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Items: 1 to 50 of 276

1.

Protein kinase D and Gβγ mediate sustained nociceptive signaling by biased agonists of protease-activated receptor-2.

Zhao P, Pattison LA, Jensen DD, Jimenez-Vargas NN, Latorre R, Lieu T, Jaramillo JO, Lopez-Lopez C, Poole DP, Vanner SJ, Schmidt BL, Bunnett NW.

J Biol Chem. 2019 May 29. pii: jbc.RA118.006935. doi: 10.1074/jbc.RA118.006935. [Epub ahead of print]

2.

Effects of Serotonin and Slow-release 5-HTP on Gastrointestinal Motility in a Mouse Model of Depression.

Israelyan N, Del Colle A, Li Z, Park Y, Xing A, Jacobsen JPR, Luna RA, Jensen DD, Madra M, Saurman V, Rahim R, Latorre R, Law K, Carson W, Bunnett NW, Caron MG, Margolis KG.

Gastroenterology. 2019 Apr 25. pii: S0016-5085(19)36715-0. doi: 10.1053/j.gastro.2019.04.022. [Epub ahead of print]

PMID:
31071306
3.

Sez6 levels are elevated in cerebrospinal fluid of patients with inflammatory pain-associated conditions.

Roitman M, Edgington-Mitchell LE, Mangum J, Ziogas J, Adamides AA, Myles P, Choo-Bunnett H, Bunnett NW, Gunnersen JM.

Pain Rep. 2019 Mar 25;4(2):e719. doi: 10.1097/PR9.0000000000000719. eCollection 2019 Mar-Apr.

4.

G-Protein-Coupled Receptors Are Dynamic Regulators of Digestion and Targets for Digestive Diseases.

Canals M, Poole DP, Veldhuis NA, Schmidt BL, Bunnett NW.

Gastroenterology. 2019 May;156(6):1600-1616. doi: 10.1053/j.gastro.2019.01.266. Epub 2019 Feb 13. Review.

5.

Revised guidelines to enhance the rigor and reproducibility of research published in American Physiological Society journals.

Yosten GLC, Adams JC, Bennett CN, Bunnett NW, Scheman R, Sigmund CD, Yates BJ, Zucker IH, Samson WK.

Am J Physiol Regul Integr Comp Physiol. 2018 Dec 1;315(6):R1251-R1253. doi: 10.1152/ajpregu.00274.2018. Epub 2018 Oct 17. No abstract available.

PMID:
30332303
6.

Therapeutic Targeting of Endosomal G-Protein-Coupled Receptors.

Thomsen ARB, Jensen DD, Hicks GA, Bunnett NW.

Trends Pharmacol Sci. 2018 Oct;39(10):879-891. doi: 10.1016/j.tips.2018.08.003. Epub 2018 Sep 1. Review.

7.

Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome.

Jimenez-Vargas NN, Pattison LA, Zhao P, Lieu T, Latorre R, Jensen DD, Castro J, Aurelio L, Le GT, Flynn B, Herenbrink CK, Yeatman HR, Edgington-Mitchell L, Porter CJH, Halls ML, Canals M, Veldhuis NA, Poole DP, McLean P, Hicks GA, Scheff N, Chen E, Bhattacharya A, Schmidt BL, Brierley SM, Vanner SJ, Bunnett NW.

Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7438-E7447. doi: 10.1073/pnas.1721891115. Epub 2018 Jul 16.

8.

TRPA1/NOX in the soma of trigeminal ganglion neurons mediates migraine-related pain of glyceryl trinitrate in mice.

Marone IM, De Logu F, Nassini R, De Carvalho Goncalves M, Benemei S, Ferreira J, Jain P, Li Puma S, Bunnett NW, Geppetti P, Materazzi S.

Brain. 2018 Aug 1;141(8):2312-2328. doi: 10.1093/brain/awy177.

9.

Inflammation-associated changes in DOR expression and function in the mouse colon.

DiCello JJ, Saito A, Rajasekhar P, Eriksson EM, McQuade RM, Nowell CJ, Sebastian BW, Fichna J, Veldhuis NA, Canals M, Bunnett NW, Carbone SE, Poole DP.

Am J Physiol Gastrointest Liver Physiol. 2018 Oct 1;315(4):G544-G559. doi: 10.1152/ajpgi.00025.2018. Epub 2018 Jun 21.

PMID:
29927325
10.

Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice.

