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Items: 41


Vav2 lacks calcium entry-promoting scaffolding functions unique to Vav1 and inhibits T cell activation via Cdc42.

Fray MA, Charpentier JC, Sylvain NR, Seminario MC, Bunnell SC.

J Cell Sci. 2020 Jan 23. pii: jcs.238337. doi: 10.1242/jcs.238337. [Epub ahead of print]


The C-type Lectin Receptor-Driven, Th17 Cell-Mediated Severe Pathology in Schistosomiasis: Not All Immune Responses to Helminth Parasites Are Th2 Dominated.

Kalantari P, Bunnell SC, Stadecker MJ.

Front Immunol. 2019 Jan 30;10:26. doi: 10.3389/fimmu.2019.00026. eCollection 2019. Review.


Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection.

Sarhan J, Liu BC, Muendlein HI, Li P, Nilson R, Tang AY, Rongvaux A, Bunnell SC, Shao F, Green DR, Poltorak A.

Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):E10888-E10897. doi: 10.1073/pnas.1809548115. Epub 2018 Oct 31.


ADAP is an upstream regulator that precedes SLP-76 at sites of TCR engagement and stabilizes signaling microclusters.

Lewis JB, Scangarello FA, Murphy JM, Eidell KP, Sodipo MO, Ophir MJ, Sargeant R, Seminario MC, Bunnell SC.

J Cell Sci. 2018 Nov 8;131(21). pii: jcs215517. doi: 10.1242/jcs.215517.


CD209a Synergizes with Dectin-2 and Mincle to Drive Severe Th17 Cell-Mediated Schistosome Egg-Induced Immunopathology.

Kalantari P, Morales Y, Miller EA, Jaramillo LD, Ponichtera HE, Wuethrich MA, Cheong C, Seminario MC, Russo JM, Bunnell SC, Stadecker MJ.

Cell Rep. 2018 Jan 30;22(5):1288-1300. doi: 10.1016/j.celrep.2018.01.001.


Phagocytic Receptors Activate Syk and Src Signaling during Borrelia burgdorferi Phagocytosis.

Killpack TL, Ballesteros M, Bunnell SC, Bedugnis A, Kobzik L, Hu LT, Petnicki-Ocwieja T.

Infect Immun. 2017 Sep 20;85(10). pii: e00004-17. doi: 10.1128/IAI.00004-17. Print 2017 Oct.


Adaptor Protein-3-Mediated Trafficking of TLR2 Ligands Controls Specificity of Inflammatory Responses but Not Adaptor Complex Assembly.

Petnicki-Ocwieja T, Kern A, Killpack TL, Bunnell SC, Hu LT.

J Immunol. 2015 Nov 1;195(9):4331-40. doi: 10.4049/jimmunol.1501268. Epub 2015 Sep 30.


p53 keeps bystanders at the gates.

Fray MA, Bunnell SC.

Immunity. 2014 May 15;40(5):633-5. doi: 10.1016/j.immuni.2014.05.001.


CD209a expression on dendritic cells is critical for the development of pathogenic Th17 cell responses in murine schistosomiasis.

Ponichtera HE, Shainheit MG, Liu BC, Raychowdhury R, Larkin BM, Russo JM, Salantes DB, Lai CQ, Parnell LD, Yun TJ, Cheong C, Bunnell SC, Hacohen N, Stadecker MJ.

J Immunol. 2014 May 15;192(10):4655-65. doi: 10.4049/jimmunol.1400121. Epub 2014 Apr 11.


Activated PLC-γ1 is catalytically induced at LAT but activated PLC-γ1 is localized at both LAT- and TCR-containing complexes.

Cruz-Orcutt N, Vacaflores A, Connolly SF, Bunnell SC, Houtman JC.

Cell Signal. 2014 Apr;26(4):797-805. doi: 10.1016/j.cellsig.2013.12.022. Epub 2014 Jan 8.


The N terminus of SKAP55 enables T cell adhesion to TCR and integrin ligands via distinct mechanisms.

Ophir MJ, Liu BC, Bunnell SC.

J Cell Biol. 2013 Dec 23;203(6):1021-41. doi: 10.1083/jcb.201305088.


Age-dependent changes in the sphingolipid composition of mouse CD4+ T cell membranes and immune synapses implicate glucosylceramides in age-related T cell dysfunction.

Molano A, Huang Z, Marko MG, Azzi A, Wu D, Wang E, Kelly SL, Merrill AH Jr, Bunnell SC, Meydani SN.

PLoS One. 2012;7(10):e47650. doi: 10.1371/journal.pone.0047650. Epub 2012 Oct 26.


Vav1-mediated scaffolding interactions stabilize SLP-76 microclusters and contribute to antigen-dependent T cell responses.

Sylvain NR, Nguyen K, Bunnell SC.

Sci Signal. 2011 Mar 8;4(163):ra14. doi: 10.1126/scisignal.2001178.


Interference reflection microscopy.

Barr VA, Bunnell SC.

Curr Protoc Cell Biol. 2009 Dec;Chapter 4:Unit 4.23. doi: 10.1002/0471143030.cb0423s45.


Multiple microclusters: diverse compartments within the immune synapse.

Bunnell SC.

Curr Top Microbiol Immunol. 2010;340:123-54. doi: 10.1007/978-3-642-03858-7_7. Review.


A view to a kill: how ligand quality controls lethal hits.

Bunnell SC.

Immunity. 2009 Oct 16;31(4):531-3. doi: 10.1016/j.immuni.2009.09.011.


Characterization of a novel interaction between transcription factor TFII-I and the inducible tyrosine kinase in T cells.

Sacristán C, Schattgen SA, Berg LJ, Bunnell SC, Roy AL, Rosenstein Y.

