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Items: 1 to 50 of 53

1.

Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase.

Blaquiere N, Castanedo GM, Burch JD, Berezhkovskiy LM, Brightbill H, Brown S, Chan C, Chiang PC, Crawford JJ, Dong T, Fan P, Feng J, Ghilardi N, Godemann R, Gogol E, Grabbe A, Hole AJ, Hu B, Hymowitz SG, Alaoui Ismaili MH, Le H, Lee P, Lee W, Lin X, Liu N, McEwan PA, McKenzie B, Silvestre HL, Suto E, Sujatha-Bhaskar S, Wu G, Wu LC, Zhang Y, Zhong Z, Staben ST.

J Med Chem. 2018 Aug 9;61(15):6801-6813. doi: 10.1021/acs.jmedchem.8b00678. Epub 2018 Jul 24.

PMID:
29940120
2.

Fragment Molecular Orbital Method Applied to Lead Optimization of Novel Interleukin-2 Inducible T-Cell Kinase (ITK) Inhibitors.

Heifetz A, Trani G, Aldeghi M, MacKinnon CH, McEwan PA, Brookfield FA, Chudyk EI, Bodkin M, Pei Z, Burch JD, Ortwine DF.

J Med Chem. 2016 May 12;59(9):4352-63. doi: 10.1021/acs.jmedchem.6b00045. Epub 2016 Mar 17.

PMID:
26950250
3.

Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response.

Sun Y, Peng I, Webster JD, Suto E, Lesch J, Wu X, Senger K, Francis G, Barrett K, Collier JL, Burch JD, Zhou M, Chen Y, Chan C, Eastham-Anderson J, Ngu H, Li O, Staton T, Havnar C, Jaochico A, Jackman J, Jeet S, Riol-Blanco L, Wu LC, Choy DF, Arron JR, McKenzie BS, Ghilardi N, Ismaili MH, Pei Z, DeVoss J, Austin CD, Lee WP, Zarrin AA.

Sci Signal. 2015 Dec 1;8(405):ra122. doi: 10.1126/scisignal.aab0949.

PMID:
26628680
4.

Tetrahydroindazoles as Interleukin-2 Inducible T-Cell Kinase Inhibitors. Part II. Second-Generation Analogues with Enhanced Potency, Selectivity, and Pharmacodynamic Modulation in Vivo.

Burch JD, Barrett K, Chen Y, DeVoss J, Eigenbrot C, Goldsmith R, Ismaili MH, Lau K, Lin Z, Ortwine DF, Zarrin AA, McEwan PA, Barker JJ, Ellebrandt C, Kordt D, Stein DB, Wang X, Chen Y, Hu B, Xu X, Yuen PW, Zhang Y, Pei Z.

J Med Chem. 2015 May 14;58(9):3806-16. doi: 10.1021/jm501998m. Epub 2015 Apr 16.

PMID:
25844760
5.

Design, synthesis and structure-activity relationships of a novel class of sulfonylpyridine inhibitors of Interleukin-2 inducible T-cell kinase (ITK).

Trani G, Barker JJ, Bromidge SM, Brookfield FA, Burch JD, Chen Y, Eigenbrot C, Heifetz A, Ismaili MHA, Johnson A, Krülle TM, MacKinnon CH, Maghames R, McEwan PA, Montalbetti CAGN, Ortwine DF, Pérez-Fuertes Y, Vaidya DG, Wang X, Zarrin AA, Pei Z.

Bioorg Med Chem Lett. 2014 Dec 15;24(24):5818-5823. doi: 10.1016/j.bmcl.2014.10.020. Epub 2014 Oct 12.

PMID:
25455497
6.

Property- and structure-guided discovery of a tetrahydroindazole series of interleukin-2 inducible T-cell kinase inhibitors.

Burch JD, Lau K, Barker JJ, Brookfield F, Chen Y, Chen Y, Eigenbrot C, Ellebrandt C, Ismaili MH, Johnson A, Kordt D, MacKinnon CH, McEwan PA, Ortwine DF, Stein DB, Wang X, Winkler D, Yuen PW, Zhang Y, Zarrin AA, Pei Z.

J Med Chem. 2014 Jul 10;57(13):5714-27. doi: 10.1021/jm500550e. Epub 2014 Jun 27.

PMID:
24918870
7.

Discovery and optimization of indazoles as potent and selective interleukin-2 inducible T cell kinase (ITK) inhibitors.

Pastor RM, Burch JD, Magnuson S, Ortwine DF, Chen Y, De La Torre K, Ding X, Eigenbrot C, Johnson A, Liimatta M, Liu Y, Shia S, Wang X, Wu LC, Pei Z.

Bioorg Med Chem Lett. 2014 Jun 1;24(11):2448-52. doi: 10.1016/j.bmcl.2014.04.023. Epub 2014 Apr 16.