De Logu F, Nassini R, Materazzi S, Carvalho Gonçalves M, Nosi D, Rossi Degl'Innocenti D, Marone IM, Ferreira J, Li Puma S, Benemei S, Trevisan G, Souza Monteiro de Araújo D, Patacchini R, Bunnett NW, Geppetti P.

Nat Commun. 2017 Dec 1;8(1):1887. doi: 10.1038/s41467-017-01739-2.

11.

Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission.

Yarwood RE, Imlach WL, Lieu T, Veldhuis NA, Jensen DD, Klein Herenbrink C, Aurelio L, Cai Z, Christie MJ, Poole DP, Porter CJH, McLean P, Hicks GA, Geppetti P, Halls ML, Canals M, Bunnett NW.

Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):12309-12314. doi: 10.1073/pnas.1706656114. Epub 2017 Oct 30.

12.

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief.

Jensen DD, Lieu T, Halls ML, Veldhuis NA, Imlach WL, Mai QN, Poole DP, Quach T, Aurelio L, Conner J, Herenbrink CK, Barlow N, Simpson JS, Scanlon MJ, Graham B, McCluskey A, Robinson PJ, Escriou V, Nassini R, Materazzi S, Geppetti P, Hicks GA, Christie MJ, Porter CJH, Canals M, Bunnett NW.

Sci Transl Med. 2017 May 31;9(392). pii: eaal3447. doi: 10.1126/scitranslmed.aal3447.

13.

G-CSF Receptor Blockade Ameliorates Arthritic Pain and Disease.

Lee MC, McCubbin JA, Christensen AD, Poole DP, Rajasekhar P, Lieu T, Bunnett NW, Garcia-Caraballo S, Erickson A, Brierley SM, Saleh R, Achuthan A, Fleetwood AJ, Anderson RL, Hamilton JA, Cook AD.

J Immunol. 2017 May 1;198(9):3565-3575. doi: 10.4049/jimmunol.1602127. Epub 2017 Mar 20.

14.

Stress activates pronociceptive endogenous opioid signalling in DRG neurons during chronic colitis.

Guerrero-Alba R, Valdez-Morales EE, Jimenez-Vargas NN, Lopez-Lopez C, Jaramillo-Polanco J, Okamoto T, Nasser Y, Bunnett NW, Lomax AE, Vanner SJ.

Gut. 2017 Dec;66(12):2121-2131. doi: 10.1136/gutjnl-2016-311456. Epub 2016 Sep 2.

PMID:
27590998
15.

Legumain is activated in macrophages during pancreatitis.

Edgington-Mitchell LE, Wartmann T, Fleming AK, Gocheva V, van der Linden WA, Withana NP, Verdoes M, Aurelio L, Edgington-Mitchell D, Lieu T, Parker BS, Graham B, Reinheckel T, Furness JB, Joyce JA, Storz P, Halangk W, Bogyo M, Bunnett NW.

Am J Physiol Gastrointest Liver Physiol. 2016 Sep 1;311(3):G548-60. doi: 10.1152/ajpgi.00047.2016. Epub 2016 Aug 11.

16.

Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease-activated receptor-2.

Lieu T, Savage E, Zhao P, Edgington-Mitchell L, Barlow N, Bron R, Poole DP, McLean P, Lohman RJ, Fairlie DP, Bunnett NW.

Br J Pharmacol. 2016 Sep;173(18):2752-65. doi: 10.1111/bph.13554. Epub 2016 Aug 3.

17.

G Protein-Coupled Receptor Trafficking and Signalling in the Enteric Nervous System: The Past, Present and Future.

Poole DP, Bunnett NW.

Adv Exp Med Biol. 2016;891:145-52. doi: 10.1007/978-3-319-27592-5_14. Review.

PMID:
27379642
18.

Distribution and trafficking of the μ-opioid receptor in enteric neurons of the guinea pig.

Lay J, Carbone SE, DiCello JJ, Bunnett NW, Canals M, Poole DP.

Am J Physiol Gastrointest Liver Physiol. 2016 Aug 1;311(2):G252-66. doi: 10.1152/ajpgi.00184.2016. Epub 2016 Jun 30.

19.

Protein Kinase D and Gβγ Subunits Mediate Agonist-evoked Translocation of Protease-activated Receptor-2 from the Golgi Apparatus to the Plasma Membrane.

Jensen DD, Zhao P, Jimenez-Vargas NN, Lieu T, Gerges M, Yeatman HR, Canals M, Vanner SJ, Poole DP, Bunnett NW.

