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Hip Fracture Discrimination Based on Statistical Multi-parametric Modeling (SMPM).

Carballido-Gamio J, Yu A, Wang L, Su Y, Burghardt AJ, Lang TF, Cheng X.

Ann Biomed Eng. 2019 May 31. doi: 10.1007/s10439-019-02298-x. [Epub ahead of print]


Structural Changes over a Short Period Are Associated with Functional Assessments in Rheumatoid Arthritis.

Shimizu T, Cruz A, Tanaka M, Mamoto K, Pedoia V, Burghardt AJ, Heilmeier U, Link TM, Graf J, Imboden JB, Li X.

J Rheumatol. 2019 Jul;46(7):676-684. doi: 10.3899/jrheum.180496. Epub 2019 Feb 15.


Accelerated Bone Loss in Older Men: Effects on Bone Microarchitecture and Strength.

Cauley JA, Burghardt AJ, Harrison SL, Cawthon PM, Schwartz AV, Connor EB, Ensrud KE, Langsetmo L, Majumdar S, Orwoll E; Osteoporotic Fractures in Men (MrOS) Research Group.

J Bone Miner Res. 2018 Oct;33(10):1859-1869. doi: 10.1002/jbmr.3468. Epub 2018 Jun 12.


Volumetric Bone Mineral Density and Failure Load of Distal Limbs Predict Incident Clinical Fracture Independent HR-pQCT BMD and Failure Load Predicts Incident Clinical Fracture of FRAX and Clinical Risk Factors Among Older Men.

Langsetmo L, Peters KW, Burghardt AJ, Ensrud KE, Fink HA, Cawthon PM, Cauley JA, Schousboe JT, Barrett-Connor E, Orwoll ES; Osteoporotic Fractures in Men (MrOS) Study Research Group.

J Bone Miner Res. 2018 Jul;33(7):1302-1311. doi: 10.1002/jbmr.3433. Epub 2018 May 22.


Weight loss in men in late life and bone strength and microarchitecture: a prospective study.

Ensrud KE, Vo TN, Burghardt AJ, Schousboe JT, Cauley JA, Taylor BC, Hoffman AR, Orwoll ES, Lane NE, Langsetmo L; Osteoporotic Fractures in Men (MrOS) Research Group.

Osteoporos Int. 2018 Jul;29(7):1549-1558. doi: 10.1007/s00198-018-4489-6. Epub 2018 Mar 23.


High dairy protein intake is associated with greater bone strength parameters at the distal radius and tibia in older men: a cross-sectional study.

Langsetmo L, Shikany JM, Burghardt AJ, Cawthon PM, Orwoll ES, Cauley JA, Taylor BC, Schousboe JT, Bauer DC, Vo TN, Ensrud KE; Osteoporotic Fractures in Men (MrOS) Study Research Group.

Osteoporos Int. 2018 Jan;29(1):69-77. doi: 10.1007/s00198-017-4261-3. Epub 2017 Oct 23.


Assessment of 3-month changes in bone microstructure under anti-TNF╬▒ therapy in patients with rheumatoid arthritis using high-resolution peripheral quantitative computed tomography (HR-pQCT).

Shimizu T, Choi HJ, Heilmeier U, Tanaka M, Burghardt AJ, Gong J, Chanchek N, Link TM, Graf J, Imboden JB, Li X.

Arthritis Res Ther. 2017 Oct 4;19(1):222. doi: 10.1186/s13075-017-1430-x.


The SPECTRA Collaboration OMERACT Special Interest Group: Current Research and Future Directions.

Stok KS, Finzel S, Burghardt AJ, Conaghan PG, Barnabe C; SPECTRA Collaboration.

J Rheumatol. 2017 Dec;44(12):1911-1915. doi: 10.3899/jrheum.161197. Epub 2017 Aug 1.


Bone microstructure in men assessed by HR-pQCT: Associations with risk factors and differences between men with normal, low, and osteoporosis-range areal BMD.

Okazaki N, Burghardt AJ, Chiba K, Schafer AL, Majumdar S.

