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Whither surgical quality assurance of breast cancer surgery (surgical margins and local recurrence) after paterson.

Bundred NJ, Thomas J, Dixon JMJ.

Breast Cancer Res Treat. 2017 Oct;165(3):473-475. doi: 10.1007/s10549-017-4369-3. Epub 2017 Jul 5.


Impact of Oncotype DX breast Recurrence Score testing on adjuvant chemotherapy use in early breast cancer: Real world experience in Greater Manchester, UK.

Loncaster J, Armstrong A, Howell S, Wilson G, Welch R, Chittalia A, Valentine WJ, Bundred NJ.

Eur J Surg Oncol. 2017 May;43(5):931-937. doi: 10.1016/j.ejso.2016.12.010. Epub 2017 Jan 9. Erratum in: Eur J Surg Oncol. 2017 Nov 23;:.


Recruitment to the "Breast-Activity and Healthy Eating After Diagnosis" (B-AHEAD) Randomized Controlled Trial.

Pegington M, Adams JE, Bundred NJ, Campbell AM, Howell A, Howell SJ, Speed S, Wolstenholme J, Harvie MN.

Integr Cancer Ther. 2018 Mar;17(1):131-137. doi: 10.1177/1534735416687850. Epub 2017 Jan 23.


Tissue Factor promotes breast cancer stem cell activity in vitro.

Shaker H, Harrison H, Clarke R, Landberg G, Bundred NJ, Versteeg HH, Kirwan CC.

Oncotarget. 2017 Apr 18;8(16):25915-25927. doi: 10.18632/oncotarget.13928.


Comparison of Local Recurrence After Simple and Skin-Sparing Mastectomy Performed in Patients with Ductal Carcinoma In Situ.

Timbrell S, Al-Himdani S, Shaw O, Tan K, Morris J, Bundred N.

Ann Surg Oncol. 2017 Apr;24(4):1071-1076. doi: 10.1245/s10434-016-5673-6. Epub 2016 Nov 11.


Impact of mutational profiles on response of primary oestrogen receptor-positive breast cancers to oestrogen deprivation.

Gellert P, Segal CV, Gao Q, López-Knowles E, Martin LA, Dodson A, Li T, Miller CA, Lu C, Mardis ER, Gillman A, Morden J, Graf M, Sidhu K, Evans A, Shere M, Holcombe C, McIntosh SA, Bundred N, Skene A, Maxwell W, Robertson J, Bliss JM, Smith I, Dowsett M; POETIC Trial Management Group and Trialists.

Nat Commun. 2016 Nov 9;7:13294. doi: 10.1038/ncomms13294.


Prediction of margin involvement and local recurrence after skin-sparing and simple mastectomy.

Al-Himdani S, Timbrell S, Tan KT, Morris J, Bundred NJ.

Eur J Surg Oncol. 2016 Jul;42(7):935-41. doi: 10.1016/j.ejso.2016.04.055. Epub 2016 May 3.


PO-36 - Thrombin Inhibition Preoperatively (TIP) in early breast cancer, the first clinical trial of NOACs as an anti-cancer agent: trial methodology.

Kirwan CC, Bundred NJ, Castle J, Clarke R, Dive C, Morris J, Holcombe C, Harvey JR.

Thromb Res. 2016 Apr;140 Suppl 1:S189-90. doi: 10.1016/S0049-3848(16)30169-4. Epub 2016 Apr 8.


PO-21 - Stromal fibroblasts in preinvasive breast cancer (ductal carcinoma in situ, DCIS) demonstrate a cancer-like procoagulant phenotypic switch that may facilitate invasion.

Shaker H, Bundred NJ, Albadry H, Nicholson S, Castle J, Lumsden LJ, Pritchard S, Landberg G, Kirwan CC.

Thromb Res. 2016 Apr;140 Suppl 1:S184. doi: 10.1016/S0049-3848(16)30154-2. Epub 2016 Apr 8.


A randomised pilot study comparing 13 G vacuum-assisted biopsy and conventional 14 G core needle biopsy of axillary lymph nodes in women with breast cancer.

Maxwell AJ, Bundred NJ, Harvey J, Hunt R, Morris J, Lim YY.

Clin Radiol. 2016 Jun;71(6):551-7. doi: 10.1016/j.crad.2016.02.024. Epub 2016 Mar 31.


