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Muscle length and joint angle influence spinal but not corticospinal excitability to the biceps brachii across forearm postures.

Forman DA, Abdel-Malek D, Bunce CMF, Holmes MWR.

J Neurophysiol. 2019 Jul 1;122(1):413-423. doi: 10.1152/jn.00620.2018. Epub 2019 May 22.


The 'known-knowns', and 'known-unknowns' of extracellular Nm23-H1/NDPK proteins.

Bunce CM, Khanim FL.

Lab Invest. 2018 May;98(5):602-608. doi: 10.1038/s41374-017-0012-5. Epub 2018 Jan 16. Review.


Response comparison of multiple myeloma and monoclonal gammopathy of undetermined significance to the same anti-myeloma therapy: a retrospective cohort study.

Campbell JP, Heaney JLJ, Pandya S, Afzal Z, Kaiser M, Owen R, Child JA, Cairns DA, Gregory W, Morgan GJ, Jackson GH, Bunce CM, Drayson MT.

Lancet Haematol. 2017 Dec;4(12):e584-e594. doi: 10.1016/S2352-3026(17)30209-0. Epub 2017 Nov 13.


Active multiple myeloma suppresses and typically eliminates coexisting MGUS.

Campbell JP, Heaney JLJ, Pandya S, Afzal Z, Kaiser M, Owen R, Child JA, Gregory W, Morgan GJ, Jackson GH, Bunce CM, Drayson MT.

Br J Cancer. 2017 Sep 5;117(6):835-839. doi: 10.1038/bjc.2017.229. Epub 2017 Jul 20.


Malonate as a ROS product is associated with pyruvate carboxylase activity in acute myeloid leukaemia cells.

Reed MAC, Ludwig C, Bunce CM, Khanim FL, Günther UL.

Cancer Metab. 2016 Aug 4;4:15. doi: 10.1186/s40170-016-0155-7. eCollection 2016.


Tracer-Based Metabolic NMR-Based Flux Analysis in a Leukaemia Cell Line.

Carrigan JB, Reed MA, Ludwig C, Khanim FL, Bunce CM, Günther UL.

Chempluschem. 2016 May;81(5):453-459. Epub 2016 Mar 22.


Tracer-Based Metabolic NMR-Based Flux Analysis in a Leukaemia Cell Line.

Carrigan JB, Reed MAC, Ludwig C, Khanim FL, Bunce CM, Günther UL.

Chempluschem. 2016 May;81(5):453-459. doi: 10.1002/cplu.201500549. Epub 2016 Mar 22.


Knockdown of AKR1C3 exposes a potential epigenetic susceptibility in prostate cancer cells.

Doig CL, Battaglia S, Khanim FL, Bunce CM, Campbell MJ.

J Steroid Biochem Mol Biol. 2016 Jan;155(Pt A):47-55. doi: 10.1016/j.jsbmb.2015.09.037. Epub 2015 Sep 30.


Metabolic plasticity in CLL: adaptation to the hypoxic niche.

Koczula KM, Ludwig C, Hayden R, Cronin L, Pratt G, Parry H, Tennant D, Drayson M, Bunce CM, Khanim FL, Günther UL.

Leukemia. 2016 Jan;30(1):65-73. doi: 10.1038/leu.2015.187. Epub 2015 Jul 23.


Drug Redeployment to Kill Leukemia and Lymphoma Cells by Disrupting SCD1-Mediated Synthesis of Monounsaturated Fatty Acids.

Southam AD, Khanim FL, Hayden RE, Constantinou JK, Koczula KM, Michell RH, Viant MR, Drayson MT, Bunce CM.

Cancer Res. 2015 Jun 15;75(12):2530-40. doi: 10.1158/0008-5472.CAN-15-0202. Epub 2015 May 5.


The case for extracellular Nm23-H1 as a driver of acute myeloid leukaemia (AML) progression.

Lilly AJ, Khanim FL, Bunce CM.

Naunyn Schmiedebergs Arch Pharmacol. 2015 Feb;388(2):225-33. doi: 10.1007/s00210-014-1027-8. Epub 2014 Aug 15. Review.


Bezafibrate and medroxyprogesterone acetate target resting and CD40L-stimulated primary marginal zone lymphoma and show promise in indolent B-cell non-Hodgkin lymphomas.

Hayden RE, Kussaibati R, Cronin LM, Pratt G, Roberts C, Drayson MT, Bunce CM.