Bone Rep. 2016 Nov 2;5:312-319. doi: 10.1016/j.bonr.2016.10.005. eCollection 2016 Dec.


The comparability of HR-pQCT bone measurements is improved by scanning anatomically standardized regions.

Bonaretti S, Majumdar S, Lang TF, Khosla S, Burghardt AJ.

Osteoporos Int. 2017 Jul;28(7):2115-2128. doi: 10.1007/s00198-017-4010-7. Epub 2017 Apr 8.


Statistical Parametric Mapping of HR-pQCT Images: A Tool for Population-Based Local Comparisons of Micro-Scale Bone Features.

Carballido-Gamio J, Bonaretti S, Kazakia GJ, Khosla S, Majumdar S, Lang TF, Burghardt AJ.

Ann Biomed Eng. 2017 Apr;45(4):949-962. doi: 10.1007/s10439-016-1754-8. Epub 2016 Nov 9.


Operator variability in scan positioning is a major component of HR-pQCT precision error and is reduced by standardized training.

Bonaretti S, Vilayphiou N, Chan CM, Yu A, Nishiyama K, Liu D, Boutroy S, Ghasem-Zadeh A, Boyd SK, Chapurlat R, McKay H, Shane E, Bouxsein ML, Black DM, Majumdar S, Orwoll ES, Lang TF, Khosla S, Burghardt AJ.

Osteoporos Int. 2017 Jan;28(1):245-257. doi: 10.1007/s00198-016-3705-5. Epub 2016 Jul 30.


Serum miRNA Signatures Are Indicative of Skeletal Fractures in Postmenopausal Women With and Without Type 2 Diabetes and Influence Osteogenic and Adipogenic Differentiation of Adipose Tissue-Derived Mesenchymal Stem Cells In Vitro.

Heilmeier U, Hackl M, Skalicky S, Weilner S, Schroeder F, Vierlinger K, Patsch JM, Baum T, Oberbauer E, Lobach I, Burghardt AJ, Schwartz AV, Grillari J, Link TM.

J Bone Miner Res. 2016 Dec;31(12):2173-2192. doi: 10.1002/jbmr.2897. Epub 2016 Sep 26.


Cortical bone laminar analysis reveals increased midcortical and periosteal porosity in type 2 diabetic postmenopausal women with history of fragility fractures compared to fracture-free diabetics.

Heilmeier U, Cheng K, Pasco C, Parrish R, Nirody J, Patsch JM, Zhang CA, Joseph GB, Burghardt AJ, Schwartz AV, Link TM, Kazakia G.

Osteoporos Int. 2016 Sep;27(9):2791-2802. doi: 10.1007/s00198-016-3614-7. Epub 2016 May 6.


Kartogenin treatment prevented joint degeneration in a rodent model of osteoarthritis: A pilot study.

Mohan G, Magnitsky S, Melkus G, Subburaj K, Kazakia G, Burghardt AJ, Dang A, Lane NE, Majumdar S.

J Orthop Res. 2016 Oct;34(10):1780-1789. doi: 10.1002/jor.23197. Epub 2016 Mar 1.


Microarchitecture and Peripheral BMD are Impaired in Postmenopausal White Women With Fracture Independently of Total Hip T-Score: An International Multicenter Study.

Boutroy S, Khosla S, Sornay-Rendu E, Zanchetta MB, McMahon DJ, Zhang CA, Chapurlat RD, Zanchetta J, Stein EM, Bogado C, Majumdar S, Burghardt AJ, Shane E.

J Bone Miner Res. 2016 Jun;31(6):1158-66. doi: 10.1002/jbmr.2796.


Automatic multi-parametric quantification of the proximal femur with quantitative computed tomography.

Carballido-Gamio J, Bonaretti S, Saeed I, Harnish R, Recker R, Burghardt AJ, Keyak JH, Harris T, Khosla S, Lang TF.

Quant Imaging Med Surg. 2015 Aug;5(4):552-68. doi: 10.3978/j.issn.2223-4292.2015.08.02.


Quantitative characterization of metacarpal and radial bone in rheumatoid arthritis using high resolution- peripheral quantitative computed tomography.

