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Items: 50


O-linked mucin-type glycosylation in breast cancer.

Burchell JM, Beatson R, Graham R, Taylor-Papadimitriou J, Tajadura-Ortega V.

Biochem Soc Trans. 2018 Aug 20;46(4):779-788. doi: 10.1042/BST20170483. Epub 2018 Jun 14. Review.


Latest developments in MUC1 immunotherapy.

Taylor-Papadimitriou J, Burchell JM, Graham R, Beatson R.

Biochem Soc Trans. 2018 Jun 19;46(3):659-668. doi: 10.1042/BST20170400. Epub 2018 May 21. Review.


Repurposing Tin Mesoporphyrin as an Immune Checkpoint Inhibitor Shows Therapeutic Efficacy in Preclinical Models of Cancer.

Muliaditan T, Opzoomer JW, Caron J, Okesola M, Kosti P, Lall S, Van Hemelrijck M, Dazzi F, Tutt A, Grigoriadis A, Gillett CE, Madden SF, Burchell JM, Kordasti S, Diebold SS, Spicer JF, Arnold JN.

Clin Cancer Res. 2018 Apr 1;24(7):1617-1628. doi: 10.1158/1078-0432.CCR-17-2587. Epub 2018 Jan 16.


The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9.

Beatson R, Tajadura-Ortega V, Achkova D, Picco G, Tsourouktsoglou TD, Klausing S, Hillier M, Maher J, Noll T, Crocker PR, Taylor-Papadimitriou J, Burchell JM.

Nat Immunol. 2016 Nov;17(11):1273-1281. doi: 10.1038/ni.3552. Epub 2016 Sep 5.


Two E-selectin ligands, BST-2 and LGALS3BP, predict metastasis and poor survival of ER-negative breast cancer.

Woodman N, Pinder SE, Tajadura V, Le Bourhis X, Gillett C, Delannoy P, Burchell JM, Julien S.

Int J Oncol. 2016 Jul;49(1):265-75. doi: 10.3892/ijo.2016.3521. Epub 2016 May 13.


The Breast Cancer-Associated Glycoforms of MUC1, MUC1-Tn and sialyl-Tn, Are Expressed in COSMC Wild-Type Cells and Bind the C-Type Lectin MGL.

Beatson R, Maurstad G, Picco G, Arulappu A, Coleman J, Wandell HH, Clausen H, Mandel U, Taylor-Papadimitriou J, Sletmoen M, Burchell JM.

PLoS One. 2015 May 7;10(5):e0125994. doi: 10.1371/journal.pone.0125994. eCollection 2015.


Microvesicle cargo of tumor-associated MUC1 to dendritic cells allows cross-presentation and specific carbohydrate processing.

Rughetti A, Rahimi H, Belleudi F, Napoletano C, Battisti F, Zizzari IG, Antonilli M, Bellati F, Wandall HH, Benedetti Panici P, Burchell JM, Torrisi MR, Nuti M.

Cancer Immunol Res. 2014 Feb;2(2):177-86. doi: 10.1158/2326-6066.CIR-13-0112-T. Epub 2013 Oct 28.


Targeting DNGR-1 (CLEC9A) with antibody/MUC1 peptide conjugates as a vaccine for carcinomas.

Picco G, Beatson R, Taylor-Papadimitriou J, Burchell JM.

Eur J Immunol. 2014 Jul;44(7):1947-55. doi: 10.1002/eji.201344076. Epub 2014 Apr 17.


Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer.

Eccles SA, Aboagye EO, Ali S, Anderson AS, Armes J, Berditchevski F, Blaydes JP, Brennan K, Brown NJ, Bryant HE, Bundred NJ, Burchell JM, Campbell AM, Carroll JS, Clarke RB, Coles CE, Cook GJ, Cox A, Curtin NJ, Dekker LV, Silva Idos S, Duffy SW, Easton DF, Eccles DM, Edwards DR, Edwards J, Evans D, Fenlon DF, Flanagan JM, Foster C, Gallagher WM, Garcia-Closas M, Gee JM, Gescher AJ, Goh V, Groves AM, Harvey AJ, Harvie M, Hennessy BT, Hiscox S, Holen I, Howell SJ, Howell A, Hubbard G, Hulbert-Williams N, Hunter MS, Jasani B, Jones LJ, Key TJ, Kirwan CC, Kong A, Kunkler IH, Langdon SP, Leach MO, Mann DJ, Marshall JF, Martin L, Martin SG, Macdougall JE, Miles DW, Miller WR, Morris JR, Moss SM, Mullan P, Natrajan R, O'Connor JP, O'Connor R, Palmieri C, Pharoah PD, Rakha EA, Reed E, Robinson SP, Sahai E, Saxton JM, Schmid P, Smalley MJ, Speirs V, Stein R, Stingl J, Streuli CH, Tutt AN, Velikova G, Walker RA, Watson CJ, Williams KJ, Young LS, Thompson AM.

