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Items: 1 to 50 of 60

1.

Identification of novel agonists by high-throughput screening and molecular modelling of human constitutive androstane receptor isoform 3.

Keminer O, Windshügel B, Essmann F, Lee SML, Schiergens TS, Schwab M, Burk O.

Arch Toxicol. 2019 Aug;93(8):2247-2264. doi: 10.1007/s00204-019-02495-6. Epub 2019 Jul 16.

PMID:
31312845
2.

Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles.

Burk O, Kuzikov M, Kronenberger T, Jeske J, Keminer O, Thasler WE, Schwab M, Wrenger C, Windshügel B.

Arch Toxicol. 2018 Apr;92(4):1435-1451. doi: 10.1007/s00204-018-2165-4. Epub 2018 Jan 22.

PMID:
29356861
3.

Ligand-dependent and -independent regulation of human hepatic sphingomyelin phosphodiesterase acid-like 3A expression by pregnane X receptor and crosstalk with liver X receptor.

Jeske J, Bitter A, Thasler WE, Weiss TS, Schwab M, Burk O.

Biochem Pharmacol. 2017 Jul 15;136:122-135. doi: 10.1016/j.bcp.2017.04.013. Epub 2017 Apr 13.

PMID:
28414139
4.

Human pregnane X receptor is activated by dibenzazepine carbamate-based inhibitors of constitutive androstane receptor.

Jeske J, Windshügel B, Thasler WE, Schwab M, Burk O.

Arch Toxicol. 2017 Jun;91(6):2375-2390. doi: 10.1007/s00204-017-1948-3. Epub 2017 Mar 13.

PMID:
28289823
5.

Genomewide comparison of the inducible transcriptomes of nuclear receptors CAR, PXR and PPARα in primary human hepatocytes.

Kandel BA, Thomas M, Winter S, Damm G, Seehofer D, Burk O, Schwab M, Zanger UM.

Biochim Biophys Acta. 2016 Sep;1859(9):1218-1227. doi: 10.1016/j.bbagrm.2016.03.007. Epub 2016 Mar 17.

PMID:
26994748
6.

Correction: Structural and Functional Similarity of Amphibian Constitutive Androstane Receptor with Mammalian Pregnane X Receptor.

Mathäs M, Nusshag C, Burk O, Gödtel-Armbrust U, Herlyn H, Wojnowski L, Windshügel B.

PLoS One. 2016 Feb 1;11(2):e0148703. doi: 10.1371/journal.pone.0148703. eCollection 2016. No abstract available.

7.

Variability in hepatic expression of organic anion transporter 7/SLC22A9, a novel pravastatin uptake transporter: impact of genetic and regulatory factors.

Emami Riedmaier A, Burk O, van Eijck BA, Schaeffeler E, Klein K, Fehr S, Biskup S, Müller S, Winter S, Zanger UM, Schwab M, Nies AT.

Pharmacogenomics J. 2016 Aug;16(4):341-51. doi: 10.1038/tpj.2015.55. Epub 2015 Aug 4.

PMID:
26239079
8.

Impact of the serum- and glucocorticoid-inducible kinase 1 on platelet dense granule biogenesis and secretion.

Walker B, Schmid E, Russo A, Schmidt EM, Burk O, Münzer P, Velic A, Macek B, Schaller M, Schwab M, Seabra MC, Gawaz M, Lang F, Borst O.

J Thromb Haemost. 2015 Jul;13(7):1325-34. doi: 10.1111/jth.12998. Epub 2015 Jun 12.

9.

Human sterol regulatory element-binding protein 1a contributes significantly to hepatic lipogenic gene expression.

Bitter A, Nüssler AK, Thasler WE, Klein K, Zanger UM, Schwab M, Burk O.

Cell Physiol Biochem. 2015;35(2):803-15. doi: 10.1159/000369739. Epub 2015 Jan 30.

10.

Carboxymefloquine, the major metabolite of the antimalarial drug mefloquine, induces drug-metabolizing enzyme and transporter expression by activation of pregnane X receptor.

Piedade R, Traub S, Bitter A, Nüssler AK, Gil JP, Schwab M, Burk O.

Antimicrob Agents Chemother. 2015 Jan;59(1):96-104. doi: 10.1128/AAC.04140-14. Epub 2014 Oct 13.

11.

Pregnane X receptor activation and silencing promote steatosis of human hepatic cells by distinct lipogenic mechanisms.

Bitter A, Rümmele P, Klein K, Kandel BA, Rieger JK, Nüssler AK, Zanger UM, Trauner M, Schwab M, Burk O.

Arch Toxicol. 2015 Nov;89(11):2089-103. doi: 10.1007/s00204-014-1348-x. Epub 2014 Sep 3.

