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Items: 1 to 50 of 183

1.

Bcl-2-Protein Family as Modulators of IP3 Receptors and Other Organellar Ca2+ Channels.

Ivanova H, Vervliet T, Monaco G, Terry LE, Rosa N, Baker MR, Parys JB, Serysheva II, Yule DI, Bultynck G.

Cold Spring Harb Perspect Biol. 2019 Sep 9. pii: a035089. doi: 10.1101/cshperspect.a035089. [Epub ahead of print]

PMID:
31501195
2.

Fundamentals of Cellular Calcium Signaling: A Primer.

Bootman MD, Bultynck G.

Cold Spring Harb Perspect Biol. 2019 Aug 19. pii: a038802. doi: 10.1101/cshperspect.a038802. [Epub ahead of print]

PMID:
31427372
3.

Interaction of α Carboxyl Terminus 1 Peptide With the Connexin 43 Carboxyl Terminus Preserves Left Ventricular Function After Ischemia-Reperfusion Injury.

Jiang J, Hoagland D, Palatinus JA, He H, Iyyathurai J, Jourdan LJ, Bultynck G, Wang Z, Zhang Z, Schey K, Poelzing S, McGowan FX, Gourdie RG.

J Am Heart Assoc. 2019 Aug 20;8(16):e012385. doi: 10.1161/JAHA.119.012385. Epub 2019 Aug 19.

4.

ER Ca2+ release and store-operated Ca2+ entry - partners in crime or independent actors in oncogenic transformation?

Pierro C, Sneyers F, Bultynck G, Roderick HL.

Cell Calcium. 2019 Sep;82:102061. doi: 10.1016/j.ceca.2019.102061. Epub 2019 Jul 27. Review.

PMID:
31394337
5.

Publisher Correction: Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics.

Carreras-Sureda A, Jaña F, Urra H, Durand S, Mortenson DE, Sagredo A, Bustos G, Hazari Y, Ramos-Fernández E, Sassano ML, Pihán P, van Vliet AR, González-Quiroz M, Torres AK, Tapia-Rojas C, Kerkhofs M, Vicente R, Kaufman RJ, Inestrosa NC, Gonzalez-Billault C, Wiseman RL, Agostinis P, Bultynck G, Court FA, Kroemer G, Cárdenas JC, Hetz C.

Nat Cell Biol. 2019 Jul;21(7):913. doi: 10.1038/s41556-019-0355-9.

PMID:
31201389
6.

Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics.

Carreras-Sureda A, Jaña F, Urra H, Durand S, Mortenson DE, Sagredo A, Bustos G, Hazari Y, Ramos-Fernández E, Sassano ML, Pihán P, van Vliet AR, González-Quiroz M, Torres AK, Tapia-Rojas C, Kerkhofs M, Vicente R, Kaufman RJ, Inestrosa NC, Gonzalez-Billault C, Wiseman RL, Agostinis P, Bultynck G, Court FA, Kroemer G, Cárdenas JC, Hetz C.

Nat Cell Biol. 2019 Jun;21(6):755-767. doi: 10.1038/s41556-019-0329-y. Epub 2019 May 20. Erratum in: Nat Cell Biol. 2019 Jun 14;:.

PMID:
31110288
7.

Bcl-2 and IP3 compete for the ligand-binding domain of IP3Rs modulating Ca2+ signaling output.

Ivanova H, Wagner LE 2nd, Tanimura A, Vandermarliere E, Luyten T, Welkenhuyzen K, Alzayady KJ, Wang L, Hamada K, Mikoshiba K, De Smedt H, Martens L, Yule DI, Parys JB, Bultynck G.

Cell Mol Life Sci. 2019 Oct;76(19):3843-3859. doi: 10.1007/s00018-019-03091-8. Epub 2019 Apr 16.

PMID:
30989245
8.

Ion and pH Sensitivity of a TMBIM Ca2+ Channel.

Guo G, Xu M, Chang Y, Luyten T, Seitaj B, Liu W, Zhu P, Bultynck G, Shi L, Quick M, Liu Q.

Structure. 2019 Jun 4;27(6):1013-1021.e3. doi: 10.1016/j.str.2019.03.003. Epub 2019 Mar 28.

PMID:
30930064
9.

