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The roles of fission yeast exonuclease 5 in nuclear and mitochondrial genome stability.

Sparks JL, Gerik KJ, Stith CM, Yoder BL, Burgers PM.

DNA Repair (Amst). 2019 Sep 21;83:102720. doi: 10.1016/j.dnarep.2019.102720. [Epub ahead of print]


Complementary roles of Pif1 helicase and single stranded DNA binding proteins in stimulating DNA replication through G-quadruplexes.

Sparks MA, Singh SP, Burgers PM, Galletto R.

Nucleic Acids Res. 2019 Jul 24. pii: gkz608. doi: 10.1093/nar/gkz608. [Epub ahead of print]


Activation of Tel1ATM kinase requires Rad50 ATPase and long nucleosome-free DNA but no DNA ends.

Hailemariam S, Kumar S, Burgers PM.

J Biol Chem. 2019 Jun 28;294(26):10120-10130. doi: 10.1074/jbc.RA119.008410. Epub 2019 May 9.


Solution to the 50-year-old Okazaki-fragment problem.

Burgers PM.

Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3358-3360. doi: 10.1073/pnas.1900372116. Epub 2019 Feb 15. No abstract available.


PCNA accelerates the nucleotide incorporation rate by DNA polymerase δ.

Mondol T, Stodola JL, Galletto R, Burgers PM.

Nucleic Acids Res. 2019 Feb 28;47(4):1977-1986. doi: 10.1093/nar/gky1321.


Mechanism of Lagging-Strand DNA Replication in Eukaryotes.

Stodola JL, Burgers PM.

Adv Exp Med Biol. 2017;1042:117-133. doi: 10.1007/978-981-10-6955-0_6. Review.


A Redox Role for the [4Fe4S] Cluster of Yeast DNA Polymerase δ.

Bartels PL, Stodola JL, Burgers PMJ, Barton JK.

J Am Chem Soc. 2017 Dec 20;139(50):18339-18348. doi: 10.1021/jacs.7b10284. Epub 2017 Dec 6.


Eukaryotic DNA Replication Fork.

Burgers PMJ, Kunkel TA.

Annu Rev Biochem. 2017 Jun 20;86:417-438. doi: 10.1146/annurev-biochem-061516-044709. Epub 2017 Mar 1. Review.


Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrations.

Kochenova OV, Bezalel-Buch R, Tran P, Makarova AV, Chabes A, Burgers PM, Shcherbakova PV.

Nucleic Acids Res. 2017 Feb 17;45(3):1200-1218. doi: 10.1093/nar/gkw1149.


Oxidative DNA damage stalls the human mitochondrial replisome.

Stojkovič G, Makarova AV, Wanrooij PH, Forslund J, Burgers PM, Wanrooij S.

Sci Rep. 2016 Jul 1;6:28942. doi: 10.1038/srep28942.


Parallel analysis of ribonucleotide-dependent deletions produced by yeast Top1 in vitro and in vivo.

Cho JE, Huang SY, Burgers PM, Shuman S, Pommier Y, Jinks-Robertson S.

Nucleic Acids Res. 2016 Sep 19;44(16):7714-21. doi: 10.1093/nar/gkw495. Epub 2016 Jun 1.


The Dimeric Architecture of Checkpoint Kinases Mec1ATR and Tel1ATM Reveal a Common Structural Organization.

Sawicka M, Wanrooij PH, Darbari VC, Tannous E, Hailemariam S, Bose D, Makarova AV, Burgers PM, Zhang X.

J Biol Chem. 2016 Jun 24;291(26):13436-47. doi: 10.1074/jbc.M115.708263. Epub 2016 Apr 28.


Proficient Replication of the Yeast Genome by a Viral DNA Polymerase.

Stodola JL, Stith CM, Burgers PM.

J Biol Chem. 2016 May 27;291(22):11698-705. doi: 10.1074/jbc.M116.728741. Epub 2016 Apr 12.


Resolving individual steps of Okazaki-fragment maturation at a millisecond timescale.

Stodola JL, Burgers PM.

Nat Struct Mol Biol. 2016 May;23(5):402-8. doi: 10.1038/nsmb.3207. Epub 2016 Apr 11.


Pif1 removes a Rap1-dependent barrier to the strand displacement activity of DNA polymerase δ.

Koc KN, Singh SP, Stodola JL, Burgers PM, Galletto R.

Nucleic Acids Res. 2016 May 5;44(8):3811-9. doi: 10.1093/nar/gkw181. Epub 2016 Mar 21.


Who Is Leading the Replication Fork, Pol ε or Pol δ?

Burgers PMJ, Gordenin D, Kunkel TA.

Mol Cell. 2016 Feb 18;61(4):492-493. doi: 10.1016/j.molcel.2016.01.017. No abstract available.


Probing the Mec1ATR Checkpoint Activation Mechanism with Small Peptides.

Wanrooij PH, Tannous E, Kumar S, Navadgi-Patil VM, Burgers PM.

J Biol Chem. 2016 Jan 1;291(1):393-401. doi: 10.1074/jbc.M115.687145. Epub 2015 Oct 23.