Yang H, Yu A, Burghardt AJ, Virayavanich W, Link TM, Imboden JB, Li X.

Int J Rheum Dis. 2017 Mar;20(3):353-362. doi: 10.1111/1756-185X.12558. Epub 2015 Apr 10.


Spatial distribution of intracortical porosity varies across age and sex.

Nirody JA, Cheng KP, Parrish RM, Burghardt AJ, Majumdar S, Link TM, Kazakia GJ.

Bone. 2015 Jun;75:88-95. doi: 10.1016/j.bone.2015.02.006. Epub 2015 Feb 17.


Volumetric femoral BMD, bone geometry, and serum sclerostin levels differ between type 2 diabetic postmenopausal women with and without fragility fractures.

Heilmeier U, Carpenter DR, Patsch JM, Harnish R, Joseph GB, Burghardt AJ, Baum T, Schwartz AV, Lang TF, Link TM.

Osteoporos Int. 2015 Apr;26(4):1283-93. doi: 10.1007/s00198-014-2988-7. Epub 2015 Jan 13.


Validation of bone marrow fat quantification in the presence of trabecular bone using MRI.

Gee CS, Nguyen JT, Marquez CJ, Heunis J, Lai A, Wyatt C, Han M, Kazakia G, Burghardt AJ, Karampinos DC, Carballido-Gamio J, Krug R.

J Magn Reson Imaging. 2015 Aug;42(2):539-44. doi: 10.1002/jmri.24795. Epub 2014 Nov 25.


Novel anthropomorphic hip phantom corrects systemic interscanner differences in proximal femoral vBMD.

Bonaretti S, Carpenter RD, Saeed I, Burghardt AJ, Yu L, Bruesewitz M, Khosla S, Lang T.

Phys Med Biol. 2014 Dec 21;59(24):7819-34. doi: 10.1088/0031-9155/59/24/7819.


Correlation of structural abnormalities of the wrist and metacarpophalangeal joints evaluated by high-resolution peripheral quantitative computed tomography, 3 Tesla magnetic resonance imaging and conventional radiographs in rheumatoid arthritis.

Lee CH, Srikhum W, Burghardt AJ, Virayavanich W, Imboden JB, Link TM, Li X.

Int J Rheum Dis. 2015 Jul;18(6):628-39. doi: 10.1111/1756-185X.12495. Epub 2014 Oct 8.


Improved trabecular bone structure of 20-month-old male spontaneously hypertensive rats.

Lee TC, Burghardt AJ, Yao W, Lane NE, Majumdar S, Gullberg GT, Seo Y.

Calcif Tissue Int. 2014 Sep;95(3):282-91. doi: 10.1007/s00223-014-9893-0. Epub 2014 Aug 9.


Bone structure and perfusion quantification of bone marrow edema pattern in the wrist of patients with rheumatoid arthritis: a multimodality study.

Teruel JR, Burghardt AJ, Rivoire J, Srikhum W, Noworolski SM, Link TM, Imboden JB, Li X.

J Rheumatol. 2014 Sep;41(9):1766-73. doi: 10.3899/jrheum.131564. Epub 2014 Aug 1.


Three-dimensional analysis of subchondral cysts in hip osteoarthritis: an ex vivo HR-pQCT study.

Chiba K, Burghardt AJ, Osaki M, Majumdar S.

Bone. 2014 Sep;66:140-5. doi: 10.1016/j.bone.2014.06.001. Epub 2014 Jun 10.


The influence of disuse on bone microstructure and mechanics assessed by HR-pQCT.

Kazakia GJ, Tjong W, Nirody JA, Burghardt AJ, Carballido-Gamio J, Patsch JM, Link T, Feeley BT, Ma CB.

Bone. 2014 Jun;63:132-40. doi: 10.1016/j.bone.2014.02.014. Epub 2014 Mar 3.


Structural analysis of cortical porosity applied to HR-pQCT data.

Tjong W, Nirody J, Burghardt AJ, Carballido-Gamio J, Kazakia GJ.

