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Disregard for Competence.

Burkhardt H.

Dtsch Arztebl Int. 2019 May 24;116(21):373-374. doi: 10.3238/arztebl.2019.0373b. No abstract available.


Addition or removal of concomitant methotrexate alters adalimumab effectiveness in rheumatoid arthritis but not psoriatic arthritis.

Behrens F, Koehm M, Schwaneck EC, Schmalzing M, Wittig BM, Gnann H, Greger G, Tony HP, Burkhardt H.

Scand J Rheumatol. 2019 Jul 16:1-8. doi: 10.1080/03009742.2019.1600717. [Epub ahead of print]


New insights into the prevalence of depressive symptoms and depression in rheumatoid arthritis - Implications from the prospective multicenter VADERA II study.

Englbrecht M, Alten R, Aringer M, Baerwald CG, Burkhardt H, Eby N, Flacke JP, Fliedner G, Henkemeier U, Hofmann MW, Kleinert S, Kneitz C, Krüger K, Pohl C, Schett G, Schmalzing M, Tausche AK, Tony HP, Wendler J.

PLoS One. 2019 May 28;14(5):e0217412. doi: 10.1371/journal.pone.0217412. eCollection 2019.


IL-38 Ameliorates Skin Inflammation and Limits IL-17 Production from γδ T Cells.

Han Y, Mora J, Huard A, da Silva P, Wiechmann S, Putyrski M, Schuster C, Elwakeel E, Lang G, Scholz A, Scholz T, Schmid T, de Bruin N, Billuart P, Sala C, Burkhardt H, Parnham MJ, Ernst A, Brüne B, Weigert A.

Cell Rep. 2019 Apr 16;27(3):835-846.e5. doi: 10.1016/j.celrep.2019.03.082.


Analyses of association of psoriatic arthritis and psoriasis vulgaris with functional NCF1 variants.

Löhr S, Ekici AB, Uebe S, Büttner C, Köhm M, Behrens F, Böhm B, Sticherling M, Schett G, Simon D, Mössner R, Nimeh A, Oji V, Assmann G, Rech J, Holmdahl R, Burkhardt H, Reis A, Hüffmeier U.

Rheumatology (Oxford). 2019 May 1;58(5):915-917. doi: 10.1093/rheumatology/key448. No abstract available.


Immunogenicity assay development and validation for biological therapy as exemplified by ustekinumab.

Mojtahed Poor S, Ulshöfer T, Gabriel LA, Henke M, Köhm M, Behrens F, Geisslinger G, Parnham MJ, Burkhardt H, Schiffmann S.

Clin Exp Immunol. 2019 May;196(2):259-275. doi: 10.1111/cei.13261. Epub 2019 Feb 3.


Higher Fit-fOR-The-Aged (FORTA) Scores Comprising Medication Errors are Associated with Impaired Cognitive and Physical Function Tests in the VALFORTA Trial.

Pazan F, Burkhardt H, Frohnhofen H, Weiss C, Throm C, Kuhn-Thiel A, Wehling M.

Drugs Aging. 2019 Mar;36(3):269-277. doi: 10.1007/s40266-018-0626-3.


Cell adhesion-induced transient interaction of ADAM15 with poly(A) binding protein at the cell membrane colocalizes with mRNA translation.

Böhm BB, Fehrl Y, Janczi T, Schneider N, Burkhardt H.

PLoS One. 2018 Sep 28;13(9):e0203847. doi: 10.1371/journal.pone.0203847. eCollection 2018.


[Value of combining biologics with methotrexate for treatment of psoriatic arthritis-questions remain].

Dauth S, Köhm M, Rossmanith T, Herrmann E, Lehn A, Burkhardt H, Behrens F.

Z Rheumatol. 2018 Nov;77(9):808-814. doi: 10.1007/s00393-018-0533-3. German.


High-sensitive troponin is associated with subclinical imaging biosignature of inflammatory cardiovascular involvement in systemic lupus erythematosus.

