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Calcium Sensors in Neuronal Function and Dysfunction.

Burgoyne RD, Helassa N, McCue HV, Haynes LP.

Cold Spring Harb Perspect Biol. 2019 May 1;11(5). pii: a035154. doi: 10.1101/cshperspect.a035154. Review.


A Caenorhabditis elegans assay of seizure-like activity optimised for identifying antiepileptic drugs and their mechanisms of action.

Wong SQ, Jones A, Dodd S, Grimes D, Barclay JW, Marson AG, Cunliffe VT, Burgoyne RD, Sills GJ, Morgan A.

J Neurosci Methods. 2018 Nov 1;309:132-142. doi: 10.1016/j.jneumeth.2018.09.004. Epub 2018 Sep 3.


α-Methyl-α-phenylsuccinimide ameliorates neurodegeneration in a C. elegans model of TDP-43 proteinopathy.

Wong SQ, Pontifex MG, Phelan MM, Pidathala C, Kraemer BC, Barclay JW, Berry NG, O'Neill PM, Burgoyne RD, Morgan A.

Neurobiol Dis. 2018 Oct;118:40-54. doi: 10.1016/j.nbd.2018.06.013. Epub 2018 Jun 22.


Ethanol Stimulates Locomotion via a Gαs-Signaling Pathway in IL2 Neurons in Caenorhabditis elegans.

Johnson JR, Edwards MR, Davies H, Newman D, Holden W, Jenkins RE, Burgoyne RD, Lucas RJ, Barclay JW.

Genetics. 2017 Nov;207(3):1023-1039. doi: 10.1534/genetics.117.300119. Epub 2017 Sep 26.


Biophysical and functional characterization of hippocalcin mutants responsible for human dystonia.

Helassa N, Antonyuk SV, Lian LY, Haynes LP, Burgoyne RD.

Hum Mol Genet. 2017 Jul 1;26(13):2426-2435. doi: 10.1093/hmg/ddx133.


Phosphorylation of Cysteine String Protein Triggers a Major Conformational Switch.

Patel P, Prescott GR, Burgoyne RD, Lian LY, Morgan A.

Structure. 2016 Aug 2;24(8):1380-1386. doi: 10.1016/j.str.2016.06.009. Epub 2016 Jul 21.


Interaction of ARF-1.1 and neuronal calcium sensor-1 in the control of the temperature-dependency of locomotion in Caenorhabditis elegans.

Todd PA, McCue HV, Haynes LP, Barclay JW, Burgoyne RD.

Sci Rep. 2016 Jul 20;6:30023. doi: 10.1038/srep30023.


Using C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseases.

Chen X, Barclay JW, Burgoyne RD, Morgan A.

Chem Cent J. 2015 Nov 26;9:65. doi: 10.1186/s13065-015-0143-y. eCollection 2015. Review.


Erratum to: Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expression.

Chen X, McCue HV, Wong SQ, Kashyap SS, Kraemer BC, Barclay JW, Burgoyne RD, Morgan A.

Mol Neurodegener. 2015 Oct 23;10:54. doi: 10.1186/s13024-015-0051-6.


Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expression.

Chen X, McCue HV, Wong SQ, Kashyap SS, Kraemer BC, Barclay JW, Burgoyne RD, Morgan A.

Mol Neurodegener. 2015 Sep 29;10:51. doi: 10.1186/s13024-015-0046-3. Erratum in: Mol Neurodegener. 2015;10:54.


Neuronal Calcium Sensor-1 Binds the D2 Dopamine Receptor and G-protein-coupled Receptor Kinase 1 (GRK1) Peptides Using Different Modes of Interactions.

Pandalaneni S, Karuppiah V, Saleem M, Haynes LP, Burgoyne RD, Mayans O, Derrick JP, Lian LY.

J Biol Chem. 2015 Jul 24;290(30):18744-56. doi: 10.1074/jbc.M114.627059. Epub 2015 May 15.