Breast Cancer Res. 2013 Oct 1;15(5):R92. doi: 10.1186/bcr3493. Review.


Autoantibodies to MUC1 glycopeptides cannot be used as a screening assay for early detection of breast, ovarian, lung or pancreatic cancer.

Burford B, Gentry-Maharaj A, Graham R, Allen D, Pedersen JW, Nudelman AS, Blixt O, Fourkala EO, Bueti D, Dawnay A, Ford J, Desai R, David L, Trinder P, Acres B, Schwientek T, Gammerman A, Reis CA, Silva L, Osório H, Hallett R, Wandall HH, Mandel U, Hollingsworth MA, Jacobs I, Fentiman I, Clausen H, Taylor-Papadimitriou J, Menon U, Burchell JM.

Br J Cancer. 2013 May 28;108(10):2045-55. doi: 10.1038/bjc.2013.214. Epub 2013 May 7.


Cyclooxygenase-2 enzyme induces the expression of the α-2,3-sialyltransferase-3 (ST3Gal-I) in breast cancer.

Sproviero D, Julien S, Burford B, Taylor-Papadimitriou J, Burchell JM.

J Biol Chem. 2012 Dec 28;287(53):44490-7. doi: 10.1074/jbc.M112.427827.


Selectin ligand sialyl-Lewis x antigen drives metastasis of hormone-dependent breast cancers.

Julien S, Ivetic A, Grigoriadis A, QiZe D, Burford B, Sproviero D, Picco G, Gillett C, Papp SL, Schaffer L, Tutt A, Taylor-Papadimitriou J, Pinder SE, Burchell JM.

Cancer Res. 2011 Dec 15;71(24):7683-93. doi: 10.1158/0008-5472.CAN-11-1139. Epub 2011 Oct 24.


Identification of new cancer biomarkers based on aberrant mucin glycoforms by in situ proximity ligation.

Pinto R, Carvalho AS, Conze T, Magalhães A, Picco G, Burchell JM, Taylor-Papadimitriou J, Reis CA, Almeida R, Mandel U, Clausen H, Söderberg O, David L.

J Cell Mol Med. 2012 Jul;16(7):1474-84. doi: 10.1111/j.1582-4934.2011.01436.x.


Transforming growth factor-β1 is constitutively secreted by Chinese hamster ovary cells and is functional in human cells.

Beatson R, Sproviero D, Maher J, Wilkie S, Taylor-Papadimitriou J, Burchell JM.

Biotechnol Bioeng. 2011 Nov;108(11):2759-64. doi: 10.1002/bit.23217. Epub 2011 Jun 9.


Autoantibodies to aberrantly glycosylated MUC1 in early stage breast cancer are associated with a better prognosis.

Blixt O, Bueti D, Burford B, Allen D, Julien S, Hollingsworth M, Gammerman A, Fentiman I, Taylor-Papadimitriou J, Burchell JM.

Breast Cancer Res. 2011 Mar 8;13(2):R25. doi: 10.1186/bcr2841.


PLU-1/JARID1B/KDM5B is required for embryonic survival and contributes to cell proliferation in the mammary gland and in ER+ breast cancer cells.

Catchpole S, Spencer-Dene B, Hall D, Santangelo S, Rosewell I, Guenatri M, Beatson R, Scibetta AG, Burchell JM, Taylor-Papadimitriou J.

Int J Oncol. 2011 May;38(5):1267-77. doi: 10.3892/ijo.2011.956. Epub 2011 Feb 28.


T cells reactive with HLA-A*0201 peptides from the histone demethylase JARID1B are found in the circulation of breast cancer patients.

Coleman JA, Correa I, Cooper L, Bohnenkamp HR, Poulsom R, Burchell JM, Taylor-Papadimitriou J.

Int J Cancer. 2011 May 1;128(9):2114-24. doi: 10.1002/ijc.25792. Epub 2011 Feb 11.


MUC1 immunotherapy.

Beatson RE, Taylor-Papadimitriou J, Burchell JM.

Immunotherapy. 2010 May;2(3):305-27. doi: 10.2217/imt.10.17. Review.


Sialyl-Tn vaccine induces antibody-mediated tumour protection in a relevant murine model.

Julien S, Picco G, Sewell R, Vercoutter-Edouart AS, Tarp M, Miles D, Clausen H, Taylor-Papadimitriou J, Burchell JM.