Med Phys. 2014 Jan;41(1):013701. doi: 10.1118/1.4851575.


Quantification of lower leg arterial calcifications by high-resolution peripheral quantitative computed tomography.

Patsch JM, Zulliger MA, Vilayphou N, Samelson EJ, Cejka D, Diarra D, Berzaczy G, Burghardt AJ, Link TM, Weber M, Loewe C.

Bone. 2014 Jan;58:42-7. doi: 10.1016/j.bone.2013.08.006. Epub 2013 Aug 14.


Quantitative in vivo HR-pQCT imaging of 3D wrist and metacarpophalangeal joint space width in rheumatoid arthritis.

Burghardt AJ, Lee CH, Kuo D, Majumdar S, Imboden JB, Link TM, Li X.

Ann Biomed Eng. 2013 Dec;41(12):2553-64. doi: 10.1007/s10439-013-0871-x. Epub 2013 Jul 26.


Heterogeneity of bone microstructure in the femoral head in patients with osteoporosis: an ex vivo HR-pQCT study.

Chiba K, Burghardt AJ, Osaki M, Majumdar S.

Bone. 2013 Sep;56(1):139-46. doi: 10.1016/j.bone.2013.05.019. Epub 2013 Jun 6.


Postmenopausal women treated with combination parathyroid hormone (1-84) and ibandronate demonstrate different microstructural changes at the radius vs. tibia: the PTH and Ibandronate Combination Study (PICS).

Schafer AL, Burghardt AJ, Sellmeyer DE, Palermo L, Shoback DM, Majumdar S, Black DM.

Osteoporos Int. 2013 Oct;24(10):2591-601. doi: 10.1007/s00198-013-2349-y. Epub 2013 Apr 16.


High-resolution peripheral quantitative computed tomography for the assessment of bone strength and structure: a review by the Canadian Bone Strength Working Group.

Cheung AM, Adachi JD, Hanley DA, Kendler DL, Davison KS, Josse R, Brown JP, Ste-Marie LG, Kremer R, Erlandson MC, Dian L, Burghardt AJ, Boyd SK.

Curr Osteoporos Rep. 2013 Jun;11(2):136-46. doi: 10.1007/s11914-013-0140-9. Review.


Quantitative and semiquantitative bone erosion assessment on high-resolution peripheral quantitative computed tomography in rheumatoid arthritis.

Srikhum W, Virayavanich W, Burghardt AJ, Yu A, Link TM, Imboden JB, Li X.

J Rheumatol. 2013 Apr;40(4):408-16. doi: 10.3899/jrheum.120780. Epub 2013 Feb 15.


Computational identification and quantification of trabecular microarchitecture classes by 3-D texture analysis-based clustering.

Valentinitsch A, Patsch JM, Burghardt AJ, Link TM, Majumdar S, Fischer L, Schueller-Weidekamm C, Resch H, Kainberger F, Langs G.

Bone. 2013 May;54(1):133-40. doi: 10.1016/j.bone.2012.12.047. Epub 2013 Jan 10.


Age- and gender-related differences in cortical geometry and microstructure: Improved sensitivity by regional analysis.

Kazakia GJ, Nirody JA, Bernstein G, Sode M, Burghardt AJ, Majumdar S.

Bone. 2013 Feb;52(2):623-31. doi: 10.1016/j.bone.2012.10.031. Epub 2012 Nov 7.


Multicenter precision of cortical and trabecular bone quality measures assessed by high-resolution peripheral quantitative computed tomography.

Burghardt AJ, Pialat JB, Kazakia GJ, Boutroy S, Engelke K, Patsch JM, Valentinitsch A, Liu D, Szabo E, Bogado CE, Zanchetta MB, McKay HA, Shane E, Boyd SK, Bouxsein ML, Chapurlat R, Khosla S, Majumdar S.

J Bone Miner Res. 2013 Mar;28(3):524-36. doi: 10.1002/jbmr.1795.


Increased cortical porosity in type 2 diabetic postmenopausal women with fragility fractures.