Editorial: Molecular neuroprotection.

Morgan A, Burgoyne RD.

Semin Cell Dev Biol. 2015 Apr;40:105. doi: 10.1016/j.semcdb.2015.04.006. No abstract available.


Cysteine string protein (CSP) and its role in preventing neurodegeneration.

Burgoyne RD, Morgan A.

Semin Cell Dev Biol. 2015 Apr;40:153-9. doi: 10.1016/j.semcdb.2015.03.008. Epub 2015 Mar 21. Review.


Modulation of phosphatidylinositol 4-phosphate levels by CaBP7 controls cytokinesis in mammalian cells.

Rajamanoharan D, McCue HV, Burgoyne RD, Haynes LP.

Mol Biol Cell. 2015 Apr 15;26(8):1428-39. doi: 10.1091/mbc.E14-07-1243. Epub 2015 Feb 25.


Sense and specificity in neuronal calcium signalling.

Burgoyne RD, Haynes LP.

Biochim Biophys Acta. 2015 Sep;1853(9):1921-32. doi: 10.1016/j.bbamcr.2014.10.029. Epub 2014 Nov 4. Review.


Demonstration of binding of neuronal calcium sensor-1 to the cav2.1 p/q-type calcium channel.

Lian LY, Pandalaneni SR, Todd PA, Martin VM, Burgoyne RD, Haynes LP.

Biochemistry. 2014 Sep 30;53(38):6052-62. doi: 10.1021/bi500568v. Epub 2014 Sep 15.


Caenorhabditis elegans dnj-14, the orthologue of the DNAJC5 gene mutated in adult onset neuronal ceroid lipofuscinosis, provides a new platform for neuroprotective drug screening and identifies a SIR-2.1-independent action of resveratrol.

Kashyap SS, Johnson JR, McCue HV, Chen X, Edmonds MJ, Ayala M, Graham ME, Jenn RC, Barclay JW, Burgoyne RD, Morgan A.

Hum Mol Genet. 2014 Nov 15;23(22):5916-27. doi: 10.1093/hmg/ddu316. Epub 2014 Jun 19.


Identification of key structural elements for neuronal calcium sensor-1 function in the regulation of the temperature-dependency of locomotion in C. elegans.

Martin VM, Johnson JR, Haynes LP, Barclay JW, Burgoyne RD.

Mol Brain. 2013 Aug 27;6:39. doi: 10.1186/1756-6606-6-39.


Mutations that disrupt PHOXB interaction with the neuronal calcium sensor HPCAL1 impede cellular differentiation in neuroblastoma.

Wang W, Zhong Q, Teng L, Bhatnagar N, Sharma B, Zhang X, Luther W 2nd, Haynes LP, Burgoyne RD, Vidal M, Volchenboum S, Hill DE, George RE.

Oncogene. 2014 Jun 19;33(25):3316-24. doi: 10.1038/onc.2013.290. Epub 2013 Jul 22.


Generation and characterization of a lysosomally targeted, genetically encoded Ca(2+)-sensor.

McCue HV, Wardyn JD, Burgoyne RD, Haynes LP.

Biochem J. 2013 Jan 15;449(2):449-57. doi: 10.1042/BJ20120898.


Solution NMR structure of the Ca2+-bound N-terminal domain of CaBP7: a regulator of golgi trafficking.

McCue HV, Patel P, Herbert AP, Lian LY, Burgoyne RD, Haynes LP.

J Biol Chem. 2012 Nov 2;287(45):38231-43. doi: 10.1074/jbc.M112.402289. Epub 2012 Sep 18.


Preface. Biochemical, biophysical and genetic approaches to intracellular calcium signalling.

Burgoyne RD, Haynes LP.

Biochim Biophys Acta. 2012 Aug;1820(8):1159. doi: 10.1016/j.bbagen.2012.02.014. No abstract available.


PKC-2 phosphorylation of UNC-18 Ser322 in AFD neurons regulates temperature dependency of locomotion.