Eur J Immunol. 2009 Sep;39(9):2584-95. doi: 10.1002/eji.200839031.


Vitamin E reverses impaired linker for activation of T cells activation in T cells from aged C57BL/6 mice.

Marko MG, Pang HJ, Ren Z, Azzi A, Huber BT, Bunnell SC, Meydani SN.

J Nutr. 2009 Jun;139(6):1192-7. doi: 10.3945/jn.108.103416. Epub 2009 Apr 29.


T cell costimulation via the integrin VLA-4 inhibits the actin-dependent centralization of signaling microclusters containing the adaptor SLP-76.

Nguyen K, Sylvain NR, Bunnell SC.

Immunity. 2008 Jun;28(6):810-21. doi: 10.1016/j.immuni.2008.04.019.


Signal initiation in T-cell receptor microclusters.

Seminario MC, Bunnell SC.

Immunol Rev. 2008 Feb;221:90-106. doi: 10.1111/j.1600-065X.2008.00593.x. Review.


Age-associated decline in effective immune synapse formation of CD4(+) T cells is reversed by vitamin E supplementation.

Marko MG, Ahmed T, Bunnell SC, Wu D, Chung H, Huber BT, Meydani SN.

J Immunol. 2007 Feb 1;178(3):1443-9.


Gelsolin overexpression alters actin dynamics and tyrosine phosphorylation of lipid raft-associated proteins in Jurkat T cells.

Morley SC, Sung J, Sun GP, Martelli MP, Bunnell SC, Bierer BE.

Mol Immunol. 2007 Mar;44(9):2469-80. Epub 2006 Dec 18.


Persistence of cooperatively stabilized signaling clusters drives T-cell activation.

Bunnell SC, Singer AL, Hong DI, Jacque BH, Jordan MS, Seminario MC, Barr VA, Koretzky GA, Samelson LE.

Mol Cell Biol. 2006 Oct;26(19):7155-66.


T-cell antigen receptor-induced signaling complexes: internalization via a cholesterol-dependent endocytic pathway.

Barr VA, Balagopalan L, Barda-Saad M, Polishchuk R, Boukari H, Bunnell SC, Bernot KM, Toda Y, Nossal R, Samelson LE.

Traffic. 2006 Sep;7(9):1143-62.


Role for the Abi/wave protein complex in T cell receptor-mediated proliferation and cytoskeletal remodeling.

Zipfel PA, Bunnell SC, Witherow DS, Gu JJ, Chislock EM, Ring C, Pendergast AM.

Curr Biol. 2006 Jan 10;16(1):35-46.


Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton.

Barda-Saad M, Braiman A, Titerence R, Bunnell SC, Barr VA, Samelson LE.

Nat Immunol. 2005 Jan;6(1):80-9. Epub 2004 Nov 21.


PTEN permits acute increases in D3-phosphoinositide levels following TCR stimulation but inhibits distal signaling events by reducing the basal activity of Akt.

Seminario MC, Precht P, Bunnell SC, Warren SE, Morris CM, Taub D, Wange RL.

Eur J Immunol. 2004 Nov;34(11):3165-75.


Determining the destiny of NF-kappa B after TCR ligation: it's CARMA1.

Bunnell SC.

Mol Interv. 2002 Oct;2(6):356-60, 338. Review.


Roles of the proline-rich domain in SLP-76 subcellular localization and T cell function.

Singer AL, Bunnell SC, Obstfeld AE, Jordan MS, Wu JN, Myung PS, Samelson LE, Koretzky GA.

J Biol Chem. 2004 Apr 9;279(15):15481-90. Epub 2004 Jan 13.


High-resolution multicolor imaging of dynamic signaling complexes in T cells stimulated by planar substrates.

Bunnell SC, Barr VA, Fuller CL, Samelson LE.

Sci STKE. 2003 Apr 8;2003(177):PL8.


T cell receptor ligation induces the formation of dynamically regulated signaling assemblies.

Bunnell SC, Hong DI, Kardon JR, Yamazaki T, McGlade CJ, Barr VA, Samelson LE.

J Cell Biol. 2002 Sep 30;158(7):1263-75.


Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT.

Bunnell SC, Kapoor V, Trible RP, Zhang W, Samelson LE.

Immunity. 2001 Mar;14(3):315-29.


Studies on the adapter molecule LAT.

Samelson LE, Bunnell SC, Trible RP, Yamazaki T, Zhang W.

Cold Spring Harb Symp Quant Biol. 1999;64:259-63. Review. No abstract available.


Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation.

Shan X, Czar MJ, Bunnell SC, Liu P, Liu Y, Schwartzberg PL, Wange RL.

Mol Cell Biol. 2000 Sep;20(18):6945-57.


Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade.

Bunnell SC, Diehn M, Yaffe MB, Findell PR, Cantley LC, Berg LJ.

J Biol Chem. 2000 Jan 21;275(3):2219-30.


The signal transduction of motion and antigen recognition: factors affecting T cell function and differentiation.

Bunnell SC, Berg LJ.

Genet Eng (N Y). 1998;20:63-110. Review. No abstract available.


Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity.

Heyeck SD, Wilcox HM, Bunnell SC, Berg LJ.

J Biol Chem. 1997 Oct 3;272(40):25401-8.


Regulatory intramolecular association in a tyrosine kinase of the Tec family.

Andreotti AH, Bunnell SC, Feng S, Berg LJ, Schreiber SL.

Nature. 1997 Jan 2;385(6611):93-7.


Identification of Itk/Tsk Src homology 3 domain ligands.

Bunnell SC, Henry PA, Kolluri R, Kirchhausen T, Rickles RJ, Berg LJ.

J Biol Chem. 1996 Oct 11;271(41):25646-56.

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