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Controlled Delivery of Dutasteride Using Dissolvable Microarrays: Initial Formulation and In Vivo Evaluation.

Giffen PS, Bhuiya R, Brackenborough K, Hobbs MJ, Qian L, Burke MD.

J Pharm Sci. 2019 Nov 18. pii: S0022-3549(19)30755-5. doi: 10.1016/j.xphs.2019.11.012. [Epub ahead of print]


Modular Syntheses of Phenanthroindolizidine Natural Products.

Jo YI, Burke MD, Cheon CH.

Org Lett. 2019 Jun 7;21(11):4201-4204. doi: 10.1021/acs.orglett.9b01397. Epub 2019 May 22.


The Effects of Social Skills Interventions for Students With EBD and ASD: A Single-Case Meta-Analysis.

Hutchins NS, Burke MD, Bowman-Perrott L, Tarlow KR, Hatton H.

Behav Modif. 2019 May 7:145445519846817. doi: 10.1177/0145445519846817. [Epub ahead of print]


Challenges and Opportunities for Patient Centric Drug Product Design: Industry Perspectives.

Burke MD, Keeney M, Kleinberg R, Burlage R.

Pharm Res. 2019 Apr 17;36(6):85. doi: 10.1007/s11095-019-2616-5. Review.


Axial shielding of Pd(II) complexes enables perfect stereoretention in Suzuki-Miyaura cross-coupling of Csp3 boronic acids.

Lehmann JW, Crouch IT, Blair DJ, Trobe M, Wang P, Li J, Burke MD.

Nat Commun. 2019 Mar 20;10(1):1263. doi: 10.1038/s41467-019-09249-z.


Small-molecule ion channels increase host defences in cystic fibrosis airway epithelia.

Muraglia KA, Chorghade RS, Kim BR, Tang XX, Shah VS, Grillo AS, Daniels PN, Cioffi AG, Karp PH, Zhu L, Welsh MJ, Burke MD.

Nature. 2019 Mar;567(7748):405-408. doi: 10.1038/s41586-019-1018-5. Epub 2019 Mar 13.


Peridinin Is an Exceptionally Potent and Membrane-Embedded Inhibitor of Bilayer Lipid Peroxidation.

Haley HMS, Hill AG, Greenwood AI, Woerly EM, Rienstra CM, Burke MD.

J Am Chem Soc. 2018 Nov 14;140(45):15227-15240. doi: 10.1021/jacs.8b06933. Epub 2018 Nov 2.


FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity.

Yien YY, Shi J, Chen C, Cheung JTM, Grillo AS, Shrestha R, Li L, Zhang X, Kafina MD, Kingsley PD, King MJ, Ablain J, Li H, Zon LI, Palis J, Burke MD, Bauer DE, Orkin SH, Koehler CM, Phillips JD, Kaplan J, Ward DM, Lodish HF, Paw BH.

J Biol Chem. 2018 Dec 21;293(51):19797-19811. doi: 10.1074/jbc.RA118.002742. Epub 2018 Oct 26.


Toward Generalization of Iterative Small Molecule Synthesis.

Lehmann JW, Blair DJ, Burke MD.

Nat Rev Chem. 2018 Feb;2(2). pii: 0115. doi: 10.1038/s41570-018-0115. Epub 2018 Mar 7.


The Molecular Industrial Revolution: Automated Synthesis of Small Molecules.

Trobe M, Burke MD.

Angew Chem Int Ed Engl. 2018 Apr 9;57(16):4192-4214. doi: 10.1002/anie.201710482. Epub 2018 Mar 7. Review.


Solid-State NMR of highly 13C-enriched cholesterol in lipid bilayers.

Della Ripa LA, Petros ZA, Cioffi AG, Piehl DW, Courtney JM, Burke MD, Rienstra CM.

Methods. 2018 Apr 1;138-139:47-53. doi: 10.1016/j.ymeth.2018.01.008. Epub 2018 Feb 21.


The natural productome.

Palazzolo AME, Simons CLW, Burke MD.

Proc Natl Acad Sci U S A. 2017 May 30;114(22):5564-5566. doi: 10.1073/pnas.1706266114. Epub 2017 May 22. No abstract available.


Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals.

Grillo AS, SantaMaria AM, Kafina MD, Cioffi AG, Huston NC, Han M, Seo YA, Yien YY, Nardone C, Menon AV, Fan J, Svoboda DC, Anderson JB, Hong JD, Nicolau BG, Subedi K, Gewirth AA, Wessling-Resnick M, Kim J, Paw BH, Burke MD.

Science. 2017 May 12;356(6338):608-616. doi: 10.1126/science.aah3862.


MIDA boronates are hydrolysed fast and slow by two different mechanisms.

Gonzalez JA, Ogba OM, Morehouse GF, Rosson N, Houk KN, Leach AG, Cheong PH, Burke MD, Lloyd-Jones GC.

Nat Chem. 2016 Nov;8(11):1067-1075. doi: 10.1038/nchem.2571. Epub 2016 Jul 25.