J Biol Chem. 2016 May 20;291(21):11285-99. doi: 10.1074/jbc.M115.710681. Epub 2016 Mar 30.

20.

Neurotensin-induced miR-133α expression regulates neurotensin receptor 1 recycling through its downstream target aftiphilin.

Law IK, Jensen D, Bunnett NW, Pothoulakis C.

Sci Rep. 2016 Feb 23;6:22195. doi: 10.1038/srep22195.

21.

Plasma membrane localization of the μ-opioid receptor controls spatiotemporal signaling.

Halls ML, Yeatman HR, Nowell CJ, Thompson GL, Gondin AB, Civciristov S, Bunnett NW, Lambert NA, Poole DP, Canals M.

Sci Signal. 2016 Feb 9;9(414):ra16. doi: 10.1126/scisignal.aac9177.

PMID:
26861044
22.

G Protein-Coupled Receptors: Dynamic Machines for Signaling Pain and Itch.

Geppetti P, Veldhuis NA, Lieu T, Bunnett NW.

Neuron. 2015 Nov 18;88(4):635-49. doi: 10.1016/j.neuron.2015.11.001. Review.

23.

P2Y1 Receptor Activation of the TRPV4 Ion Channel Enhances Purinergic Signaling in Satellite Glial Cells.

Rajasekhar P, Poole DP, Liedtke W, Bunnett NW, Veldhuis NA.

J Biol Chem. 2015 Nov 27;290(48):29051-62. doi: 10.1074/jbc.M115.689729. Epub 2015 Oct 16.

24.

Prognostic and mechanistic potential of progesterone sulfates in intrahepatic cholestasis of pregnancy and pruritus gravidarum.

Abu-Hayyeh S, Ovadia C, Lieu T, Jensen DD, Chambers J, Dixon PH, Lövgren-Sandblom A, Bolier R, Tolenaars D, Kremer AE, Syngelaki A, Noori M, Williams D, Marin JJ, Monte MJ, Nicolaides KH, Beuers U, Oude-Elferink R, Seed PT, Chappell L, Marschall HU, Bunnett NW, Williamson C.

Hepatology. 2016 Apr;63(4):1287-98. doi: 10.1002/hep.28265. Epub 2015 Dec 28.

25.

Antibodies: friend or foe?

Bron R, Bunnett NW.

Am J Physiol Gastrointest Liver Physiol. 2015 Nov 1;309(9):G717-8. doi: 10.1152/ajpgi.00312.2015. Epub 2015 Sep 17. No abstract available.

26.

Transient receptor potential vanilloid 4 inhibits mouse colonic motility by activating NO-dependent enteric neurotransmission.

Fichna J, Poole DP, Veldhuis N, MacEachern SJ, Saur D, Zakrzewski PK, Cygankiewicz AI, Mokrowiecka A, Małecka-Panas E, Krajewska WM, Liedtke W, Steinhoff MS, Timmermans JP, Bunnett NW, Sharkey KA, Storr MA.

J Mol Med (Berl). 2015 Dec;93(12):1297-309. doi: 10.1007/s00109-015-1336-5. Epub 2015 Sep 2.

PMID:
26330151
27.

Demonstration of elevated levels of active cathepsin S in dextran sulfate sodium colitis using a new activatable probe.

Barlow N, Nasser Y, Zhao P, Sharma N, Guerrero-Alba R, Edgington-Mitchell LE, Lieu T, Veldhuis NA, Poole DP, Conner JW, Lindström E, Craig AW, Graham B, Vanner SJ, Bunnett NW.

Neurogastroenterol Motil. 2015 Nov;27(11):1675-80. doi: 10.1111/nmo.12656. Epub 2015 Aug 24.

PMID:
26303377
28.

Inflammation-induced abnormalities in the subcellular localization and trafficking of the neurokinin 1 receptor in the enteric nervous system.

Poole DP, Lieu T, Pelayo JC, Eriksson EM, Veldhuis NA, Bunnett NW.

Am J Physiol Gastrointest Liver Physiol. 2015 Aug 15;309(4):G248-59. doi: 10.1152/ajpgi.00118.2015. Epub 2015 Jul 2.

29.

CGRP induction in cystic fibrosis airways alters the submucosal gland progenitor cell niche in mice.

Xie W, Fisher JT, Lynch TJ, Luo M, Evans TI, Neff TL, Zhou W, Zhang Y, Ou Y, Bunnett NW, Russo AF, Goodheart MJ, Parekh KR, Liu X, Engelhardt JF.

