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Items: 6

1.

The KRASG12C Inhibitor, MRTX849, Provides Insight Toward Therapeutic Susceptibility of KRAS Mutant Cancers in Mouse Models and Patients.

Hallin J, Engstrom LD, Hargis L, Calinisan A, Aranda R, Briere DM, Sudhakar N, Bowcut V, Baer BR, Ballard JA, Burkard MR, Fell JB, Fischer JP, Vigers GP, Xue JY, Gatto S, Fernandez-Banet J, Pavlicek A, Velastegui K, Chao RC, Barton J, Pierobon M, Baldelli E, Patricoin EF, Cassidy DP, Marx MA, Rybkin II, Johnson ML, Ou SI, Lito P, Papadopoulos KP, Janne PA, Olson P, Christensen JG.

Cancer Discov. 2019 Oct 28. pii: CD-19-1167. doi: 10.1158/2159-8290.CD-19-1167. [Epub ahead of print]

PMID:
31658955
2.

Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity.

Fell JB, Fischer JP, Baer BR, Ballard J, Blake JF, Bouhana K, Brandhuber BJ, Briere DM, Burgess LE, Burkard MR, Chiang H, Chicarelli MJ, Davidson K, Gaudino JJ, Hallin J, Hanson L, Hee K, Hicken EJ, Hinklin RJ, Marx MA, Mejia MJ, Olson P, Savechenkov P, Sudhakar N, Tang TP, Vigers GP, Zecca H, Christensen JG.

ACS Med Chem Lett. 2018 Nov 7;9(12):1230-1234. doi: 10.1021/acsmedchemlett.8b00382. eCollection 2018 Dec 13.

PMID:
30613331
3.

Transient reexpression of an embryonic autonomous growth phenotype by adult carotid artery smooth muscle cells after vascular injury.

Weiser-Evans MC, Quinn BE, Burkard MR, Stenmark KR.

J Cell Physiol. 2000 Jan;182(1):12-23.

PMID:
10567912
4.

In vitro studies of a bradykinin B1/B2 antagonist linked to a human neutrophil elastase inhibitor; a heterodimer for the treatment of inflammatory disorders.

Leimer AH, Kroona HB, Blodgett JK, Whalley ET, Ross SE, Burkard MR, Zuzack JS, Gernert DL, Dyckes DF.

Can J Physiol Pharmacol. 1997 Jun;75(6):633-8.

PMID:
9276141
5.

Inducible bradykinin B1 receptor in isolated human ileum.

Zuzack JS, Burkard MR, Cuadrado DK, Greer RA, Selig WM, Whalley ET.

Immunopharmacology. 1996 Jun;33(1-3):113-5. No abstract available.

PMID:
8856127
6.

Evidence of a bradykinin B1 receptor in human ileum: pharmacological comparison to the rabbit aorta B1 receptor.

Zuzack JS, Burkard MR, Cuadrado DK, Greer RA, Selig WM, Whalley ET.

J Pharmacol Exp Ther. 1996 Jun;277(3):1337-43.

PMID:
8667195

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