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Items: 28

1.

Identification and biochemical analyses of selective CB2 agonists.

Scott CE, Tang Y, Alt A, Burford NT, Gerritz SW, Ogawa LM, Zhang L, Kendall DA.

Eur J Pharmacol. 2019 Jul 5;854:1-8. doi: 10.1016/j.ejphar.2019.03.054. Epub 2019 Apr 3.

PMID:
30951717
2.

Discovery of Selective Cannabinoid CB2 Receptor Agonists by High-Throughput Screening.

Ogawa LM, Burford NT, Liao YH, Scott CE, Hine AM, Dowling C, Chin J, Power M, Hunnicutt EJ Jr, Emerick VL, Banks M, Zhang L, Gerritz SW, Alt A, Kendall DA.

SLAS Discov. 2018 Apr;23(4):375-383. doi: 10.1177/2472555217748403. Epub 2017 Dec 19.

3.

Pharmacologic Evidence for a Putative Conserved Allosteric Site on Opioid Receptors.

Livingston KE, Stanczyk MA, Burford NT, Alt A, Canals M, Traynor JR.

Mol Pharmacol. 2018 Feb;93(2):157-167. doi: 10.1124/mol.117.109561. Epub 2017 Dec 12.

4.

Standard Curves Are Necessary to Determine Pharmacological Properties for Ligands in Functional Assays Using Competition Binding Technologies.

Burford NT, Watson J, Alt A.

Assay Drug Dev Technol. 2017 Oct/Nov;15(7):320-329. doi: 10.1089/adt.2017.811.

PMID:
29120673
5.

Endogenous opioids regulate moment-to-moment neuronal communication and excitability.

Winters BL, Gregoriou GC, Kissiwaa SA, Wells OA, Medagoda DI, Hermes SM, Burford NT, Alt A, Aicher SA, Bagley EE.

Nat Commun. 2017 Mar 22;8:14611. doi: 10.1038/ncomms14611.

6.

Evidence for Classical Cholinergic Toxicity Associated with Selective Activation of M1 Muscarinic Receptors.

Alt A, Pendri A, Bertekap RL Jr, Li G, Benitex Y, Nophsker M, Rockwell KL, Burford NT, Sum CS, Chen J, Herbst JJ, Ferrante M, Hendricson A, Cvijic ME, Westphal RS, O'Connell J, Banks M, Zhang L, Gentles RG, Jenkins S, Loy J, Macor JE.

J Pharmacol Exp Ther. 2016 Feb;356(2):293-304. doi: 10.1124/jpet.115.226910. Epub 2015 Nov 18.

PMID:
26582730
7.

Ligand-Based Discovery of a New Scaffold for Allosteric Modulation of the μ-Opioid Receptor.

Bisignano P, Burford NT, Shang Y, Marlow B, Livingston KE, Fenton AM, Rockwell K, Budenholzer L, Traynor JR, Gerritz SW, Alt A, Filizola M.

J Chem Inf Model. 2015 Sep 28;55(9):1836-43. doi: 10.1021/acs.jcim.5b00388. Epub 2015 Sep 15.

8.

High-Throughput Screening for Allosteric Modulators of GPCRs.

Bertekap RL Jr, Burford NT, Li Z, Alt A.

Methods Mol Biol. 2015;1335:223-40. doi: 10.1007/978-1-4939-2914-6_15.

PMID:
26260604
9.

Discovery, synthesis, and molecular pharmacology of selective positive allosteric modulators of the δ-opioid receptor.

Burford NT, Livingston KE, Canals M, Ryan MR, Budenholzer LM, Han Y, Shang Y, Herbst JJ, O'Connell J, Banks M, Zhang L, Filizola M, Bassoni DL, Wehrman TS, Christopoulos A, Traynor JR, Gerritz SW, Alt A.

J Med Chem. 2015 May 28;58(10):4220-9. doi: 10.1021/acs.jmedchem.5b00007. Epub 2015 May 7.

10.

Identification of selective agonists and positive allosteric modulators for µ- and δ-opioid receptors from a single high-throughput screen.

Burford NT, Wehrman T, Bassoni D, O'Connell J, Banks M, Zhang L, Alt A.

J Biomol Screen. 2014 Oct;19(9):1255-65. doi: 10.1177/1087057114542975. Epub 2014 Jul 21.

PMID:
25047277
11.

Positive allosteric modulators of the μ-opioid receptor: a novel approach for future pain medications.

Burford NT, Traynor JR, Alt A.

Br J Pharmacol. 2015 Jan;172(2):277-86. doi: 10.1111/bph.12599. Epub 2014 Jul 1. Review.

