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Pharmacometabolomics of Meglumine Antimoniate in Patients With Cutaneous Leishmaniasis.

Vargas DA, Prieto MD, Martínez-Valencia AJ, Cossio A, Burgess KEV, Burchmore RJS, Gómez MA.

Front Pharmacol. 2019 Jun 20;10:657. doi: 10.3389/fphar.2019.00657. eCollection 2019.


Blood serum acute phase proteins and iron dynamics during acute phase response of Salmonella enterica serotype Dublin experimentally infected buffalo calves.

Santana AM, Silva DG, Thomas FC, Bernardes PA, Pizauro LJL, Santana CH, Burchmore RJS, Eckersall PD, Fagliari JJ.

Vet Immunol Immunopathol. 2018 Sep;203:30-39. doi: 10.1016/j.vetimm.2018.07.014. Epub 2018 Aug 4.


Vascular Nox (NADPH Oxidase) Compartmentalization, Protein Hyperoxidation, and Endoplasmic Reticulum Stress Response in Hypertension.

Camargo LL, Harvey AP, Rios FJ, Tsiropoulou S, Da Silva RNO, Cao Z, Graham D, McMaster C, Burchmore RJ, Hartley RC, Bulleid N, Montezano AC, Touyz RM.

Hypertension. 2018 Jul;72(1):235-246. doi: 10.1161/HYPERTENSIONAHA.118.10824. Epub 2018 May 29.


Reference 1D and 2D electrophoresis maps for potential disease related proteins in milk whey from lactating buffaloes and blood serum from buffalo calves (Water buffalo, Bubalus bubalis).

Santana AM, Thomas FC, Silva DG, McCulloch E, Vidal AMC, Burchmore RJS, Fagliari JJ, Eckersall PD.

Res Vet Sci. 2018 Jun;118:449-465. doi: 10.1016/j.rvsc.2018.04.010. Epub 2018 Apr 26.


Deletion of transketolase triggers a stringent metabolic response in promastigotes and loss of virulence in amastigotes of Leishmania mexicana.

Kovářová J, Pountain AW, Wildridge D, Weidt S, Bringaud F, Burchmore RJS, Achcar F, Barrett MP.

PLoS Pathog. 2018 Mar 19;14(3):e1006953. doi: 10.1371/journal.ppat.1006953. eCollection 2018 Mar.


Rapid changes in Atlantic grey seal milk from birth to weaning - immune factors and indicators of metabolic strain.

Lowe AD, Bawazeer S, Watson DG, McGill S, Burchmore RJS, Pomeroy PPP, Kennedy MW.

Sci Rep. 2017 Nov 23;7(1):16093. doi: 10.1038/s41598-017-16187-7.


Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana.

Mwenechanya R, Kovářová J, Dickens NJ, Mudaliar M, Herzyk P, Vincent IM, Weidt SK, Burgess KE, Burchmore RJS, Pountain AW, Smith TK, Creek DJ, Kim DH, Lepesheva GI, Barrett MP.

PLoS Negl Trop Dis. 2017 Jun 16;11(6):e0005649. doi: 10.1371/journal.pntd.0005649. eCollection 2017 Jun.


The effect of microbial challenge on the intestinal proteome of broiler chickens.

O'Reilly EL, Burchmore RJ, Sparks NH, Eckersall PD.

Proteome Sci. 2017 May 30;15:10. doi: 10.1186/s12953-017-0118-0. eCollection 2016.


Pulse of inflammatory proteins in the pregnant uterus of European polecats (Mustela putorius) leading to the time of implantation.

Lindeberg H, Burchmore RJ, Kennedy MW.

R Soc Open Sci. 2017 Mar 22;4(3):161085. doi: 10.1098/rsos.161085. eCollection 2017 Mar.


Trypanosoma cruzi contains two galactokinases; molecular and biochemical characterization.

Lobo-Rojas ÁE, González-Marcano EB, Valera-Vera EA, Acosta HR, Quiñones WA, Burchmore RJ, Concepción JL, Cáceres AJ.

Parasitol Int. 2016 Oct;65(5 Pt A):472-82. doi: 10.1016/j.parint.2016.06.008. Epub 2016 Jun 14.


PNT1 Is a C11 Cysteine Peptidase Essential for Replication of the Trypanosome Kinetoplast.

Grewal JS, McLuskey K, Das D, Myburgh E, Wilkes J, Brown E, Lemgruber L, Gould MK, Burchmore RJ, Coombs GH, Schnaufer A, Mottram JC.

J Biol Chem. 2016 Apr 29;291(18):9492-500. doi: 10.1074/jbc.M116.714972. Epub 2016 Mar 3.