Phase II Randomized Preoperative Window-of-Opportunity Study of the PI3K Inhibitor Pictilisib Plus Anastrozole Compared With Anastrozole Alone in Patients With Estrogen Receptor-Positive Breast Cancer.

Schmid P, Pinder SE, Wheatley D, Macaskill J, Zammit C, Hu J, Price R, Bundred N, Hadad S, Shia A, Sarker SJ, Lim L, Gazinska P, Woodman N, Korbie D, Trau M, Mainwaring P, Gendreau S, Lackner MR, Derynck M, Wilson TR, Butler H, Earl G, Parker P, Purushotham A, Thompson A.

J Clin Oncol. 2016 Jun 10;34(17):1987-94. doi: 10.1200/JCO.2015.63.9179. Epub 2016 Mar 14.


Anastrozole versus tamoxifen for the prevention of locoregional and contralateral breast cancer in postmenopausal women with locally excised ductal carcinoma in situ (IBIS-II DCIS): a double-blind, randomised controlled trial.

Forbes JF, Sestak I, Howell A, Bonanni B, Bundred N, Levy C, von Minckwitz G, Eiermann W, Neven P, Stierer M, Holcombe C, Coleman RE, Jones L, Ellis I, Cuzick J; IBIS-II investigators.

Lancet. 2016 Feb 27;387(10021):866-73. doi: 10.1016/S0140-6736(15)01129-0. Epub 2015 Dec 11.


Randomized controlled trial of stereotactic 11-G vacuum-assisted core biopsy for the diagnosis and management of mammographic microcalcification.

Bundred SM, Maxwell AJ, Morris J, Lim YY, Harake MJ, Whiteside S, Bundred NJ.

Br J Radiol. 2016;89(1058):20150504. doi: 10.1259/bjr.20150504. Epub 2015 Dec 14.


Comparison of multi-frequency bioimpedance with perometry for the early detection and intervention of lymphoedema after axillary node clearance for breast cancer.

Bundred NJ, Stockton C, Keeley V, Riches K, Ashcroft L, Evans A, Skene A, Purushotham A, Bramley M, Hodgkiss T; Investigators of BEA/PLACE studies.

Breast Cancer Res Treat. 2015 May;151(1):121-9. doi: 10.1007/s10549-015-3357-8. Epub 2015 Apr 8.


Pretreatment health measures and complications after surgical management of elderly women with breast cancer.

Lavelle K, Sowerbutts AM, Bundred N, Pilling M, Todd C.

Br J Surg. 2015 May;102(6):653-67. doi: 10.1002/bjs.9796. Epub 2015 Mar 18.


Molecular phenotypes of DCIS predict overall and invasive recurrence.

Williams KE, Barnes NL, Cramer A, Johnson R, Cheema K, Morris J, Howe M, Bundred NJ.

Ann Oncol. 2015 May;26(5):1019-25. doi: 10.1093/annonc/mdv062. Epub 2015 Feb 12.


Radiotherapy or surgery of the axilla after a positive sentinel node in breast cancer (EORTC 10981-22023 AMAROS): a randomised, multicentre, open-label, phase 3 non-inferiority trial.

Donker M, van Tienhoven G, Straver ME, Meijnen P, van de Velde CJ, Mansel RE, Cataliotti L, Westenberg AH, Klinkenbijl JH, Orzalesi L, Bouma WH, van der Mijle HC, Nieuwenhuijzen GA, Veltkamp SC, Slaets L, Duez NJ, de Graaf PW, van Dalen T, Marinelli A, Rijna H, Snoj M, Bundred NJ, Merkus JW, Belkacemi Y, Petignat P, Schinagl DA, Coens C, Messina CG, Bogaerts J, Rutgers EJ.

Lancet Oncol. 2014 Nov;15(12):1303-10. doi: 10.1016/S1470-2045(14)70460-7. Epub 2014 Oct 15.


Antiproliferative Effect of Lapatinib in HER2-Positive and HER2-Negative/HER3-High Breast Cancer: Results of the Presurgical Randomized MAPLE Trial (CRUK E/06/039).

Leary A, Evans A, Johnston SR, A'Hern R, Bliss JM, Sahoo R, Detre S, Haynes BP, Hills M, Harper-Wynne C, Bundred N, Coombes G, Smith I, Dowsett M.