Winau L, Hinojar Baydes R, Braner A, Drott U, Burkhardt H, Sangle S, D'Cruz DP, Carr-White G, Marber M, Schnoes K, Arendt C, Klingel K, Vogl TJ, Zeiher AM, Nagel E, Puntmann VO.

Ann Rheum Dis. 2018 Nov;77(11):1590-1598. doi: 10.1136/annrheumdis-2018-213661. Epub 2018 Aug 4.


Minimal disease activity is a stable measure of therapeutic response in psoriatic arthritis patients receiving treatment with adalimumab.

Behrens F, Koehm M, Schwaneck EC, Schmalzing M, Gnann H, Greger G, Tony HP, Burkhardt H.

Rheumatology (Oxford). 2018 Nov 1;57(11):1938-1946. doi: 10.1093/rheumatology/key203.


ADAM15 in Apoptosis Resistance of Synovial Fibroblasts: Converting Fas/CD95 Death Signals Into the Activation of Prosurvival Pathways by Calmodulin Recruitment.

Janczi T, Böhm BB, Fehrl Y, DeGiacomo P, Kinne RW, Burkhardt H.

Arthritis Rheumatol. 2019 Jan;71(1):63-72. doi: 10.1002/art.40667. Epub 2018 Nov 20.


[S2e guideline: treatment of rheumatoid arthritis with disease-modifying drugs].

Fiehn C, Holle J, Iking-Konert C, Leipe J, Weseloh C, Frerix M, Alten R, Behrens F, Baerwald C, Braun J, Burkhardt H, Burmester G, Detert J, Gaubitz M, Gause A, Gromnica-Ihle E, Kellner H, Krause A, Kuipers J, Lorenz HM, Müller-Ladner U, Nothacker M, Nüsslein H, Rubbert-Roth A, Schneider M, Schulze-Koops H, Seitz S, Sitter H, Specker C, Tony HP, Wassenberg S, Wollenhaupt J, Krüger K.

Z Rheumatol. 2018 Aug;77(Suppl 2):35-53. doi: 10.1007/s00393-018-0481-y. Review. German.


Mannan-induced Nos2 in macrophages enhances IL-17-driven psoriatic arthritis by innate lymphocytes.

Zhong J, Scholz T, Yau ACY, Guerard S, Hüffmeier U, Burkhardt H, Holmdahl R.

Sci Adv. 2018 May 16;4(5):eaas9864. doi: 10.1126/sciadv.aas9864. eCollection 2018 May.


[Biomarkers and imaging for diagnosis and stratification of rheumatoid arthritis and spondylarthritis in the BMBF consortium ArthroMark].

Häupl T, Skapenko A, Hoppe B, Skriner K, Burkhardt H, Poddubnyy D, Ohrndorf S, Sewerin P, Mansmann U, Stuhlmüller B, Schulze-Koops H, Burmester GR.

Z Rheumatol. 2018 May;77(Suppl 1):16-23. doi: 10.1007/s00393-018-0458-x. Review. German.


Abatacept used in combination with non-methotrexate disease-modifying antirheumatic drugs: a descriptive analysis of data from interventional trials and the real-world setting.

Alten R, Burkhardt H, Feist E, Krüger K, Rech J, Rubbert-Roth A, Voll RE, Elbez Y, Rauch C.

Arthritis Res Ther. 2018 Jan 2;20(1):1. doi: 10.1186/s13075-017-1488-5.


Changes in prescription patterns in older hospitalized patients: the impact of FORTA on disease-related over- and under-treatments.

Pazan F, Burkhardt H, Frohnhofen H, Weiss C, Throm C, Kuhn-Thiel A, Wehling M.

Eur J Clin Pharmacol. 2018 Mar;74(3):339-347. doi: 10.1007/s00228-017-2383-3. Epub 2017 Dec 2.


Zytopenien : Anämie, Leukopenie und Thrombopenie.

Kneitz C, Atta J, Burkhardt H.