Prolonged transition time between colostrum and mature milk in a bear, the giant panda, Ailuropoda melanoleuca.

Griffiths K, Hou R, Wang H, Zhang Z, Zhang L, Zhang T, Watson DG, Burchmore RJ, Loeffler IK, Kennedy MW.

R Soc Open Sci. 2015 Oct 21;2(10):150395. doi: 10.1098/rsos.150395. eCollection 2015 Oct.


Serially coupling hydrophobic interaction and reversed-phase chromatography with simultaneous gradients provides greater coverage of the metabolome.

Haggarty J, Oppermann M, Dalby MJ, Burchmore RJ, Cook K, Weidt S, Burgess KE.

Metabolomics. 2015;11(5):1465-1470. Epub 2015 Jan 11.


Structure of protease-cleaved Escherichia coli α-2-macroglobulin reveals a putative mechanism of conformational activation for protease entrapment.

Fyfe CD, Grinter R, Josts I, Mosbahi K, Roszak AW, Cogdell RJ, Wall DM, Burchmore RJ, Byron O, Walker D.

Acta Crystallogr D Biol Crystallogr. 2015 Jul;71(Pt 7):1478-86. doi: 10.1107/S1399004715008548. Epub 2015 Jun 30.


The metabolic enzyme AdhE controls the virulence of Escherichia coli O157:H7.

Beckham KS, Connolly JP, Ritchie JM, Wang D, Gawthorne JA, Tahoun A, Gally DL, Burgess K, Burchmore RJ, Smith BO, Beatson SA, Byron O, Wolfe AJ, Douce GR, Roe AJ.

Mol Microbiol. 2014 Jul;93(1):199-211. doi: 10.1111/mmi.12651. Epub 2014 Jun 9.


Handling uncertainty in dynamic models: the pentose phosphate pathway in Trypanosoma brucei.

Kerkhoven EJ, Achcar F, Alibu VP, Burchmore RJ, Gilbert IH, Trybiło M, Driessen NN, Gilbert D, Breitling R, Bakker BM, Barrett MP.

PLoS Comput Biol. 2013;9(12):e1003371. doi: 10.1371/journal.pcbi.1003371. Epub 2013 Dec 5.


Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs.

Munday JC, Eze AA, Baker N, Glover L, Clucas C, Aguinaga Andrés D, Natto MJ, Teka IA, McDonald J, Lee RS, Graf FE, Ludin P, Burchmore RJ, Turner CM, Tait A, MacLeod A, Mäser P, Barrett MP, Horn D, De Koning HP.

J Antimicrob Chemother. 2014 Mar;69(3):651-63. doi: 10.1093/jac/dkt442. Epub 2013 Nov 13.


The serum proteome of Atlantic salmon, Salmo salar, during pancreas disease (PD) following infection with salmonid alphavirus subtype 3 (SAV3).

Braceland M, Bickerdike R, Tinsley J, Cockerill D, Mcloughlin MF, Graham DA, Burchmore RJ, Weir W, Wallace C, Eckersall PD.

J Proteomics. 2013 Dec 6;94:423-36. doi: 10.1016/j.jprot.2013.10.016. Epub 2013 Oct 18.


The threonine degradation pathway of the Trypanosoma brucei procyclic form: the main carbon source for lipid biosynthesis is under metabolic control.

Millerioux Y, Ebikeme C, Biran M, Morand P, Bouyssou G, Vincent IM, Mazet M, Riviere L, Franconi JM, Burchmore RJ, Moreau P, Barrett MP, Bringaud F.

Mol Microbiol. 2013 Oct;90(1):114-29. doi: 10.1111/mmi.12351. Epub 2013 Aug 25.


Proteomics as a tool to explore human milk in health and disease.

Roncada P, Stipetic LH, Bonizzi L, Burchmore RJ, Kennedy MW.

J Proteomics. 2013 Aug 2;88:47-57. doi: 10.1016/j.jprot.2013.04.008. Epub 2013 Apr 13. Review.


Characterisation of the normal canine serum proteome using a novel electrophoretic technique combined with mass spectrometry.

Atherton MJ, Braceland M, Harvie J, Burchmore RJ, Eadie S, Eckersall PD, Morris JS.

Vet J. 2013 Jun;196(3):315-9. doi: 10.1016/j.tvjl.2012.12.011. Epub 2013 Jan 29.


Changes in the serum proteome of canine lymphoma identified by electrophoresis and mass spectrometry.

Atherton MJ, Braceland M, Fontaine S, Waterston MM, Burchmore RJ, Eadie S, Eckersall PD, Morris JS.

