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Items: 1 to 50 of 220

1.

Antitumor Activity of 1,18-Octadecanedioic Acid-Paclitaxel Complexed with Human Serum Albumin.

Callmann CE, LeGuyader CLM, Burton ST, Thompson MP, Hennis R, Barback C, Henriksen NM, Chan WC, Jaremko MJ, Yang J, Garcia A, Burkart MD, Gilson MK, Momper JD, Bertin PA, Gianneschi NC.

J Am Chem Soc. 2019 Jul 18. doi: 10.1021/jacs.9b04272. [Epub ahead of print]

PMID:
31317744
2.

A single tool to monitor multiple protein-protein interactions of the Escherichia coli acyl carrier protein.

Charov K, Burkart MD.

ACS Infect Dis. 2019 Jul 18. doi: 10.1021/acsinfecdis.9b00150. [Epub ahead of print]

PMID:
31317739
3.

Molecular basis for interactions between an acyl carrier protein and a ketosynthase.

Milligan JC, Lee DJ, Jackson DR, Schaub AJ, Beld J, Barajas JF, Hale JJ, Luo R, Burkart MD, Tsai SC.

Nat Chem Biol. 2019 Jul;15(7):669-671. doi: 10.1038/s41589-019-0301-y. Epub 2019 Jun 17.

PMID:
31209348
4.

Modifying the Thioester Linkage Affects the Structure of the Acyl Carrier Protein.

Sztain T, Patel A, Lee DJ, Davis TD, McCammon JA, Burkart MD.

Angew Chem Int Ed Engl. 2019 May 28. doi: 10.1002/anie.201903815. [Epub ahead of print]

PMID:
31140212
5.

Active site labeling of fatty acid and polyketide acyl-carrier protein transacylases.

Davis TD, Michaud JM, Burkart MD.

Org Biomol Chem. 2019 May 15;17(19):4720-4724. doi: 10.1039/c8ob03229g.

PMID:
31044196
6.

Evaluation of the impact of cachexia on clinical outcomes in aggressive lymphoma.

Burkart M, Schieber M, Basu S, Shah P, Venugopal P, Borgia JA, Gordon L, Karmali R.

Br J Haematol. 2019 Jul;186(1):45-53. doi: 10.1111/bjh.15889. Epub 2019 Apr 2.

PMID:
30941741
7.

Intermittent tinnitus-an empirical description.

Burkart M, Brueggemann P, Szczepek AJ, Frank D, Mazurek B.

HNO. 2019 Jun;67(Suppl 2):51-58. doi: 10.1007/s00106-019-0623-9.

PMID:
30927014
8.

Structural and dynamical rationale for fatty acid unsaturation in Escherichia coli.

Dodge GJ, Patel A, Jaremko KL, McCammon JA, Smith JL, Burkart MD.

Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6775-6783. doi: 10.1073/pnas.1818686116. Epub 2019 Mar 14.

PMID:
30872475
9.

[Intermittent tinnitus-an empirical description. German version].

Burkart M, Brueggemann P, Szczepek AJ, Frank D, Mazurek B.

HNO. 2019 Jun;67(6):440-448. doi: 10.1007/s00106-019-0622-x. German.

PMID:
30796499
10.

Discovering de novo peptide substrates for enzymes using machine learning.

Tallorin L, Wang J, Kim WE, Sahu S, Kosa NM, Yang P, Thompson M, Gilson MK, Frazier PI, Burkart MD, Gianneschi NC.

Nat Commun. 2018 Dec 7;9(1):5253. doi: 10.1038/s41467-018-07717-6.

11.

Daedal Facets of Splice Modulator Optimization.

Chan WC, León B, Krug KA, Patel A, La Clair JJ, Burkart MD.

ACS Med Chem Lett. 2018 Oct 29;9(11):1070-1072. doi: 10.1021/acsmedchemlett.8b00456. eCollection 2018 Nov 8.

PMID:
30429946
12.

Trapping the Complex Molecular Machinery of Polyketide and Fatty Acid Synthases with Tunable Silylcyanohydrin Crosslinkers.

Konno S, La Clair JJ, Burkart MD.

Angew Chem Int Ed Engl. 2018 Dec 21;57(52):17009-17013. doi: 10.1002/anie.201806865. Epub 2018 Nov 27.

PMID:
30379389
13.

Future health of AYA survivors.

Burkart M, Sanford S, Dinner S, Sharp L, Kinahan K.

Pediatr Blood Cancer. 2019 Feb;66(2):e27516. doi: 10.1002/pbc.27516. Epub 2018 Oct 26. Review.