Leuk Lymphoma. 2015 Apr;56(4):1079-87. doi: 10.3109/10428194.2014.939962. Epub 2014 Sep 8.


Bezafibrate and medroxyprogesterone acetate in resistant and relapsed endemic Burkitt lymphoma in Malawi; an open-label, single-arm, phase 2 study (ISRCTN34303497).

Molyneux E, Merrick B, Khanim FL, Banda K, Dunn JA, Iqbal G, Bunce CM, Drayson MT.

Br J Haematol. 2014 Mar;164(6):888-90. doi: 10.1111/bjh.12681. Epub 2013 Nov 25. No abstract available.


Proton NMR-based metabolite analyses of archived serial paired serum and urine samples from myeloma patients at different stages of disease activity identifies acetylcarnitine as a novel marker of active disease.

Lodi A, Tiziani S, Khanim FL, Günther UL, Viant MR, Morgan GJ, Bunce CM, Drayson MT.

PLoS One. 2013;8(2):e56422. doi: 10.1371/journal.pone.0056422. Epub 2013 Feb 19.


Redeployment-based drug screening identifies the anti-helminthic niclosamide as anti-myeloma therapy that also reduces free light chain production.

Khanim FL, Merrick BA, Giles HV, Jankute M, Jackson JB, Giles LJ, Birtwistle J, Bunce CM, Drayson MT.

Blood Cancer J. 2011 Oct;1(10):e39. doi: 10.1038/bcj.2011.38. Epub 2011 Oct 21.


The haematopoietic stem cell niche: new insights into the mechanisms regulating haematopoietic stem cell behaviour.

Lilly AJ, Johnson WE, Bunce CM.

Stem Cells Int. 2011;2011:274564. doi: 10.4061/2011/274564. Epub 2011 Oct 30.


A quick, simple and unbiased method to quantify C2C12 myogenic differentiation.

Veliça P, Bunce CM.

Muscle Nerve. 2011 Sep;44(3):366-70. doi: 10.1002/mus.22056.


Treatment of chronic lymphocytic leukemia requires targeting of the protective lymph node environment with novel therapeutic approaches.

Hayden RE, Pratt G, Roberts C, Drayson MT, Bunce CM.

Leuk Lymphoma. 2012 Apr;53(4):537-49. doi: 10.3109/10428194.2011.610014. Epub 2011 Sep 23. Review.


Nm23-h1 indirectly promotes the survival of acute myeloid leukemia blast cells by binding to more mature components of the leukemic clone.

Lilly AJ, Khanim FL, Hayden RE, Luong QT, Drayson MT, Bunce CM.

Cancer Res. 2011 Feb 1;71(3):1177-86. doi: 10.1158/0008-5472.CAN-10-1704. Epub 2010 Dec 17.


Hypoxia triggers major metabolic changes in AML cells without altering indomethacin-induced TCA cycle deregulation.

Lodi A, Tiziani S, Khanim FL, Drayson MT, Günther UL, Bunce CM, Viant MR.

ACS Chem Biol. 2011 Feb 18;6(2):169-75. doi: 10.1021/cb900300j. Epub 2010 Oct 18.


Extracellular Nm23H1 stimulates neurite outgrowth from dorsal root ganglia neurons in vitro independently of nerve growth factor supplementation or its nucleoside diphosphate kinase activity.

Wright KT, Seabright R, Logan A, Lilly AJ, Khanim F, Bunce CM, Johnson WE.

Biochem Biophys Res Commun. 2010 Jul 16;398(1):79-85. doi: 10.1016/j.bbrc.2010.06.039. Epub 2010 Jun 15.


Elevated NCOR1 disrupts PPARalpha/gamma signaling in prostate cancer and forms a targetable epigenetic lesion.

Battaglia S, Maguire O, Thorne JL, Hornung LB, Doig CL, Liu S, Sucheston LE, Bianchi A, Khanim FL, Gommersall LM, Coulter HS, Rakha S, Giddings I, O'Neill LP, Cooper CS, McCabe CJ, Bunce CM, Campbell MJ.

Carcinogenesis. 2010 Sep;31(9):1650-60. doi: 10.1093/carcin/bgq086. Epub 2010 May 13.


Prostaglandin D2 inhibits C2C12 myogenesis.

Veliça P, Khanim FL, Bunce CM.

Mol Cell Endocrinol. 2010 May 5;319(1-2):71-8. doi: 10.1016/j.mce.2010.01.023. Epub 2010 Jan 28.