PMID:
25182422
12.

Structural and functional similarity of amphibian constitutive androstane receptor with mammalian pregnane X receptor.

Mathäs M, Nusshag C, Burk O, Gödtel-Armbrust U, Herlyn H, Wojnowski L, Windshügel B.

PLoS One. 2014 May 5;9(5):e96263. doi: 10.1371/journal.pone.0096263. eCollection 2014. Erratum in: PLoS One. 2014;9(7):e104594. PLoS One. 2016;11(2):e0148703. Nuβhag, Christian [corrected to Nusshag, Christian].

13.

Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1.

Nies AT, Niemi M, Burk O, Winter S, Zanger UM, Stieger B, Schwab M, Schaeffeler E.

Genome Med. 2013 Jan 11;5(1):1. doi: 10.1186/gm405. eCollection 2013.

14.

Direct transcriptional regulation of human hepatic cytochrome P450 3A4 (CYP3A4) by peroxisome proliferator-activated receptor alpha (PPARα).

Thomas M, Burk O, Klumpp B, Kandel BA, Damm G, Weiss TS, Klein K, Schwab M, Zanger UM.

Mol Pharmacol. 2013 Mar;83(3):709-18. doi: 10.1124/mol.112.082503. Epub 2013 Jan 7.

PMID:
23295386
15.

Differential effects of clinically used derivatives and metabolites of artemisinin in the activation of constitutive androstane receptor isoforms.

Burk O, Piedade R, Ghebreghiorghis L, Fait JT, Nussler AK, Gil JP, Windshügel B, Schwab M.

Br J Pharmacol. 2012 Oct;167(3):666-81. doi: 10.1111/j.1476-5381.2012.02033.x.

16.

Human pregnane X receptor genotype of the donor but not of the recipient is a risk factor for delayed graft function after renal transplantation.

Hauser IA, Kruck S, Gauer S, Nies AT, Winter S, Bedke J, Geiger H, Hoefeld H, Kleemann J, Asbe-Vollkopf A, Engel J, Burk O, Schwab M, Schaeffeler E.

Clin Pharmacol Ther. 2012 May;91(5):905-16. doi: 10.1038/clpt.2011.346. Epub 2012 Mar 28.

PMID:
22453193
17.

PXR variants and artemisinin use in Vietnamese subjects: frequency distribution and impact on the interindividual variability of CYP3A induction by artemisinin.

Piedade R, Schaeffeler E, Winter S, Asimus S, Schwab M, Ashton M, Burk O, Gil JP.

Antimicrob Agents Chemother. 2012 Apr;56(4):2153-7. doi: 10.1128/AAC.06009-11. Epub 2012 Jan 17.

18.

Evolutionary history and functional characterization of the amphibian xenosensor CAR.

Mathäs M, Burk O, Qiu H, Nusshag C, Gödtel-Armbrust U, Baranyai D, Deng S, Römer K, Nem D, Windshügel B, Wojnowski L.

Mol Endocrinol. 2012 Jan;26(1):14-26. doi: 10.1210/me.2011-1235. Epub 2011 Nov 10.

19.

Effects of atorvastatin metabolites on induction of drug-metabolizing enzymes and membrane transporters through human pregnane X receptor.

Hoffart E, Ghebreghiorghis L, Nussler AK, Thasler WE, Weiss TS, Schwab M, Burk O.

Br J Pharmacol. 2012 Mar;165(5):1595-608. doi: 10.1111/j.1476-5381.2011.01665.x.

20.

Inferring statin-induced gene regulatory relationships in primary human hepatocytes.

Schröder A, Wollnik J, Wrzodek C, Dräger A, Bonin M, Burk O, Thomas M, Thasler WE, Zanger UM, Zell A.

Bioinformatics. 2011 Sep 15;27(18):2473-7. doi: 10.1093/bioinformatics/btr416. Epub 2011 Jul 14.

PMID:
21757465
21.

The impact of thyroid disease on the regulation, expression, and function of ABCB1 (MDR1/P glycoprotein) and consequences for the disposition of digoxin.

Burk O, Brenner SS, Hofmann U, Tegude H, Igel S, Schwab M, Eichelbaum M, Alscher MD.

Clin Pharmacol Ther. 2010 Nov;88(5):685-94. doi: 10.1038/clpt.2010.176. Epub 2010 Sep 15.

PMID:
20844484
22.

Regulation of CYP3A4 by pregnane X receptor: The role of nuclear receptors competing for response element binding.

Istrate MA, Nussler AK, Eichelbaum M, Burk O.

Biochem Biophys Res Commun. 2010 Mar 19;393(4):688-93. doi: 10.1016/j.bbrc.2010.02.058. Epub 2010 Feb 18.