PMID:
24767842
8.

Back pocket flexibility provides group II p21-activated kinase (PAK) selectivity for type I 1/2 kinase inhibitors.

Staben ST, Feng JA, Lyle K, Belvin M, Boggs J, Burch JD, Chua CC, Cui H, DiPasquale AG, Friedman LS, Heise C, Koeppen H, Kotey A, Mintzer R, Oh A, Roberts DA, Rouge L, Rudolph J, Tam C, Wang W, Xiao Y, Young A, Zhang Y, Hoeflich KP.

J Med Chem. 2014 Feb 13;57(3):1033-45. doi: 10.1021/jm401768t. Epub 2014 Feb 4.

PMID:
24432870
9.

Discovery of MK-1439, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV viruses.

Côté B, Burch JD, Asante-Appiah E, Bayly C, Bédard L, Blouin M, Campeau LC, Cauchon E, Chan M, Chefson A, Coulombe N, Cromlish W, Debnath S, Deschênes D, Dupont-Gaudet K, Falgueyret JP, Forget R, Gagné S, Gauvreau D, Girardin M, Guiral S, Langlois E, Li CS, Nguyen N, Papp R, Plamondon S, Roy A, Roy S, Seliniotakis R, St-Onge M, Ouellet S, Tawa P, Truchon JF, Vacca J, Wrona M, Yan Y, Ducharme Y.

Bioorg Med Chem Lett. 2014 Feb 1;24(3):917-22. doi: 10.1016/j.bmcl.2013.12.070. Epub 2013 Dec 24.

PMID:
24412110
10.

Structure-based design and synthesis of potent benzothiazole inhibitors of interleukin-2 inducible T cell kinase (ITK).

MacKinnon CH, Lau K, Burch JD, Chen Y, Dines J, Ding X, Eigenbrot C, Heifetz A, Jaochico A, Johnson A, Kraemer J, Kruger S, Krülle TM, Liimatta M, Ly J, Maghames R, Montalbetti CA, Ortwine DF, Pérez-Fuertes Y, Shia S, Stein DB, Trani G, Vaidya DG, Wang X, Bromidge SM, Wu LC, Pei Z.

Bioorg Med Chem Lett. 2013 Dec 1;23(23):6331-5. doi: 10.1016/j.bmcl.2013.09.069. Epub 2013 Oct 1.

PMID:
24138940
11.

Naphthalene/quinoline amides and sulfonylureas as potent and selective antagonists of the EP4 receptor.

Burch JD, Farand J, Colucci J, Sturino C, Ducharme Y, Friesen RW, Lévesque JF, Gagné S, Wrona M, Therien AG, Mathieu MC, Denis D, Vigneault E, Xu D, Clark P, Rowland S, Han Y.

Bioorg Med Chem Lett. 2011 Feb 1;21(3):1041-6. doi: 10.1016/j.bmcl.2010.12.014. Epub 2010 Dec 8.

PMID:
21215624
12.

One-pot synthesis of benzofurans via palladium-catalyzed enolate arylation with o-bromophenols.

Eidamshaus C, Burch JD.

Org Lett. 2008 Oct 2;10(19):4211-4. doi: 10.1021/ol801510n. Epub 2008 Aug 29.

PMID:
18754667
13.

Mutual antagonistic relationship between prostaglandin E(2) and IFN-gamma: Implications for rheumatoid arthritis.

Mathieu MC, Lord-Dufour S, Bernier V, Boie Y, Burch JD, Clark P, Denis D, Han Y, Mortimer JR, Therien AG.

Eur J Immunol. 2008 Jul;38(7):1900-12. doi: 10.1002/eji.200838170.

14.

Enantioselective total synthesis of callipeltoside A: two approaches to the macrolactone fragment.

Evans DA, Burch JD, Hu E, Jaeschke G.

Tetrahedron. 2008 May 19;64(21):4674-4699.

15.

Structure-activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP(4) receptor.

Burch JD, Belley M, Fortin R, Deschênes D, Girard M, Colucci J, Farand J, Therien AG, Mathieu MC, Denis D, Vigneault E, Lévesque JF, Gagné S, Wrona M, Xu D, Clark P, Rowland S, Han Y.

Bioorg Med Chem Lett. 2008 Mar 15;18(6):2048-54. doi: 10.1016/j.bmcl.2008.01.103. Epub 2008 Jan 31.

PMID:
18291643
16.

Synthesis and confirmation of the absolute stereochemistry of the (-)-aflastatin A C9-C27 degradation polyol.

Evans DA, Trenkle WC, Zhang J, Burch JD.

Org Lett. 2005 Jul 21;7(15):3335-8.

PMID:
16018654
17.
18.

