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Items: 1 to 50 of 183

1.

A Novel Role for Cathepsin S as a Potential Biomarker in Triple Negative Breast Cancer.

Wilkinson RDA, Burden RE, McDowell SH, McArt DG, McQuaid S, Bingham V, Williams R, Cox ÓT, O'Connor R, McCabe N, Kennedy RD, Buckley NE, Scott CJ.

J Oncol. 2019 Jun 27;2019:3980273. doi: 10.1155/2019/3980273. eCollection 2019.

2.

Application of nanotechnology to target and exploit tumour associated proteases.

Cogo F, Williams R, Burden RE, Scott CJ.

Biochimie. 2019 Nov;166:112-131. doi: 10.1016/j.biochi.2019.04.021. Epub 2019 Apr 25. Review.

PMID:
31029743
3.

Identification and SAR exploration of a novel series of Legumain inhibitors.

Eddie SL, Gregson A, Graham E, Burton S, Harrison T, Burden R, Scott CJ, Mullan PB, Williams R.

Bioorg Med Chem Lett. 2019 Jun 15;29(12):1546-1548. doi: 10.1016/j.bmcl.2019.03.019. Epub 2019 Mar 29.

PMID:
31005445
4.

Biomarkers in elite sport: Where innovations in technology and application combine.

Burden RJ, Pedlar CR, Lewis NA.

Exp Physiol. 2019 Mar;104(3):275-277. doi: 10.1113/EP087556. Epub 2019 Jan 16. No abstract available.

PMID:
30614574
5.

Development of an advanced nanoformulation for the intracellular delivery of a caspase-3 selective activity-based probe.

Cogo F, Poreba M, Rut W, Groborz K, Smyth P, Johnston MC, Williams R, Longley DB, Burden RE, Salvesen GS, Drag M, Scott CJ.

Nanoscale. 2019 Jan 3;11(2):742-751. doi: 10.1039/c8nr07859a.

PMID:
30566168
6.

USP17 is required for trafficking and oncogenic signaling of mutant EGFR in NSCLC cells.

McCann AP, Smyth P, Cogo F, McDaid WJ, Jiang L, Lin J, Evergren E, Burden RE, Van Schaeybroeck S, Scott CJ, Burrows JF.

Cell Commun Signal. 2018 Nov 8;16(1):77. doi: 10.1186/s12964-018-0291-5.

7.

Discovery of two skin-derived dermaseptins and design of a TAT-fusion analogue with broad-spectrum antimicrobial activity and low cytotoxicity on healthy cells.

Zhu H, Ding X, Li W, Lu T, Ma C, Xi X, Wang L, Zhou M, Burden R, Chen T.

PeerJ. 2018 Sep 19;6:e5635. doi: 10.7717/peerj.5635. eCollection 2018.

8.

Understanding Iron Deficiency and Exercise: Looking Beyond Ferritin.

Burden RJ, Pedlar CR.

Acta Haematol. 2018;139(3):183-184. doi: 10.1159/000487583. Epub 2018 Apr 5. No abstract available.

9.

Iron balance and iron supplementation for the female athlete: A practical approach.

Pedlar CR, Brugnara C, Bruinvels G, Burden R.

Eur J Sport Sci. 2018 Mar;18(2):295-305. doi: 10.1080/17461391.2017.1416178. Epub 2017 Dec 27. Review.

PMID:
29280410
10.

Validation of whole-blood transcriptome signature during microdose recombinant human erythropoietin (rHuEpo) administration.

Wang G, Durussel J, Shurlock J, Mooses M, Fuku N, Bruinvels G, Pedlar C, Burden R, Murray A, Yee B, Keenan A, McClure JD, Sottas PE, Pitsiladis YP.

BMC Genomics. 2017 Nov 14;18(Suppl 8):817. doi: 10.1186/s12864-017-4191-7.

11.

Alterations in Redox Homeostasis During Recovery From Unexplained Underperformance Syndrome in an Elite International Rower.

Lewis NA, Redgrave A, Homer M, Burden R, Martinson W, Moore B, Pedlar CR.

Int J Sports Physiol Perform. 2018 Jan 1;13(1):107-111. doi: 10.1123/ijspp.2016-0777. Epub 2018 Jan 18.

PMID:
28422588
12.

Sport, exercise and the menstrual cycle: where is the research?

Bruinvels G, Burden RJ, McGregor AJ, Ackerman KE, Dooley M, Richards T, Pedlar C.

Br J Sports Med. 2017 Mar;51(6):487-488. doi: 10.1136/bjsports-2016-096279. Epub 2016 Jun 6. No abstract available.

PMID:
27267895
13.

Extracellular cathepsin S and intracellular caspase 1 activation are surrogate biomarkers of particulate-induced lysosomal disruption in macrophages.

