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Items: 27


Retinoic acid and 6-formylindolo(3,2-b)carbazole (FICZ) combination therapy reveals putative targets for enhancing response in non-APL AML.

Bunaciu RP, MacDonald RJ, Jensen HA, Gao F, Wang X, Johnson L, Varner JD, Yen A.

Leuk Lymphoma. 2018 Dec 20:1-12. doi: 10.1080/10428194.2018.1543880. [Epub ahead of print]


Src family kinase inhibitor bosutinib enhances retinoic acid-induced differentiation of HL-60 leukemia cells.

MacDonald RJ, Bunaciu RP, Ip V, Dai D, Tran D, Varner JD, Yen A.

Leuk Lymphoma. 2018 Dec;59(12):2941-2951. doi: 10.1080/10428194.2018.1452213. Epub 2018 Mar 23.


The c-Raf modulator RRD-251 enhances nuclear c-Raf/GSK-3/VDR axis signaling and augments 1,25-dihydroxyvitamin D3-induced differentiation of HL-60 myeloblastic leukemia cells.

Supnick HT, Bunaciu RP, Yen A.

Oncotarget. 2018 Jan 19;9(11):9808-9824. doi: 10.18632/oncotarget.24275. eCollection 2018 Feb 9.


Potential for subsets of wt-NPM1 primary AML blasts to respond to retinoic acid treatment.

Bunaciu RP, MacDonald RJ, Gao F, Johnson LM, Varner JD, Wang X, Nataraj S, Guzman ML, Yen A.

Oncotarget. 2017 Dec 23;9(3):4134-4149. doi: 10.18632/oncotarget.23642. eCollection 2018 Jan 9.


An Effective Model of the Retinoic Acid Induced HL-60 Differentiation Program.

Tasseff R, Jensen HA, Congleton J, Dai D, Rogers KV, Sagar A, Bunaciu RP, Yen A, Varner JD.

Sci Rep. 2017 Oct 30;7(1):14327. doi: 10.1038/s41598-017-14523-5.


RRD-251 enhances all-trans retinoic acid (RA)-induced differentiation of HL-60 myeloblastic leukemia cells.

Wallace AS, Supnick HT, Bunaciu RP, Yen A.

Oncotarget. 2016 Jul 19;7(29):46401-46418. doi: 10.18632/oncotarget.10136.


Induced myelomonocytic differentiation in leukemia cells is accompanied by noncanonical transcription factor expression.

Jensen HA, Yourish HB, Bunaciu RP, Varner JD, Yen A.

FEBS Open Bio. 2015 Sep 28;5:789-800. doi: 10.1016/j.fob.2015.09.008. eCollection 2015.


Retinoid Chemoprevention: Who Can Benefit?

Bunaciu RP, Yen A.

Curr Pharmacol Rep. 2015 Dec 1;1(6):391-400. Epub 2015 Apr 15.


Resveratrol and Malignancies.

Bunaciu RP, Yen A.

Curr Pharmacol Rep. 2015 Aug;1(4):266-271. Epub 2015 Mar 10.


6-Formylindolo(3,2-b)Carbazole (FICZ) Modulates the Signalsome Responsible for RA-Induced Differentiation of HL-60 Myeloblastic Leukemia Cells.

Bunaciu RP, Jensen HA, MacDonald RJ, LaTocha DH, Varner JD, Yen A.

PLoS One. 2015 Aug 19;10(8):e0135668. doi: 10.1371/journal.pone.0135668. eCollection 2015.


The AhR agonist VAF347 augments retinoic acid-induced differentiation in leukemia cells.

Ibabao CN, Bunaciu RP, Schaefer DM, Yen A.

FEBS Open Bio. 2015 Apr 8;5:308-18. doi: 10.1016/j.fob.2015.04.002. eCollection 2015.


GW5074 and PP2 kinase inhibitors implicate nontraditional c-Raf and Lyn function as drivers of retinoic acid-induced maturation.

Jensen HA, Bunaciu RP, Varner JD, Yen A.

Cell Signal. 2015 Aug;27(8):1666-75. doi: 10.1016/j.cellsig.2015.03.014. Epub 2015 Mar 26.