Yet another job for Dna2: Checkpoint activation.

Wanrooij PH, Burgers PM.

DNA Repair (Amst). 2015 Aug;32:17-23. doi: 10.1016/j.dnarep.2015.04.009. Epub 2015 May 1. Review.


Regulation of yeast DNA polymerase δ-mediated strand displacement synthesis by 5'-flaps.

Koc KN, Stodola JL, Burgers PM, Galletto R.

Nucleic Acids Res. 2015 Apr 30;43(8):4179-90. doi: 10.1093/nar/gkv260. Epub 2015 Mar 26.


Error-free and mutagenic processing of topoisomerase 1-provoked damage at genomic ribonucleotides.

Sparks JL, Burgers PM.

EMBO J. 2015 May 5;34(9):1259-69. doi: 10.15252/embj.201490868. Epub 2015 Mar 16.


Evidence that processing of ribonucleotides in DNA by topoisomerase 1 is leading-strand specific.

Williams JS, Clausen AR, Lujan SA, Marjavaara L, Clark AB, Burgers PM, Chabes A, Kunkel TA.

Nat Struct Mol Biol. 2015 Apr;22(4):291-7. doi: 10.1038/nsmb.2989. Epub 2015 Mar 9.


Eukaryotic DNA polymerase ζ.

Makarova AV, Burgers PM.

DNA Repair (Amst). 2015 May;29:47-55. doi: 10.1016/j.dnarep.2015.02.012. Epub 2015 Feb 19. Review.


Sequential switching of binding partners on PCNA during in vitro Okazaki fragment maturation.

Dovrat D, Stodola JL, Burgers PM, Aharoni A.

Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):14118-23. doi: 10.1073/pnas.1321349111. Epub 2014 Sep 16.


Delivering nonidentical twins.

Kunkel TA, Burgers PM.

Nat Struct Mol Biol. 2014 Aug;21(8):649-51. doi: 10.1038/nsmb.2852. Epub 2014 Jul 6. No abstract available.


Error-prone replication bypass of the primary aflatoxin B1 DNA adduct, AFB1-N7-Gua.

Lin YC, Li L, Makarova AV, Burgers PM, Stone MP, Lloyd RS.

J Biol Chem. 2014 Jun 27;289(26):18497-506. doi: 10.1074/jbc.M114.561563. Epub 2014 May 16.


Ribonucleotide incorporation by yeast DNA polymerase ζ.

Makarova AV, Nick McElhinny SA, Watts BE, Kunkel TA, Burgers PM.

DNA Repair (Amst). 2014 Jun;18:63-7. doi: 10.1016/j.dnarep.2014.02.017. Epub 2014 Mar 24.


Molecular basis of aflatoxin-induced mutagenesis-role of the aflatoxin B1-formamidopyrimidine adduct.

Lin YC, Li L, Makarova AV, Burgers PM, Stone MP, Lloyd RS.

Carcinogenesis. 2014 Jul;35(7):1461-8. doi: 10.1093/carcin/bgu003. Epub 2014 Jan 7.


DNA polymerases ζ and Rev1 mediate error-prone bypass of non-B DNA structures.

Northam MR, Moore EA, Mertz TM, Binz SK, Stith CM, Stepchenkova EI, Wendt KL, Burgers PM, Shcherbakova PV.

Nucleic Acids Res. 2014 Jan;42(1):290-306. doi: 10.1093/nar/gkt830. Epub 2013 Sep 18.


RNase H2 roles in genome integrity revealed by unlinking its activities.

Chon H, Sparks JL, Rychlik M, Nowotny M, Burgers PM, Crouch RJ, Cerritelli SM.

Nucleic Acids Res. 2013 Mar 1;41(5):3130-43. doi: 10.1093/nar/gkt027. Epub 2013 Jan 25.


Lagging strand maturation factor Dna2 is a component of the replication checkpoint initiation machinery.

Kumar S, Burgers PM.

Genes Dev. 2013 Feb 1;27(3):313-21. doi: 10.1101/gad.204750.112. Epub 2013 Jan 25.


Ribonucleotide incorporation, proofreading and bypass by human DNA polymerase δ.

Clausen AR, Zhang S, Burgers PM, Lee MY, Kunkel TA.

DNA Repair (Amst). 2013 Feb 1;12(2):121-7. doi: 10.1016/j.dnarep.2012.11.006. Epub 2012 Dec 12.


Human exonuclease 5 is a novel sliding exonuclease required for genome stability.

Sparks JL, Kumar R, Singh M, Wold MS, Pandita TK, Burgers PM.

J Biol Chem. 2012 Dec 14;287(51):42773-83. doi: 10.1074/jbc.M112.422444. Epub 2012 Oct 24.


A four-subunit DNA polymerase ζ complex containing Pol δ accessory subunits is essential for PCNA-mediated mutagenesis.

Makarova AV, Stodola JL, Burgers PM.

Nucleic Acids Res. 2012 Dec;40(22):11618-26. doi: 10.1093/nar/gks948. Epub 2012 Oct 12.


RNase H2-initiated ribonucleotide excision repair.

Sparks JL, Chon H, Cerritelli SM, Kunkel TA, Johansson E, Crouch RJ, Burgers PM.

