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Items: 1 to 50 of 57

1.

Carbonyl scavengers as pharmacotherapies in degenerative disease: Hydralazine repurposing and challenges in clinical translation.

Burcham PC.

Biochem Pharmacol. 2018 Aug;154:397-406. doi: 10.1016/j.bcp.2018.06.006. Epub 2018 Jun 6. Review.

PMID:
29883705
2.

Taking Pharmaceutical Innovation to the Masses.

Burcham PC.

ACS Med Chem Lett. 2017 May 31;8(7):686-689. doi: 10.1021/acsmedchemlett.7b00173. eCollection 2017 Jul 13.

3.

Functional characterisation and application of an ex vivo perfusion-superfusion system in murine airways.

Cheah EY, Mann TS, Burcham PC, Henry PJ.

J Pharmacol Toxicol Methods. 2017 Mar - Apr;84:66-77. doi: 10.1016/j.vascn.2016.11.003. Epub 2016 Nov 16.

PMID:
27865847
4.

Acrolein and Human Disease: Untangling the Knotty Exposure Scenarios Accompanying Several Diverse Disorders.

Burcham PC.

Chem Res Toxicol. 2017 Jan 17;30(1):145-161. doi: 10.1021/acs.chemrestox.6b00310. Epub 2016 Nov 17.

5.

Influenza A infection attenuates relaxation responses of mouse tracheal smooth muscle evoked by acrolein.

Cheah EY, Mann TS, Burcham PC, Henry PJ.

Biochem Pharmacol. 2015 Feb 15;93(4):519-26. doi: 10.1016/j.bcp.2014.12.015. Epub 2014 Dec 31.

PMID:
25557294
6.

Airborne acrolein induces keratin-8 (Ser-73) hyperphosphorylation and intermediate filament ubiquitination in bronchiolar lung cell monolayers.

Burcham PC, Raso A, Henry PJ.

Toxicology. 2014 May 7;319:44-52. doi: 10.1016/j.tox.2014.02.010. Epub 2014 Mar 2.

PMID:
24594012
7.

Acrolein relaxes mouse isolated tracheal smooth muscle via a TRPA1-dependent mechanism.

Cheah EY, Burcham PC, Mann TS, Henry PJ.

Biochem Pharmacol. 2014 May 1;89(1):148-56. doi: 10.1016/j.bcp.2014.02.009. Epub 2014 Feb 19.

8.

Chaperone heat shock protein 90 mobilization and hydralazine cytoprotection against acrolein-induced carbonyl stress.

Burcham PC, Raso A, Kaminskas LM.

Mol Pharmacol. 2012 Nov;82(5):876-86. doi: 10.1124/mol.112.078956. Epub 2012 Aug 6.

PMID:
22869587
9.

Prior exposure to acrolein accelerates pulmonary inflammation in influenza A-infected mice.

Ong FH, Henry PJ, Burcham PC.

Toxicol Lett. 2012 Aug 3;212(3):241-51. doi: 10.1016/j.toxlet.2012.06.003. Epub 2012 Jun 13.

PMID:
22705057
10.

Toxicity of smoke extracts towards A549 lung cells: role of acrolein and suppression by carbonyl scavengers.

Burcham PC, Raso A, Thompson CA.

Chem Biol Interact. 2010 Feb 12;183(3):416-24. doi: 10.1016/j.cbi.2009.12.006. Epub 2009 Dec 16.

PMID:
20015449
11.
12.

Genome-wide transcriptional responses to acrolein.

Thompson CA, Burcham PC.

Chem Res Toxicol. 2008 Dec;21(12):2245-56. doi: 10.1021/tx8001934.

PMID:
19548348
13.

Carbonyl-scavenging drugs & protection against carbonyl stress-associated cell injury.

Burcham PC, Kaminskas LM, Tan D, Pyke SM.

Mini Rev Med Chem. 2008 Apr;8(4):319-30. Review.