Therapeutic implications of novel peptides targeting ER-mitochondria Ca2+-flux systems.

Kerkhofs M, Bultynck G, Vervliet T, Monaco G.

Drug Discov Today. 2019 May;24(5):1092-1103. doi: 10.1016/j.drudis.2019.03.020. Epub 2019 Mar 22. Review.

PMID:
30910738
10.

Calcium signaling in health, disease and therapy.

Parys JB, Bultynck G.

Biochim Biophys Acta Mol Cell Res. 2018 Nov;1865(11 Pt B):1657-1659. doi: 10.1016/j.bbamcr.2018.08.019. Epub 2018 Aug 30. No abstract available.

PMID:
30798945
11.

Recent advances in uncovering the mechanisms contributing to BIRD-2-induced cell death in B-cell cancer cells.

Kerkhofs M, Vervloessem T, Bittremieux M, Bultynck G.

Cell Death Dis. 2019 Jan 17;10(2):42. doi: 10.1038/s41419-018-1297-z. No abstract available.

12.

HIF-1α metabolically controls collagen synthesis and modification in chondrocytes.

Stegen S, Laperre K, Eelen G, Rinaldi G, Fraisl P, Torrekens S, Van Looveren R, Loopmans S, Bultynck G, Vinckier S, Meersman F, Maxwell PH, Rai J, Weis M, Eyre DR, Ghesquière B, Fendt SM, Carmeliet P, Carmeliet G.

Nature. 2019 Jan;565(7740):511-515. doi: 10.1038/s41586-019-0874-3. Epub 2019 Jan 16.

PMID:
30651640
13.

The ER Stress Inducer l-Azetidine-2-Carboxylic Acid Elevates the Levels of Phospho-eIF2α and of LC3-II in a Ca2+-Dependent Manner.

Roest G, Hesemans E, Welkenhuyzen K, Luyten T, Engedal N, Bultynck G, Parys JB.

Cells. 2018 Nov 30;7(12). pii: E239. doi: 10.3390/cells7120239.

14.

Therapeutic Targeting of Connexin Channels: New Views and Challenges.

Delvaeye T, Vandenabeele P, Bultynck G, Leybaert L, Krysko DV.

Trends Mol Med. 2018 Dec;24(12):1036-1053. doi: 10.1016/j.molmed.2018.10.005. Epub 2018 Nov 10. Review.

PMID:
30424929
15.

Extracellular and ER-stored Ca2+ contribute to BIRD-2-induced cell death in diffuse large B-cell lymphoma cells.

Bittremieux M, La Rovere RM, Schuermans M, Luyten T, Mikoshiba K, Vangheluwe P, Parys JB, Bultynck G.

Cell Death Discov. 2018 Nov 2;4:101. doi: 10.1038/s41420-018-0118-6. eCollection 2018.

16.

Sensory neuropathy-causing mutations in ATL3 affect ER-mitochondria contact sites and impair axonal mitochondrial distribution.

Krols M, Asselbergh B, De Rycke R, De Winter V, Seyer A, Müller FJ, Kurth I, Bultynck G, Timmerman V, Janssens S.

Hum Mol Genet. 2019 Feb 15;28(4):615-627. doi: 10.1093/hmg/ddy352.

17.

ABT-199 (Venetoclax), a BH3-mimetic Bcl-2 inhibitor, does not cause Ca2+ -signalling dysregulation or toxicity in pancreatic acinar cells.

Jakubowska MA, Kerkhofs M, Martines C, Efremov DG, Gerasimenko JV, Gerasimenko OV, Petersen OH, Bultynck G, Vervliet T, Ferdek PE.

Br J Pharmacol. 2018 Sep 28. doi: 10.1111/bph.14505. [Epub ahead of print]

18.

Nonlinear relationship between ER Ca2+ depletion versus induction of the unfolded protein response, autophagy inhibition, and cell death.

Szalai P, Parys JB, Bultynck G, Christensen SB, Nissen P, Møller JV, Engedal N.

Cell Calcium. 2018 Dec;76:48-61. doi: 10.1016/j.ceca.2018.09.005. Epub 2018 Sep 17.

PMID:
30261424
19.

Carbohydrate Loading to Combat Acute Pancreatitis.

Vervliet T, Yule DI, Bultynck G.