Br J Cancer. 2009 Jun 2;100(11):1746-54. doi: 10.1038/sj.bjc.6605083. Epub 2009 May 12.


Characterizing the glycome of the mammalian immune system.

Haslam SM, Julien S, Burchell JM, Monk CR, Ceroni A, Garden OA, Dell A.

Immunol Cell Biol. 2008 Oct;86(7):564-73. doi: 10.1038/icb.2008.54. Epub 2008 Aug 26. Review.


Mammosphere culture of metastatic breast cancer cells enriches for tumorigenic breast cancer cells.

Grimshaw MJ, Cooper L, Papazisis K, Coleman JA, Bohnenkamp HR, Chiapero-Stanke L, Taylor-Papadimitriou J, Burchell JM.

Breast Cancer Res. 2008;10(3):R52. doi: 10.1186/bcr2106. Epub 2008 Jun 9.


Retargeting of human T cells to tumor-associated MUC1: the evolution of a chimeric antigen receptor.

Wilkie S, Picco G, Foster J, Davies DM, Julien S, Cooper L, Arif S, Mather SJ, Taylor-Papadimitriou J, Burchell JM, Maher J.

J Immunol. 2008 Apr 1;180(7):4901-9.


RFA strongly modulates the immune system and anti-tumor immune responses in metastatic liver patients.

Napoletano C, Taurino F, Biffoni M, De Majo A, Coscarella G, Bellati F, Rahimi H, Pauselli S, Pellicciotta I, Burchell JM, Gaspari LA, Ercoli L, Rossi P, Rughetti A.

Int J Oncol. 2008 Feb;32(2):481-90.


Sialyl-Lewis(x) on P-selectin glycoprotein ligand-1 is regulated during differentiation and maturation of dendritic cells: a mechanism involving the glycosyltransferases C2GnT1 and ST3Gal I.

Julien S, Grimshaw MJ, Sutton-Smith M, Coleman J, Morris HR, Dell A, Taylor-Papadimitriou J, Burchell JM.

J Immunol. 2007 Nov 1;179(9):5701-10.


Recombinant tumor-associated MUC1 glycoprotein impairs the differentiation and function of dendritic cells.

Rughetti A, Pellicciotta I, Biffoni M, Bäckström M, Link T, Bennet EP, Clausen H, Noll T, Hansson GC, Burchell JM, Frati L, Taylor-Papadimitriou J, Nuti M.

J Immunol. 2005 Jun 15;174(12):7764-72.


Breast carcinoma cell lysate-pulsed dendritic cells cross-prime MUC1-specific CD8+ T cells identified by peptide-MHC-class-I tetramers.

Bohnenkamp HR, Coleman J, Burchell JM, Taylor-Papadimitriou J, Noll T.

Cell Immunol. 2004 Sep-Oct;231(1-2):112-25. Epub 2005 Feb 8.


Responses of human T cells to peptides flanking the tandem repeat and overlapping the signal sequence of MUC1.

Correa I, Plunkett T, Coleman J, Galani E, Windmill E, Burchell JM, Taylor-Papdimitriou J.

Int J Cancer. 2005 Jul 10;115(5):760-8.


Apoptosis of monocytes and the influence on yield of monocyte-derived dendritic cells.

Bohnenkamp HR, Burchell JM, Taylor-Papadimitriou J, Noll T.

J Immunol Methods. 2004 Nov;294(1-2):67-80.


Sialylated core 1 based O-linked glycans enhance the growth rate of mammary carcinoma cells in MUC1 transgenic mice.

Mungul A, Cooper L, Brockhausen I, Ryder K, Mandel U, Clausen H, Rughetti A, Miles DW, Taylor-Papadimitriou J, Burchell JM.

Int J Oncol. 2004 Oct;25(4):937-43.


PLU-1, a transcriptional repressor and putative testis-cancer antigen, has a specific expression and localisation pattern during meiosis.

Madsen B, Tarsounas M, Burchell JM, Hall D, Poulsom R, Taylor-Papadimitriou J.

Chromosoma. 2003 Oct;112(3):124-32. Epub 2003 Sep 10.


Characterisation and developmental expression of mouse Plu-1, a homologue of a human nuclear protein (PLU-1) which is specifically up-regulated in breast cancer.

Madsen B, Spencer-Dene B, Poulsom R, Hall D, Lu PJ, Scott K, Shaw AT, Burchell JM, Freemont P, Taylor-Papadimitriou J.

Mech Dev. 2002 Dec;119 Suppl 1:S239-46.


Characterisation and developmental expression of mouse Plu-1, a homologue of a human nuclear protein (PLU-1) which is specifically up-regulated in breast cancer.

