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Items: 1 to 50 of 105

1.

Demographic model for inheritable cardiac disease.

Burghardt TP.

Arch Biochem Biophys. 2019 Sep 15;672:108056. doi: 10.1016/j.abb.2019.07.021. Epub 2019 Jul 26.

PMID:
31356777
2.

Cardiac and skeletal actin substrates uniquely tune cardiac myosin strain-dependent mechanics.

Wang Y, Ajtai K, Burghardt TP.

Open Biol. 2018 Nov 21;8(11). pii: 180143. doi: 10.1098/rsob.180143.

3.

Uncured PDMS inhibits myosin in vitro motility in a microfluidic flow cell.

Wang Y, Burghardt TP.

Anal Biochem. 2018 Dec 15;563:56-60. doi: 10.1016/j.ab.2018.10.007. Epub 2018 Oct 6.

PMID:
30300623
4.

Single cardiac ventricular myosins are autonomous motors.

Wang Y, Yuan CC, Kazmierczak K, Szczesna-Cordary D, Burghardt TP.

Open Biol. 2018 Apr;8(4). pii: 170240. doi: 10.1098/rsob.170240.

5.

Neural/Bayes network predictor for inheritable cardiac disease pathogenicity and phenotype.

Burghardt TP, Ajtai K.

J Mol Cell Cardiol. 2018 Jun;119:19-27. doi: 10.1016/j.yjmcc.2018.04.006. Epub 2018 Apr 11.

6.

Auxotonic to isometric contraction transitioning in a beating heart causes myosin step-size to down shift.

Burghardt TP, Sun X, Wang Y, Ajtai K.

PLoS One. 2017 Apr 19;12(4):e0174690. doi: 10.1371/journal.pone.0174690. eCollection 2017.

7.

Hypercontractile mutant of ventricular myosin essential light chain leads to disruption of sarcomeric structure and function and results in restrictive cardiomyopathy in mice.

Yuan CC, Kazmierczak K, Liang J, Kanashiro-Takeuchi R, Irving TC, Gomes AV, Wang Y, Burghardt TP, Szczesna-Cordary D.

Cardiovasc Res. 2017 Aug 1;113(10):1124-1136. doi: 10.1093/cvr/cvx060.

8.

In vitro actin motility velocity varies linearly with the number of myosin impellers.

Wang Y, Burghardt TP.

Arch Biochem Biophys. 2017 Mar 15;618:1-8. doi: 10.1016/j.abb.2017.01.012. Epub 2017 Jan 25.

9.

In vivo myosin step-size from zebrafish skeletal muscle.

Burghardt TP, Ajtai K, Sun X, Takubo N, Wang Y.

Open Biol. 2016 May;6(5). pii: 160075. doi: 10.1098/rsob.160075. Epub 2016 May 25.

10.

In vitro and in vivo single myosin step-sizes in striated muscle.

Burghardt TP, Sun X, Wang Y, Ajtai K.

J Muscle Res Cell Motil. 2015 Dec;36(6):463-77. doi: 10.1007/s10974-015-9440-2. Epub 2016 Jan 4.

11.

N-Terminus of Cardiac Myosin Essential Light Chain Modulates Myosin Step-Size.

Wang Y, Ajtai K, Kazmierczak K, Szczesna-Cordary D, Burghardt TP.

Biochemistry. 2016 Jan 12;55(1):186-98. doi: 10.1021/acs.biochem.5b00817. Epub 2015 Dec 29.

12.

In vivo orientation of single myosin lever arms in zebrafish skeletal muscle.

Sun X, Ekker SC, Shelden EA, Takubo N, Wang Y, Burghardt TP.

Biophys J. 2014 Sep 16;107(6):1403-14. doi: 10.1016/j.bpj.2014.07.055.

13.

Analytical comparison of natural and pharmaceutical ventricular myosin activators.

Wang Y, Ajtai K, Burghardt TP.

Biochemistry. 2014 Aug 19;53(32):5298-306. doi: 10.1021/bi500730t. Epub 2014 Aug 7.

14.

Ventricular myosin modifies in vitro step-size when phosphorylated.

Wang Y, Ajtai K, Burghardt TP.

J Mol Cell Cardiol. 2014 Jul;72:231-7. doi: 10.1016/j.yjmcc.2014.03.022. Epub 2014 Apr 12.

15.

The Qdot-labeled actin super-resolution motility assay measures low-duty cycle muscle myosin step size.

Wang Y, Ajtai K, Burghardt TP.

Biochemistry. 2013 Mar 5;52(9):1611-21. doi: 10.1021/bi301702p. Epub 2013 Feb 21.

