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Results of a phase 1 multicentre investigation of dexmedetomidine bolus and infusion in corrective infant cardiac surgery.

Zuppa AF, Nicolson SC, Wilder NS, Ibla JC, Gottlieb EA, Burns KM, Stylianou M, Trachtenberg F, Ni H, Skeen TH, Andropoulos DB; Pediatric Heart Network Investigators.

Br J Anaesth. 2019 Oct 14. pii: S0007-0912(19)30645-2. doi: 10.1016/j.bja.2019.06.026. [Epub ahead of print]


Gender differences in grant and personnel award funding rates at the Canadian Institutes of Health Research based on research content area: A retrospective analysis.

Burns KEA, Straus SE, Liu K, Rizvi L, Guyatt G.

PLoS Med. 2019 Oct 15;16(10):e1002935. doi: 10.1371/journal.pmed.1002935. eCollection 2019 Oct.


Frequency of Screening and SBT Technique Trial - North American Weaning Collaboration (FAST-NAWC): a protocol for a multicenter, factorial randomized trial.

Burns KEA, Rizvi L, Cook DJ, Seely AJE, Rochwerg B, Lamontagne F, Devlin JW, Dodek P, Mayette M, Tanios M, Gouskos A, Kay P, Mitchell S, Kiedrowski KC, Hill NS; Canadian Critical Care Trials Group.

Trials. 2019 Oct 11;20(1):587. doi: 10.1186/s13063-019-3641-8.


The therapeutic effects of microRNAs in preclinical studies of acute kidney injury: a systematic review protocol.

Zankar S, Rodriguez RA, Vinas JL, Burns KD.

Syst Rev. 2019 Oct 10;8(1):235. doi: 10.1186/s13643-019-1150-1.


Cytoplasmic "ciliary inclusions" in isolation are not sufficient for the diagnosis of primary ciliary dyskinesia.

Vece TJ, Sagel SD, Zariwala MA, Sullivan KM, Burns KA, Dutcher SK, Yusupov R, Leigh MW, Knowles MR.

Pediatr Pulmonol. 2019 Sep 23. doi: 10.1002/ppul.24528. [Epub ahead of print]


2019 ACC Health Policy Statement on Cardiologist Compensation and Opportunity Equity.

Douglas PS, Biga C, Burns KM, Chazal RA, Cuffe MS, Daniel JM Jr, Garzio C, Harrington RA, Patel HN, Walsh MN, Wolk MJ.

J Am Coll Cardiol. 2019 Oct 15;74(15):1947-1965. doi: 10.1016/j.jacc.2019.07.040. Epub 2019 Sep 16. No abstract available.


Prostaglandin E2 receptor EP1 (PGE2/EP1) deletion promotes glomerular podocyte and endothelial cell injury in hypertensive TTRhRen mice.

Nasrallah R, Zimpelmann J, Robertson SJ, Ghossein J, Thibodeau JF, Kennedy CRJ, Gutsol A, Xiao F, Burger D, Burns KD, Hébert RL.

Lab Invest. 2019 Sep 16. doi: 10.1038/s41374-019-0317-7. [Epub ahead of print]


Getting the timing right- Is it worthwhile to vaccinate long-stay hospital inpatients to prevent influenza?

Skelly E, Skally M, Foley M, Gaughan L, Duffy F, Burns K, Humphreys H, Fitzpatrick F.

J Hosp Infect. 2019 Sep 11. pii: S0195-6701(19)30366-4. doi: 10.1016/j.jhin.2019.09.006. [Epub ahead of print] No abstract available.


BioID performed on Golgi enriched fractions identify C10orf76 as aGBF1 Binding Protein essential for Golgi maintenance and secretion.

Chan CJ, Le R, Burns K, Ahmed K, Coyaud E, Laurent EMN, Raught B, Melancon P.

Mol Cell Proteomics. 2019 Sep 13. pii: mcp.RA119.001645. doi: 10.1074/mcp.RA119.001645. [Epub ahead of print]


Transposable elements in human genetic disease.

Payer LM, Burns KH.

Nat Rev Genet. 2019 Sep 12. doi: 10.1038/s41576-019-0165-8. [Epub ahead of print] Review.