Mol Cell. 2012 Sep 28;47(6):980-6. doi: 10.1016/j.molcel.2012.06.035. Epub 2012 Aug 2.


RNase H and postreplication repair protect cells from ribonucleotides incorporated in DNA.

Lazzaro F, Novarina D, Amara F, Watt DL, Stone JE, Costanzo V, Burgers PM, Kunkel TA, Plevani P, Muzi-Falconi M.

Mol Cell. 2012 Jan 13;45(1):99-110. doi: 10.1016/j.molcel.2011.12.019.


Eukaryotic DNA polymerases require an iron-sulfur cluster for the formation of active complexes.

Netz DJ, Stith CM, Stümpfig M, Köpf G, Vogel D, Genau HM, Stodola JL, Lill R, Burgers PM, Pierik AJ.

Nat Chem Biol. 2011 Nov 27;8(1):125-32. doi: 10.1038/nchembio.721.


The unstructured C-terminal tail of yeast Dpb11 (human TopBP1) protein is dispensable for DNA replication and the S phase checkpoint but required for the G2/M checkpoint.

Navadgi-Patil VM, Kumar S, Burgers PM.

J Biol Chem. 2011 Nov 25;286(47):40999-1007. doi: 10.1074/jbc.M111.283994. Epub 2011 Sep 28.


It's all about flaps: Dna2 and checkpoint activation.

Burgers PM.

Cell Cycle. 2011 Aug 1;10(15):2417-8. Epub 2011 Aug 1. No abstract available.


Replication of ribonucleotide-containing DNA templates by yeast replicative polymerases.

Watt DL, Johansson E, Burgers PM, Kunkel TA.

DNA Repair (Amst). 2011 Aug 15;10(8):897-902. doi: 10.1016/j.dnarep.2011.05.009. Epub 2011 Jun 23.


Lesion bypass by S. cerevisiae Pol ζ alone.

Stone JE, Kumar D, Binz SK, Inase A, Iwai S, Chabes A, Burgers PM, Kunkel TA.

DNA Repair (Amst). 2011 Aug 15;10(8):826-34. doi: 10.1016/j.dnarep.2011.04.032. Epub 2011 May 31.


Cell-cycle-specific activators of the Mec1/ATR checkpoint kinase.

Navadgi-Patil VM, Burgers PM.

Biochem Soc Trans. 2011 Apr;39(2):600-5. doi: 10.1042/BST0390600. Review.


An alternative pathway for Okazaki fragment processing: resolution of fold-back flaps by Pif1 helicase.

Pike JE, Henry RA, Burgers PM, Campbell JL, Bambara RA.

J Biol Chem. 2010 Dec 31;285(53):41712-23. doi: 10.1074/jbc.M110.146894. Epub 2010 Oct 19.


Pre-Steady-State Kinetic Analysis of Truncated and Full-Length Saccharomyces cerevisiae DNA Polymerase Eta.

Brown JA, Zhang L, Sherrer SM, Taylor JS, Burgers PM, Suo Z.

J Nucleic Acids. 2010 Jul 25;2010. pii: 871939. doi: 10.4061/2010/871939.


Break-induced replication requires all essential DNA replication factors except those specific for pre-RC assembly.

Lydeard JR, Lipkin-Moore Z, Sheu YJ, Stillman B, Burgers PM, Haber JE.

Genes Dev. 2010 Jun 1;24(11):1133-44. doi: 10.1101/gad.1922610.


Abundant ribonucleotide incorporation into DNA by yeast replicative polymerases.

Nick McElhinny SA, Watts BE, Kumar D, Watt DL, Lundström EB, Burgers PM, Johansson E, Chabes A, Kunkel TA.

Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):4949-54. doi: 10.1073/pnas.0914857107. Epub 2010 Mar 1.


Parallel multiplicative target screening against divergent bacterial replicases: identification of specific inhibitors with broad spectrum potential.

Dallmann HG, Fackelmayer OJ, Tomer G, Chen J, Wiktor-Becker A, Ferrara T, Pope C, Oliveira MT, Burgers PM, Kaguni LS, McHenry CS.

Biochemistry. 2010 Mar 23;49(11):2551-62. doi: 10.1021/bi9020764.


Yeast exonuclease 5 is essential for mitochondrial genome maintenance.

Burgers PM, Stith CM, Yoder BL, Sparks JL.

Mol Cell Biol. 2010 Mar;30(6):1457-66. doi: 10.1128/MCB.01321-09. Epub 2010 Jan 19.


The unstructured C-terminal tail of the 9-1-1 clamp subunit Ddc1 activates Mec1/ATR via two distinct mechanisms.

Navadgi-Patil VM, Burgers PM.

Mol Cell. 2009 Dec 11;36(5):743-53. doi: 10.1016/j.molcel.2009.10.014.


PCNA is required for initiation of recombination-associated DNA synthesis by DNA polymerase delta.

Li X, Stith CM, Burgers PM, Heyer WD.

Mol Cell. 2009 Nov 25;36(4):704-13. doi: 10.1016/j.molcel.2009.09.036.

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