217. No abstract available.

PMID:
31688876
3.

A case-control study to assess the ability of the thymine challenge test to predict patients with severe to life threatening fluoropyrimidine-induced gastrointestinal toxicity.

Helsby NA, Duley J, Burns KE, Bonnet C, Jeong SH, Brenman E, Barlow P, Sharples K, Porter D, Findlay M.

Br J Clin Pharmacol. 2019 Oct 28. doi: 10.1111/bcp.14153. [Epub ahead of print]

PMID:
31658382
4.

Correction to: Project management lessons learned from the multicentre CYCLE pilot randomized controlled trial.

McCaskell DS, Molloy AJ, Childerhose L, Costigan FA, Reid JC, McCaughan M, Clarke F, Cook DJ, Rudkowski JC, Farley C, Karachi T, Rochwerg B, Newman A, Fox-Robichaud A, Herridge MS, Lo V, Feltracco D, Burns KEA, Porteous R, Seely AJE, Ball IM, Seczek A, Kho ME.

Trials. 2019 Oct 25;20(1):606. doi: 10.1186/s13063-019-3716-6.

5.

Gender differences in grant and personnel award funding rates at the Canadian Institutes of Health Research based on research content area: A retrospective analysis.

Burns KEA, Straus SE, Liu K, Rizvi L, Guyatt G.

PLoS Med. 2019 Oct 15;16(10):e1002935. doi: 10.1371/journal.pmed.1002935. eCollection 2019 Oct.

6.

Frequency of Screening and SBT Technique Trial - North American Weaning Collaboration (FAST-NAWC): a protocol for a multicenter, factorial randomized trial.

Burns KEA, Rizvi L, Cook DJ, Seely AJE, Rochwerg B, Lamontagne F, Devlin JW, Dodek P, Mayette M, Tanios M, Gouskos A, Kay P, Mitchell S, Kiedrowski KC, Hill NS; Canadian Critical Care Trials Group.

Trials. 2019 Oct 11;20(1):587. doi: 10.1186/s13063-019-3641-8.

7.

Variation in the practice of discontinuing mechanical ventilation in critically ill adults: study protocol for an international prospective observational study.

Burns KEA, Rizvi L, Cook DJ, Dodek P, Slutsky AS, Jones A, Villar J, Kapadia FN, Gattas DJ, Epstein SK, Meade MO; Canadian Critical Care Trials Group.

BMJ Open. 2019 Sep 8;9(9):e031775. doi: 10.1136/bmjopen-2019-031775.

8.

Comparison of ventilatory modes to facilitate liberation from mechanical ventilation: protocol for a systematic review and network meta-analysis.

Lewis KA, Chaudhuri D, Guyatt G, Burns KEA, Bosma K, Ge L, Karachi T, Piraino T, Fernando SM, Ranganath N, Brochard L, Rochwerg B.

BMJ Open. 2019 Sep 5;9(9):e030407. doi: 10.1136/bmjopen-2019-030407.

9.

Fostering community hospital research.

Gehrke P, Binnie A, Chan SPT, Cook DJ, Burns KEA, Rewa OG, Herridge M, Tsang JLY.

CMAJ. 2019 Sep 3;191(35):E962-E966. doi: 10.1503/cmaj.190055. No abstract available.

PMID:
31481424
10.

Practice Patterns and Ethical Considerations in the Management of Venovenous Extracorporeal Membrane Oxygenation Patients: An International Survey.

Abrams D, Pham T, Burns KEA, Combes A, Curtis JR, Mueller T, Prager KM, Serra A, Slutsky AS, Brodie D, Schmidt M; International ECMO Network (ECMONet).

Crit Care Med. 2019 Oct;47(10):1346-1355. doi: 10.1097/CCM.0000000000003910.

PMID:
31356471
11.

Unconscious bias in the selection and interpretation of data on sex and burnout - Authors' reply.

Burns KEA, Burnham EL, Dodek PM, Moss M.

Lancet Respir Med. 2019 Aug;7(8):e24. doi: 10.1016/S2213-2600(19)30223-1. Epub 2019 Jul 23. No abstract available.

PMID:
31342898
12.

A simple ex vivo bioassay for 5-FU transport into healthy buccal mucosal cells.

Burns KE, Allright D, Porter D, Findlay MP, Helsby NA.

Cancer Chemother Pharmacol. 2019 Oct;84(4):739-748. doi: 10.1007/s00280-019-03904-4. Epub 2019 Jul 19.

PMID:
31324934
13.

Pneumatic Compression in Venous Thromboprophylaxis. Reply.