Z Rheumatol. 2017 Oct;76(Suppl 2):63-74. doi: 10.1007/s00393-017-0364-7. Review. German.


The sneaking ligand approach for cell type-specific modulation of intracellular signalling pathways.

Sehnert B, Burkhardt H, Finzel S, Dübel S, Voll RE.

Clin Immunol. 2018 Jan;186:14-20. doi: 10.1016/j.clim.2017.08.018. Epub 2017 Sep 1.


Genome-wide association and targeted analysis of copy number variants with psoriatic arthritis in German patients.

Uebe S, Ehrlicher M, Ekici AB, Behrens F, Böhm B, Homuth G, Schurmann C, Völker U, Jünger M, Nauck M, Völzke H, Traupe H, Krawczak M, Burkhardt H, Reis A, Hüffmeier U.

BMC Med Genet. 2017 Aug 23;18(1):92. doi: 10.1186/s12881-017-0447-y.


GM-CSF in murine psoriasiform dermatitis: Redundant and pathogenic roles uncovered by antibody-induced neutralization and genetic deficiency.

Scholz T, Weigert A, Brüne B, Sadik CD, Böhm B, Burkhardt H.

PLoS One. 2017 Aug 4;12(8):e0182646. doi: 10.1371/journal.pone.0182646. eCollection 2017.


Polysialylation at Early Stages of Oligodendrocyte Differentiation Promotes Myelin Repair.

Werneburg S, Fuchs HLS, Albers I, Burkhardt H, Gudi V, Skripuletz T, Stangel M, Gerardy-Schahn R, Hildebrandt H.

J Neurosci. 2017 Aug 23;37(34):8131-8141. doi: 10.1523/JNEUROSCI.1147-17.2017. Epub 2017 Jul 31.


Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage.

Ge C, Tong D, Liang B, Lönnblom E, Schneider N, Hagert C, Viljanen J, Ayoglu B, Stawikowska R, Nilsson P, Fields GB, Skogh T, Kastbom A, Kihlberg J, Burkhardt H, Dobritzsch D, Holmdahl R.

JCI Insight. 2017 Jul 6;2(13). pii: 93688. doi: 10.1172/jci.insight.93688. eCollection 2017 Jul 6.


[Expectations and attitudes concerning geriatric counseling : Results of a survey among general practitioners and hospital-based providers in two German states].

Burkhardt H, Trojan C.

Z Gerontol Geriatr. 2018 Jun;51(4):411-417. doi: 10.1007/s00391-017-1180-z. Epub 2017 Jan 31. German.


Association of Improvement in Pain With Therapeutic Response as Determined by Individual Improvement Criteria in Patients With Rheumatoid Arthritis.

Scharbatke EC, Behrens F, Schmalzing M, Koehm M, Greger G, Gnann H, Burkhardt H, Tony HP.

Arthritis Care Res (Hoboken). 2016 Nov;68(11):1607-1615. doi: 10.1002/acr.22884. Epub 2016 Oct 1.


Validation of Standardized Questionnaires Evaluating Symptoms of Depression in Rheumatoid Arthritis Patients: Approaches to Screening for a Frequent Yet Underrated Challenge.

Englbrecht M, Alten R, Aringer M, Baerwald CG, Burkhardt H, Eby N, Fliedner G, Gauger B, Henkemeier U, Hofmann MW, Kleinert S, Kneitz C, Krueger K, Pohl C, Roske AE, Schett G, Schmalzing M, Tausche AK, Peter Tony H, Wendler J.

Arthritis Care Res (Hoboken). 2017 Jan;69(1):58-66. doi: 10.1002/acr.23002.


Anti-citrullinated protein antibodies are linked to erosive disease in an observational study of patients with psoriatic arthritis.

Behrens F, Koehm M, Thaçi D, Gnann H, Greger G, Maria Wittig B, Burkhardt H.

Rheumatology (Oxford). 2016 Oct;55(10):1791-5. doi: 10.1093/rheumatology/kew229. Epub 2016 Jun 21.