16.

Regulatory light chain mutants linked to heart disease modify the cardiac myosin lever arm.

Burghardt TP, Sikkink LA.

Biochemistry. 2013 Feb 19;52(7):1249-59. doi: 10.1021/bi301500d. Epub 2013 Feb 6.

17.

Human Tonic and Phasic Smooth Muscle Myosin Isoforms Are Unresponsive to the Loop 1 Insert.

Ajtai K, Mayanglambam A, Wang Y, Burghardt TP.

ISRN Struct Biol. 2013 Jan 1;2013:634341.

18.

Measuring incidence angle for through-the-objective total internal reflection fluorescence microscopy.

Burghardt TP.

J Biomed Opt. 2012 Dec;17(12):126007. doi: 10.1117/1.JBO.17.12.126007.

19.

Cell biology. Heart brakes.

Burghardt TP, Ajtai K.

Science. 2012 Sep 7;337(6099):1182-3. doi: 10.1126/science.1227943. No abstract available.

PMID:
22955824
20.

Evanescent field shapes excitation profile under axial epi-illumination.

Burghardt TP.

J Biomed Opt. 2012 Jun;17(6):066021. doi: 10.1117/1.JBO.17.6.066021.

21.

Smooth muscle myosin light chain kinase efficiently phosphorylates serine 15 of cardiac myosin regulatory light chain.

Josephson MP, Sikkink LA, Penheiter AR, Burghardt TP, Ajtai K.

Biochem Biophys Res Commun. 2011 Dec 16;416(3-4):367-71. doi: 10.1016/j.bbrc.2011.11.044. Epub 2011 Nov 19.

22.

Single myosin cross-bridge orientation in cardiac papillary muscle detects lever-arm shear strain in transduction.

Burghardt TP, Josephson MP, Ajtai K.

Biochemistry. 2011 Sep 13;50(36):7809-21. doi: 10.1021/bi2008992. Epub 2011 Aug 18.

23.
24.

Single-molecule fluorescence characterization in native environment.

Burghardt TP, Ajtai K.

Biophys Rev. 2010 Dec 1;2(4):159-167.

25.

Myosin individualized: single nucleotide polymorphisms in energy transduction.

Burghardt TP, Neff KL, Wieben ED, Ajtai K.

BMC Genomics. 2010 Mar 15;11:172. doi: 10.1186/1471-2164-11-172.

26.

Around-the-objective total internal reflection fluorescence microscopy.

Burghardt TP, Hipp AD, Ajtai K.

Appl Opt. 2009 Nov 10;48(32):6120-31. doi: 10.1364/AO.48.006120.

27.

Mapping microscope object polarized emission to the back focal plane pattern.

Burghardt TP, Ajtai K.

J Biomed Opt. 2009 May-Jun;14(3):034036. doi: 10.1117/1.3155520.

28.

The myosin C-loop is an allosteric actin contact sensor in actomyosin.

Ajtai K, Halstead MF, Nyitrai M, Penheiter AR, Zheng Y, Burghardt TP.

Biochemistry. 2009 Jun 16;48(23):5263-75. doi: 10.1021/bi900584q.

29.

PDLIM4, an actin binding protein, suppresses prostate cancer cell growth.

Vanaja DK, Grossmann ME, Cheville JC, Gazi MH, Gong A, Zhang JS, Ajtai K, Burghardt TP, Young CY.

Cancer Invest. 2009 Mar;27(3):264-72. doi: 10.1080/07357900802406319.

30.

Single myosin lever arm orientation in a muscle fiber detected with photoactivatable GFP.

Burghardt TP, Li J, Ajtai K.

Biochemistry. 2009 Feb 3;48(4):754-65. doi: 10.1021/bi8017703.

31.

Myosin dynamics on the millisecond time scale.

Burghardt TP, Hu JY, Ajtai K.

Biophys Chem. 2007 Dec;131(1-3):15-28. Epub 2007 Sep 11.

32.

An unusual transduction pathway in human tonic smooth muscle myosin.

Halstead MF, Ajtai K, Penheiter AR, Spencer JD, Zheng Y, Morrison EA, Burghardt TP.

Biophys J. 2007 Nov 15;93(10):3555-66. Epub 2007 Aug 17.

33.

GFP-tagged regulatory light chain monitors single myosin lever-arm orientation in a muscle fiber.

Burghardt TP, Ajtai K, Chan DK, Halstead MF, Li J, Zheng Y.

Biophys J. 2007 Sep 15;93(6):2226-39. Epub 2007 May 18.