Edwards MR, Johnson JR, Rankin K, Jenkins RE, Maguire C, Morgan A, Burgoyne RD, Barclay JW.

J Neurosci. 2012 May 16;32(20):7042-51. doi: 10.1523/JNEUROSCI.4029-11.2012.


Neurotransmitter release mechanisms studied in Caenorhabditis elegans.

Barclay JW, Morgan A, Burgoyne RD.

Cell Calcium. 2012 Sep-Oct;52(3-4):289-95. doi: 10.1016/j.ceca.2012.03.005. Epub 2012 Apr 20. Review.


Evolution and functional diversity of the Calcium Binding Proteins (CaBPs).

Haynes LP, McCue HV, Burgoyne RD.

Front Mol Neurosci. 2012 Feb 21;5:9. doi: 10.3389/fnmol.2012.00009. eCollection 2012 Jan 23.


Understanding the physiological roles of the neuronal calcium sensor proteins.

Burgoyne RD, Haynes LP.

Mol Brain. 2012 Jan 23;5(1):2. doi: 10.1186/1756-6606-5-2. Review.


Characterisation of the interaction of the C-terminus of the dopamine D2 receptor with neuronal calcium sensor-1.

Lian LY, Pandalaneni SR, Patel P, McCue HV, Haynes LP, Burgoyne RD.

PLoS One. 2011;6(11):e27779. doi: 10.1371/journal.pone.0027779. Epub 2011 Nov 16.


Munc18-1 tuning of vesicle merger and fusion pore properties.

Jorgacevski J, Potokar M, Grilc S, Kreft M, Liu W, Barclay JW, Bückers J, Medda R, Hell SW, Parpura V, Burgoyne RD, Zorec R.

J Neurosci. 2011 Jun 15;31(24):9055-66. doi: 10.1523/JNEUROSCI.0185-11.2011.


InsP₃receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences.

Lur G, Sherwood MW, Ebisui E, Haynes L, Feske S, Sutton R, Burgoyne RD, Mikoshiba K, Petersen OH, Tepikin AV.

Biochem J. 2011 Jun 1;436(2):231-9. doi: 10.1042/BJ20110083.


Determination of the membrane topology of the small EF-hand Ca2+-sensing proteins CaBP7 and CaBP8.

McCue HV, Burgoyne RD, Haynes LP.

PLoS One. 2011 Mar 22;6(3):e17853. doi: 10.1371/journal.pone.0017853.


Structure-function study of mammalian Munc18-1 and C. elegans UNC-18 implicates domain 3b in the regulation of exocytosis.

Graham ME, Prescott GR, Johnson JR, Jones M, Walmesley A, Haynes LP, Morgan A, Burgoyne RD, Barclay JW.

PLoS One. 2011 Mar 21;6(3):e17999. doi: 10.1371/journal.pone.0017999.


Chaperoning the SNAREs: a role in preventing neurodegeneration?

Burgoyne RD, Morgan A.

Nat Cell Biol. 2011 Jan;13(1):8-9. doi: 10.1038/ncb0111-8.


Neuronal calcium sensor-1 regulation of calcium channels, secretion, and neuronal outgrowth.

Weiss JL, Hui H, Burgoyne RD.

Cell Mol Neurobiol. 2010 Nov;30(8):1283-92. doi: 10.1007/s10571-010-9588-7. Epub 2010 Nov 23. Review.


Neuronal calcium sensor proteins: emerging roles in membrane traffic and synaptic plasticity.

Burgoyne RD, Haynes LP.

F1000 Biol Rep. 2010 Jan 27;2. pii: 5. doi: 10.3410/B2-5.


Decoding glutamate receptor activation by the Ca2+ sensor protein hippocalcin in rat hippocampal neurons.

Dovgan AV, Cherkas VP, Stepanyuk AR, Fitzgerald DJ, Haynes LP, Tepikin AV, Burgoyne RD, Belan PV.