Association analysis of psoriasis vulgaris and psoriatic arthritis with loss-of-function mutations in IL36RN in German patients.

Löhr S, Uebe S, Behrens F, Böhm B, Köhm M, Traupe H, Oji V, Burkhardt H, Reis A, Hüffmeier U.

Br J Dermatol. 2016 Sep;175(3):639-41. doi: 10.1111/bjd.14624. Epub 2016 Jul 24. No abstract available.


Replication of a distinct psoriatic arthritis risk variant at the IL23R locus.

Budu-Aggrey A, Bowes J, Loehr S, Uebe S, Zervou MI, Helliwell P, Ryan AW, Kane D, Korendowych E, Giardina E, Packham J, McManus R, FitzGerald O, McHugh N, Behrens F, Burkhardt H, Huffmeier U, Ho P, Martin J, Castañeda S, Goulielmos G, Reis A, Barton A.

Ann Rheum Dis. 2016 Jul;75(7):1417-8. doi: 10.1136/annrheumdis-2016-209290. Epub 2016 Mar 25. Review. No abstract available.


[Malignancies of the skin and immunomodulatory antirheumatic therapy].

Burkhardt H, Weisenseel P, Radtke MA, Krüger K.

Z Rheumatol. 2016 Feb;75(1):32-40. doi: 10.1007/s00393-015-0037-3. Review. German.


VALFORTA: a randomised trial to validate the FORTA (Fit fOR The Aged) classification.

Wehling M, Burkhardt H, Kuhn-Thiel A, Pazan F, Throm C, Weiss C, Frohnhofen H.

Age Ageing. 2016 Mar;45(2):262-7. doi: 10.1093/ageing/afv200. Epub 2016 Jan 18.


Journal Club.

Burkhardt H.

Z Gerontol Geriatr. 2016 Feb;49(2):166-7. doi: 10.1007/s00391-015-1017-6. German. No abstract available. Erratum in: Z Gerontol Geriatr. 2016 Apr;49(3):260-1. Dovjak, P and Püllen, R [Removed]; Burkhardt, H [Added].


The Predict Study: low risk for digital ulcer development in patients with systemic sclerosis with increasing disease duration and lack of topoisomerase-1 antibodies.

Hunzelmann N, Riemekasten G, Becker MO, Moinzadeh P, Kreuter A, Melchers I, Mueller-Ladner U, Meier F, Worm M, Lee H, Herrgott I, Pfeiffer C, Fierlbeck G, Henes J, Juche A, Zeidler G, Mensing H, Günther C, Sárdy M, Burkhardt H, Koehm M, Kuhr K, Krieg T, Sunderkötter C.

Br J Dermatol. 2016 Jun;174(6):1384-7. doi: 10.1111/bjd.14367. Epub 2016 Mar 20. No abstract available.


[Do we still need clinical studies in rheumatology?].

Henkemeier U, Alten R, Bannert B, Baraliakos X, Behrens F, Heldmann F, Kiltz U, Köhm M, König R, Leipe J, Müller-Ladner U, Rech J, Riechers E, Rubbert-Roth A, Schmidt RE, Schulze-Koops H, Specker C, Tausche AK, Wassenberg S, Witt M, Witte T, Zernicke J, Burkhardt H.

Z Rheumatol. 2016 Feb;75(1):4-10. doi: 10.1007/s00393-015-1687-x. German.


Does Concomitant Methotrexate with Adalimumab Influence Treatment Outcomes in Patients with Psoriatic Arthritis? Data from a Large Observational Study.

Behrens F, Koehm M, Arndt U, Wittig BM, Greger G, Thaçi D, Scharbatke E, Tony HP, Burkhardt H.

J Rheumatol. 2016 Mar;43(3):632-9. doi: 10.3899/jrheum.141596. Epub 2015 Dec 15.


Vasoactive Therapy in Systemic Sclerosis: Real-life Therapeutic Practice in More Than 3000 Patients.