Variation in the practice of discontinuing mechanical ventilation in critically ill adults: study protocol for an international prospective observational study.

Burns KEA, Rizvi L, Cook DJ, Dodek P, Slutsky AS, Jones A, Villar J, Kapadia FN, Gattas DJ, Epstein SK, Meade MO; Canadian Critical Care Trials Group.

BMJ Open. 2019 Sep 8;9(9):e031775. doi: 10.1136/bmjopen-2019-031775.


A multi-national trial of a direct oral anticoagulant in children with cardiac disease: Design and rationale of the Safety of ApiXaban On Pediatric Heart disease On the preventioN of Embolism (SAXOPHONE) study.

Payne RM, Burns KM, Glatz AC, Li D, Li X, Monagle P, Newburger JW, Swan EA, Wheaton O, Male C; Pediatric Heart Network Investigators.

Am Heart J. 2019 Aug 9;217:52-63. doi: 10.1016/j.ahj.2019.08.002. [Epub ahead of print]


Comparison of ventilatory modes to facilitate liberation from mechanical ventilation: protocol for a systematic review and network meta-analysis.

Lewis KA, Chaudhuri D, Guyatt G, Burns KEA, Bosma K, Ge L, Karachi T, Piraino T, Fernando SM, Ranganath N, Brochard L, Rochwerg B.

BMJ Open. 2019 Sep 5;9(9):e030407. doi: 10.1136/bmjopen-2019-030407.


Fostering community hospital research.

Gehrke P, Binnie A, Chan SPT, Cook DJ, Burns KEA, Rewa OG, Herridge M, Tsang JLY.

CMAJ. 2019 Sep 3;191(35):E962-E966. doi: 10.1503/cmaj.190055. No abstract available.


Project management lessons learned from the multicentre CYCLE pilot randomized controlled trial.

McCaskell DS, Molloy AJ, Childerhose L, Costigan FA, Reid JC, McCaughan M, Clarke F, Cook DJ, Rudkowski JC, Farley C, Karachi T, Rochwerg B, Newman A, Fox-Robichaud A, Herridge MS, Lo V, Feltracco D, Burns K, Porteous R, Seely AJE, Ball IM, Seczek A, Kho ME.

Trials. 2019 Aug 28;20(1):532. doi: 10.1186/s13063-019-3634-7.


A Systematic Review and Meta-analysis of Nonpharmacologic-based Interventions for Aortic Stiffness in End-Stage Renal Disease.

Rodriguez RA, Hae R, Spence M, Shea B, Agharazii M, Burns KD.

Kidney Int Rep. 2019 May 22;4(8):1109-1121. doi: 10.1016/j.ekir.2019.05.011. eCollection 2019 Aug.


Memory Performance Influences Male Reproductive Success in a Wild Bird.

Shaw RC, MacKinlay RD, Clayton NS, Burns KC.

Curr Biol. 2019 Aug 19;29(16):2773. doi: 10.1016/j.cub.2019.07.049. No abstract available.


Plants obey (and disobey) the island rule.

Biddick M, Hendriks A, Burns KC.

Proc Natl Acad Sci U S A. 2019 Sep 3;116(36):17632-17634. doi: 10.1073/pnas.1907424116. Epub 2019 Aug 19.


Practice Patterns and Ethical Considerations in the Management of Venovenous Extracorporeal Membrane Oxygenation Patients: An International Survey.

Abrams D, Pham T, Burns KEA, Combes A, Curtis JR, Mueller T, Prager KM, Serra A, Slutsky AS, Brodie D, Schmidt M; International ECMO Network (ECMONet).

Crit Care Med. 2019 Oct;47(10):1346-1355. doi: 10.1097/CCM.0000000000003910.


Unconscious bias in the selection and interpretation of data on sex and burnout - Authors' reply.

Burns KEA, Burnham EL, Dodek PM, Moss M.

Lancet Respir Med. 2019 Aug;7(8):e24. doi: 10.1016/S2213-2600(19)30223-1. Epub 2019 Jul 23. No abstract available.