A cohort study of thyroid cancer and other thyroid diseases after the Chornobyl accident: objectives, design and methods.

Stezhko VA, Buglova EE, Danilova LI, Drozd VM, Krysenko NA, Lesnikova NR, Minenko VF, Ostapenko VA, Petrenko SV, Polyanskaya ON, Rzheutski VA, Tronko MD, Bobylyova OO, Bogdanova TI, Ephstein OV, Kairo IA, Kostin OV, Likhtarev IA, Markov VV, Oliynik VA, Shpak VM, Tereshchenko VP, Zamotayeva GA, Beebe GW, Bouville AC, Brill AB, Burch JD, Fink DJ, Greenebaum E, Howe GR, Luckyanov NK, Masnyk IJ, McConnell RJ, Robbins J, Thomas TL, Voillequé PG, Zablotska LB; Chornobyl Thyroid Diseases Study Group of Belarus; Chornobyl Thyroid Diseases Study Group of Ukraine; Chornobyl Thyroid Diseases Study Group of the USA.

Radiat Res. 2004 Apr;161(4):481-92.

PMID:
15038762
19.

Histologic verification of leukemia, myelodysplasia, and multiple myeloma diagnoses in patients in Ukraine, 1987-1998.

Dyagil I, Adam M, Beebe GW, Burch JD, Gaidukova SN, Gluzman D, Gudzenko N, Klimenko V, Peterson L, Reiss RF, Finch SC.

Int J Hematol. 2002 Jul;76(1):55-60. Review.

PMID:
12138896
20.

Enantioselective total synthesis of callipeltoside A.

Evans DA, Hu E, Burch JD, Jaeschke G.

J Am Chem Soc. 2002 May 22;124(20):5654-5.

PMID:
12010035
21.

Asymmetric synthesis of the chlorocyclopropane-containing callipeltoside A side chain.

Evans DA, Burch JD.

Org Lett. 2001 Feb 22;3(4):503-5.

PMID:
11178810
22.

Alcohol and other beverage use and prostate cancer risk among Canadian men.

Jain MG, Hislop GT, Howe GR, Burch JD, Ghadirian P.

Int J Cancer. 1998 Dec 9;78(6):707-11.

23.

Nutrition and pancreatic cancer.

Howe GR, Burch JD.

Cancer Causes Control. 1996 Jan;7(1):69-82. Review.

PMID:
8850436
24.

Do the nonsmoking daughters of smokers tend to marry smokers? Implications for epidemiological research on environmental tobacco smoke: the IARC collaborative study.

Riboli E, Haley NJ, Trédaniel J, Saracci R, Preston-Martin S, Trichopoulos D, Becher H, Burch JD, Fontham ET, Gao YT, et al.

Cancer Epidemiol Biomarkers Prev. 1995 Dec;4(8):821-4.

25.

Prostate cancer in relation to diet, physical activity, and body size in blacks, whites, and Asians in the United States and Canada.

Whittemore AS, Kolonel LN, Wu AH, John EM, Gallagher RP, Howe GR, Burch JD, Hankin J, Dreon DM, West DW, et al.

J Natl Cancer Inst. 1995 May 3;87(9):652-61.

PMID:
7752270
26.

Dietary factors and risk of prostate cancer: a case-control study in Ontario, Canada.

Rohan TE, Howe GR, Burch JD, Jain M.

Cancer Causes Control. 1995 Mar;6(2):145-54.

PMID:
7749054
27.

Lung cancer risk for female smokers.

Risch HA, Howe GR, Jain M, Burch JD, Holowaty EJ, Miller AB.

Science. 1994 Mar 4;263(5151):1206-8. No abstract available.

PMID:
8122096
28.

Are female smokers at higher risk for lung cancer than male smokers? A case-control analysis by histologic type.

Risch HA, Howe GR, Jain M, Burch JD, Holowaty EJ, Miller AB.

Am J Epidemiol. 1993 Sep 1;138(5):281-93.

PMID:
8395141
29.

Occupational exposure to sulfuric acid in southern Ontario, Canada, in association with laryngeal cancer.

Soskolne CL, Jhangri GS, Siemiatycki J, Lakhani R, Dewar R, Burch JD, Howe GR, Miller AB.

Scand J Work Environ Health. 1992 Aug;18(4):225-32.

30.

Lung cancer in women in the Niagara Region, Ontario: a case-control study.

Holowaty EJ, Risch HA, Miller AB, Burch JD.

Can J Public Health. 1991 Sep-Oct;82(5):304-9.

PMID:
1768987
31.

Radon exposure, cigarette smoking, and other mining experience in the beaverlodge uranium miners cohort.

L'Abbé KA, Howe GR, Burch JD, Miller AB, Abbatt J, Band P, Choi W, Du J, Feather J, Gallagher R, et al.

Health Phys. 1991 Apr;60(4):489-95.