12.

Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor.

Burford NT, Clark MJ, Wehrman TS, Gerritz SW, Banks M, O'Connell J, Traynor JR, Alt A.

Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10830-5. doi: 10.1073/pnas.1300393110. Epub 2013 Jun 10.

13.

Development of a high-throughput calcium flux assay for identification of all ligand types including positive, negative, and silent allosteric modulators for G protein-coupled receptors.

Noblin DJ, Bertekap RL Jr, Burford NT, Hendricson A, Zhang L, Knox R, Banks M, O'Connell J, Alt A.

Assay Drug Dev Technol. 2012 Oct;10(5):457-67. doi: 10.1089/adt.2011.443. Epub 2012 Jun 29.

PMID:
22746835
14.

Identification and optimization of small molecule antagonists of vasoactive intestinal peptide receptor-1 (VIPR1).

Harikrishnan LS, Srivastava N, Kayser LE, Nirschl DS, Kumaragurubaran K, Roy A, Gupta A, Karmakar S, Karatt T, Mathur A, Burford NT, Chen J, Kong Y, Cvijic M, Cooper CB, Poss MA, Trainor GL, Wong TW.

Bioorg Med Chem Lett. 2012 Mar 15;22(6):2287-90. doi: 10.1016/j.bmcl.2012.01.082. Epub 2012 Feb 2.

PMID:
22365758
15.

Solid phase synthesis of 1,5-diarylpyrazole-4-carboxamides: discovery of antagonists of the CB-1 receptor.

Pendri A, Dodd DS, Chen J, Cvijic ME, Kang L, Baska RA, Carlson KE, Burford NT, Sun C, Ewing WR, Gerritz SW.

ACS Comb Sci. 2012 Mar 12;14(3):197-204. doi: 10.1021/co200147y. Epub 2012 Feb 16.

PMID:
22340081
16.

Strategies for the identification of allosteric modulators of G-protein-coupled receptors.

Burford NT, Watson J, Bertekap R, Alt A.

Biochem Pharmacol. 2011 Mar 15;81(6):691-702. doi: 10.1016/j.bcp.2010.12.012. Epub 2010 Dec 22. Review.

PMID:
21184747
17.

Discovery of pyrazine carboxamide CB1 antagonists: the introduction of a hydroxyl group improves the pharmaceutical properties and in vivo efficacy of the series.

Ellsworth BA, Wang Y, Zhu Y, Pendri A, Gerritz SW, Sun C, Carlson KE, Kang L, Baska RA, Yang Y, Huang Q, Burford NT, Cullen MJ, Johnghar S, Behnia K, Pelleymounter MA, Washburn WN, Ewing WR.

Bioorg Med Chem Lett. 2007 Jul 15;17(14):3978-82. Epub 2007 Apr 29.

PMID:
17513109
18.

Discovery of a potent and novel motilin agonist.

Li JJ, Chao HG, Wang H, Tino JA, Lawrence RM, Ewing WR, Ma Z, Yan M, Slusarchyk D, Seethala R, Sun H, Li D, Burford NT, Stoffel RH, Salyan ME, Li CY, Witkus M, Zhao N, Rich A, Gordon DA.

J Med Chem. 2004 Mar 25;47(7):1704-8.

PMID:
15027861
19.

G-protein coupling of mu-opioid receptors (OP3): elevated basal signalling activity.

Burford NT, Wang D, Sadée W.

Biochem J. 2000 Jun 15;348 Pt 3:531-7.

20.

Specific G protein activation and mu-opioid receptor internalization caused by morphine, DAMGO and endomorphin I.

Burford NT, Tolbert LM, Sadee W.

Eur J Pharmacol. 1998 Jan 19;342(1):123-6.

PMID:
9544801
21.

A constitutively internalizing and recycling mutant of the mu-opioid receptor.

Segredo V, Burford NT, Lameh J, Sadée W.

J Neurochem. 1997 Jun;68(6):2395-404.

22.

Binding and activity of the nine possible regioisomers of myo-inositol tetrakisphosphate at the inositol 1,4,5-trisphosphate receptor.

Burford NT, Nahorski SR, Chung SK, Chang YT, Wilcox RA.

Cell Calcium. 1997 Apr;21(4):301-10.

PMID:
9160166
23.
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28.

Muscarinic receptor subtypes: inositol phosphates and intracellular calcium.

Lambert DG, Burford NT, Nahorski SR.

Biochem Soc Trans. 1992 Feb;20(1):130-5. Review. No abstract available.

PMID:
1633938

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