J Clin Invest. 2015 May;125(5):2179. doi: 10.1172/JCI82138. Epub 2015 May 1. No abstract available.

30.

Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome.

Cenac N, Bautzova T, Le Faouder P, Veldhuis NA, Poole DP, Rolland C, Bertrand J, Liedtke W, Dubourdeau M, Bertrand-Michel J, Zecchi L, Stanghellini V, Bunnett NW, Barbara G, Vergnolle N.

Gastroenterology. 2015 Aug;149(2):433-44.e7. doi: 10.1053/j.gastro.2015.04.011. Epub 2015 Apr 22.

PMID:
25911511
31.

Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain.

Zhao P, Lieu T, Barlow N, Sostegni S, Haerteis S, Korbmacher C, Liedtke W, Jimenez-Vargas NN, Vanner SJ, Bunnett NW.

J Biol Chem. 2015 May 29;290(22):13875-87. doi: 10.1074/jbc.M115.642736. Epub 2015 Apr 15.

32.

Fatty Acid-binding Proteins 1 and 2 Differentially Modulate the Activation of Peroxisome Proliferator-activated Receptor α in a Ligand-selective Manner.

Hughes ML, Liu B, Halls ML, Wagstaff KM, Patil R, Velkov T, Jans DA, Bunnett NW, Scanlon MJ, Porter CJ.

J Biol Chem. 2015 May 29;290(22):13895-906. doi: 10.1074/jbc.M114.605998. Epub 2015 Apr 6.

33.

Corrigendum: biased signaling of protease-activated receptors.

Zhao P, Metcalf M, Bunnett NW.

Front Endocrinol (Lausanne). 2015 Jan 6;5:228. doi: 10.3389/fendo.2014.00228. eCollection 2014. No abstract available.

34.

GPCR-mediated EGF receptor transactivation regulates TRPV4 action in the vasculature.

Saifeddine M, El-Daly M, Mihara K, Bunnett NW, McIntyre P, Altier C, Hollenberg MD, Ramachandran R.

Br J Pharmacol. 2015 May;172(10):2493-506. doi: 10.1111/bph.13072. Epub 2015 Mar 18.

35.

The G protein-coupled receptor-transient receptor potential channel axis: molecular insights for targeting disorders of sensation and inflammation.

Veldhuis NA, Poole DP, Grace M, McIntyre P, Bunnett NW.

Pharmacol Rev. 2015;67(1):36-73. doi: 10.1124/pr.114.009555. Review.

PMID:
25361914
36.

The bile acid receptor TGR5 activates the TRPA1 channel to induce itch in mice.

Lieu T, Jayaweera G, Zhao P, Poole DP, Jensen D, Grace M, McIntyre P, Bron R, Wilson YM, Krappitz M, Haerteis S, Korbmacher C, Steinhoff MS, Nassini R, Materazzi S, Geppetti P, Corvera CU, Bunnett NW.

Gastroenterology. 2014 Dec;147(6):1417-28. doi: 10.1053/j.gastro.2014.08.042. Epub 2014 Sep 3.

37.

Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4.

Zhao P, Lieu T, Barlow N, Metcalf M, Veldhuis NA, Jensen DD, Kocan M, Sostegni S, Haerteis S, Baraznenok V, Henderson I, Lindström E, Guerrero-Alba R, Valdez-Morales EE, Liedtke W, McIntyre P, Vanner SJ, Korbmacher C, Bunnett NW.

J Biol Chem. 2014 Sep 26;289(39):27215-34. doi: 10.1074/jbc.M114.599712. Epub 2014 Aug 12. Erratum in: J Biol Chem. 2014 Dec 26;289(52):35858.

38.

Endothelin-converting enzyme 1 and β-arrestins exert spatiotemporal control of substance P-induced inflammatory signals.

Jensen DD, Halls ML, Murphy JE, Canals M, Cattaruzza F, Poole DP, Lieu T, Koon HW, Pothoulakis C, Bunnett NW.

J Biol Chem. 2014 Jul 18;289(29):20283-94. doi: 10.1074/jbc.M114.578179. Epub 2014 Jun 4.

39.

Biased signaling of protease-activated receptors.

Zhao P, Metcalf M, Bunnett NW.

Front Endocrinol (Lausanne). 2014 May 13;5:67. doi: 10.3389/fendo.2014.00067. eCollection 2014. Review.