C3-OH of Amphotericin B Plays an Important Role in Ion Conductance.

Davis SA, Della Ripa LA, Hu L, Cioffi AG, Pogorelov TV, Rienstra CM, Burke MD.

J Am Chem Soc. 2015 Dec 9;137(48):15102-4. doi: 10.1021/jacs.5b05766. Epub 2015 Nov 30.


Restored Physiology in Protein-Deficient Yeast by a Small Molecule Channel.

Cioffi AG, Hou J, Grillo AS, Diaz KA, Burke MD.

J Am Chem Soc. 2015 Aug 19;137(32):10096-9. doi: 10.1021/jacs.5b05765. Epub 2015 Aug 7.


From synthesis to function via iterative assembly of N-methyliminodiacetic acid boronate building blocks.

Li J, Grillo AS, Burke MD.

Acc Chem Res. 2015 Aug 18;48(8):2297-307. doi: 10.1021/acs.accounts.5b00128. Epub 2015 Jul 22.


Evaluating the Accuracy of Results for Teacher Implemented Trial-Based Functional Analyses.

Rispoli M, Ninci J, Burke MD, Zaini S, Hatton H, Sanchez L.

Behav Modif. 2015 Sep;39(5):627-53. doi: 10.1177/0145445515590456. Epub 2015 Jun 11.


Nontoxic antimicrobials that evade drug resistance.

Davis SA, Vincent BM, Endo MM, Whitesell L, Marchillo K, Andes DR, Lindquist S, Burke MD.

Nat Chem Biol. 2015 Jul;11(7):481-7. doi: 10.1038/nchembio.1821. Epub 2015 Jun 1.


Synthesis of many different types of organic small molecules using one automated process.

Li J, Ballmer SG, Gillis EP, Fujii S, Schmidt MJ, Palazzolo AM, Lehmann JW, Morehouse GF, Burke MD.

Science. 2015 Mar 13;347(6227):1221-6. doi: 10.1126/science.aaa5414.


A meta-analysis of single-case research on behavior contracts: effects on behavioral and academic outcomes among children and youth.

Bowman-Perrott L, Burke MD, de Marin S, Zhang N, Davis H.

Behav Modif. 2015 Mar;39(2):247-69. doi: 10.1177/0145445514551383. Epub 2014 Sep 26.


Reading interventions for middle and secondary students with emotional and behavioral disorders: a quantitative review of single-case studies.

Burke MD, Boon RT, Hatton H, Bowman-Perrott L.

Behav Modif. 2015 Jan;39(1):43-68. doi: 10.1177/0145445514547958. Epub 2014 Aug 26. Review.


Synthesis of most polyene natural product motifs using just 12 building blocks and one coupling reaction.

Woerly EM, Roy J, Burke MD.

Nat Chem. 2014 Jun;6(6):484-91. Erratum in: Nat Chem. 2014 Jun 20;6(7):650.


Amphotericin forms an extramembranous and fungicidal sterol sponge.

Anderson TM, Clay MC, Cioffi AG, Diaz KA, Hisao GS, Tuttle MD, Nieuwkoop AJ, Comellas G, Maryum N, Wang S, Uno BE, Wildeman EL, Gonen T, Rienstra CM, Burke MD.

Nat Chem Biol. 2014 May;10(5):400-6. doi: 10.1038/nchembio.1496. Epub 2014 Mar 30.


(1-bromovinyl)-MIDA boronate: a readily accessible and highly versatile building block for small molecule synthesis.

Woerly EM, Miller JE, Burke MD.

Tetrahedron. 2013 Sep 9;69(36). doi: 10.1016/j.tet.2013.05.050. No abstract available.


C2'-OH of amphotericin B plays an important role in binding the primary sterol of human cells but not yeast cells.

Wilcock BC, Endo MM, Uno BE, Burke MD.

J Am Chem Soc. 2013 Jun 12;135(23):8488-91. doi: 10.1021/ja403255s. Epub 2013 Jun 3.


Stability enhancement of drug layered pellets in a fixed dose combination tablet.

Burke MD, He X, Cook C, Petrov GA, Long S, Coffin MD.

AAPS PharmSciTech. 2013 Mar;14(1):312-20. doi: 10.1208/s12249-012-9911-3. Epub 2013 Jan 15.


Electronic tuning of site-selectivity.

Wilcock BC, Uno BE, Bromann GL, Clark MJ, Anderson TM, Burke MD.

Nat Chem. 2012 Dec;4(12):996-1003.


(Z)-(2-bromovinyl)-MIDA boronate: a readily accessible and highly versatile building block for small molecule synthesis.

Woerly EM, Struble JR, Palyam N, O'Hara SP, Burke MD.

Tetrahedron. 2011 Jun 17;67(24):4333-4343. No abstract available.


Moderating factors of video-modeling with other as model: a meta-analysis of single-case studies.

Mason RA, Ganz JB, Parker RI, Burke MD, Camargo SP.