PMID:
2001944
32.

Cigarette smoking and cancer of the pancreas: evidence from a population-based case-control study in Toronto, Canada.

Howe GR, Jain M, Burch JD, Miller AB.

Int J Cancer. 1991 Feb 1;47(3):323-8.

PMID:
1993539
33.

Fire fighters and risk of cancer: an assessment and overview of the epidemiologic evidence.

Howe GR, Burch JD.

Am J Epidemiol. 1990 Dec;132(6):1039-50. Review. No abstract available.

PMID:
2260535
34.

Exposure of nonsmoking women to environmental tobacco smoke: a 10-country collaborative study.

Riboli E, Preston-Martin S, Saracci R, Haley NJ, Trichopoulos D, Becher H, Burch JD, Fontham ET, Gao YT, Jindal SK, et al.

Cancer Causes Control. 1990 Nov;1(3):243-52.

PMID:
2102297
35.

Dietary factors and risk of lung cancer: results from a case-control study, Toronto, 1981-1985.

Jain M, Burch JD, Howe GR, Risch HA, Miller AB.

Int J Cancer. 1990 Feb 15;45(2):287-93.

PMID:
2303295
36.

Risk of bladder cancer by source and type of tobacco exposure: a case-control study.

Burch JD, Rohan TE, Howe GR, Risch HA, Hill GB, Steele R, Miller AB.

Int J Cancer. 1989 Oct 15;44(4):622-8.

PMID:
2793235
37.

An exploratory case-control study of brain tumors in children.

Howe GR, Burch JD, Chiarelli AM, Risch HA, Choi BC.

Cancer Res. 1989 Aug 1;49(15):4349-52.

38.

Occupational factors and the incidence of cancer of the bladder in Canada.

Risch HA, Burch JD, Miller AB, Hill GB, Steele R, Howe GR.

Br J Ind Med. 1988 Jun;45(6):361-7.

39.

Dietary factors and the incidence of cancer of the urinary bladder.

Risch HA, Burch JD, Miller AB, Hill GB, Steele R, Howe GR.

Am J Epidemiol. 1988 Jun;127(6):1179-91.

PMID:
3369417
40.

The reliability of passive smoking histories reported in a case-control study of lung cancer.

Pron GE, Burch JD, Howe GR, Miller AB.

Am J Epidemiol. 1988 Feb;127(2):267-73.

PMID:
3337082
41.
42.

An exploratory case-control study of brain tumors in adults.

Burch JD, Craib KJ, Choi BC, Miller AB, Risch HA, Howe GR.

J Natl Cancer Inst. 1987 Apr;78(4):601-9.

PMID:
3104645
43.

Epidemiological assessment of risk to humans from exposure to nitrosamines.

Miller AB, Choi BC, Howe GR, Burch JD, Sherman GJ.

IARC Sci Publ. 1984;(57):929-36.

PMID:
6533077
44.

Tobacco, alcohol, asbestos, and nickel in the etiology of cancer of the larynx: a case-control study.

Burch JD, Howe GR, Miller AB, Semenciw R.

J Natl Cancer Inst. 1981 Dec;67(6):1219-24.

PMID:
6947107
45.

Breast cancer in relation to weight in women aged 65 years and over.

Burch JD, Howe GR, Miller AB.

Can Med Assoc J. 1981 May 15;124(10):1326, 1328. No abstract available.

46.

Artificial sweeteners in relation to the epidemiology of bladder cancer.

Howe GR, Burch JD.

Nutr Cancer. 1981;2(4):213-6. Review. No abstract available.

PMID:
7050919
47.

Tobacco use, occupation, coffee, various nutrients, and bladder cancer.

Howe GR, Burch JD, Miller AB, Cook GM, Esteve J, Morrison B, Gordon P, Chambers LW, Fodor G, Winsor GM.

J Natl Cancer Inst. 1980 Apr;64(4):701-13.

PMID:
6928984
48.

An epidemiologic study of breast cancer.

Choi NW, Howe GR, Miller AB, Matthews V, Morgan RW, Munan L, Burch JD, Feather J, Jain M, Kelly A.

Am J Epidemiol. 1978 Jun;107(6):510-21.

PMID:
665665
49.

A study of diet and breast cancer.

Miller AB, Kelly A, Choi NW, Matthews V, Morgan RW, Munan L, Burch JD, Feather J, Howe GR, Jain M.

Am J Epidemiol. 1978 Jun;107(6):499-509.

PMID:
665664
50.

A comparison of dietary methods in epidemiologic studies.

Morgan RW, Jain M, Miller AB, Choi NW, Matthews V, Munan L, Burch JD, Feather J, Howe GR, Kelly A.

Am J Epidemiol. 1978 Jun;107(6):488-98.

PMID:
665663

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