40.

Proteolytic activation of the human epithelial sodium channel by trypsin IV and trypsin I involves distinct cleavage sites.

Haerteis S, Krappitz A, Krappitz M, Murphy JE, Bertog M, Krueger B, Nacken R, Chung H, Hollenberg MD, Knecht W, Bunnett NW, Korbmacher C.

J Biol Chem. 2014 Jul 4;289(27):19067-78. doi: 10.1074/jbc.M113.538470. Epub 2014 May 19.

41.

Neural peptidase endothelin-converting enzyme 1 regulates endothelin 1-induced pruritus.

Kido-Nakahara M, Buddenkotte J, Kempkes C, Ikoma A, Cevikbas F, Akiyama T, Nunes F, Seeliger S, Hasdemir B, Mess C, Buhl T, Sulk M, Müller FU, Metze D, Bunnett NW, Bhargava A, Carstens E, Furue M, Steinhoff M.

J Clin Invest. 2014 Jun;124(6):2683-95. doi: 10.1172/JCI67323. Epub 2014 May 8.

42.

The tyrosine kinase inhibitor bafetinib inhibits PAR2-induced activation of TRPV4 channels in vitro and pain in vivo.

Grace MS, Lieu T, Darby B, Abogadie FC, Veldhuis N, Bunnett NW, McIntyre P.

Br J Pharmacol. 2014 Aug;171(16):3881-94. doi: 10.1111/bph.12750.

43.

Serine proteases and protease-activated receptor 2 mediate the proinflammatory and algesic actions of diverse stimulants.

Cattaruzza F, Amadesi S, Carlsson JF, Murphy JE, Lyo V, Kirkwood K, Cottrell GS, Bogyo M, Knecht W, Bunnett NW.

Br J Pharmacol. 2014 Aug;171(16):3814-26. doi: 10.1111/bph.12738.

44.

Localisation and activation of the neurokinin 1 receptor in the enteric nervous system of the mouse distal colon.

Pelayo JC, Veldhuis NA, Eriksson EM, Bunnett NW, Poole DP.

Cell Tissue Res. 2014 May;356(2):319-32. doi: 10.1007/s00441-014-1822-z. Epub 2014 Apr 12.

PMID:
24728885
45.

Activation of mu opioid receptors sensitizes transient receptor potential vanilloid type 1 (TRPV1) via β-arrestin-2-mediated cross-talk.

Rowan MP, Bierbower SM, Eskander MA, Szteyn K, Por ED, Gomez R, Veldhuis N, Bunnett NW, Jeske NA.

PLoS One. 2014 Apr 2;9(4):e93688. doi: 10.1371/journal.pone.0093688. eCollection 2014.

46.

Neuro-humoral signalling by bile acids and the TGR5 receptor in the gastrointestinal tract.

Bunnett NW.

J Physiol. 2014 Jul 15;592(14):2943-50. doi: 10.1113/jphysiol.2014.271155. Epub 2014 Mar 10. Review.

47.

Feeding-dependent activation of enteric cells and sensory neurons by lymphatic fluid: evidence for a neurolymphocrine system.

Poole DP, Lee M, Tso P, Bunnett NW, Yo SJ, Lieu T, Shiu A, Wang JC, Nomura DK, Aponte GW.

Am J Physiol Gastrointest Liver Physiol. 2014 Apr 15;306(8):G686-98. doi: 10.1152/ajpgi.00433.2013. Epub 2014 Feb 27.

48.

Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease.

Steinhoff MS, von Mentzer B, Geppetti P, Pothoulakis C, Bunnett NW.

Physiol Rev. 2014 Jan;94(1):265-301. doi: 10.1152/physrev.00031.2013. Review.

49.

Localization of receptors for calcitonin-gene-related peptide to intraganglionic laminar endings of the mouse esophagus: peripheral interaction between vagal and spinal afferents?

Horling L, Bunnett NW, Messlinger K, Neuhuber WL, Raab M.

Histochem Cell Biol. 2014 Mar;141(3):321-35. doi: 10.1007/s00418-013-1162-1. Epub 2013 Nov 8.

PMID:
24203088
50.

GPBA: a GPCR for bile acids and an emerging therapeutic target for disorders of digestion and sensation.

Lieu T, Jayaweera G, Bunnett NW.

Br J Pharmacol. 2014 Mar;171(5):1156-66. doi: 10.1111/bph.12426. Review.

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