Alpha-Blocker Use and the Risk of Hypotension and Hypotension-Related Clinical Events in Women of Advanced Age.

Hiremath S, Ruzicka M, Petrcich W, McCallum MK, Hundemer GL, Tanuseputro P, Manuel D, Burns K, Edwards C, Bugeja A, Magner P, McCormick B, Garg AX, Rhodes E, Sood MM.

Hypertension. 2019 Sep;74(3):645-651. doi: 10.1161/HYPERTENSIONAHA.119.13289. Epub 2019 Jul 22.


A simple ex vivo bioassay for 5-FU transport into healthy buccal mucosal cells.

Burns KE, Allright D, Porter D, Findlay MP, Helsby NA.

Cancer Chemother Pharmacol. 2019 Oct;84(4):739-748. doi: 10.1007/s00280-019-03904-4. Epub 2019 Jul 19.


Bone Marrow Findings in Patients With Acute Promyelocytic Leukemia Treated With Arsenic Trioxide.

Miller KP, Venkataraman G, Gocke CD, Batista DA, Borowitz MJ, Burns KH, Pratz K, Duffield AS.

Am J Clin Pathol. 2019 Oct 7;152(5):675-685. doi: 10.1093/ajcp/aqz087.


Pneumatic Compression in Venous Thromboprophylaxis. Reply.

Arabi YM, Burns KEA, Finfer S.

N Engl J Med. 2019 Jul 4;381(1):95. doi: 10.1056/NEJMc1905933. No abstract available.


Improving Forensic Pathologic Investigation of Sudden Death in the Young: Tools, Guidance, and Methods of Cardiovascular Dissection from the Sudden Death in the Young Case Registry.

Gulino SP, Burns K, Gunther WM, MacLeod H.

Acad Forensic Pathol. 2018 Jun;8(2):347-391. doi: 10.1177/1925362118782077. Epub 2018 Jun 6.


High-flow nasal cannula compared with conventional oxygen therapy for acute hypoxemic respiratory failure: author's reply.

Rochwerg B, Granton D, Wang DX, Einav S, Burns KEA.

Intensive Care Med. 2019 Aug;45(8):1171. doi: 10.1007/s00134-019-05658-2. Epub 2019 Jun 24. No abstract available.


The importance of both CYP2C19 and CYP2B6 germline variations in cyclophosphamide pharmacokinetics and clinical outcomes.

Helsby NA, Yong M, van Kan M, de Zoysa JR, Burns KE.

Br J Clin Pharmacol. 2019 Sep;85(9):1925-1934. doi: 10.1111/bcp.14031. Epub 2019 Jul 22. Review.


Factors influencing decisions by critical care physicians to withdraw life-sustaining treatments in critically ill adult patients with severe traumatic brain injury.

Turgeon AF, Dorrance K, Archambault P, Lauzier F, Lamontagne F, Zarychanski R, Fowler R, Moore L, Lacroix J, English S, Boutin A, Muscedere J, Burns KEA, Griesdale D, McIntyre LA, Scales D, Bernard F, Yamada J, Squires JE; Canadian Traumatic Brain Injury Research Consortium and the Canadian Critical Care Trials Group.

CMAJ. 2019 Jun 17;191(24):E652-E663. doi: 10.1503/cmaj.190154.


Creating Consumer-Generated Health Data: Interviews and a Pilot Trial Exploring How and Why Patients Engage.

Burns K, McBride CA, Patel B, FitzGerald G, Mathews S, Drennan J.

J Med Internet Res. 2019 Jun 13;21(6):e12367. doi: 10.2196/12367.


Revisiting, Reframing, and Casting a New Light on Liberation From Mechanical Ventilation.

Girard TD, Burns KEA.

JAMA. 2019 Jun 11;321(22):2167-2169. doi: 10.1001/jama.2019.7364. No abstract available.


Practice Patterns in the Treatment of Patients With Severe Alcohol Withdrawal: A Multidisciplinary, Cross-Sectional Survey.

Buell D, Filewod N, Ailon J, Burns KEA.