Trends Biochem Sci. 2018 Oct;43(10):741-744. doi: 10.1016/j.tibs.2018.08.001. Epub 2018 Aug 28.

PMID:
30170888
20.

Superoxide Anion Production and Bioenergetic Profile in Young and Elderly Human Primary Myoblasts.

Marrone M, La Rovere RML, Guarnieri S, Di Filippo ES, Monaco G, Pietrangelo T, Bultynck G, Fulle S, Mancinelli R.

Oxid Med Cell Longev. 2018 Jul 24;2018:2615372. doi: 10.1155/2018/2615372. eCollection 2018.

21.

Pathophysiological consequences of isoform-specific IP3 receptor mutations.

Kerkhofs M, Seitaj B, Ivanova H, Monaco G, Bultynck G, Parys JB.

Biochim Biophys Acta Mol Cell Res. 2018 Nov;1865(11 Pt B):1707-1717. doi: 10.1016/j.bbamcr.2018.06.004. Epub 2018 Jun 12. Review.

PMID:
29906486
22.

Constitutive IP3 signaling underlies the sensitivity of B-cell cancers to the Bcl-2/IP3 receptor disruptor BIRD-2.

Bittremieux M, La Rovere RM, Akl H, Martines C, Welkenhuyzen K, Dubron K, Baes M, Janssens A, Vandenberghe P, Laurenti L, Rietdorf K, Morciano G, Pinton P, Mikoshiba K, Bootman MD, Efremov DG, De Smedt H, Parys JB, Bultynck G.

Cell Death Differ. 2019 Mar;26(3):531-547. doi: 10.1038/s41418-018-0142-3. Epub 2018 Jun 13.

23.

BH4 domain peptides derived from Bcl-2/Bcl-XL as novel tools against acute pancreatitis.

Vervliet T, Gerasimenko JV, Ferdek PE, Jakubowska MA, Petersen OH, Gerasimenko OV, Bultynck G.

Cell Death Discov. 2018 May 10;4:58. doi: 10.1038/s41420-018-0054-5. eCollection 2018.

24.

Deleterious effects of calcium indicators within cells; an inconvenient truth.

Bootman MD, Allman S, Rietdorf K, Bultynck G.

Cell Calcium. 2018 Jul;73:82-87. doi: 10.1016/j.ceca.2018.04.005. Epub 2018 Apr 15. Review.

PMID:
29689523
25.

Role of Mitochondria-Associated ER Membranes in Calcium Regulation in Cancer-Specific Settings.

Morciano G, Marchi S, Morganti C, Sbano L, Bittremieux M, Kerkhofs M, Corricelli M, Danese A, Karkucinska-Wieckowska A, Wieckowski MR, Bultynck G, Giorgi C, Pinton P.

Neoplasia. 2018 May;20(5):510-523. doi: 10.1016/j.neo.2018.03.005. Epub 2018 Apr 5. Review.

26.

A critical appraisal of the role of intracellular Ca2+-signaling pathways in Kawasaki disease.

Bijnens J, Missiaen L, Bultynck G, Parys JB.

Cell Calcium. 2018 May;71:95-103. doi: 10.1016/j.ceca.2018.01.002. Epub 2018 Feb 3. Review.

PMID:
29604968
27.

Emerging molecular mechanisms in chemotherapy: Ca2+ signaling at the mitochondria-associated endoplasmic reticulum membranes.

Kerkhofs M, Bittremieux M, Morciano G, Giorgi C, Pinton P, Parys JB, Bultynck G.

Cell Death Dis. 2018 Feb 28;9(3):334. doi: 10.1038/s41419-017-0179-0. Review.

28.

Editorial: Inter-Organelle Calcium Communication in Cancer.

Cardenas C, Pinton P, Bultynck G.

Front Oncol. 2018 Feb 6;8:14. doi: 10.3389/fonc.2018.00014. eCollection 2018. No abstract available.

29.

Reciprocal sensitivity of diffuse large B-cell lymphoma cells to Bcl-2 inhibitors BIRD-2 versus venetoclax.

Vervloessem T, Akl H, Tousseyn T, De Smedt H, Parys JB, Bultynck G.