Combined bezafibrate and medroxyprogesterone acetate have efficacy without haematological toxicity in elderly and relapsed acute myeloid leukaemia (AML).

Murray JA, Khanim FL, Hayden RE, Craddock CF, Holyoake TL, Jackson N, Lumley M, Bunce CM, Drayson MT.

Br J Haematol. 2010 Apr;149(1):65-9. doi: 10.1111/j.1365-2141.2009.08055.x. Epub 2010 Jan 13.


Lack of functional and expression homology between human and mouse aldo-keto reductase 1C enzymes: implications for modelling human cancers.

Veliça P, Davies NJ, Rocha PP, Schrewe H, Ride JP, Bunce CM.

Mol Cancer. 2009 Dec 14;8:121. doi: 10.1186/1476-4598-8-121. Erratum in: Mol Cancer. 2010;9:21.


Combined bezafibrate and medroxyprogesterone acetate: potential novel therapy for acute myeloid leukaemia.

Khanim FL, Hayden RE, Birtwistle J, Lodi A, Tiziani S, Davies NJ, Ride JP, Viant MR, Gunther UL, Mountford JC, Schrewe H, Green RM, Murray JA, Drayson MT, Bunce CM.

PLoS One. 2009 Dec 7;4(12):e8147. doi: 10.1371/journal.pone.0008147.


Characterization of two novel aldo-keto reductases from Arabidopsis: expression patterns, broad substrate specificity, and an open active-site structure suggest a role in toxicant metabolism following stress.

Simpson PJ, Tantitadapitak C, Reed AM, Mather OC, Bunce CM, White SA, Ride JP.

J Mol Biol. 2009 Sep 18;392(2):465-80. doi: 10.1016/j.jmb.2009.07.023. Epub 2009 Jul 15.


AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects.

Davies NJ, Hayden RE, Simpson PJ, Birtwistle J, Mayer K, Ride JP, Bunce CM.

Cancer Res. 2009 Jun 1;69(11):4769-75. doi: 10.1158/0008-5472.CAN-08-4533.


Analysis of the role of COP9 Signalosome (CSN) subunits in K562; the first link between CSN and autophagy.

Pearce C, Hayden RE, Bunce CM, Khanim FL.

BMC Cell Biol. 2009 Apr 28;10:31. doi: 10.1186/1471-2121-10-31.


The aldo-keto reductase AKR1C3 contributes to 7,12-dimethylbenz(a)anthracene-3,4-dihydrodiol mediated oxidative DNA damage in myeloid cells: implications for leukemogenesis.

Birtwistle J, Hayden RE, Khanim FL, Green RM, Pearce C, Davies NJ, Wake N, Schrewe H, Ride JP, Chipman JK, Bunce CM.

Mutat Res. 2009 Mar 9;662(1-2):67-74. doi: 10.1016/j.mrfmmm.2008.12.010. Epub 2008 Dec 31.


Metabolomic profiling of drug responses in acute myeloid leukaemia cell lines.

Tiziani S, Lodi A, Khanim FL, Viant MR, Bunce CM, Günther UL.

PLoS One. 2009;4(1):e4251. doi: 10.1371/journal.pone.0004251. Epub 2009 Jan 22. Erratum in: PLoS One. 2009;4(4). doi: 10.1371/annotation/39584d38-04f5-4b37-bfd8-eae2318ec6f9.


Supramolecular iron cylinder with unprecedented DNA binding is a potent cytostatic and apoptotic agent without exhibiting genotoxicity.

Hotze AC, Hodges NJ, Hayden RE, Sanchez-Cano C, Paines C, Male N, Tse MK, Bunce CM, Chipman JK, Hannon MJ.

Chem Biol. 2008 Dec 22;15(12):1258-67. doi: 10.1016/j.chembiol.2008.10.016.


Prostaglandins in muscle regeneration.

Veliça P, Bunce CM.

J Muscle Res Cell Motil. 2008;29(6-8):163-7. doi: 10.1007/s10974-008-9154-9. Epub 2008 Dec 4. Review.


Elevated FOSB-expression; a potential marker of valproate sensitivity in AML.

Khanim FL, Bradbury CA, Arrazi J, Hayden RE, Rye A, Basu S, MacWhannell A, Sawers A, Griffiths M, Cook M, Freeman S, Nightingale KP, Grimwade D, Falciani F, Turner BM, Bunce CM, Craddock C.

Br J Haematol. 2009 Feb;144(3):332-41. doi: 10.1111/j.1365-2141.2008.07449.x. Epub 2008 Nov 22.