J Intensive Care Med. 2019 May 23:885066619847119. doi: 10.1177/0885066619847119. [Epub ahead of print]


A novel method for comparison of arterial remodeling in hypertension: Quantification of arterial trees and recognition of remodeling patterns on histological sections.

Gutsol AA, Blanco P, Samokhina SI, Afanasiev SA, Kennedy CRJ, Popov SV, Burns KD.

PLoS One. 2019 May 21;14(5):e0216734. doi: 10.1371/journal.pone.0216734. eCollection 2019.


Changes in Body Weight Before and After Kidney Donation.

Bugeja A, Harris S, Ernst J, Burns KD, Knoll G, Clark EG.

Can J Kidney Health Dis. 2019 May 7;6:2054358119847203. doi: 10.1177/2054358119847203. eCollection 2019.


Genetic counseling job market in the United States and Canada: An analysis of job advertisements 2014-2016.

Burns K, Swanson A, Hoskovec J, Leonhard J, Hahn S, Stein QP.

J Genet Couns. 2019 Aug;28(4):869-877. doi: 10.1002/jgc4.1129. Epub 2019 May 6.


Prognostic value of circulating tumour cells in limited-stage small-cell lung cancer: analysis of the concurrent once-daily versus twice-daily radiotherapy (CONVERT) randomised controlled trial.

Tay RY, Fernández-Gutiérrez F, Foy V, Burns K, Pierce J, Morris K, Priest L, Tugwood J, Ashcroft L, Lindsay CR, Faivre-Finn C, Dive C, Blackhall F.

Ann Oncol. 2019 Jul 1;30(7):1114-1120. doi: 10.1093/annonc/mdz122.


Memory Performance Influences Male Reproductive Success in a Wild Bird.

Shaw RC, MacKinlay RD, Clayton NS, Burns KC.

Curr Biol. 2019 May 6;29(9):1498-1502.e3. doi: 10.1016/j.cub.2019.03.027. Epub 2019 Apr 18. Erratum in: Curr Biol. 2019 Aug 19;29(16):2773.


Integrated Transcriptomic and Proteomic Analysis of Primary Human Umbilical Vein Endothelial Cells.

Madugundu AK, Na CH, Nirujogi RS, Renuse S, Kim KP, Burns KH, Wilks C, Langmead B, Ellis SE, Collado-Torres L, Halushka MK, Kim MS, Pandey A.

Proteomics. 2019 Aug;19(15):e1800315. doi: 10.1002/pmic.201800315. Epub 2019 Jun 26.


Is point-of-care ultrasound a reliable predictor of outcome during atraumatic, non-shockable cardiac arrest? A systematic review and meta-analysis from the SHoC investigators.

Lalande E, Burwash-Brennan T, Burns K, Atkinson P, Lambert M, Jarman B, Lamprecht H, Banerjee A, Woo MY; SHoC Investigators.

Resuscitation. 2019 Jun;139:159-166. doi: 10.1016/j.resuscitation.2019.03.027. Epub 2019 Apr 9. Review.


Aligning airway management strategy with resuscitation priorities for out-of-hospital cardiac arrest.

Burjek NE, Burns KM, Jagannathan N.

J Thorac Dis. 2019 Feb;11(2):364-368. doi: 10.21037/jtd.2018.12.38. No abstract available.


Multicentre pilot randomised clinical trial of early in-bed cycle ergometry with ventilated patients.

Kho ME, Molloy AJ, Clarke FJ, Reid JC, Herridge MS, Karachi T, Rochwerg B, Fox-Robichaud AE, Seely AJ, Mathur S, Lo V, Burns KE, Ball IM, Pellizzari JR, Tarride JE, Rudkowski JC, Koo K, Heels-Ansdell D, Cook DJ.

BMJ Open Respir Res. 2019 Feb 18;6(1):e000383. doi: 10.1136/bmjresp-2018-000383. eCollection 2019.


Renal Angiotensinogen and Sodium-Glucose Cotransporter-2 Inhibition: Insights from Experimental Diabetic Kidney Disease.

Burns KD, Cherney D.

Am J Nephrol. 2019;49(4):328-330. doi: 10.1159/000499598. Epub 2019 Mar 28. No abstract available.