A 3D in situ cell counter reveals that breast tumor cell (MDA-MB-231) proliferation rate is reduced by the collagen matrix density.

Kim BJ, Zhao S, Bunaciu RP, Yen A, Wu M.

Biotechnol Prog. 2015 Jul-Aug;31(4):990-996. doi: 10.1002/btpr.2062. Epub 2015 Mar 1.


Retinoic acid therapy resistance progresses from unilineage to bilineage in HL-60 leukemic blasts.

Jensen HA, Bunaciu RP, Ibabao CN, Myers R, Varner JD, Yen A.

PLoS One. 2014 Jun 12;9(6):e98929. doi: 10.1371/journal.pone.0098929. eCollection 2014.


The Src-family kinase inhibitor PP2 rescues inducible differentiation events in emergent retinoic acid-resistant myeloblastic leukemia cells.

Jensen HA, Styskal LE, Tasseff R, Bunaciu RP, Congleton J, Varner JD, Yen A.

PLoS One. 2013;8(3):e58621. doi: 10.1371/journal.pone.0058621. Epub 2013 Mar 15.


Role of oil vehicle on hepatic cell proliferation in PCB-treated rats.

Bunaciu RP, Tharappel JC, Lehmler HJ, Lee EY, Robertson LW, Bruckner GG, Spear BT, Glauert HP.

J Environ Pathol Toxicol Oncol. 2011;30(4):273-82.


Interferon regulatory factor-1 binds c-Cbl, enhances mitogen activated protein kinase signaling and promotes retinoic acid-induced differentiation of HL-60 human myelo-monoblastic leukemia cells.

Shen M, Bunaciu RP, Congleton J, Jensen HA, Sayam LG, Varner JD, Yen A.

Leuk Lymphoma. 2011 Dec;52(12):2372-9. doi: 10.3109/10428194.2011.603449. Epub 2011 Aug 24.


Retinoic acid induces nuclear accumulation of Raf1 during differentiation of HL-60 cells.

Smith J, Bunaciu RP, Reiterer G, Coder D, George T, Asaly M, Yen A.

Exp Cell Res. 2009 Aug 1;315(13):2241-8. doi: 10.1016/j.yexcr.2009.03.004. Epub 2009 Mar 17.


Human myeloblastic leukemia cells (HL-60) express a membrane receptor for estrogen that signals and modulates retinoic acid-induced cell differentiation.

Kauss MA, Reiterer G, Bunaciu RP, Yen A.

Exp Cell Res. 2008 Oct 1;314(16):2999-3006. doi: 10.1016/j.yexcr.2008.07.015. Epub 2008 Jul 26.


Differential expression of Wnt13 isoforms during leukemic cell differentiation.

Bunaciu RP, Tang T, Mao CD.

Oncol Rep. 2008 Jul;20(1):195-201.


Inhibiting the platelet derived growth factor receptor increases signs of retinoic acid syndrome in myeloid differentiated HL-60 cells.

Reiterer G, Bunaciu RP, Smith JL, Yen A.

FEBS Lett. 2008 Jul 23;582(17):2508-14. doi: 10.1016/j.febslet.2008.06.016. Epub 2008 Jun 20.


The effect of dietary glycine on the hepatic tumor promoting activity of polychlorinated biphenyls (PCBs) in rats.

Bunaciu RP, Tharappel JC, Lehmler HJ, Kania-Korwel I, Robertson LW, Srinivasan C, Spear BT, Glauert HP.

Toxicology. 2007 Oct 8;239(3):147-55. Epub 2007 Jul 7.


Dietary vitamin E does not inhibit the promotion of liver carcinogenesis by polychlorinated biphenyls in rats.

Glauert HP, Lu Z, Kumar A, Bunaciu RP, Patel S, Tharappel JC, Stemm DN, Lehmler HJ, Lee EY, Robertson LW, Spear BT.

J Nutr. 2005 Feb;135(2):283-6.


Changes in performance, blood parameters, humoral and cellular immune responses in weanling piglets exposed to low doses of aflatoxin.

Marin DE, Taranu I, Bunaciu RP, Pascale F, Tudor DS, Avram N, Sarca M, Cureu I, Criste RD, Suta V, Oswald IP.

J Anim Sci. 2002 May;80(5):1250-7.


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