Patsch JM, Burghardt AJ, Yap SP, Baum T, Schwartz AV, Joseph GB, Link TM.

J Bone Miner Res. 2013 Feb;28(2):313-24. doi: 10.1002/jbmr.1763.


The effect of voxel size on high-resolution peripheral computed tomography measurements of trabecular and cortical bone microstructure.

Tjong W, Kazakia GJ, Burghardt AJ, Majumdar S.

Med Phys. 2012 Apr;39(4):1893-903. doi: 10.1118/1.3689813.


Does vertebral bone marrow fat content correlate with abdominal adipose tissue, lumbar spine bone mineral density, and blood biomarkers in women with type 2 diabetes mellitus?

Baum T, Yap SP, Karampinos DC, Nardo L, Kuo D, Burghardt AJ, Masharani UB, Schwartz AV, Li X, Link TM.

J Magn Reson Imaging. 2012 Jan;35(1):117-24. doi: 10.1002/jmri.22757. Epub 2011 Aug 16.


Noninvasive imaging of bone microarchitecture.

Patsch JM, Burghardt AJ, Kazakia G, Majumdar S.

Ann N Y Acad Sci. 2011 Dec;1240:77-87. doi: 10.1111/j.1749-6632.2011.06282.x. Review.


Vascular patterning and permeability in prostate cancer models with differing osteogenic properties.

Dafni H, Burghardt AJ, Majumdar S, Navone NM, Ronen SM.

NMR Biomed. 2012 Jun;25(6):843-51. doi: 10.1002/nbm.1800. Epub 2011 Dec 2.


Imaging longitudinal changes in articular cartilage and bone following doxycycline treatment in a rabbit anterior cruciate ligament transection model of osteoarthritis.

Pinney JR, Taylor C, Doan R, Burghardt AJ, Li X, Kim HT, Benjamin Ma C, Majumdar S.

Magn Reson Imaging. 2012 Feb;30(2):271-82. doi: 10.1016/j.mri.2011.09.025. Epub 2011 Nov 8.


Visual grading of motion induced image degradation in high resolution peripheral computed tomography: impact of image quality on measures of bone density and micro-architecture.

Pialat JB, Burghardt AJ, Sode M, Link TM, Majumdar S.

Bone. 2012 Jan;50(1):111-8. doi: 10.1016/j.bone.2011.10.003. Epub 2011 Oct 13.


Trabecular reorganization in consecutive iliac crest biopsies when switching from bisphosphonate to strontium ranelate treatment.

Jobke B, Burghardt AJ, Muche B, Hahn M, Semler J, Amling M, Majumdar S, Busse B.

PLoS One. 2011;6(8):e23638. doi: 10.1371/journal.pone.0023638. Epub 2011 Aug 16.


Morphology of the human vertebral endplate.

Rodriguez AG, Rodriguez-Soto AE, Burghardt AJ, Berven S, Majumdar S, Lotz JC.

J Orthop Res. 2012 Feb;30(2):280-7. doi: 10.1002/jor.21513. Epub 2011 Aug 2.


Ultrashort echo time MRI of cortical bone at 7 tesla field strength: a feasibility study.

Krug R, Larson PE, Wang C, Burghardt AJ, Kelley DA, Link TM, Zhang X, Vigneron DB, Majumdar S.

J Magn Reson Imaging. 2011 Sep;34(3):691-5. doi: 10.1002/jmri.22648. Epub 2011 Jul 18.


Teriparatide in bisphosphonate-resistant osteoporosis: microarchitectural changes and clinical results after 6 and 18 months.

Jobke B, Muche B, Burghardt AJ, Semler J, Link TM, Majumdar S.

Calcif Tissue Int. 2011 Aug;89(2):130-9. doi: 10.1007/s00223-011-9500-6. Epub 2011 May 28.


Quantitative characterization of subject motion in HR-pQCT images of the distal radius and tibia.

Sode M, Burghardt AJ, Pialat JB, Link TM, Majumdar S.

Bone. 2011 Jun 1;48(6):1291-7. doi: 10.1016/j.bone.2011.03.755. Epub 2011 Mar 21.

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