Moinzadeh P, Riemekasten G, Siegert E, Fierlbeck G, Henes J, Blank N, Melchers I, Mueller-Ladner U, Frerix M, Kreuter A, Tigges C, Lahner N, Susok L, Guenther C, Zeidler G, Pfeiffer C, Worm M, Karrer S, Aberer E, Bretterklieber A, Genth E, Simon JC, Distler JH, Hein R, Schneider M, Seitz CS, Herink C, Steinbrink K, Sárdy M, Varga R, Mensing H, Mensing C, Lehmann P, Neeck G, Fiehn C, Weber M, Goebeler M, Burkhardt H, Buslau M, Ahmadi-Simab K, Himsel A, Juche A, Koetter I, Kuhn A, Sticherling M, Hellmich M, Kuhr K, Krieg T, Ehrchen J, Sunderkoetter C, Hunzelmann N; German Network for Systemic Scleroderma.

J Rheumatol. 2016 Jan;43(1):66-74. doi: 10.3899/jrheum.150382. Epub 2015 Nov 15.


Anti-TNFα-therapy as an evidence-based treatment option for different clinical manifestations of psoriatic arthritis.

Köhm M, Burkhardt H, Behrens F.

Clin Exp Rheumatol. 2015 Sep-Oct;33(5 Suppl 93):S109-14. Epub 2015 Oct 15. Review.


[Non-opioid pain medication in the elderly].

Burkhardt H, Wehling M.

Schmerz. 2015 Aug;29(4):371-9. doi: 10.1007/s00482-015-0032-2. Review. German.


Corrigendum: Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis.

Bowes J, Budu-Aggrey A, Huffmeier U, Uebe S, Steel K, Hebert HL, Wallace C, Massey J, Bruce IN, Bluett J, Feletar M, Morgan AW, Marzo-Ortega H, Donohoe G, Morris DW, Helliwell P, Ryan AW, Kane D, Warren RB, Korendowych E, Alenius GM, Giardina E, Packham J, McManus R, FitzGerald O, McHugh N, Brown MA, Ho P, Behrens F, Burkhardt H, Reis A, Barton A.

Nat Commun. 2015 Jul 6;6:7741. doi: 10.1038/ncomms8741. No abstract available.


Palmoplantar Pustular Psoriasis Is Associated with Missense Variants in CARD14, but Not with Loss-of-Function Mutations in IL36RN in European Patients.

Mössner R, Frambach Y, Wilsmann-Theis D, Löhr S, Jacobi A, Weyergraf A, Müller M, Philipp S, Renner R, Traupe H, Burkhardt H, Kingo K, Kõks S, Uebe S, Sticherling M, Sticht H, Oji V, Hüffmeier U.

J Invest Dermatol. 2015 Oct;135(10):2538-2541. doi: 10.1038/jid.2015.186. Epub 2015 May 19. No abstract available.


Treating rheumatoid arthritis to target: 2014 update of the recommendations of an international task force.

Smolen JS, Breedveld FC, Burmester GR, Bykerk V, Dougados M, Emery P, Kvien TK, Navarro-Compán MV, Oliver S, Schoels M, Scholte-Voshaar M, Stamm T, Stoffer M, Takeuchi T, Aletaha D, Andreu JL, Aringer M, Bergman M, Betteridge N, Bijlsma H, Burkhardt H, Cardiel M, Combe B, Durez P, Fonseca JE, Gibofsky A, Gomez-Reino JJ, Graninger W, Hannonen P, Haraoui B, Kouloumas M, Landewe R, Martin-Mola E, Nash P, Ostergaard M, Östör A, Richards P, Sokka-Isler T, Thorne C, Tzioufas AG, van Vollenhoven R, de Wit M, van der Heijde D.

Ann Rheum Dis. 2016 Jan;75(1):3-15. doi: 10.1136/annrheumdis-2015-207524. Epub 2015 May 12. Review.