PMID:
18473924
14.

Toxicology down under: past achievements, present realities, and future prospects.

Burcham PC.

Chem Res Toxicol. 2008 May;21(5):967-70. doi: 10.1021/tx8001252. Epub 2008 Apr 29. No abstract available.

PMID:
18442270
15.

Protein alkylation, transcriptional responses and cytochrome c release during acrolein toxicity in A549 cells: influence of nucleophilic culture media constituents.

Thompson CA, Burcham PC.

Toxicol In Vitro. 2008 Jun;22(4):844-53. doi: 10.1016/j.tiv.2007.12.018. Epub 2008 Jan 15.

PMID:
18282682
16.

Potentialities and pitfalls accompanying chemico-pharmacological strategies against endogenous electrophiles and carbonyl stress.

Burcham PC.

Chem Res Toxicol. 2008 Apr;21(4):779-86. doi: 10.1021/tx700399q. Epub 2008 Feb 15.

PMID:
18275160
17.
18.

Carboxylic acid drug-induced DNA nicking in HEK293 cells expressing human UDP-glucuronosyltransferases: role of acyl glucuronide metabolites and glycation pathways.

Southwood HT, DeGraaf YC, Mackenzie PI, Miners JO, Burcham PC, Sallustio BC.

Chem Res Toxicol. 2007 Oct;20(10):1520-7. Epub 2007 Sep 20.

PMID:
17880178
19.

Inactivation of glutathione peroxidase activity contributes to UV-induced squamous cell carcinoma formation.

Walshe J, Serewko-Auret MM, Teakle N, Cameron S, Minto K, Smith L, Burcham PC, Russell T, Strutton G, Griffin A, Chu FF, Esworthy S, Reeve V, Saunders NA.

Cancer Res. 2007 May 15;67(10):4751-8.

20.
21.

Michael addition of acrolein to lysinyl and N-terminal residues of a model peptide: targets for cytoprotective hydrazino drugs.

Kaminskas LM, Pyke SM, Burcham PC.

Rapid Commun Mass Spectrom. 2007;21(7):1155-64.

PMID:
17318925
22.
24.
25.

Reactivity of hydrazinophthalazine drugs with the lipid peroxidation products acrolein and crotonaldehyde.

Kaminskas LM, Pyke SM, Burcham PC.

Org Biomol Chem. 2004 Sep 21;2(18):2578-84. Epub 2004 Aug 20.

PMID:
15351821
26.

Strong protein adduct trapping accompanies abolition of acrolein-mediated hepatotoxicity by hydralazine in mice.

Kaminskas LM, Pyke SM, Burcham PC.

J Pharmacol Exp Ther. 2004 Sep;310(3):1003-10. Epub 2004 May 6.

PMID:
15131244
27.

Optimisation of the comet genotoxicity assay in freshly isolated murine hepatocytes: detection of strong in vitro DNA damaging properties for styrene.

Fontaine FR, DeGraaf YC, Ghaoui R, Sallustio BC, Edwards J, Burcham PC.

Toxicol In Vitro. 2004 Jun;18(3):343-50.

PMID:
15046782
28.

Protein adduct-trapping by hydrazinophthalazine drugs: mechanisms of cytoprotection against acrolein-mediated toxicity.

Burcham PC, Fontaine FR, Kaminskas LM, Petersen DR, Pyke SM.

Mol Pharmacol. 2004 Mar;65(3):655-64.

PMID:
14978244
29.

Reactivity with Tris(hydroxymethyl)aminomethane confounds immunodetection of acrolein-adducted proteins.

Burcham PC, Fontaine FR, Petersen DR, Pyke SM.

Chem Res Toxicol. 2003 Oct;16(10):1196-201.

PMID:
14565760
30.

Cylindrospermopsin-induced protein synthesis inhibition and its dissociation from acute toxicity in mouse hepatocytes.