Arabi YM, Burns KEA, Finfer S.

N Engl J Med. 2019 Jul 4;381(1):95. doi: 10.1056/NEJMc1905933. No abstract available.

PMID:
31269377
14.

High-flow nasal cannula compared with conventional oxygen therapy for acute hypoxemic respiratory failure: author's reply.

Rochwerg B, Granton D, Wang DX, Einav S, Burns KEA.

Intensive Care Med. 2019 Aug;45(8):1171. doi: 10.1007/s00134-019-05658-2. Epub 2019 Jun 24. No abstract available.

PMID:
31236637
15.

The importance of both CYP2C19 and CYP2B6 germline variations in cyclophosphamide pharmacokinetics and clinical outcomes.

Helsby NA, Yong M, van Kan M, de Zoysa JR, Burns KE.

Br J Clin Pharmacol. 2019 Sep;85(9):1925-1934. doi: 10.1111/bcp.14031. Epub 2019 Jul 22. Review.

PMID:
31218720
16.

Factors influencing decisions by critical care physicians to withdraw life-sustaining treatments in critically ill adult patients with severe traumatic brain injury.

Turgeon AF, Dorrance K, Archambault P, Lauzier F, Lamontagne F, Zarychanski R, Fowler R, Moore L, Lacroix J, English S, Boutin A, Muscedere J, Burns KEA, Griesdale D, McIntyre LA, Scales D, Bernard F, Yamada J, Squires JE; Canadian Traumatic Brain Injury Research Consortium and the Canadian Critical Care Trials Group.

CMAJ. 2019 Jun 17;191(24):E652-E663. doi: 10.1503/cmaj.190154.

17.

Revisiting, Reframing, and Casting a New Light on Liberation From Mechanical Ventilation.

Girard TD, Burns KEA.

JAMA. 2019 Jun 11;321(22):2167-2169. doi: 10.1001/jama.2019.7364. No abstract available.

PMID:
31184723
18.

Practice Patterns in the Treatment of Patients With Severe Alcohol Withdrawal: A Multidisciplinary, Cross-Sectional Survey.

Buell D, Filewod N, Ailon J, Burns KEA.

J Intensive Care Med. 2019 May 23:885066619847119. doi: 10.1177/0885066619847119. [Epub ahead of print]

PMID:
31122170
19.

Multicentre pilot randomised clinical trial of early in-bed cycle ergometry with ventilated patients.

Kho ME, Molloy AJ, Clarke FJ, Reid JC, Herridge MS, Karachi T, Rochwerg B, Fox-Robichaud AE, Seely AJ, Mathur S, Lo V, Burns KE, Ball IM, Pellizzari JR, Tarride JE, Rudkowski JC, Koo K, Heels-Ansdell D, Cook DJ.

BMJ Open Respir Res. 2019 Feb 18;6(1):e000383. doi: 10.1136/bmjresp-2018-000383. eCollection 2019.

20.

Frequency of Screening for Weaning From Mechanical Ventilation: Two Contemporaneous Proof-of-Principle Randomized Controlled Trials.

Burns KEA, Wong JTY, Dodek P, Cook DJ, Lamontagne F, Cohen A, Mehta S, Kho ME, Hebert PC, Aslanian P, Friedrich JO, Brochard L, Rizvi L, Hand L, Meade MO, Amaral AC, Seely AJ; Canadian Critical Care Trials Group.

Crit Care Med. 2019 Jun;47(6):817-825. doi: 10.1097/CCM.0000000000003722.

PMID:
30920411
21.

Selection and Receipt of Kidney Replacement in Critically Ill Older Patients with AKI.

Bagshaw SM, Adhikari NKJ, Burns KEA, Friedrich JO, Bouchard J, Lamontagne F, McIntrye LA, Cailhier JF, Dodek P, Stelfox HT, Herridge M, Lapinsky S, Muscedere J, Barton J, Griesdale D, Soth M, Ambosta A, Lebovic G, Wald R; Canadian Critical Care Trials Group.

Clin J Am Soc Nephrol. 2019 Apr 5;14(4):496-505. doi: 10.2215/CJN.05530518. Epub 2019 Mar 21.

PMID:
30898872
22.

Noninvasive ventilation: education and training. A narrative analysis and an international consensus document.