PTPN22 is associated with susceptibility to psoriatic arthritis but not psoriasis: evidence for a further PsA-specific risk locus.

Bowes J, Loehr S, Budu-Aggrey A, Uebe S, Bruce IN, Feletar M, Marzo-Ortega H, Helliwell P, Ryan AW, Kane D, Korendowych E, Alenius GM, Giardina E, Packham J, McManus R, FitzGerald O, Brown MA, Behrens F, Burkhardt H, McHugh N, Huffmeier U, Ho P, Reis A, Barton A.

Ann Rheum Dis. 2015 Oct;74(10):1882-5. doi: 10.1136/annrheumdis-2014-207187. Epub 2015 Apr 28.


[Common German language nomenclature for systemic sclerosis].

Aringer M, Müller-Ladner U, Burkhardt H, Distler JH, Distler O, Graninger WB, Günther C, Hunzelmann N, Kiener H, Sticherling M, Sunderkötter C, Walker UA, Riemekasten G.

Z Rheumatol. 2015 Mar;74(2):100-3. doi: 10.1007/s00393-014-1550-5. German.


Sneaking-ligand fusion proteins attenuate serum transfer arthritis by endothelium-targeted NF-κB inhibition.

Sehnert B, Burkhardt H, May MJ, Zwerina J, Voll RE.

Methods Mol Biol. 2015;1280:579-91. doi: 10.1007/978-1-4939-2422-6_34.


The "sneaking-ligand" approach: cell-type specific inhibition of the classical NF-κB pathway.

Sehnert B, Burkhardt H, Dübel S, Voll RE.

Methods Mol Biol. 2015;1280:559-78. doi: 10.1007/978-1-4939-2422-6_33.


Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis.

Bowes J, Budu-Aggrey A, Huffmeier U, Uebe S, Steel K, Hebert HL, Wallace C, Massey J, Bruce IN, Bluett J, Feletar M, Morgan AW, Marzo-Ortega H, Donohoe G, Morris DW, Helliwell P, Ryan AW, Kane D, Warren RB, Korendowych E, Alenius GM, Giardina E, Packham J, McManus R, FitzGerald O, McHugh N, Brown MA, Ho P, Behrens F, Burkhardt H, Reis A, Barton A.

Nat Commun. 2015 Feb 5;6:6046. doi: 10.1038/ncomms7046. Erratum in: Nat Commun. 2015;6:7741.


Association between skin and joint involvement in patients with psoriatic arthritis treated with adalimumab: analysis of data from a German non-interventional study.

Thaçi D, Behrens F, Greger G, Burkhardt H, Gnann H, Schopf R, Wittig BM.

Dermatology. 2015;230(3):213-21. doi: 10.1159/000371546. Epub 2015 Jan 27.


St8sia2 deficiency plus juvenile cannabis exposure in mice synergistically affect higher cognition in adulthood.

Tantra M, Kröcher T, Papiol S, Winkler D, Röckle I, Jatho J, Burkhardt H, Ronnenberg A, Gerardy-Schahn R, Ehrenreich H, Hildebrandt H.

Behav Brain Res. 2014 Dec 15;275:166-75. doi: 10.1016/j.bbr.2014.08.062. Epub 2014 Sep 6.


A crucial role for polysialic acid in developmental interneuron migration and the establishment of interneuron densities in the mouse prefrontal cortex.

Kröcher T, Röckle I, Diederichs U, Weinhold B, Burkhardt H, Yanagawa Y, Gerardy-Schahn R, Hildebrandt H.

Development. 2014 Aug;141(15):3022-32. doi: 10.1242/dev.111773. Epub 2014 Jul 3.


Autoimmune priming, tissue attack and chronic inflammation - the three stages of rheumatoid arthritis.

Holmdahl R, Malmström V, Burkhardt H.

Eur J Immunol. 2014 Jun;44(6):1593-9. doi: 10.1002/eji.201444486. Epub 2014 May 3. Review.

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