Frequency of Screening for Weaning From Mechanical Ventilation: Two Contemporaneous Proof-of-Principle Randomized Controlled Trials.

Burns KEA, Wong JTY, Dodek P, Cook DJ, Lamontagne F, Cohen A, Mehta S, Kho ME, Hebert PC, Aslanian P, Friedrich JO, Brochard L, Rizvi L, Hand L, Meade MO, Amaral AC, Seely AJ; Canadian Critical Care Trials Group.

Crit Care Med. 2019 Jun;47(6):817-825. doi: 10.1097/CCM.0000000000003722.


Transposon insertion profiling by sequencing (TIPseq) for mapping LINE-1 insertions in the human genome.

Steranka JP, Tang Z, Grivainis M, Huang CRL, Payer LM, Rego FOR, Miller TLA, Galante PAF, Ramaswami S, Heguy A, Fenyö D, Boeke JD, Burns KH.

Mob DNA. 2019 Mar 8;10:8. doi: 10.1186/s13100-019-0148-5. eCollection 2019.


Selection and Receipt of Kidney Replacement in Critically Ill Older Patients with AKI.

Bagshaw SM, Adhikari NKJ, Burns KEA, Friedrich JO, Bouchard J, Lamontagne F, McIntrye LA, Cailhier JF, Dodek P, Stelfox HT, Herridge M, Lapinsky S, Muscedere J, Barton J, Griesdale D, Soth M, Ambosta A, Lebovic G, Wald R; Canadian Critical Care Trials Group.

Clin J Am Soc Nephrol. 2019 Apr 5;14(4):496-505. doi: 10.2215/CJN.05530518. Epub 2019 Mar 21.


Mice with a Deletion of Rsph1 Exhibit a Low Level of Mucociliary Clearance and Develop a Primary Ciliary Dyskinesia Phenotype.

Yin W, Livraghi-Butrico A, Sears PR, Rogers TD, Burns KA, Grubb BR, Ostrowski LE.

Am J Respir Cell Mol Biol. 2019 Sep;61(3):312-321. doi: 10.1165/rcmb.2017-0387OC.


A comparative analysis of prophylactic antimicrobial use in long-term care facilities in Ireland, 2013 and 2016.

Tandan M, O'Connor R, Burns K, Murphy H, Hennessy S, Roche F, Donlon S, Cormican M, Vellinga A.

Euro Surveill. 2019 Mar;24(11). doi: 10.2807/1560-7917.ES.2019.24.11.1800102.


Accuracy of ultrasound for endotracheal intubation between different transducer types.

Gottlieb M, Holladay D, Burns K, Gore SR, Wulff C, Shah S, Bailitz J.

Am J Emerg Med. 2019 Mar 12. pii: S0735-6757(19)30165-2. doi: 10.1016/j.ajem.2019.03.016. [Epub ahead of print]


High flow nasal cannula compared with conventional oxygen therapy for acute hypoxemic respiratory failure: a systematic review and meta-analysis.

Rochwerg B, Granton D, Wang DX, Helviz Y, Einav S, Frat JP, Mekontso-Dessap A, Schreiber A, Azoulay E, Mercat A, Demoule A, Lemiale V, Pesenti A, Riviello ED, Mauri T, Mancebo J, Brochard L, Burns K.

Intensive Care Med. 2019 May;45(5):563-572. doi: 10.1007/s00134-019-05590-5. Epub 2019 Mar 19. Review.


Xenbase: Facilitating the Use of Xenopus to Model Human Disease.

Nenni MJ, Fisher ME, James-Zorn C, Pells TJ, Ponferrada V, Chu S, Fortriede JD, Burns KA, Wang Y, Lotay VS, Wang DZ, Segerdell E, Chaturvedi P, Karimi K, Vize PD, Zorn AM.

Front Physiol. 2019 Feb 26;10:154. doi: 10.3389/fphys.2019.00154. eCollection 2019. Review.


Parasite-offspring competition for female resources can explain male-biased parasitism in plants.

Yule KJ, Burns KC.

Biol Lett. 2019 Mar 29;15(3):20180761. doi: 10.1098/rsbl.2018.0761.


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