Clin Cancer Res. 2015 Jul 1;21(13):2932-40. doi: 10.1158/1078-0432.CCR-14-1428. Epub 2014 Nov 14.


Is axillary lymph node clearance required in node-positive breast cancer?

Bundred NJ, Barnes NL, Rutgers E, Donker M.

Nat Rev Clin Oncol. 2015 Jan;12(1):55-61. doi: 10.1038/nrclinonc.2014.188. Epub 2014 Nov 4. Review.


Focal adhesion kinase and Wnt signaling regulate human ductal carcinoma in situ stem cell activity and response to radiotherapy.

Williams KE, Bundred NJ, Landberg G, Clarke RB, Farnie G.

Stem Cells. 2015 Feb;33(2):327-41. doi: 10.1002/stem.1843.


Pleomorphic lobular carcinoma in situ of the breast: Can the evidence guide practice?

Pieri A, Harvey J, Bundred N.

World J Clin Oncol. 2014 Aug 10;5(3):546-53. doi: 10.5306/wjco.v5.i3.546. Review.


The sensitivity of pre-operative axillary staging in breast cancer: comparison of invasive lobular and ductal carcinoma.

Topps A, Clay V, Absar M, Howe M, Lim Y, Johnson R, Bundred N.

Eur J Surg Oncol. 2014 Jul;40(7):813-7. doi: 10.1016/j.ejso.2014.03.026. Epub 2014 Apr 4.


The frequency of presentation and clinico-pathological characteristics of symptomatic versus screen detected ductal carcinoma in situ of the breast.

Barnes NL, Dimopoulos N, Williams KE, Howe M, Bundred NJ.

Eur J Surg Oncol. 2014 Mar;40(3):249-54. doi: 10.1016/j.ejso.2013.12.013. Epub 2014 Jan 3.


Carcinoma in situ.

Bundred N, Dixon JM.

BMJ. 2013 Dec 23;347:f3289. doi: 10.1136/bmj.f3289. Review. No abstract available.


Impact of full-field digital mammography on pre-operative diagnosis and surgical treatment of mammographic microcalcification.

Bundred SM, Zhou J, Whiteside S, Morris J, Wilson M, Hurley E, Bundred N.

Breast Cancer Res Treat. 2014 Jan;143(2):359-66. doi: 10.1007/s10549-013-2803-8. Epub 2013 Dec 7.


Is lack of surgery for older breast cancer patients in the UK explained by patient choice or poor health? A prospective cohort study.

Lavelle K, Sowerbutts AM, Bundred N, Pilling M, Degner L, Stockton C, Todd C.

Br J Cancer. 2014 Feb 4;110(3):573-83. doi: 10.1038/bjc.2013.734. Epub 2013 Nov 28.


Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer.

Eccles SA, Aboagye EO, Ali S, Anderson AS, Armes J, Berditchevski F, Blaydes JP, Brennan K, Brown NJ, Bryant HE, Bundred NJ, Burchell JM, Campbell AM, Carroll JS, Clarke RB, Coles CE, Cook GJ, Cox A, Curtin NJ, Dekker LV, Silva Idos S, Duffy SW, Easton DF, Eccles DM, Edwards DR, Edwards J, Evans D, Fenlon DF, Flanagan JM, Foster C, Gallagher WM, Garcia-Closas M, Gee JM, Gescher AJ, Goh V, Groves AM, Harvey AJ, Harvie M, Hennessy BT, Hiscox S, Holen I, Howell SJ, Howell A, Hubbard G, Hulbert-Williams N, Hunter MS, Jasani B, Jones LJ, Key TJ, Kirwan CC, Kong A, Kunkler IH, Langdon SP, Leach MO, Mann DJ, Marshall JF, Martin L, Martin SG, Macdougall JE, Miles DW, Miller WR, Morris JR, Moss SM, Mullan P, Natrajan R, O'Connor JP, O'Connor R, Palmieri C, Pharoah PD, Rakha EA, Reed E, Robinson SP, Sahai E, Saxton JM, Schmid P, Smalley MJ, Speirs V, Stein R, Stingl J, Streuli CH, Tutt AN, Velikova G, Walker RA, Watson CJ, Williams KJ, Young LS, Thompson AM.