34.

Rotation of actin monomers during isometric contraction of skeletal muscle.

Borejdo J, Muthu P, Talent J, Akopova I, Burghardt TP.

J Biomed Opt. 2007 Jan-Feb;12(1):014013.

35.

Solution NMR of acetylcholine binding protein reveals agonist-mediated conformational change of the C-loop.

Gao F, Mer G, Tonelli M, Hansen SB, Burghardt TP, Taylor P, Sine SM.

Mol Pharmacol. 2006 Oct;70(4):1230-5. Epub 2006 Jul 17.

PMID:
16847142
36.
37.

In situ fluorescent protein imaging with metal film-enhanced total internal reflection microscopy.

Burghardt TP, Charlesworth JE, Halstead MF, Tarara JE, Ajtai K.

Biophys J. 2006 Jun 15;90(12):4662-71. Epub 2006 Mar 24.

38.

Rotations of a few cross-bridges in muscle by confocal total internal reflection microscopy.

Borejdo J, Talent J, Akopova I, Burghardt TP.

Biochim Biophys Acta. 2006 Feb;1763(2):137-40. Epub 2005 Dec 20.

39.

Agonist-mediated conformational changes in acetylcholine-binding protein revealed by simulation and intrinsic tryptophan fluorescence.

Gao F, Bren N, Burghardt TP, Hansen S, Henchman RH, Taylor P, McCammon JA, Sine SM.

J Biol Chem. 2005 Mar 4;280(9):8443-51. Epub 2004 Dec 9.

40.

Changes in orientation of actin during contraction of muscle.

Borejdo J, Shepard A, Dumka D, Akopova I, Talent J, Malka A, Burghardt TP.

Biophys J. 2004 Apr;86(4):2308-17.

41.

The myosin cardiac loop participates functionally in the actomyosin interaction.

Ajtai K, Garamszegi SP, Watanabe S, Ikebe M, Burghardt TP.

J Biol Chem. 2004 May 28;279(22):23415-21. Epub 2004 Mar 11.

42.

Cosolvent-induced aggregation inhibits myosin ATPase activity by stabilizing the predominant transition intermediate.

Peyser YM, Shaya S, Ajtai K, Burghardt TP, Muhlrad A.

Biochemistry. 2003 Nov 4;42(43):12669-75.

PMID:
14580214
43.

A novel approach to the characterization of substrate specificity in short/branched chain Acyl-CoA dehydrogenase.

He M, Burghardt TP, Vockley J.

J Biol Chem. 2003 Sep 26;278(39):37974-86. Epub 2003 Jul 10.

44.

Mass spectral determination of skeletal/cardiac actin isoform ratios in cardiac muscle.

Bergen HR 3rd, Ajtai K, Burghardt TP, Nepomuceno AI, Muddiman DC.

Rapid Commun Mass Spectrom. 2003;17(13):1467-71.

PMID:
12820213
45.

Energy transduction optical sensor in skeletal myosin.

Burghardt TP, Park S, Dong WJ, Xing J, Cheung HC, Ajtai K.

Biochemistry. 2003 May 20;42(19):5877-84.

PMID:
12741846
46.

Chemical decoupling of ATPase activation and force production from the contractile cycle in myosin by steric hindrance of lever-arm movement.

Muhlrad A, Peyser YM, Nili M, Ajtai K, Reisler E, Burghardt TP.

Biophys J. 2003 Feb;84(2 Pt 1):1047-56.

47.

Purification and characterization of two polymorphic variants of short chain acyl-CoA dehydrogenase reveal reduction of catalytic activity and stability of the Gly185Ser enzyme.

Nguyen TV, Riggs C, Babovic-Vuksanovic D, Kim YS, Carpenter JF, Burghardt TP, Gregersen N, Vockley J.

Biochemistry. 2002 Sep 17;41(37):11126-33.

PMID:
12220177
48.

Tyrosine mediated tryptophan ATP sensitivity in skeletal myosin.

Park S, Burghardt TP.

Biochemistry. 2002 Feb 5;41(5):1436-44.

PMID:
11814335
49.

Cation-pi interaction in a folded polypeptide.

Burghardt TP, Juranić N, Macura S, Ajtai K.

Biopolymers. 2002 Apr 5;63(4):261-72.

PMID:
11807753
50.

Structural characterization of beta-cardiac myosin subfragment 1 in solution.

Ajtai K, Garamszegi SP, Park S, Velazquez Dones AL, Burghardt TP.

Biochemistry. 2001 Oct 9;40(40):12078-93.

PMID:
11580283

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