Karim HMR, Burns KEA, Ciobanu LD, El-Khatib M, Nicolini A, Vargas N, Hernández-Gilsoul T, Skoczyński S, Falcone VA, Arnal JM, Bach J, De Santo LS, Lucchini A, Steier J, Purro A, Petroianni A, Sassoon CS, Bambi S, Aguiar M, Soubani AO, Taniguchi C, Mollica C, Berlin DA, Piervincenzi E, Rao F, Luigi FS, Ferrari R, Garuti G, Laier-Groeneveld G, Fiorentino G, Ho KM, Alqahtani JS, Luján M, Moerer O, Resta O, Pierucci P, Papadakos P, Steiner S, Stieglitz S, Dikmen Y, Duan J, Bhakta P, Iglesias AU, Corcione N, Caldeira V, Karakurt Z, Valli G, Kondili E, Ruggieri MP, Raposo MS, Bottino F, Soler-González R, Gurjar M, Sandoval-Gutierrez JL, Jafari B, Arroyo-Cozar M, Noval AR, Corcione N, Barjaktarevic I, Sarc I, Mina B, Szkulmowski Z, Taniguchi C, Esquinas AM.

Adv Respir Med. 2019;87(1):36-45. doi: 10.5603/ARM.a2019.0006. Epub 2019 Mar 4.

23.

Gender differences in career satisfaction, moral distress, and incivility: a national, cross-sectional survey of Canadian critical care physicians.

Burns KEA, Fox-Robichaud A, Lorens E, Martin CM; Canadian Critical Care Society.

Can J Anaesth. 2019 May;66(5):503-511. doi: 10.1007/s12630-019-01321-y. Epub 2019 Feb 20.

PMID:
30805903
24.

Adjunctive Intermittent Pneumatic Compression for Venous Thromboprophylaxis.

Arabi YM, Al-Hameed F, Burns KEA, Mehta S, Alsolamy SJ, Alshahrani MS, Mandourah Y, Almekhlafi GA, Almaani M, Al Bshabshe A, Finfer S, Arshad Z, Khalid I, Mehta Y, Gaur A, Hawa H, Buscher H, Lababidi H, Al Aithan A, Abdukahil SAI, Jose J, Afesh LY, Al-Dawood A; Saudi Critical Care Trials Group.

N Engl J Med. 2019 Apr 4;380(14):1305-1315. doi: 10.1056/NEJMoa1816150. Epub 2019 Feb 18.

PMID:
30779530
25.

Burnout in women intensivists: a hidden epidemic?

Burnham EL, Burns KEA, Moss M, Dodek PM.

Lancet Respir Med. 2019 Apr;7(4):292-294. doi: 10.1016/S2213-2600(19)30029-3. Epub 2019 Feb 8. No abstract available.

PMID:
30744938
26.

Characteristic of Subjects Who Fail a 120-Minute Spontaneous Breathing Trial: When Minutes Are Taken Into Account.

Burns KEA, Karim HMR, Esquinas AM.

Respir Care. 2019 Jan;64(1):114. doi: 10.4187/respcare.06404. No abstract available.

PMID:
30578365
27.

High-flow nasal cannula in adults with acute respiratory failure and after extubation: a systematic review and meta-analysis.

Xu Z, Li Y, Zhou J, Li X, Huang Y, Liu X, Burns KEA, Zhong N, Zhang H.

Respir Res. 2018 Oct 16;19(1):202. doi: 10.1186/s12931-018-0908-7.

28.

Qualitative pilot study of veterinarians' perceptions of and experiences with counseling about dog walking in companion-animal practice in southern Ontario.

Burns KE, Dwyer JJM, Coe JB, Tam GCY, Wong SNR.

J Vet Med Educ. 2018 Oct 4:1-12. doi: 10.3138/jvme.0117-011r1. [Epub ahead of print]

PMID:
30285600
29.

Surveillance or no surveillance for deep venous thrombosis and outcomes of critically ill patients: A study protocol and statistical analysis plan.

Arabi YM, Burns KEA, Al-Hameed F, Alsolamy S, Almaani M, Mandourah Y, Almekhlafi GA, Al Bshabshe A, Alshahrani M, Khalid I, Hawa H, Arshad Z, Lababidi H, Al Aithan A, Jose J, Abdukahil SAI, Afesh LY, Al-Dawood A; and the PREVENT trial Group.

Medicine (Baltimore). 2018 Sep;97(36):e12258. doi: 10.1097/MD.0000000000012258.

30.

Canadian Critical Care Society revised process for guideline development and endorsement.

Lamontagne F, D'Aragon F, Burns KEA, Belley-Côté É, Kho M, Menon K, Duan E, Masse MH, Archambault P, Hrymak C, Rochwerg B.

Can J Anaesth. 2018 Oct;65(10):1163-1164. doi: 10.1007/s12630-018-1182-3. Epub 2018 Jul 30. No abstract available.