Hughes CS, Colhoun LM, Bains BK, Kilgour JD, Burden RE, Burrows JF, Lavelle EC, Gilmore BF, Scott CJ.

Part Fibre Toxicol. 2016 Apr 23;13:19. doi: 10.1186/s12989-016-0129-5.

14.

A bioavailable cathepsin S nitrile inhibitor abrogates tumor development.

Wilkinson RD, Young A, Burden RE, Williams R, Scott CJ.

Mol Cancer. 2016 Apr 21;15:29. doi: 10.1186/s12943-016-0513-7.

15.

Critical Difference and Biological Variation in Biomarkers of Oxidative Stress and Nutritional Status in Athletes.

Lewis NA, Newell J, Burden R, Howatson G, Pedlar CR.

PLoS One. 2016 Mar 1;11(3):e0149927. doi: 10.1371/journal.pone.0149927. eCollection 2016.

16.

The Prevalence and Impact of Heavy Menstrual Bleeding (Menorrhagia) in Elite and Non-Elite Athletes.

Bruinvels G, Burden R, Brown N, Richards T, Pedlar C.

PLoS One. 2016 Feb 22;11(2):e0149881. doi: 10.1371/journal.pone.0149881. eCollection 2016.

17.

The application of a novel, cell permeable activity-based probe for the detection of cysteine cathepsins.

Hughes CS, Shaw G, Burden RE, Scott CJ, Gilmore BF.

Biochem Biophys Res Commun. 2016 Apr 8;472(3):444-50. doi: 10.1016/j.bbrc.2016.01.062. Epub 2016 Jan 12.

PMID:
26792724
18.

The prevalence and impact of heavy menstrual bleeding among athletes and mass start runners of the 2015 London Marathon.

Bruinvels G, Burden R, Brown N, Richards T, Pedlar C.

Br J Sports Med. 2016 May;50(9):566. doi: 10.1136/bjsports-2015-095505. Epub 2015 Nov 26. No abstract available.

PMID:
26612843
19.

Development of a potent and selective cell penetrant Legumain inhibitor.

Ness KA, Eddie SL, Higgins CA, Templeman A, D'Costa Z, Gaddale KK, Bouzzaoui S, Jordan L, Janssen D, Harrison T, Burkamp F, Young A, Burden R, Scott CJ, Mullan PB, Williams R.

Bioorg Med Chem Lett. 2015 Dec 1;25(23):5642-5. doi: 10.1016/j.bmcl.2015.10.001. Epub 2015 Oct 9.

PMID:
26522952
20.

CCL2 is transcriptionally controlled by the lysosomal protease cathepsin S in a CD74-dependent manner.

Wilkinson RD, Magorrian SM, Williams R, Young A, Small DM, Scott CJ, Burden RE.

Oncotarget. 2015 Oct 6;6(30):29725-39. doi: 10.18632/oncotarget.5065.

21.

Polyaxial Screws in Locked Plating of Tibial Pilon Fractures.

Yenna ZC, Bhadra AK, Ojike NI, Burden RL, Voor MJ, Roberts CS.

Orthopedics. 2015 Aug;38(8):e663-7. doi: 10.3928/01477447-20150804-51.

PMID:
26270750
22.

Strategies for detection and quantification of cysteine cathepsins-evolution from bench to bedside.

Hughes CS, Burden RE, Gilmore BF, Scott CJ.

Biochimie. 2016 Mar;122:48-61. doi: 10.1016/j.biochi.2015.07.029. Epub 2015 Aug 4. Review.

PMID:
26253694
23.

In situ comparison of varying composite tibial tunnel interference screws used for ACL soft tissue graft fixation.

Nyland J, Krupp R, Greene J, Bowles R, Burden R, Caborn DN.

Knee. 2015 Dec;22(6):554-8. doi: 10.1016/j.knee.2015.03.009. Epub 2015 Jun 16.

PMID:
26092113
24.

Cathepsin S: therapeutic, diagnostic, and prognostic potential.

Wilkinson RD, Williams R, Scott CJ, Burden RE.

Biol Chem. 2015 Aug;396(8):867-82. doi: 10.1515/hsz-2015-0114. Review.

25.

Effect of Intravenous Iron on Aerobic Capacity and Iron Metabolism in Elite Athletes.

Burden RJ, Pollock N, Whyte GP, Richards T, Moore B, Busbridge M, Srai SK, Otto J, Pedlar CR.

Med Sci Sports Exerc. 2015 Jul;47(7):1399-407. doi: 10.1249/MSS.0000000000000568.

PMID:
25386711
26.

Is iron treatment beneficial in, iron-deficient but non-anaemic (IDNA) endurance athletes? A systematic review and meta-analysis.

Burden RJ, Morton K, Richards T, Whyte GP, Pedlar CR.