Oncotarget. 2017 Dec 4;8(67):111656-111671. doi: 10.18632/oncotarget.22898. eCollection 2017 Dec 19.

30.

The SH3-binding domain of Cx43 participates in loop/tail interactions critical for Cx43-hemichannel activity.

Iyyathurai J, Wang N, D'hondt C, Jiang JX, Leybaert L, Bultynck G.

Cell Mol Life Sci. 2018 Jun;75(11):2059-2073. doi: 10.1007/s00018-017-2722-7. Epub 2017 Dec 7.

31.

Ca2+ signaling and cell death: Focus on the role of Ca2+ signals in the regulation of cell death & survival processes in health, disease and therapy.

Parys JB, Bultynck G.

Cell Calcium. 2018 Mar;70:1-2. doi: 10.1016/j.ceca.2017.11.003. Epub 2017 Nov 22. No abstract available.

PMID:
29187297
32.

A double point mutation at residues Ile14 and Val15 of Bcl-2 uncovers a role for the BH4 domain in both protein stability and function.

Monaco G, La Rovere R, Karamanou S, Welkenhuyzen K, Ivanova H, Vandermarliere E, Di Martile M, Del Bufalo D, De Smedt H, Parys JB, Economou A, Bultynck G.

FEBS J. 2018 Jan;285(1):127-145. doi: 10.1111/febs.14324. Epub 2017 Dec 2.

33.

Tumor suppressive Ca2+ signaling is driven by IP3 receptor fitness.

Bultynck G, Campanella M.

Cell Stress. 2017 Nov 1;1(2):73-78. doi: 10.15698/cst2017.11.109. No abstract available.

34.

Organelle membrane derived patches: reshaping classical methods for new targets.

Shapovalov G, Ritaine A, Bidaux G, Slomianny C, Borowiec AS, Gordienko D, Bultynck G, Skryma R, Prevarskaya N.

Sci Rep. 2017 Oct 26;7(1):14082. doi: 10.1038/s41598-017-13968-y.

35.

Ca2+ signaling and cell death: Focus on Ca2+-transport systems and their implication in cell death and survival.

Bultynck G, Parys JB.

Cell Calcium. 2018 Jan;69:1-3. doi: 10.1016/j.ceca.2017.09.001. Epub 2017 Sep 8. No abstract available.

PMID:
28965649
36.

The regulation of autophagy by calcium signals: Do we have a consensus?

Bootman MD, Chehab T, Bultynck G, Parys JB, Rietdorf K.

Cell Calcium. 2018 Mar;70:32-46. doi: 10.1016/j.ceca.2017.08.005. Epub 2017 Aug 19. Review.

PMID:
28847414
37.

Alterations in Ca2+ Signalling via ER-Mitochondria Contact Site Remodelling in Cancer.

Kerkhofs M, Giorgi C, Marchi S, Seitaj B, Parys JB, Pinton P, Bultynck G, Bittremieux M.

Adv Exp Med Biol. 2017;997:225-254. doi: 10.1007/978-981-10-4567-7_17. Review.

PMID:
28815534
38.

Endoplasmic Reticulum-Mitochondria Communication Through Ca2+ Signaling: The Importance of Mitochondria-Associated Membranes (MAMs).

Marchi S, Bittremieux M, Missiroli S, Morganti C, Patergnani S, Sbano L, Rimessi A, Kerkhofs M, Parys JB, Bultynck G, Giorgi C, Pinton P.

Adv Exp Med Biol. 2017;997:49-67. doi: 10.1007/978-981-10-4567-7_4. Review.

PMID:
28815521
39.

IP3 Receptor-Mediated Calcium Signaling and Its Role in Autophagy in Cancer.

Kania E, Roest G, Vervliet T, Parys JB, Bultynck G.

Front Oncol. 2017 Jul 5;7:140. doi: 10.3389/fonc.2017.00140. eCollection 2017. Review.

40.

Bcl-2 inhibitors as anti-cancer therapeutics: The impact of and on calcium signaling.

Vervloessem T, Kerkhofs M, La Rovere RM, Sneyers F, Parys JB, Bultynck G.

Cell Calcium. 2018 Mar;70:102-116. doi: 10.1016/j.ceca.2017.05.014. Epub 2017 Jun 4. Review.

PMID:
28705421
41.