Treatment of primary CLL cells with bezafibrate and medroxyprogesterone acetate induces apoptosis and represses the pro-proliferative signal of CD40-ligand, in part through increased 15dDelta12,14,PGJ2.

Hayden RE, Pratt G, Davies NJ, Khanim FL, Birtwistle J, Delgado J, Pearce C, Sant T, Drayson MT, Bunce CM.

Leukemia. 2009 Feb;23(2):292-304. doi: 10.1038/leu.2008.283. Epub 2008 Oct 16.


Induction of sodium iodide symporter gene and molecular characterisation of HNF3 beta/FoxA2, TTF-1 and C/EBP beta in thyroid carcinoma cells.

Akagi T, Luong QT, Gui D, Said J, Selektar J, Yung A, Bunce CM, Braunstein GD, Koeffler HP.

Br J Cancer. 2008 Sep 2;99(5):781-8. doi: 10.1038/sj.bjc.6604544.


Optimized metabolite extraction from blood serum for 1H nuclear magnetic resonance spectroscopy.

Tiziani S, Emwas AH, Lodi A, Ludwig C, Bunce CM, Viant MR, Günther UL.

Anal Biochem. 2008 Jun 1;377(1):16-23. doi: 10.1016/j.ab.2008.01.037. Epub 2008 Feb 5.


Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors.

Bradbury CA, Khanim FL, Hayden R, Bunce CM, White DA, Drayson MT, Craddock C, Turner BM.

Leukemia. 2005 Oct;19(10):1751-9.


The serotonin transporter (SLC6A4) is present in B-cell clones of diverse malignant origin: probing a potential anti-tumor target for psychotropics.

Meredith EJ, Holder MJ, Chamba A, Challa A, Drake-Lee A, Bunce CM, Drayson MT, Pilkington G, Blakely RD, Dyer MJ, Barnes NM, Gordon J.

FASEB J. 2005 Jul;19(9):1187-9. Epub 2005 May 3.


PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC.

Hampson P, Chahal H, Khanim F, Hayden R, Mulder A, Assi LK, Bunce CM, Lord JM.

Blood. 2005 Aug 15;106(4):1362-8. Epub 2005 Apr 21.


Fibrates and medroxyprogesterone acetate induce apoptosis of primary Burkitt's lymphoma cells and cell lines: potential for applying old drugs to a new disease.

Fenton SL, Luong QT, Sarafeim A, Mustard KJ, Pound J, Desmond JC, Gordon J, Drayson MT, Bunce CM.

Leukemia. 2003 Mar;17(3):568-75.


The aldo-keto reductase AKR1C3 is a novel suppressor of cell differentiation that provides a plausible target for the non-cyclooxygenase-dependent antineoplastic actions of nonsteroidal anti-inflammatory drugs.

Desmond JC, Mountford JC, Drayson MT, Walker EA, Hewison M, Ride JP, Luong QT, Hayden RE, Vanin EF, Bunce CM.

Cancer Res. 2003 Jan 15;63(2):505-12.


Selective serotonin reuptake inhibitors directly signal for apoptosis in biopsy-like Burkitt lymphoma cells.

Serafeim A, Holder MJ, Grafton G, Chamba A, Drayson MT, Luong QT, Bunce CM, Gregory CD, Barnes NM, Gordon J.

Blood. 2003 Apr 15;101(8):3212-9. Epub 2002 Dec 19.


Collagen or collagen-related peptide cause (Ca2+)i elevation and increased tyrosine phosphorylation in human megakaryocytes.

Mountford JC, Melford SK, Bunce CM, Gibbins J, Watson SP.

Thromb Haemost. 1999 Sep;82(3):1153-9.


Bistratene A induces a microtubule-dependent block in cytokinesis and altered stathmin expression in HL60 cells.

Johnson WE, Watters DJ, Suniara RK, Brown G, Bunce CM.

Biochem Biophys Res Commun. 1999 Jun 24;260(1):80-8.


Clofibric acid: a potential therapeutic agent in AML and MDS.

Fenton SL, Drayson MT, Hewison M, Vickers E, Brown G, Bunce CM.

Br J Haematol. 1999 May;105(2):448-51.


Estrone potentiates myeloid cell differentiation: a role for 17 beta-hydroxysteroid dehydrogenase in modulating hemopoiesis.

Mountford JC, Bunce CM, Hughes SV, Drayson MT, Webb D, Brown G, Hewison M.

Exp Hematol. 1999 Mar;27(3):451-60.


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