Vet J. 2013 Jun;196(3):320-4. doi: 10.1016/j.tvjl.2012.12.010. Epub 2013 Jan 29.


'Transient' genetic suppression facilitates generation of hexose transporter null mutants in Leishmania mexicana.

Feng X, Rodriguez-Contreras D, Polley T, Lye LF, Scott D, Burchmore RJ, Beverley SM, Landfear SM.

Mol Microbiol. 2013 Jan;87(2):412-29. doi: 10.1111/mmi.12106. Epub 2012 Dec 10.


Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against Trypanosoma brucei.

Vincent IM, Creek DJ, Burgess K, Woods DJ, Burchmore RJ, Barrett MP.

PLoS Negl Trop Dis. 2012;6(5):e1618. doi: 10.1371/journal.pntd.0001618. Epub 2012 May 1.


Drug resistance in human African trypanosomiasis.

Barrett MP, Vincent IM, Burchmore RJ, Kazibwe AJ, Matovu E.

Future Microbiol. 2011 Sep;6(9):1037-47. doi: 10.2217/fmb.11.88. Review.


Outer membrane protein A of bovine and ovine isolates of Mannheimia haemolytica is surface exposed and contains host species-specific epitopes.

Hounsome JD, Baillie S, Noofeli M, Riboldi-Tunnicliffe A, Burchmore RJ, Isaacs NW, Davies RL.

Infect Immun. 2011 Nov;79(11):4332-41. doi: 10.1128/IAI.05469-11. Epub 2011 Sep 6.


Protein Expression of STRO-1 Cells in Response to Different Topographic Features.

Kantawong F, Robertson ME, Gadegaard N, Oreffo RO, Burchmore RJ, Dalby MJ.

J Tissue Eng. 2011;2011:534603. doi: 10.4061/2011/534603. Epub 2011 Jul 3.


Agarose gel serum protein electrophoresis in cats with and without lymphoma and preliminary results of tandem mass fingerprinting analysis.

Gerou-Ferriani M, McBrearty AR, Burchmore RJ, Jayawardena KG, Eckersall PD, Morris JS.

Vet Clin Pathol. 2011 Jun;40(2):159-73. doi: 10.1111/j.1939-165X.2011.00310.x. Epub 2011 May 10.


Trypanocidal furamidine analogues: influence of pyridine nitrogens on trypanocidal activity, transport kinetics, and resistance patterns.

Ward CP, Wong PE, Burchmore RJ, de Koning HP, Barrett MP.

Antimicrob Agents Chemother. 2011 May;55(5):2352-61. doi: 10.1128/AAC.01551-10. Epub 2011 Mar 14.


A molecular mechanism for eflornithine resistance in African trypanosomes.

Vincent IM, Creek D, Watson DG, Kamleh MA, Woods DJ, Wong PE, Burchmore RJ, Barrett MP.

PLoS Pathog. 2010 Nov 24;6(11):e1001204. doi: 10.1371/journal.ppat.1001204.


A fluorescence-based assay for the uptake of CPD0801 (DB829) by African trypanosomes.

Ward CP, Burgess KE, Burchmore RJ, Barrett MP, de Koning HP.

Mol Biochem Parasitol. 2010 Dec;174(2):145-9. doi: 10.1016/j.molbiopara.2010.07.002. Epub 2010 Jul 15.


A glucose transporter can mediate ribose uptake: definition of residues that confer substrate specificity in a sugar transporter.

Naula CM, Logan FJ, Wong PE, Barrett MP, Burchmore RJ.

J Biol Chem. 2010 Sep 24;285(39):29721-8. doi: 10.1074/jbc.M110.106815. Epub 2010 Jul 2. Erratum in: J Biol Chem. 2011 Mar 11;286(10):8708. Logan, Flora M [corrected to Logan, Flora J].


Multiple genetic mechanisms lead to loss of functional TbAT1 expression in drug-resistant trypanosomes.

Stewart ML, Burchmore RJ, Clucas C, Hertz-Fowler C, Brooks K, Tait A, Macleod A, Turner CM, De Koning HP, Wong PE, Barrett MP.

Eukaryot Cell. 2010 Feb;9(2):336-43. doi: 10.1128/EC.00200-09. Epub 2009 Dec 4.


Identification of promoter-binding proteins of the fbp A and C genes in Mycobacterium tuberculosis.

Romero IC, Mehaffy C, Burchmore RJ, Dobos-Elder K, Brennan P, Walker J.

Tuberculosis (Edinb). 2010 Jan;90(1):25-30. doi: 10.1016/ Epub 2009 Dec 3.


Whole proteome analysis of osteoprogenitor differentiation induced by disordered nanotopography and mediated by ERK signalling.