DebULKing fat in the heart: a fascinating role for autophagy.

Vervliet T, Bultynck G.

Cardiovasc Res. 2017 Aug 1;113(10):1089-1092. doi: 10.1093/cvr/cvx127. No abstract available.

PMID:
28666348
42.

Modulation of Ca2+ Signaling by Anti-apoptotic B-Cell Lymphoma 2 Proteins at the Endoplasmic Reticulum-Mitochondrial Interface.

Vervliet T, Clerix E, Seitaj B, Ivanova H, Monaco G, Bultynck G.

Front Oncol. 2017 May 3;7:75. doi: 10.3389/fonc.2017.00075. eCollection 2017. Review.

43.

Endoplasmic Reticulum-Mitochondrial Ca2+ Fluxes Underlying Cancer Cell Survival.

Ivanova H, Kerkhofs M, La Rovere RM, Bultynck G.

Front Oncol. 2017 May 3;7:70. doi: 10.3389/fonc.2017.00070. eCollection 2017. Review.

44.

Data on cytotoxicity in HeLa and SU-DHL-4 cells exposed to DPB162-AE compound.

Bittremieux M, Mikoshiba K, Bultynck G.

Data Brief. 2017 Mar 23;12:91-96. doi: 10.1016/j.dib.2017.03.034. eCollection 2017 Jun.

45.

Mitochondrial Cx43 hemichannels contribute to mitochondrial calcium entry and cell death in the heart.

Gadicherla AK, Wang N, Bulic M, Agullo-Pascual E, Lissoni A, De Smet M, Delmar M, Bultynck G, Krysko DV, Camara A, Schlüter KD, Schulz R, Kwok WM, Leybaert L.

Basic Res Cardiol. 2017 May;112(3):27. doi: 10.1007/s00395-017-0618-1. Epub 2017 Mar 31.

PMID:
28364353
46.

Basal ryanodine receptor activity suppresses autophagic flux.

Vervliet T, Pintelon I, Welkenhuyzen K, Bootman MD, Bannai H, Mikoshiba K, Martinet W, Nadif Kasri N, Parys JB, Bultynck G.

Biochem Pharmacol. 2017 May 15;132:133-142. doi: 10.1016/j.bcp.2017.03.011. Epub 2017 Mar 18.

PMID:
28322744
47.

Resveratrol-induced autophagy is dependent on IP3Rs and on cytosolic Ca2.

Luyten T, Welkenhuyzen K, Roest G, Kania E, Wang L, Bittremieux M, Yule DI, Parys JB, Bultynck G.

Biochim Biophys Acta Mol Cell Res. 2017 Jun;1864(6):947-956. doi: 10.1016/j.bbamcr.2017.02.013. Epub 2017 Feb 28.

48.

DPB162-AE, an inhibitor of store-operated Ca2+ entry, can deplete the endoplasmic reticulum Ca2+ store.

Bittremieux M, Gerasimenko JV, Schuermans M, Luyten T, Stapleton E, Alzayady KJ, De Smedt H, Yule DI, Mikoshiba K, Vangheluwe P, Gerasimenko OV, Parys JB, Bultynck G.

Cell Calcium. 2017 Mar;62:60-70. doi: 10.1016/j.ceca.2017.01.015. Epub 2017 Feb 1.

PMID:
28196740
49.

Calcium, oxidative stress and connexin channels, a harmonious orchestra directing the response to radiotherapy treatment?

Decrock E, Hoorelbeke D, Ramadan R, Delvaeye T, De Bock M, Wang N, Krysko DV, Baatout S, Bultynck G, Aerts A, Vinken M, Leybaert L.

Biochim Biophys Acta Mol Cell Res. 2017 Jun;1864(6):1099-1120. doi: 10.1016/j.bbamcr.2017.02.007. Epub 2017 Feb 11. Review.

50.

The BH4 domain of Bcl-2 orthologues from different classes of vertebrates can act as an evolutionary conserved inhibitor of IP3 receptor channels.

Ivanova H, Luyten T, Decrock E, Vervliet T, Leybaert L, Parys JB, Bultynck G.

Cell Calcium. 2017 Mar;62:41-46. doi: 10.1016/j.ceca.2017.01.010. Epub 2017 Jan 25.

PMID:
28179071

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