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Items: 16


Endotoxin regulates matrix genes increasing reactive oxygen species generation by intercellular communication between palmitate-treated hepatocyte and stellate cell.

Dornas W, Glaise D, Bodin A, Sharanek A, Burban A, Le Guillou D, Robert S, Dutertre S, Aninat C, Corlu A, Lagente V.

J Cell Physiol. 2018 Jan;234(1):122-133. doi: 10.1002/jcp.27175. Epub 2018 Sep 7.


Endoplasmic reticulum stress precedes oxidative stress in antibiotic-induced cholestasis and cytotoxicity in human hepatocytes.

Burban A, Sharanek A, Guguen-Guillouzo C, Guillouzo A.

Free Radic Biol Med. 2018 Feb 1;115:166-178. doi: 10.1016/j.freeradbiomed.2017.11.017. Epub 2017 Dec 2.


Progressive and Preferential Cellular Accumulation of Hydrophobic Bile Acids Induced by Cholestatic Drugs Is Associated with Inhibition of Their Amidation and Sulfation.

Sharanek A, Burban A, Humbert L, Guguen-Guillouzo C, Rainteau D, Guillouzo A.

Drug Metab Dispos. 2017 Dec;45(12):1292-1303. doi: 10.1124/dmd.117.077420. Epub 2017 Sep 19.


Penicillinase-resistant antibiotics induce non-immune-mediated cholestasis through HSP27 activation associated with PKC/P38 and PI3K/AKT signaling pathways.

Burban A, Sharanek A, Hüe R, Gay M, Routier S, Guillouzo A, Guguen-Guillouzo C.

Sci Rep. 2017 May 12;7(1):1815. doi: 10.1038/s41598-017-01171-y.


From the Cover: MechanisticInsights in Cytotoxic and Cholestatic Potential of the Endothelial Receptor Antagonists Using HepaRG Cells.

Burbank MG, Sharanek A, Burban A, Mialanne H, Aerts H, Guguen-Guillouzo C, Weaver RJ, Guillouzo A.

Toxicol Sci. 2017 Jun 1;157(2):451-464. doi: 10.1093/toxsci/kfx062.


Early Alterations of Bile Canaliculi Dynamics and the Rho Kinase/Myosin Light Chain Kinase Pathway Are Characteristics of Drug-Induced Intrahepatic Cholestasis.

Burbank MG, Burban A, Sharanek A, Weaver RJ, Guguen-Guillouzo C, Guillouzo A.

Drug Metab Dispos. 2016 Nov;44(11):1780-1793. Epub 2016 Aug 18.


Enhanced starch hydrolysis using α-amylase immobilized on cellulose ultrafiltration affinity membrane.

Konovalova V, Guzikevich K, Burban A, Kujawski W, Jarzynka K, Kujawa J.

Carbohydr Polym. 2016 Nov 5;152:710-717. doi: 10.1016/j.carbpol.2016.07.065. Epub 2016 Jul 18.


Differential sensitivity of metabolically competent and non-competent HepaRG cells to apoptosis induced by diclofenac combined or not with TNF-α.

Al-Attrache H, Sharanek A, Burban A, Burbank M, Gicquel T, Abdel-Razzak Z, Guguen-Guillouzo C, Morel I, Guillouzo A.

Toxicol Lett. 2016 Sep 6;258:71-86. doi: 10.1016/j.toxlet.2016.06.008. Epub 2016 Jun 14.


Rho-kinase/myosin light chain kinase pathway plays a key role in the impairment of bile canaliculi dynamics induced by cholestatic drugs.

Sharanek A, Burban A, Burbank M, Le Guevel R, Li R, Guillouzo A, Guguen-Guillouzo C.

Sci Rep. 2016 May 12;6:24709. doi: 10.1038/srep24709.


Cellular Accumulation and Toxic Effects of Bile Acids in Cyclosporine A-Treated HepaRG Hepatocytes.

Sharanek A, Burban A, Humbert L, Bachour-El Azzi P, Felix-Gomes N, Rainteau D, Guillouzo A.

Toxicol Sci. 2015 Oct;147(2):573-87. doi: 10.1093/toxsci/kfv155. Epub 2015 Jul 20.


Comparative Localization and Functional Activity of the Main Hepatobiliary Transporters in HepaRG Cells and Primary Human Hepatocytes.

Bachour-El Azzi P, Sharanek A, Burban A, Li R, Guével RL, Abdel-Razzak Z, Stieger B, Guguen-Guillouzo C, Guillouzo A.

Toxicol Sci. 2015 May;145(1):157-68. doi: 10.1093/toxsci/kfv041. Epub 2015 Feb 17.


[The histaminergic system: a target for innovative treatments of cognitive deficits].

Motawaj M, Burban A, Davenas E, Gbahou F, Faucard R, Morisset S, Arrang JM.

Therapie. 2010 Sep-Oct;65(5):415-22. doi: 10.2515/therapie/2010058. Epub 2010 Dec 13. French.


Activation of brain histaminergic neurotransmission: a mechanism for cognitive effects of memantine in Alzheimer's disease.

Motawaj M, Burban A, Davenas E, Arrang JM.

J Pharmacol Exp Ther. 2011 Feb;336(2):479-87. doi: 10.1124/jpet.110.174458. Epub 2010 Nov 5.


Modulation of prepulse inhibition and stereotypies in rodents: no evidence for antipsychotic-like properties of histamine H3-receptor inverse agonists.

Burban A, Sadakhom C, Dumoulin D, Rose C, Le Pen G, Frances H, Arrang JM.

Psychopharmacology (Berl). 2010 Jul;210(4):591-604. doi: 10.1007/s00213-010-1863-2. Epub 2010 May 1.


Histamine potentiates N-methyl-D-aspartate receptors by interacting with an allosteric site distinct from the polyamine binding site.

Burban A, Faucard R, Armand V, Bayard C, Vorobjev V, Arrang JM.

J Pharmacol Exp Ther. 2010 Mar;332(3):912-21. doi: 10.1124/jpet.109.158543. Epub 2009 Dec 15.


Brain histamine and schizophrenia: potential therapeutic applications of H3-receptor inverse agonists studied with BF2.649.

Ligneau X, Landais L, Perrin D, Piriou J, Uguen M, Denis E, Robert P, Parmentier R, Anaclet C, Lin JS, Burban A, Arrang JM, Schwartz JC.

Biochem Pharmacol. 2007 Apr 15;73(8):1215-24. Epub 2007 Jan 21.


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