Madsen B, Spencer-Dene B, Poulsom R, Hall D, Lu PJ, Scott K, Shaw AT, Burchell JM, Freemont P, Taylor-Papadimitriou J.

Gene Expr Patterns. 2002 Dec;2(3-4):275-82.


Form and pattern of MUC1 expression on T cells activated in vivo or in vitro suggests a function in T-cell migration.

Correa I, Plunkett T, Vlad A, Mungul A, Candelora-Kettel J, Burchell JM, Taylor-Papadimitriou J, Finn OJ.

Immunology. 2003 Jan;108(1):32-41.


MUC1 and the immunobiology of cancer.

Taylor-Papadimitriou J, Burchell JM, Plunkett T, Graham R, Correa I, Miles D, Smith M.

J Mammary Gland Biol Neoplasia. 2002 Apr;7(2):209-21. Review.


Effective immunotherapy of cancer in MUC1-transgenic mice using clonal cytotoxic T lymphocytes directed against an immunodominant MUC1 epitope.

Heukamp LC, van Hall T, Ossendorp F, Burchell JM, Melief CJ, Taylor-Papadimitriou J, Offringa R.

J Immunother. 2002 Jan-Feb;25(1):46-56.


Functional conservation of subfamilies of putative UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferases in Drosophila, Caenorhabditis elegans, and mammals. One subfamily composed of l(2)35Aa is essential in Drosophila.

Schwientek T, Bennett EP, Flores C, Thacker J, Hollmann M, Reis CA, Behrens J, Mandel U, Keck B, Schäfer MA, Haselmann K, Zubarev R, Roepstorff P, Burchell JM, Taylor-Papadimitriou J, Hollingsworth MA, Clausen H.

J Biol Chem. 2002 Jun 21;277(25):22623-38. Epub 2002 Mar 29.


NMR-based determination of the binding epitope and conformational analysis of MUC-1 glycopeptides and peptides bound to the breast cancer-selective monoclonal antibody SM3.

Möller H, Serttas N, Paulsen H, Burchell JM, Taylor-Papadimitriou J; Bernd Meyer.

Eur J Biochem. 2002 Mar;269(5):1444-55.


O-linked glycosylation in the mammary gland: changes that occur during malignancy.

Burchell JM, Mungul A, Taylor-Papadimitriou J.

J Mammary Gland Biol Neoplasia. 2001 Jul;6(3):355-64. Review.


The relative activities of the C2GnT1 and ST3Gal-I glycosyltransferases determine O-glycan structure and expression of a tumor-associated epitope on MUC1.

Dalziel M, Whitehouse C, McFarlane I, Brockhausen I, Gschmeissner S, Schwientek T, Clausen H, Burchell JM, Taylor-Papadimitriou J.

J Biol Chem. 2001 Apr 6;276(14):11007-15. Epub 2000 Dec 15.


Crystal structure at 1.95 A resolution of the breast tumour-specific antibody SM3 complexed with its peptide epitope reveals novel hypervariable loop recognition.

Dokurno P, Bates PA, Band HA, Stewart LM, Lally JM, Burchell JM, Taylor-Papadimitriou J, Snary D, Sternberg MJ, Freemont PS.

J Mol Biol. 1998 Dec 4;284(3):713-28.


Intramuscular immunisation with MUC1 cDNA can protect C57 mice challenged with MUC1-expressing syngeneic mouse tumour cells.

Graham RA, Burchell JM, Beverley P, Taylor-Papadimitriou J.

Int J Cancer. 1996 Mar 1;65(5):664-70.


The polymorphic epithelial mucin: potential as an immunogen for a cancer vaccine.

Graham RA, Burchell JM, Taylor-Papadimitriou J.

Cancer Immunol Immunother. 1996 Feb;42(2):71-80. Review.


Cloning of partial cDNA encoding differentiation and tumor-associated mucin glycoproteins expressed by human mammary epithelium.

Gendler SJ, Burchell JM, Duhig T, Lamport D, White R, Parker M, Taylor-Papadimitriou J.

Proc Natl Acad Sci U S A. 1987 Sep;84(17):6060-4.


Effects of testosterone on sequence complexity of polyadenylated RNA from rat seminal vesicle.

Higgins SJ, Burchell JM, Parker MG, Herries DG.

Eur J Biochem. 1978 Nov 15;91(2):327-34. No abstract available.


Non-therapeutic medical research on children.

Burchell JM.

S Afr Law J. 1978 Jun;95(Part 2):193-216. No abstract available.


Androgen-dependent synthesis of basic secretory proteins by the rat seminal vesicle.

Higgins SJ, Burchell JM, Mainwaring WI.

Biochem J. 1976 Aug 15;158(2):271-82.

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