PMID:
30362237
14.

Mechanistic Probes for the Epimerization Domain of Nonribosomal Peptide Synthetases.

Kim WE, Patel A, Hur GH, Tufar P, Wuo MG, McCammon JA, Burkart MD.

Chembiochem. 2019 Jan 18;20(2):147-152. doi: 10.1002/cbic.201800439. Epub 2018 Nov 9.

PMID:
30194895
15.

[Influence of medical BPS treatment on sexual function].

Bschleipfer T, Burkart M.

Urologe A. 2018 Dec;57(12):1464-1471. doi: 10.1007/s00120-018-0739-7. Review. German.

PMID:
30046855
16.

Type II fatty acid and polyketide synthases: deciphering protein-protein and protein-substrate interactions.

Chen A, Re RN, Burkart MD.

Nat Prod Rep. 2018 Oct 17;35(10):1029-1045. doi: 10.1039/c8np00040a. Review.

PMID:
30046786
17.

Development of a cyanobacterial heterologous polyketide production platform.

Roulet J, Taton A, Golden JW, Arabolaza A, Burkart MD, Gramajo H.

Metab Eng. 2018 Sep;49:94-104. doi: 10.1016/j.ymben.2018.07.013. Epub 2018 Jul 21.

PMID:
30036678
18.

Taxon-specific aerosolization of bacteria and viruses in an experimental ocean-atmosphere mesocosm.

Michaud JM, Thompson LR, Kaul D, Espinoza JL, Richter RA, Xu ZZ, Lee C, Pham KM, Beall CM, Malfatti F, Azam F, Knight R, Burkart MD, Dupont CL, Prather KA.

Nat Commun. 2018 May 22;9(1):2017. doi: 10.1038/s41467-018-04409-z.

19.

Preparation, Assay, and Application of Chlorinase SalL for the Chemoenzymatic Synthesis of S-Adenosyl-l-Methionine and Analogs.

Davis TD, Kunakom S, Burkart MD, Eustaquio AS.

Methods Enzymol. 2018;604:367-388. doi: 10.1016/bs.mie.2018.02.012. Epub 2018 Apr 2.

20.

Matching Protein Interfaces for Improved Medium-Chain Fatty Acid Production.

Sarria S, Bartholow TG, Verga A, Burkart MD, Peralta-Yahya P.

ACS Synth Biol. 2018 May 18;7(5):1179-1187. doi: 10.1021/acssynbio.7b00334. Epub 2018 May 3.

21.

A coupled in vitro/in vivo approach for engineering a heterologous type III PKS to enhance polyketide biosynthesis in Saccharomyces cerevisiae.

Vickery CR, Cardenas J, Bowman ME, Burkart MD, Da Silva NA, Noel JP.

Biotechnol Bioeng. 2018 Jun;115(6):1394-1402. doi: 10.1002/bit.26564. Epub 2018 Mar 13.

PMID:
29457628
22.

Similar treatment outcomes with Ginkgo biloba extract EGb 761 and donepezil in Alzheimer's dementia in very old age: A retrospective observational study.

Rapp M, Burkart M, Kohlmann T, Bohlken J.

Int J Clin Pharmacol Ther. 2018 Mar;56(3):130-133. doi: 10.5414/CP203103.

23.

Utilizing Mechanistic Cross-Linking Technology to Study Protein-Protein Interactions: An Experiment Designed for an Undergraduate Biochemistry Lab.

Finzel K, Beld J, Burkart MD, Charkoudian LK.

J Chem Educ. 2017 Mar 14;94(3):375-379. doi: 10.1021/acs.jchemed.6b00453. Epub 2017 Feb 3.

24.

Manipulating Protein-Protein Interactions in Nonribosomal Peptide Synthetase Type II Peptidyl Carrier Proteins.

Jaremko MJ, Lee DJ, Patel A, Winslow V, Opella SJ, McCammon JA, Burkart MD.

Biochemistry. 2017 Oct 10;56(40):5269-5273. doi: 10.1021/acs.biochem.7b00884. Epub 2017 Oct 2.

25.

Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases.

Barajas JF, Shakya G, Moreno G, Rivera H Jr, Jackson DR, Topper CL, Vagstad AL, La Clair JJ, Townsend CA, Burkart MD, Tsai SC.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4142-E4148. doi: 10.1073/pnas.1609001114. Epub 2017 May 8.

26.

A Challenging Pie to Splice: Drugging the Spliceosome.

León B, Kashyap MK, Chan WC, Krug KA, Castro JE, La Clair JJ, Burkart MD.