Eur J Neurosci. 2010 Aug;32(3):347-58. doi: 10.1111/j.1460-9568.2010.07303.x.


The diversity of calcium sensor proteins in the regulation of neuronal function.

McCue HV, Haynes LP, Burgoyne RD.

Cold Spring Harb Perspect Biol. 2010 Aug;2(8):a004085. doi: 10.1101/cshperspect.a004085. Epub 2010 Jul 28. Review.


Evidence for an interaction between Golli and STIM1 in store-operated calcium entry.

Walsh CM, Doherty MK, Tepikin AV, Burgoyne RD.

Biochem J. 2010 Sep 15;430(3):453-60. doi: 10.1042/BJ20100650.


Structural and functional deficits in a neuronal calcium sensor-1 mutant identified in a case of autistic spectrum disorder.

Handley MT, Lian LY, Haynes LP, Burgoyne RD.

PLoS One. 2010 May 7;5(5):e10534. doi: 10.1371/journal.pone.0010534.


Bioinformatic analysis of CaBP/calneuron proteins reveals a family of highly conserved vertebrate Ca2+-binding proteins.

McCue HV, Haynes LP, Burgoyne RD.

BMC Res Notes. 2010 Apr 28;3:118. doi: 10.1186/1756-0500-3-118.


Caenorhabditis elegans: a useful tool to decipher neurodegenerative pathways.

Johnson JR, Jenn RC, Barclay JW, Burgoyne RD, Morgan A.

Biochem Soc Trans. 2010 Apr;38(2):559-63. doi: 10.1042/BST0380559. Review.


Presynaptic targets for acute ethanol sensitivity.

Barclay JW, Graham ME, Edwards MR, Johnson JR, Morgan A, Burgoyne RD.

Biochem Soc Trans. 2010 Feb;38(Pt 1):172-6. doi: 10.1042/BST0380172. Review.


Role of phosphoinositides in STIM1 dynamics and store-operated calcium entry.

Walsh CM, Chvanov M, Haynes LP, Petersen OH, Tepikin AV, Burgoyne RD.

Biochem J. 2009 Dec 14;425(1):159-68. doi: 10.1042/BJ20090884.


Ribosome-free terminals of rough ER allow formation of STIM1 puncta and segregation of STIM1 from IP(3) receptors.

Lur G, Haynes LP, Prior IA, Gerasimenko OV, Feske S, Petersen OH, Burgoyne RD, Tepikin AV.

Curr Biol. 2009 Oct 13;19(19):1648-53. doi: 10.1016/j.cub.2009.07.072. Epub 2009 Sep 17.


Membrane targeting of the EF-hand containing calcium-sensing proteins CaBP7 and CaBP8.

McCue HV, Burgoyne RD, Haynes LP.

Biochem Biophys Res Commun. 2009 Mar 20;380(4):825-31. doi: 10.1016/j.bbrc.2009.01.177. Epub 2009 Feb 4.


The functions of Munc18-1 in regulated exocytosis.

Burgoyne RD, Barclay JW, Ciufo LF, Graham ME, Handley MT, Morgan A.

Ann N Y Acad Sci. 2009 Jan;1152:76-86. doi: 10.1111/j.1749-6632.2008.03987.x.


Binding of UNC-18 to the N-terminus of syntaxin is essential for neurotransmission in Caenorhabditis elegans.

Johnson JR, Ferdek P, Lian LY, Barclay JW, Burgoyne RD, Morgan A.

Biochem J. 2009 Feb 15;418(1):73-80. doi: 10.1042/BJ20081956.


UNC-18 modulates ethanol sensitivity in Caenorhabditis elegans.

Graham ME, Edwards MR, Holden-Dye L, Morgan A, Burgoyne RD, Barclay JW.

Mol Biol Cell. 2009 Jan;20(1):43-55. doi: 10.1091/mbc.E08-07-0689. Epub 2008 Oct 15.

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