PMID:
30062530
31.

Hamilton-DONATE: a city-wide pilot observational study of the ICU management of deceased organ donors.

D'Aragon F, Cook D, Dhanani S, Ribic C, Burns KEA, Akhtar A, Hand L, Arseneau E, Cupido C, Whittigham H, Healey A, Frenette AJ, Lamontagne F, Meade MO; Canadian Critical Care Trials Group and the Canadian National Transplant Research Program.

Can J Anaesth. 2018 Oct;65(10):1110-1119. doi: 10.1007/s12630-018-1179-y. Epub 2018 Jul 9.

PMID:
29987806
32.

Intensity of care and withdrawal of life-sustaining therapies in severe traumatic brain injury patients: a post-hoc analysis of a multicentre retrospective cohort study.

Gerges PRA, Moore L, Léger C, Lauzier F, Shemilt M, Zarychanski R, Scales DC, Burns KEA, Bernard F, Zygun D, Neveu X, Turgeon AF; Canadian Critical Care Trials Group.

Can J Anaesth. 2018 Sep;65(9):996-1003. doi: 10.1007/s12630-018-1171-6. Epub 2018 Jun 14.

PMID:
29949093
33.

The role of nanoparticles in the improvement of systemic anticancer drug delivery.

Field LD, Nag OK, Sangtani A, Burns KE, Delehanty JB.

Ther Deliv. 2018 Jul;9(7):527-545. doi: 10.4155/tde-2018-0015. Review.

PMID:
29943689
34.

Evidence Supporting Clinical Use of Proportional Assist Ventilation: A Systematic Review and Meta-Analysis of Clinical Trials.

Tirupakuzhi Vijayaraghavan BK, Hamed S, Jain A, Chimunda T, Telias I, Friedrich JO, Burns KEA.

J Intensive Care Med. 2018 Jan 1:885066618769021. doi: 10.1177/0885066618769021. [Epub ahead of print]

PMID:
29724123
35.

Cellular delivery of doxorubicin mediated by disulfide reduction of a peptide-dendrimer bioconjugate.

Burns KE, Delehanty JB.

Int J Pharm. 2018 Jul 10;545(1-2):64-73. doi: 10.1016/j.ijpharm.2018.04.027. Epub 2018 Apr 27.

PMID:
29709616
36.

A time-driven, activity-based costing methodology for determining the costs of red blood cell transfusion in patients with beta thalassaemia major.

Burns KE, Haysom HE, Higgins AM, Waters N, Tahiri R, Rushford K, Dunstan T, Saxby K, Kaplan Z, Chunilal S, McQuilten ZK, Wood EM.

Transfus Med. 2019 Feb;29(1):33-40. doi: 10.1111/tme.12523. Epub 2018 Apr 10.

PMID:
29637650
37.

Patient and Family Engagement in the ICU. Untapped Opportunities and Underrecognized Challenges.

Burns KEA, Misak C, Herridge M, Meade MO, Oczkowski S; Patient and Family Partnership Committee of the Canadian Critical Care Trials Group.

Am J Respir Crit Care Med. 2018 Aug 1;198(3):310-319. doi: 10.1164/rccm.201710-2032CI. Review.

PMID:
29624408
38.

Implementation of physiological fluids to provide insight into the characterization, fate, and biological interactions of silver nanoparticles.

Breitner EK, Burns KE, Hussain SM, Comfort KK.

Nanotechnology. 2018 Jun 22;29(25):254001. doi: 10.1088/1361-6528/aabb9d. Epub 2018 Apr 4.

PMID:
29617270
39.

Statistical analysis plan for the Pneumatic CompREssion for PreVENting Venous Thromboembolism (PREVENT) trial: a study protocol for a randomized controlled trial.

Arabi Y, Al-Hameed F, Burns KEA, Mehta S, Alsolamy S, Almaani M, Mandourah Y, Almekhlafi GA, Al Bshabshe A, Finfer S, Alshahrani M, Khalid I, Mehta Y, Gaur A, Hawa H, Buscher H, Arshad Z, Lababidi H, Al Aithan A, Jose J, Abdukahil SAI, Afesh LY, Dbsawy M, Al-Dawood A; PREVENT trial Group.

Trials. 2018 Mar 15;19(1):182. doi: 10.1186/s13063-018-2534-6.

40.

International Practice Variation in Weaning Critically Ill Adults from Invasive Mechanical Ventilation.