Angew Chem Int Ed Engl. 2017 Sep 25;56(40):12052-12063. doi: 10.1002/anie.201701065. Epub 2017 Aug 15. Review.

27.

Restoration of perivascular adipose tissue function in diet-induced obese mice without changing bodyweight.

Xia N, Weisenburger S, Koch E, Burkart M, Reifenberg G, Förstermann U, Li H.

Br J Pharmacol. 2017 Oct;174(20):3443-3453. doi: 10.1111/bph.13703. Epub 2017 Jan 31.

28.

Corrigendum to "Unveiling the functional diversity of the alpha/beta hydrolase superfamily in the plant kingdom" [Curr Opin Struct Biol 2016, 41:233-246].

Mindrebo JT, Nartey CM, Seto Y, Burkart MD, Noel JP.

Curr Opin Struct Biol. 2016 Dec;41:256-257. doi: 10.1016/j.sbi.2016.11.008. Epub 2016 Nov 21. No abstract available.

PMID:
27884574
29.

Recent progress and future challenges in algal biofuel production.

Shurin JB, Burkart MD, Mayfield SP, Smith VH.

F1000Res. 2016 Oct 4;5. pii: F1000 Faculty Rev-2434. eCollection 2016. Review.

30.

Selectivity in Small Molecule Splicing Modulation.

Kumar D, Kashyap MK, La Clair JJ, Villa R, Spaanderman I, Chien S, Rassenti LZ, Kipps TJ, Burkart MD, Castro JE.

ACS Chem Biol. 2016 Oct 21;11(10):2716-2723. Epub 2016 Aug 8.

PMID:
27499047
31.

Unveiling the functional diversity of the alpha/beta hydrolase superfamily in the plant kingdom.

Mindrebo JT, Nartey CM, Seto Y, Burkart MD, Noel JP.

Curr Opin Struct Biol. 2016 Dec;41:233-246. doi: 10.1016/j.sbi.2016.08.005. Epub 2016 Sep 21. Review. Erratum in: Curr Opin Struct Biol. 2016 Dec;41:256-257.

32.

Structural and Biochemical Analysis of Protein-Protein Interactions Between the Acyl-Carrier Protein and Product Template Domain.

Barajas JF, Finzel K, Valentic TR, Shakya G, Gamarra N, Martinez D, Meier JL, Vagstad AL, Newman AG, Townsend CA, Burkart MD, Tsai SC.

Angew Chem Int Ed Engl. 2016 Oct 10;55(42):13005-13009. doi: 10.1002/anie.201605401.

33.

Presence versus absence of CYP734A50 underlies the style-length dimorphism in primroses.

Huu CN, Kappel C, Keller B, Sicard A, Takebayashi Y, Breuninger H, Nowak MD, Bäurle I, Himmelbach A, Burkart M, Ebbing-Lohaus T, Sakakibara H, Altschmied L, Conti E, Lenhard M.

Elife. 2016 Sep 6;5. pii: e17956. doi: 10.7554/eLife.17956.

34.

RNA Splicing Modulation Selectively Impairs Leukemia Stem Cell Maintenance in Secondary Human AML.

Crews LA, Balaian L, Delos Santos NP, Leu HS, Court AC, Lazzari E, Sadarangani A, Zipeto MA, La Clair JJ, Villa R, Kulidjian A, Storb R, Morris SR, Ball ED, Burkart MD, Jamieson CHM.

Cell Stem Cell. 2016 Nov 3;19(5):599-612. doi: 10.1016/j.stem.2016.08.003. Epub 2016 Aug 25.

35.

An unusual intramolecular trans-amidation.

Rivera H Jr, Dhar S, La Clair JJ, Tsai SC, Burkart MD.

Tetrahedron. 2016 Jun 23;72(25):3605-3608.

36.

Biosynthetic potential of sesquiterpene synthases: product profiles of Egyptian Henbane premnaspirodiene synthase and related mutants.

Koo HJ, Vickery CR, Xu Y, Louie GV, O'Maille PE, Bowman M, Nartey CM, Burkart MD, Noel JP.

J Antibiot (Tokyo). 2016 Jul;69(7):524-33. doi: 10.1038/ja.2016.68. Epub 2016 Jun 22.

PMID:
27328867
37.

Data from mass spectrometry, NMR spectra, GC-MS of fatty acid esters produced by Lasiodiplodia theobromae.

Uranga CC, Beld J, Mrse A, Córdova-Guerrero I, Burkart MD, Hernández-Martínez R.

Data Brief. 2016 May 9;8:31-9. doi: 10.1016/j.dib.2016.05.003. eCollection 2016 Sep.

38.