Br J Sports Med. 2015 Nov;49(21):1389-97. doi: 10.1136/bjsports-2014-093624. Epub 2014 Oct 31. Review.

PMID:
25361786
27.

Eight weeks of intermittent hypoxic training improves submaximal physiological variables in highly trained runners.

Holliss BA, Burden RJ, Jones AM, Pedlar CR.

J Strength Cond Res. 2014 Aug;28(8):2195-203. doi: 10.1519/JSC.0000000000000406.

PMID:
24513622
28.

The development of an experimental multiple serogroups vaccine for Neisseria meningitidis.

Pinto VB, Burden R, Wagner A, Moran EE, Lee CH.

PLoS One. 2013 Nov 14;8(11):e79304. doi: 10.1371/journal.pone.0079304. eCollection 2013.

29.

Outside-in continuous suturing is superior to interrupted suturing for repairing peripheral meniscus lesions: an in vitro biomechanical study using a porcine model.

Breland R, Nyland J, Lee YH, Culy D, Burden R, Caborn D.

Arthroscopy. 2013 Dec;29(12):1974-80. doi: 10.1016/j.arthro.2013.08.026. Epub 2013 Oct 18.

PMID:
24140141
30.

Progressive resistance, whole body long-axis rotational training improves kicking motion motor performance.

Nyland J, Love M, Burden R, Krupp R, Caborn DN.

Phys Ther Sport. 2014 Feb;15(1):26-32. doi: 10.1016/j.ptsp.2013.01.003. Epub 2013 May 1.

PMID:
23643048
31.

Exposure to phthalic acid, phthalate diesters and phthalate monoesters from foodstuffs: UK total diet study results.

Bradley EL, Burden RA, Bentayeb K, Driffield M, Harmer N, Mortimer DN, Speck DR, Ticha J, Castle L.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2013;30(4):735-42. doi: 10.1080/19440049.2013.781684. Epub 2013 May 3.

PMID:
23641808
32.

Cathepsin S from both tumor and tumor-associated cells promote cancer growth and neovascularization.

Small DM, Burden RE, Jaworski J, Hegarty SM, Spence S, Burrows JF, McFarlane C, Kissenpfennig A, McCarthy HO, Johnston JA, Walker B, Scott CJ.

Int J Cancer. 2013 Nov;133(9):2102-12. doi: 10.1002/ijc.28238. Epub 2013 May 29.

33.

Determination of phthalate diesters in foods.

Bradley EL, Burden RA, Leon I, Mortimer DN, Speck DR, Castle L.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2013;30(4):722-34. doi: 10.1080/19440049.2013.781683. Epub 2013 Apr 24.

PMID:
23614781
34.

Repair of peripheral vertical meniscus lesions in porcine menisci: in vitro biomechanical testing of 3 different meniscus repair devices.

Lee YH, Nyland J, Burden R, Caborn DN.

Am J Sports Med. 2013 May;41(5):1074-81. doi: 10.1177/0363546513479775. Epub 2013 Mar 8.

PMID:
23475943
35.

A case study of an iron-deficient female Olympic 1500-m runner.

Pedlar CR, Whyte GP, Burden R, Moore B, Horgan G, Pollock N.

Int J Sports Physiol Perform. 2013 Nov;8(6):695-8. Epub 2013 Feb 20. Erratum in: Int J Sports Physiol Perform. 2014 Jan;9(1):187.

PMID:
23436684
36.

Cyclic test comparison of all-inside device and inside-out sutures for radial meniscus lesion repair: an in vitro porcine model study.

Lee YH, Nyland J, Burden R, Caborn DN.

Arthroscopy. 2012 Dec;28(12):1873-81. doi: 10.1016/j.arthro.2012.06.015. Epub 2012 Oct 22.

PMID:
23085200
37.

Analysis of the bactericidal response to an experimental Neisseria meningitidis vesicle vaccine.

Moran EE, Burden R, Labrie JE 3rd, Wen Z, Wang XM, Zollinger WD, Zhang L, Pinto VB.

Clin Vaccine Immunol. 2012 May;19(5):659-65. doi: 10.1128/CVI.00070-12. Epub 2012 Mar 29. Erratum in: Clin Vaccine Immunol. 2012 Oct;19(10)1705.

38.

Bone loss following spinal cord injury in a rat model.

Voor MJ, Brown EH, Xu Q, Waddell SW, Burden RL Jr, Burke DA, Magnuson DS.

J Neurotrauma. 2012 May 20;29(8):1676-82. doi: 10.1089/neu.2011.2037. Epub 2012 Feb 22.

39.

Antibody targeting of Cathepsin S induces antibody-dependent cellular cytotoxicity.