Froscio SM, Humpage AR, Burcham PC, Falconer IR.

Environ Toxicol. 2003 Aug;18(4):243-51.

PMID:
12900943
31.

UDP-glucuronosyltransferase-dependent bioactivation of clofibric acid to a DNA-damaging intermediate in mouse hepatocytes.

Ghaoui R, Sallustio BC, Burcham PC, Fontaine FR.

Chem Biol Interact. 2003 May 6;145(2):201-11.

PMID:
12686496
32.

Aldehyde-sequestering drugs: tools for studying protein damage by lipid peroxidation products.

Burcham PC, Kaminskas LM, Fontaine FR, Petersen DR, Pyke SM.

Toxicology. 2002 Dec 27;181-182:229-36. Review.

PMID:
12505316
33.
34.

Extensive protein carbonylation precedes acrolein-mediated cell death in mouse hepatocytes.

Burcham PC, Fontaine F.

J Biochem Mol Toxicol. 2001;15(6):309-16.

PMID:
11835630
35.

Cell-free protein synthesis inhibition assay for the cyanobacterial toxin cylindrospermopsin.

Froscio SM, Humpage AR, Burcham PC, Falconer IR.

Environ Toxicol. 2001 Oct;16(5):408-12.

PMID:
11594027
36.

Clofibrate pretreatment in mice confers resistance against hepatic lipid peroxidation.

Nicholls-Grzemski FA, Belling GB, Priestly BG, Calder IC, Burcham PC.

J Biochem Mol Toxicol. 2000;14(6):335-45.

PMID:
11083087
37.

The antihypertensive hydralazine is an efficient scavenger of acrolein.

Burcham PC, Kerr PG, Fontaine F.

Redox Rep. 2000;5(1):47-9.

PMID:
10905545
38.

Clofibrate-induced in vitro hepatoprotection against acetaminophen is not due to altered glutathione homeostasis.

Nicholls-Grzemski FA, Calder IC, Priestly BG, Burcham PC.

Toxicol Sci. 2000 Jul;56(1):220-8.

PMID:
10869471
39.

Role of cytochrome P450 3A in the metabolism of mefloquine in human and animal hepatocytes.

Fontaine F, de Sousa G, Burcham PC, DuchĂȘne P, Rahmani R.

Life Sci. 2000 Apr 21;66(22):2193-212.

PMID:
10834303
40.
41.

Internal hazards: baseline DNA damage by endogenous products of normal metabolism.

Burcham PC.

Mutat Res. 1999 Jul 15;443(1-2):11-36. Review.

PMID:
10415429
42.
43.
44.

Formation of novel C1-oxidised abasic sites in alkylperoxyl radical-damaged plasmid DNA.

Harkin LA, Burcham PC.

Biochem Biophys Res Commun. 1997 Aug 8;237(1):1-5.

PMID:
9266818
45.
47.

Pretreatment with peroxisome proliferators protects mice against some but not all hepatotoxins.

Nicholls-Grzemski FA, Burcham PC, Calder IC, Priestly BG.

Ann N Y Acad Sci. 1996 Dec 27;804:742-4. No abstract available.

PMID:
8993611
48.

Introduction of carbonyl groups into proteins by the lipid peroxidation product, malondialdehyde.

Burcham PC, Kuhan YT.

Biochem Biophys Res Commun. 1996 Mar 27;220(3):996-1001.

PMID:
8607882
49.

Abasic sites stimulate double-stranded DNA cleavage mediated by topoisomerase II. DNA lesions as endogenous topoisomerase II poisons.

Kingma PS, Corbett AH, Burcham PC, Marnett LJ, Osheroff N.

J Biol Chem. 1995 Sep 15;270(37):21441-4.

50.

Site-specific mutagenesis by a propanodeoxyguanosine adduct carried on an M13 genome.

Burcham PC, Marnett LJ.

J Biol Chem. 1994 Nov 18;269(46):28844-50.

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