Res Dev Disabil. 2012 Jul-Aug;33(4):1076-86. doi: 10.1016/j.ridd.2012.01.016. Epub 2012 Feb 23.


Amphotericin primarily kills yeast by simply binding ergosterol.

Gray KC, Palacios DS, Dailey I, Endo MM, Uno BE, Wilcock BC, Burke MD.

Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2234-9. doi: 10.1073/pnas.1117280109. Epub 2012 Jan 17.


A general solution for the 2-pyridyl problem.

Dick GR, Woerly EM, Burke MD.

Angew Chem Int Ed Engl. 2012 Mar 12;51(11):2667-72. doi: 10.1002/anie.201108608. Epub 2012 Jan 27.


Total synthesis of synechoxanthin through iterative cross-coupling.

Fujii S, Chang SY, Burke MD.

Angew Chem Int Ed Engl. 2011 Aug 16;50(34):7862-4. doi: 10.1002/anie.201102688. Epub 2011 Jun 16. No abstract available.


Synthesis-enabled functional group deletions reveal key underpinnings of amphotericin B ion channel and antifungal activities.

Palacios DS, Dailey I, Siebert DM, Wilcock BC, Burke MD.

Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6733-8. doi: 10.1073/pnas.1015023108. Epub 2011 Feb 28.


A simple and general platform for generating stereochemically complex polyene frameworks by iterative cross-coupling.

Lee SJ, Anderson TM, Burke MD.

Angew Chem Int Ed Engl. 2010 Nov 15;49(47):8860-3. doi: 10.1002/anie.201004911. No abstract available.


General method for synthesis of 2-heterocyclic N-methyliminodiacetic acid boronates.

Dick GR, Knapp DM, Gillis EP, Burke MD.

Org Lett. 2010 May 21;12(10):2314-7. doi: 10.1021/ol100671v.


Stereoretentive Suzuki-Miyaura coupling of haloallenes enables fully stereocontrolled access to (-)-peridinin.

Woerly EM, Cherney AH, Davis EK, Burke MD.

J Am Chem Soc. 2010 May 26;132(20):6941-3. doi: 10.1021/ja102721p.


A general solution for unstable boronic acids: slow-release cross-coupling from air-stable MIDA boronates.

Knapp DM, Gillis EP, Burke MD.

J Am Chem Soc. 2009 May 27;131(20):6961-3. doi: 10.1021/ja901416p.


Flexible tetracycline synthesis yields promising antibiotics.

Burke MD.

Nat Chem Biol. 2009 Feb;5(2):77-9. doi: 10.1038/nchembio0209-77. No abstract available.


Iterative Cross-Couplng with MIDA Boronates: Towards a General Platform for Small Molecule Synthesis.

Gillis EP, Burke MD.

Aldrichimica Acta. 2009;42(1):17-27. No abstract available.


Multistep synthesis of complex boronic acids from simple MIDA boronates.

Gillis EP, Burke MD.

J Am Chem Soc. 2008 Oct 29;130(43):14084-5. doi: 10.1021/ja8063759. Epub 2008 Oct 7.


Simple, efficient, and modular syntheses of polyene natural products via iterative cross-coupling.

Lee SJ, Gray KC, Paek JS, Burke MD.

J Am Chem Soc. 2008 Jan 16;130(2):466-8. No abstract available.


A post-PKS oxidation of the amphotericin B skeleton predicted to be critical for channel formation is not required for potent antifungal activity.

Palacios DS, Anderson TM, Burke MD.

J Am Chem Soc. 2007 Nov 14;129(45):13804-5. Epub 2007 Oct 23. No abstract available.


A simple and modular strategy for small molecule synthesis: iterative Suzuki-Miyaura coupling of B-protected haloboronic acid building blocks.

Gillis EP, Burke MD.

J Am Chem Soc. 2007 May 30;129(21):6716-7. Epub 2007 May 9. No abstract available.


A novel method to radiolabel gastric retentive formulations for gamma scintigraphy assessment.

Burke MD, Staton JS, Vickers AW, Peters EE, Coffin MD.

Pharm Res. 2007 Apr;24(4):695-704. Epub 2007 Feb 15.


A novel enzymatic technique for limiting drug mobility in a hydrogel matrix.

Burke MD, Park JO, Srinivasarao M, Khan SA.

J Control Release. 2005 May 5;104(1):141-53. Epub 2005 Apr 2.


A synthesis strategy yielding skeletally diverse small molecules combinatorially.

Burke MD, Berger EM, Schreiber SL.

J Am Chem Soc. 2004 Nov 3;126(43):14095-104.


Nutrient removal in a sequencing batch biofilm reactor (SBBR) using a vertically moving biofilm system.

Rodgers M, Zhan XM, Burke MD.

Environ Technol. 2004 Feb;25(2):211-8.


A planning strategy for diversity-oriented synthesis.

Burke MD, Schreiber SL.

Angew Chem Int Ed Engl. 2004 Jan;43(1):46-58.


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