Kwok HF, Buick RJ, Kuehn D, Gormley JA, Doherty D, Jaquin TJ, McClurg A, Ward C, Byrne T, Jaworski J, Leung KL, Snoddy P, McAnally C, Burden RE, Gray B, Lowry J, Sermadiras I, Gruszka N, Courtenay-Luck N, Kissenpfennig A, Scott CJ, Johnston JA, Olwill SA.

Mol Cancer. 2011 Dec 14;10:147. doi: 10.1186/1476-4598-10-147.

40.

Recent advances in the application of antibodies as therapeutics.

Burden RE, Caswell J, Fay F, Scott CJ.

Future Med Chem. 2012 Jan;4(1):73-86. doi: 10.4155/fmc.11.165. Review.

PMID:
22168165
41.

The effects of ionized and nonionized compression garments on sprint and endurance cycling.

Burden RJ, Glaister M.

J Strength Cond Res. 2012 Oct;26(10):2837-43.

PMID:
22124356
42.

The role of Cathepsin S as a marker of prognosis and predictor of chemotherapy benefit in adjuvant CRC: a pilot study.

Gormley JA, Hegarty SM, O'Grady A, Stevenson MR, Burden RE, Barrett HL, Scott CJ, Johnston JA, Wilson RH, Kay EW, Johnston PG, Olwill SA.

Br J Cancer. 2011 Nov 8;105(10):1487-94. doi: 10.1038/bjc.2011.408. Epub 2011 Oct 11.

43.

Cysteine cathepsins S and L modulate anti-angiogenic activities of human endostatin.

Veillard F, Saidi A, Burden RE, Scott CJ, Gillet L, Lecaille F, Lalmanach G.

J Biol Chem. 2011 Oct 28;286(43):37158-67. doi: 10.1074/jbc.M111.284869. Epub 2011 Sep 6.

44.

Inhibition of Cathepsin S by Fsn0503 enhances the efficacy of chemotherapy in colorectal carcinomas.

Burden RE, Gormley JA, Kuehn D, Ward C, Kwok HF, Gazdoiu M, McClurg A, Jaquin TJ, Johnston JA, Scott CJ, Olwill SA.

Biochimie. 2012 Feb;94(2):487-93. doi: 10.1016/j.biochi.2011.08.017. Epub 2011 Aug 31.

PMID:
21896304
45.

An experimental outer membrane vesicle vaccine from N. meningitidis serogroup B strains that induces serum bactericidal activity to multiple serogroups.

Pinto VB, Moran EE, Cruz F, Wang XM, Fridman A, Zollinger WD, Przysiecki CT, Burden R.

Vaccine. 2011 Oct 13;29(44):7752-8. doi: 10.1016/j.vaccine.2011.07.124. Epub 2011 Aug 7.

PMID:
21827811
46.

Stable expression and purification of a functional processed Fab' fragment from a single nascent polypeptide in CHO cells expressing the mCAT-1 retroviral receptor.

Camper N, Byrne T, Burden RE, Lowry J, Gray B, Johnston JA, Migaud ME, Olwill SA, Buick RJ, Scott CJ.

J Immunol Methods. 2011 Sep 30;372(1-2):30-41. doi: 10.1016/j.jim.2011.06.029. Epub 2011 Jul 19.

PMID:
21782818
47.

Xenograft bone inclusion improves incorporation of hydroxyapatite cement into cancellous defects.

Voor MJ, Yoder EM, Burden RL Jr.

J Orthop Trauma. 2011 Aug;25(8):483-7. doi: 10.1097/BOT.0b013e318224a3c2.

PMID:
21738066
48.

Anterolateral and medial locking plate stiffness in distal tibial fracture model.

Yenna ZC, Bhadra AK, Ojike NI, ShahulHameed A, Burden RL, Voor MJ, Roberts CS.

Foot Ankle Int. 2011 Jun;32(6):630-7. doi: 10.3113/FAI.2011.0630.

PMID:
21733427
49.

Ionic catch and release oligosaccharide synthesis (ICROS).

Tran AT, Burden R, Racys DT, Galan MC.

Chem Commun (Camb). 2011 Apr 21;47(15):4526-8. doi: 10.1039/c0cc05580h. Epub 2011 Mar 9.

PMID:
21390376
50.

A phase 1 study of a meningococcal native outer membrane vesicle vaccine made from a group B strain with deleted lpxL1 and synX, over-expressed factor H binding protein, two PorAs and stabilized OpcA expression.

Keiser PB, Biggs-Cicatelli S, Moran EE, Schmiel DH, Pinto VB, Burden RE, Miller LB, Moon JE, Bowden RA, Cummings JF, Zollinger WD.

Vaccine. 2011 Feb 4;29(7):1413-20. doi: 10.1016/j.vaccine.2010.12.039. Epub 2011 Jan 1.

PMID:
21199704

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