Fluorescent Mechanism-Based Probe for Aerobic Flavin-Dependent Enzyme Activity.

McCulloch IP, La Clair JJ, Jaremko MJ, Burkart MD.

Chembiochem. 2016 Sep 2;17(17):1598-601. doi: 10.1002/cbic.201600275. Epub 2016 Aug 5.

39.

Chemoenzymatic synthesis and utilization of a SAM analog with an isomorphic nucleobase.

Vranken C, Fin A, Tufar P, Hofkens J, Burkart MD, Tor Y.

Org Biomol Chem. 2016 Jul 14;14(26):6189-92. doi: 10.1039/c6ob00844e. Epub 2016 Jun 6.

40.

A Platform to Enable the Pharmacological Profiling of Small Molecules in Gel-Based Electrophoretic Mobility Shift Assays.

Foley TL, Dorjsuren D, Dexheimer TS, Burkart MD, Wight WC, Simeonov A.

J Biomol Screen. 2016 Dec;21(10):1125-1131. doi: 10.1177/1087057116652895. Epub 2016 Jul 10.

41.

Traffic Control in Modular Polyketide Synthases.

Finzel K, Burkart MD.

ACS Cent Sci. 2016 Jan 27;2(1):9-11. doi: 10.1021/acscentsci.6b00007. Epub 2016 Jan 15. No abstract available.

43.

A Carbohydrate-Derived Splice Modulator.

Dhar S, La Clair JJ, León B, Hammons JC, Yu Z, Kashyap MK, Castro JE, Burkart MD.

J Am Chem Soc. 2016 Apr 20;138(15):5063-8. doi: 10.1021/jacs.5b13427. Epub 2016 Apr 8.

PMID:
27058259
44.

Trapping of the Enoyl-Acyl Carrier Protein Reductase-Acyl Carrier Protein Interaction.

Tallorin L, Finzel K, Nguyen QG, Beld J, La Clair JJ, Burkart MD.

J Am Chem Soc. 2016 Mar 30;138(12):3962-5. doi: 10.1021/jacs.5b13456. Epub 2016 Mar 15.

45.

Fatty acid esters produced by Lasiodiplodia theobromae function as growth regulators in tobacco seedlings.

Uranga CC, Beld J, Mrse A, Córdova-Guerrero I, Burkart MD, Hernández-Martínez R.

Biochem Biophys Res Commun. 2016 Apr 1;472(2):339-45. doi: 10.1016/j.bbrc.2016.02.104. Epub 2016 Feb 27.

PMID:
26926564
46.

Probing fatty acid metabolism in bacteria, cyanobacteria, green microalgae and diatoms with natural and unnatural fatty acids.

Beld J, Abbriano R, Finzel K, Hildebrand M, Burkart MD.

Mol Biosyst. 2016 Apr;12(4):1299-312. doi: 10.1039/c5mb00804b. Epub 2016 Feb 17.

PMID:
26886879
47.

Sea Spray Aerosol Structure and Composition Using Cryogenic Transmission Electron Microscopy.

Patterson JP, Collins DB, Michaud JM, Axson JL, Sultana CM, Moser T, Dommer AC, Conner J, Grassian VH, Stokes MD, Deane GB, Evans JE, Burkart MD, Prather KA, Gianneschi NC.

ACS Cent Sci. 2016 Jan 27;2(1):40-47. Epub 2016 Jan 15.

48.

Harvesting the biosynthetic machineries that cultivate a variety of indispensable plant natural products.

Vickery CR, La Clair JJ, Burkart MD, Noel JP.

Curr Opin Chem Biol. 2016 Apr;31:66-73. doi: 10.1016/j.cbpa.2016.01.008. Epub 2016 Feb 4. Review.

49.

A Substrate Mimic Allows High-Throughput Assay of the FabA Protein and Consequently the Identification of a Novel Inhibitor of Pseudomonas aeruginosa FabA.

Moynié L, Hope AG, Finzel K, Schmidberger J, Leckie SM, Schneider G, Burkart MD, Smith AD, Gray DW, Naismith JH.

J Mol Biol. 2016 Jan 16;428(1):108-120. doi: 10.1016/j.jmb.2015.10.027. Epub 2015 Nov 10.

50.

Probing the Substrate Specificity and Protein-Protein Interactions of the E. coli Fatty Acid Dehydratase, FabA.

Finzel K, Nguyen C, Jackson DR, Gupta A, Tsai SC, Burkart MD.

Chem Biol. 2015 Nov 19;22(11):1453-1460. doi: 10.1016/j.chembiol.2015.09.009. Epub 2015 Oct 29.

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