Burns KEA, Raptis S, Nisenbaum R, Rizvi L, Jones A, Bakshi J, Tan W, Meret A, Cook DJ, Lellouche F, Epstein SK, Gattas D, Kapadia FN, Villar J, Brochard L, Lessard MR, Meade MO.

Ann Am Thorac Soc. 2018 Apr;15(4):494-502. doi: 10.1513/AnnalsATS.201705-410OC. Erratum in: Ann Am Thorac Soc. 2018 Jul;15(7):894.

PMID:
29509509
41.

Characterizing Citizens' Preferences for Engagement in Patient Care and Research in Adult and Pediatric Intensive Care Units.

Burns KEA, Rizvi L, Charteris A, Laskey S, Bhatti SB, Chokar K, Choong KLM.

J Intensive Care Med. 2017 Jan 1:885066617729127. doi: 10.1177/0885066617729127. [Epub ahead of print]

PMID:
28901207
42.

Indirect regulation of CYP2C19 gene expression via DNA methylation.

Burns KE, Shepherd P, Finlay G, Tingle MD, Helsby NA.

Xenobiotica. 2018 Aug;48(8):781-792. doi: 10.1080/00498254.2017.1372648. Epub 2017 Sep 19.

PMID:
28840784
43.

Protocol adherence for continuously titrated interventions in randomized trials: an overview of the current methodology and case study.

Lauzier F, Adhikari NK, Seely A, Koo KKY, Belley-Côté EP, Burns KEA, Cook DJ, D'Aragon F, Rochwerg B, Kho ME, Oczkowksi SJW, Duan EH, Meade MO, Day AG, Lamontagne F; for ACCADEMY (Academy of Critical Care – Development, Evaluation, and Methodology).

BMC Med Res Methodol. 2017 Jul 17;17(1):106. doi: 10.1186/s12874-017-0388-3.

44.

Patient and Family Engagement in Designing and Implementing a Weaning Trial: A Novel Research Paradigm in Critical Care.

Burns KEA, Devlin JW, Hill NS.

Chest. 2017 Oct;152(4):707-711. doi: 10.1016/j.chest.2017.06.028. Epub 2017 Jul 4. Review.

PMID:
28687380
45.

Variation in Definition of Prolonged Mechanical Ventilation.

Rose L, McGinlay M, Amin R, Burns KE, Connolly B, Hart N, Jouvet P, Katz S, Leasa D, Mawdsley C, McAuley DF, Schultz MJ, Blackwood B.

Respir Care. 2017 Oct;62(10):1324-1332. doi: 10.4187/respcare.05485. Epub 2017 Jun 13. Review.

46.

Characteristics, clinical course, and outcomes of homeless and non-homeless patients admitted to ICU: A retrospective cohort study.

Smith OM, Chant C, Burns KEA, Kaur M, Ashraf S, DosSantos CC, Hwang SW, Friedrich JO.

PLoS One. 2017 Jun 12;12(6):e0179207. doi: 10.1371/journal.pone.0179207. eCollection 2017.

47.

Trials directly comparing alternative spontaneous breathing trial techniques: a systematic review and meta-analysis.

Burns KEA, Soliman I, Adhikari NKJ, Zwein A, Wong JTY, Gomez-Builes C, Pellegrini JA, Chen L, Rittayamai N, Sklar M, Brochard LJ, Friedrich JO.

Crit Care. 2017 Jun 1;21(1):127. doi: 10.1186/s13054-017-1698-x. Review.

48.

Targeting therapeutics to the plasma membrane: opportunities for nanoparticle-mediated delivery abound.

Burns KE, Delehanty JB.

Ther Deliv. 2017 Mar;8(5):235-237. doi: 10.4155/tde-2016-0091. No abstract available.

49.

Gender Parity in Critical Care Medicine.

Mehta S, Burns KEA, Machado FR, Fox-Robichaud AE, Cook DJ, Calfee CS, Ware LB, Burnham EL, Kissoon N, Marshall JC, Mancebo J, Finfer S, Hartog C, Reinhart K, Maitland K, Stapleton RD, Kwizera A, Amin P, Abroug F, Smith O, Laake JH, Shrestha GS, Herridge MS.

Am J Respir Crit Care Med. 2017 Aug 15;196(4):425-429. doi: 10.1164/rccm.201701-0076CP. Review.

50.

Therapeutic Efficacy of a Family of pHLIP-MMAF Conjugates in Cancer Cells and Mouse Models.

Burns KE, Hensley H, Robinson MK, Thévenin D.

Mol Pharm. 2017 Feb 6;14(2):415-422. doi: 10.1021/acs.molpharmaceut.6b00847. Epub 2017 Jan 13.

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