Kantawong F, Burgess KE, Jayawardena K, Hart A, Burchmore RJ, Gadegaard N, Oreffo RO, Dalby MJ.

Biomaterials. 2009 Sep;30(27):4723-31. doi: 10.1016/j.biomaterials.2009.05.040. Epub 2009 Jun 26.


Metabolomic profiling using Orbitrap Fourier transform mass spectrometry with hydrophilic interaction chromatography: a method with wide applicability to analysis of biomolecules.

Kamleh A, Barrett MP, Wildridge D, Burchmore RJ, Scheltema RA, Watson DG.

Rapid Commun Mass Spectrom. 2008 Jun;22(12):1912-8. doi: 10.1002/rcm.3564.


Characterisation of the plasma membrane subproteome of bloodstream form Trypanosoma brucei.

Bridges DJ, Pitt AR, Hanrahan O, Brennan K, Voorheis HP, Herzyk P, de Koning HP, Burchmore RJ.

Proteomics. 2008 Jan;8(1):83-99.


A new erythrose 4-phosphate dehydrogenase coupled assay for transketolase.

Naula C, Alibu VP, Brock JM, Veitch NJ, Burchmore RJ, Barrett MP.

J Biochem Biophys Methods. 2008 Apr 24;70(6):1185-7. Epub 2007 Nov 12.


Loss of the high-affinity pentamidine transporter is responsible for high levels of cross-resistance between arsenical and diamidine drugs in African trypanosomes.

Bridges DJ, Gould MK, Nerima B, Mäser P, Burchmore RJ, de Koning HP.

Mol Pharmacol. 2007 Apr;71(4):1098-108. Epub 2007 Jan 18.


Detection of arsenical drug resistance in Trypanosoma brucei with a simple fluorescence test.

Stewart ML, Krishna S, Burchmore RJ, Brun R, de Koning HP, Boykin DW, Tidwell RR, Hall JE, Barrett MP.

Lancet. 2005 Aug 6-12;366(9484):486-7.


Purine and pyrimidine transport in pathogenic protozoa: from biology to therapy.

de Koning HP, Bridges DJ, Burchmore RJ.

FEMS Microbiol Rev. 2005 Nov;29(5):987-1020. Epub 2005 Jul 1. Review.


The trypanocide diminazene aceturate is accumulated predominantly through the TbAT1 purine transporter: additional insights on diamidine resistance in african trypanosomes.

de Koning HP, Anderson LF, Stewart M, Burchmore RJ, Wallace LJ, Barrett MP.

Antimicrob Agents Chemother. 2004 May;48(5):1515-9.


The trypanosomiases.

Barrett MP, Burchmore RJ, Stich A, Lazzari JO, Frasch AC, Cazzulo JJ, Krishna S.

Lancet. 2003 Nov 1;362(9394):1469-80. Review.


Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei.

Matovu E, Stewart ML, Geiser F, Brun R, Mäser P, Wallace LJ, Burchmore RJ, Enyaru JC, Barrett MP, Kaminsky R, Seebeck T, de Koning HP.

Eukaryot Cell. 2003 Oct;2(5):1003-8.


Pentose phosphate metabolism in Leishmania mexicana.

Maugeri DA, Cazzulo JJ, Burchmore RJ, Barrett MP, Ogbunude PO.

Mol Biochem Parasitol. 2003 Aug 31;130(2):117-25.


Cloning, heterologous expression, and in situ characterization of the first high affinity nucleobase transporter from a protozoan.

Burchmore RJ, Wallace LJ, Candlish D, Al-Salabi MI, Beal PR, Barrett MP, Baldwin SA, de Koning HP.

J Biol Chem. 2003 Jun 27;278(26):23502-7. Epub 2003 Apr 21.


Genetic characterization of glucose transporter function in Leishmania mexicana.

Burchmore RJ, Rodriguez-Contreras D, McBride K, Merkel P, Barrett MP, Modi G, Sacks D, Landfear SM.

Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3901-6. Epub 2003 Mar 21. Erratum in: Proc Natl Acad Sci U S A. 2003 May 13;100(10):6287.


Sleeping sickness and the brain.

Enanga B, Burchmore RJ, Stewart ML, Barrett MP.

Cell Mol Life Sci. 2002 May;59(5):845-58. Review.


Chemotherapy of human African trypanosomiasis.

Burchmore RJ, Ogbunude PO, Enanga B, Barrett MP.

Curr Pharm Des. 2002;8(4):256-67. Review.


Life in vacuoles--nutrient acquisition by Leishmania amastigotes.

Burchmore RJ, Barrett MP.

Int J Parasitol. 2001 Oct;31(12):1311-20. Review.


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