Breast Cancer Res. 2013 Oct 1;15(5):R92. doi: 10.1186/bcr3493. Review.


Lapatinib inhibits stem/progenitor proliferation in preclinical in vitro models of ductal carcinoma in situ (DCIS).

Farnie G, Johnson RL, Williams KE, Clarke RB, Bundred NJ.

Cell Cycle. 2014;13(3):418-25. doi: 10.4161/cc.27201. Epub 2013 Nov 18.


Targeting IL-8 signalling to inhibit breast cancer stem cell activity.

Singh JK, Simões BM, Clarke RB, Bundred NJ.

Expert Opin Ther Targets. 2013 Nov;17(11):1235-41. doi: 10.1517/14728222.2013.835398. Epub 2013 Sep 14.


Combined inhibition of ErbB1/2 and Notch receptors effectively targets breast ductal carcinoma in situ (DCIS) stem/progenitor cell activity regardless of ErbB2 status.

Farnie G, Willan PM, Clarke RB, Bundred NJ.

PLoS One. 2013;8(2):e56840. doi: 10.1371/journal.pone.0056840. Epub 2013 Feb 14.


Evaluation of the pharmacodynamics and pharmacokinetics of the PARP inhibitor olaparib: a phase I multicentre trial in patients scheduled for elective breast cancer surgery.

Bundred N, Gardovskis J, Jaskiewicz J, Eglitis J, Paramonov V, McCormack P, Swaisland H, Cavallin M, Parry T, Carmichael J, Dixon JM.

Invest New Drugs. 2013 Aug;31(4):949-58. doi: 10.1007/s10637-012-9922-7. Epub 2013 Jan 13.


Targeting CXCR1/2 significantly reduces breast cancer stem cell activity and increases the efficacy of inhibiting HER2 via HER2-dependent and -independent mechanisms.

Singh JK, Farnie G, Bundred NJ, Simões BM, Shergill A, Landberg G, Howell SJ, Clarke RB.

Clin Cancer Res. 2013 Feb 1;19(3):643-56. doi: 10.1158/1078-0432.CCR-12-1063. Epub 2012 Nov 13.


Zoledronic acid (zoledronate) for postmenopausal women with early breast cancer receiving adjuvant letrozole (ZO-FAST study): final 60-month results.

Coleman R, de Boer R, Eidtmann H, Llombart A, Davidson N, Neven P, von Minckwitz G, Sleeboom HP, Forbes J, Barrios C, Frassoldati A, Campbell I, Paija O, Martin N, Modi A, Bundred N.

Ann Oncol. 2013 Feb;24(2):398-405. doi: 10.1093/annonc/mds277. Epub 2012 Oct 9.


Cancer treatment-induced bone loss in premenopausal women: a need for therapeutic intervention?

Hadji P, Gnant M, Body JJ, Bundred NJ, Brufsky A, Coleman RE, Guise TA, Lipton A, Aapro MS.

Cancer Treat Rev. 2012 Oct;38(6):798-806. doi: 10.1016/j.ctrv.2012.02.008. Epub 2012 Mar 18. Review.


Ductal carcinoma in situ of the breast.

Barnes NL, Ooi JL, Yarnold JR, Bundred NJ.

BMJ. 2012 Feb 29;344:e797. doi: 10.1136/bmj.e797. Review. No abstract available.


Antiresorptive therapies in oncology and their effects on cancer progression.

Bundred N.

Cancer Treat Rev. 2012 Oct;38(6):776-86. doi: 10.1016/j.ctrv.2012.02.002. Epub 2012 Feb 26. Review.


Tibolone increases bone mineral density but also relapse in breast cancer survivors: LIBERATE trial bone substudy.

Bundred NJ, Kenemans P, Yip CH, Beckmann MW, Foidart JM, Sismondi P, Schoultz Bv, Vassilopoulou-Sellin R, Galta RE, Lieshout EV, Mol-Arts M, Planellas J, Kubista E.

Breast Cancer Res. 2012 Jan 17;14(1):R13.


Are symptomatic guidelines for chemotherapy appropriate to ER-positive screen-detected breast cancer (SDBC)?

Bundred NJ, Prasad R, Morris J, Knox WF, Byrne G, Cheung S, Wilson M, Lawrence G.