PMID:
20171174
23.

The unique complexity of the CYP3A4 upstream region suggests a nongenetic explanation of its expression variability.

Qiu H, Mathäs M, Nestler S, Bengel C, Nem D, Gödtel-Armbrust U, Lang T, Taudien S, Burk O, Wojnowski L.

Pharmacogenet Genomics. 2010 Mar;20(3):167-78. doi: 10.1097/FPC.0b013e328336bbeb.

PMID:
20147837
24.

Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver.

Nies AT, Koepsell H, Winter S, Burk O, Klein K, Kerb R, Zanger UM, Keppler D, Schwab M, Schaeffeler E.

Hepatology. 2009 Oct;50(4):1227-40. doi: 10.1002/hep.23103.

PMID:
19591196
25.

Effects of rifampicin on global gene expression in human small intestine.

Oscarson M, Burk O, Winter S, Schwab M, Wolbold R, Dippon J, Eichelbaum M, Meyer UA.

Pharmacogenet Genomics. 2007 Nov;17(11):907-18.

PMID:
18075461
26.

The limited impact of CYP3A5 genotype for the pharmacokinetics of CYP3A substrates.

Burk O, Schwab M.

Eur J Clin Pharmacol. 2007 Dec;63(12):1097-8. No abstract available.

PMID:
17932664
27.

The Paneth cell alpha-defensin deficiency of ileal Crohn's disease is linked to Wnt/Tcf-4.

Wehkamp J, Wang G, Kübler I, Nuding S, Gregorieff A, Schnabel A, Kays RJ, Fellermann K, Burk O, Schwab M, Clevers H, Bevins CL, Stange EF.

J Immunol. 2007 Sep 1;179(5):3109-18.

28.

Selective induction of human hepatic cytochromes P450 2B6 and 3A4 by metamizole.

Saussele T, Burk O, Blievernicht JK, Klein K, Nussler A, Nussler N, Hengstler JG, Eichelbaum M, Schwab M, Zanger UM.

Clin Pharmacol Ther. 2007 Sep;82(3):265-74. Epub 2007 Mar 7.

PMID:
17344806
29.

Molecular mechanism of basal CYP3A4 regulation by hepatocyte nuclear factor 4alpha: evidence for direct regulation in the intestine.

Tegude H, Schnabel A, Zanger UM, Klein K, Eichelbaum M, Burk O.

Drug Metab Dispos. 2007 Jun;35(6):946-54. Epub 2007 Mar 7.

PMID:
17344340
30.

Functional analysis of the polymorphism -211C>T in the regulatory region of the human ABCC3 gene.

Gradhand U, Tegude H, Burk O, Eichelbaum M, Fromm MF, König J.

Life Sci. 2007 Mar 27;80(16):1490-4. Epub 2007 Jan 20.

PMID:
17300812
31.

Effects of ursodeoxycholic acid on P-glycoprotein and cytochrome P450 3A4-dependent pharmacokinetics in humans.

Becquemont L, Glaeser H, Drescher S, Hitzl M, Simon N, Murdter TE, Heinkele G, Hofmann U, Schaefer C, Burk O, Verstuyft C, Eichelbaum M, Fromm MF.

Clin Pharmacol Ther. 2006 May;79(5):449-60. Epub 2006 Apr 11.

PMID:
16678547
32.

A role for constitutive androstane receptor in the regulation of human intestinal MDR1 expression.

Burk O, Arnold KA, Geick A, Tegude H, Eichelbaum M.

Biol Chem. 2005 Jun;386(6):503-13.

PMID:
16006237
33.

Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor.

Burk O, Arnold KA, Nussler AK, Schaeffeler E, Efimova E, Avery BA, Avery MA, Fromm MF, Eichelbaum M.

Mol Pharmacol. 2005 Jun;67(6):1954-65. Epub 2005 Mar 10.

PMID:
15761118
34.

The induction of cytochrome P450 3A5 (CYP3A5) in the human liver and intestine is mediated by the xenobiotic sensors pregnane X receptor (PXR) and constitutively activated receptor (CAR).

Burk O, Koch I, Raucy J, Hustert E, Eichelbaum M, Brockmöller J, Zanger UM, Wojnowski L.

J Biol Chem. 2004 Sep 10;279(37):38379-85. Epub 2004 Jul 12.

35.

Genetic polymorphisms in the multidrug resistance-associated protein 3 (ABCC3, MRP3) gene and relationship to its mRNA and protein expression in human liver.

Lang T, Hitzl M, Burk O, Mornhinweg E, Keil A, Kerb R, Klein K, Zanger UM, Eichelbaum M, Fromm MF.

Pharmacogenetics. 2004 Mar;14(3):155-64.