Breast Cancer Res Treat. 2013 Apr;138(2):359-68. doi: 10.1007/s10549-011-1652-6. Epub 2011 Jul 10.


Management of aromatase inhibitor-associated bone loss in postmenopausal women with breast cancer: practical guidance for prevention and treatment.

Hadji P, Aapro MS, Body JJ, Bundred NJ, Brufsky A, Coleman RE, Gnant M, Guise T, Lipton A.

Ann Oncol. 2011 Dec;22(12):2546-55. doi: 10.1093/annonc/mdr017. Epub 2011 Mar 17. Review.


Effect of tamoxifen and radiotherapy in women with locally excised ductal carcinoma in situ: long-term results from the UK/ANZ DCIS trial.

Cuzick J, Sestak I, Pinder SE, Ellis IO, Forsyth S, Bundred NJ, Forbes JF, Bishop H, Fentiman IS, George WD.

Lancet Oncol. 2011 Jan;12(1):21-9. doi: 10.1016/S1470-2045(10)70266-7. Epub 2010 Dec 7.


Uptake of breast cancer prevention and screening trials.

Evans DG, Harvie M, Bundred N, Howell A.

J Med Genet. 2010 Dec;47(12):853-5. doi: 10.1136/jmg.2010.082768. Epub 2010 Oct 23.


Efficacy of zoledronic acid in postmenopausal women with early breast cancer receiving adjuvant letrozole: 36-month results of the ZO-FAST Study.

Eidtmann H, de Boer R, Bundred N, Llombart-Cussac A, Davidson N, Neven P, von Minckwitz G, Miller J, Schenk N, Coleman R.

Ann Oncol. 2010 Nov;21(11):2188-94. doi: 10.1093/annonc/mdq217. Epub 2010 May 5.


Cyclooxygenase-2 inhibition does not improve the reduction in ductal carcinoma in situ proliferation with aromatase inhibitor therapy: results of the ERISAC randomized placebo-controlled trial.

Bundred NJ, Cramer A, Morris J, Renshaw L, Cheung KL, Flint P, Johnson R, Young O, Landberg G, Grassby S, Turner L, Baildam A, Barr L, Dixon JM.

Clin Cancer Res. 2010 Mar 1;16(5):1605-12. doi: 10.1158/1078-0432.CCR-09-1623. Epub 2010 Feb 23.


Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor.

Harrison H, Farnie G, Howell SJ, Rock RE, Stylianou S, Brennan KR, Bundred NJ, Clarke RB.

Cancer Res. 2010 Jan 15;70(2):709-18. doi: 10.1158/0008-5472.CAN-09-1681. Epub 2010 Jan 12.


Targeting inhibitor of apoptosis proteins in combination with ErbB antagonists in breast cancer.

Foster FM, Owens TW, Tanianis-Hughes J, Clarke RB, Brennan K, Bundred NJ, Streuli CH.

Breast Cancer Res. 2009;11(3):R41. doi: 10.1186/bcr2328. Epub 2009 Jun 29.


Safety and efficacy of tibolone in breast-cancer patients with vasomotor symptoms: a double-blind, randomised, non-inferiority trial.

Kenemans P, Bundred NJ, Foidart JM, Kubista E, von Schoultz B, Sismondi P, Vassilopoulou-Sellin R, Yip CH, Egberts J, Mol-Arts M, Mulder R, van Os S, Beckmann MW; LIBERATE Study Group.

Lancet Oncol. 2009 Feb;10(2):135-46. doi: 10.1016/S1470-2045(08)70341-3. Epub 2009 Jan 23.


Aromatase inhibitors and bone health.

Bundred NJ.

Curr Opin Obstet Gynecol. 2009 Feb;21(1):60-7. doi: 10.1097/GCO.0b013e32831da80e. Review.


Integrated analysis of zoledronic acid for prevention of aromatase inhibitor-associated bone loss in postmenopausal women with early breast cancer receiving adjuvant letrozole.

Brufsky A, Bundred N, Coleman R, Lambert-Falls R, Mena R, Hadji P, Jin L, Schenk N, Ericson S, Perez EA; Z-FAST and ZO-FAST Study Groups.

Oncologist. 2008 May;13(5):503-14. doi: 10.1634/theoncologist.2007-0206.

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