PMID:
15167703
36.
37.

Cytochrome P450 3A4 and P-glycoprotein expression in human small intestinal enterocytes and hepatocytes: a comparative analysis in paired tissue specimens.

von Richter O, Burk O, Fromm MF, Thon KP, Eichelbaum M, Kivistö KT.

Clin Pharmacol Ther. 2004 Mar;75(3):172-83.

PMID:
15001968
38.

Cytochrome P450 3A and their regulation.

Burk O, Wojnowski L.

Naunyn Schmiedebergs Arch Pharmacol. 2004 Jan;369(1):105-24. Epub 2003 Oct 21. Review.

PMID:
14569421
39.

Sex is a major determinant of CYP3A4 expression in human liver.

Wolbold R, Klein K, Burk O, Nüssler AK, Neuhaus P, Eichelbaum M, Schwab M, Zanger UM.

Hepatology. 2003 Oct;38(4):978-88.

PMID:
14512885
40.

Interindividual variability and tissue-specificity in the expression of cytochrome P450 3A mRNA.

Koch I, Weil R, Wolbold R, Brockmöller J, Hustert E, Burk O, Nuessler A, Neuhaus P, Eichelbaum M, Zanger U, Wojnowski L.

Drug Metab Dispos. 2002 Oct;30(10):1108-14.

PMID:
12228187
41.

Association of the P-glycoprotein transporter MDR1(C3435T) polymorphism with the susceptibility to renal epithelial tumors.

Siegsmund M, Brinkmann U, Scháffeler E, Weirich G, Schwab M, Eichelbaum M, Fritz P, Burk O, Decker J, Alken P, Rothenpieler U, Kerb R, Hoffmeyer S, Brauch H.

J Am Soc Nephrol. 2002 Jul;13(7):1847-54.

42.

Molecular mechanisms of polymorphic CYP3A7 expression in adult human liver and intestine.

Burk O, Tegude H, Koch I, Hustert E, Wolbold R, Glaeser H, Klein K, Fromm MF, Nuessler AK, Neuhaus P, Zanger UM, Eichelbaum M, Wojnowski L.

J Biol Chem. 2002 Jul 5;277(27):24280-8. Epub 2002 Apr 8.

43.

Shed human enterocytes as a tool for the study of expression and function of intestinal drug-metabolizing enzymes and transporters.

Glaeser H, Drescher S, van der Kuip H, Behrens C, Geick A, Burk O, Dent J, Somogyi A, Von Richter O, Griese EU, Eichelbaum M, Fromm MF.

Clin Pharmacol Ther. 2002 Mar;71(3):131-40.

PMID:
11907487
44.

The genetic determinants of the CYP3A5 polymorphism.

Hustert E, Haberl M, Burk O, Wolbold R, He YQ, Klein K, Nuessler AC, Neuhaus P, Klattig J, Eiselt R, Koch I, Zibat A, Brockmöller J, Halpert JR, Zanger UM, Wojnowski L.

Pharmacogenetics. 2001 Dec;11(9):773-9.

PMID:
11740341
45.

Natural protein variants of pregnane X receptor with altered transactivation activity toward CYP3A4.

Hustert E, Zibat A, Presecan-Siedel E, Eiselt R, Mueller R, Fuss C, Brehm I, Brinkmann U, Eichelbaum M, Wojnowski L, Burk O.

Drug Metab Dispos. 2001 Nov;29(11):1454-9.

PMID:
11602521
46.

The chicken Pdcd4 gene is regulated by v-Myb.

Schlichter U, Burk O, Worpenberg S, Klempnauer KH.

Oncogene. 2001 Jan 11;20(2):231-9.

47.

Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin.

Geick A, Eichelbaum M, Burk O.

J Biol Chem. 2001 May 4;276(18):14581-7. Epub 2001 Jan 31.

48.

Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene.

Gellner K, Eiselt R, Hustert E, Arnold H, Koch I, Haberl M, Deglmann CJ, Burk O, Buntefuss D, Escher S, Bishop C, Koebe HG, Brinkmann U, Klenk HP, Kleine K, Meyer UA, Wojnowski L.

Pharmacogenetics. 2001 Mar;11(2):111-21.

PMID:
11266076
49.

CYP3A genetics in drug metabolism.

Eichelbaum M, Burk O.

Nat Med. 2001 Mar;7(3):285-7. No abstract available.

PMID:
11231620
50.

Regulation of human beta-glucuronidase by A23187 and thapsigargin in the hepatoma cell line HepG2.

Sperker B, Tomkiewicz C, Burk O, Barouki R, Kroemer HK.

Mol Pharmacol. 2001 Feb;59(2):177-82.

PMID:
11160851

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