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Items: 1 to 50 of 179

1.

Publisher Correction: Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics.

Carreras-Sureda A, Jaña F, Urra H, Durand S, Mortenson DE, Sagredo A, Bustos G, Hazari Y, Ramos-Fernández E, Sassano ML, Pihán P, van Vliet AR, González-Quiroz M, Torres AK, Tapia-Rojas C, Kerkhofs M, Vicente R, Kaufman RJ, Inestrosa NC, Gonzalez-Billault C, Wiseman RL, Agostinis P, Bultynck G, Court FA, Kroemer G, Cárdenas JC, Hetz C.

Nat Cell Biol. 2019 Jun 14. doi: 10.1038/s41556-019-0355-9. [Epub ahead of print]

PMID:
31201389
2.

Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics.

Carreras-Sureda A, Jaña F, Urra H, Durand S, Mortenson DE, Sagredo A, Bustos G, Hazari Y, Ramos-Fernández E, Sassano ML, Pihán P, van Vliet AR, González-Quiroz M, Torres AK, Tapia-Rojas C, Kerkhofs M, Vicente R, Kaufman RJ, Inestrosa NC, Gonzalez-Billault C, Wiseman RL, Agostinis P, Bultynck G, Court FA, Kroemer G, Cárdenas JC, Hetz C.

Nat Cell Biol. 2019 Jun;21(6):755-767. doi: 10.1038/s41556-019-0329-y. Epub 2019 May 20. Erratum in: Nat Cell Biol. 2019 Jun 14;:.

PMID:
31110288
3.

Bcl-2 and IP3 compete for the ligand-binding domain of IP3Rs modulating Ca2+ signaling output.

Ivanova H, Wagner LE 2nd, Tanimura A, Vandermarliere E, Luyten T, Welkenhuyzen K, Alzayady KJ, Wang L, Hamada K, Mikoshiba K, De Smedt H, Martens L, Yule DI, Parys JB, Bultynck G.

Cell Mol Life Sci. 2019 Apr 16. doi: 10.1007/s00018-019-03091-8. [Epub ahead of print]

PMID:
30989245
4.

Ion and pH Sensitivity of a TMBIM Ca2+ Channel.

Guo G, Xu M, Chang Y, Luyten T, Seitaj B, Liu W, Zhu P, Bultynck G, Shi L, Quick M, Liu Q.

Structure. 2019 Jun 4;27(6):1013-1021.e3. doi: 10.1016/j.str.2019.03.003. Epub 2019 Mar 28.

PMID:
30930064
5.

Therapeutic implications of novel peptides targeting ER-mitochondria Ca2+-flux systems.

Kerkhofs M, Bultynck G, Vervliet T, Monaco G.

Drug Discov Today. 2019 May;24(5):1092-1103. doi: 10.1016/j.drudis.2019.03.020. Epub 2019 Mar 22. Review.

PMID:
30910738
6.

Calcium signaling in health, disease and therapy.

Parys JB, Bultynck G.

Biochim Biophys Acta Mol Cell Res. 2018 Nov;1865(11 Pt B):1657-1659. doi: 10.1016/j.bbamcr.2018.08.019. Epub 2018 Aug 30. No abstract available.

PMID:
30798945
7.

Recent advances in uncovering the mechanisms contributing to BIRD-2-induced cell death in B-cell cancer cells.

Kerkhofs M, Vervloessem T, Bittremieux M, Bultynck G.

Cell Death Dis. 2019 Jan 17;10(2):42. doi: 10.1038/s41419-018-1297-z. No abstract available.

8.

HIF-1α metabolically controls collagen synthesis and modification in chondrocytes.

Stegen S, Laperre K, Eelen G, Rinaldi G, Fraisl P, Torrekens S, Van Looveren R, Loopmans S, Bultynck G, Vinckier S, Meersman F, Maxwell PH, Rai J, Weis M, Eyre DR, Ghesquière B, Fendt SM, Carmeliet P, Carmeliet G.

Nature. 2019 Jan;565(7740):511-515. doi: 10.1038/s41586-019-0874-3. Epub 2019 Jan 16.

PMID:
30651640
9.

The ER Stress Inducer l-Azetidine-2-Carboxylic Acid Elevates the Levels of Phospho-eIF2α and of LC3-II in a Ca2+-Dependent Manner.

Roest G, Hesemans E, Welkenhuyzen K, Luyten T, Engedal N, Bultynck G, Parys JB.

Cells. 2018 Nov 30;7(12). pii: E239. doi: 10.3390/cells7120239.

10.

Therapeutic Targeting of Connexin Channels: New Views and Challenges.

Delvaeye T, Vandenabeele P, Bultynck G, Leybaert L, Krysko DV.

Trends Mol Med. 2018 Dec;24(12):1036-1053. doi: 10.1016/j.molmed.2018.10.005. Epub 2018 Nov 10. Review.

PMID:
30424929
11.

Extracellular and ER-stored Ca2+ contribute to BIRD-2-induced cell death in diffuse large B-cell lymphoma cells.

Bittremieux M, La Rovere RM, Schuermans M, Luyten T, Mikoshiba K, Vangheluwe P, Parys JB, Bultynck G.

Cell Death Discov. 2018 Nov 2;4:101. doi: 10.1038/s41420-018-0118-6. eCollection 2018.

12.

Sensory neuropathy-causing mutations in ATL3 affect ER-mitochondria contact sites and impair axonal mitochondrial distribution.

Krols M, Asselbergh B, De Rycke R, De Winter V, Seyer A, Müller FJ, Kurth I, Bultynck G, Timmerman V, Janssens S.

Hum Mol Genet. 2019 Feb 15;28(4):615-627. doi: 10.1093/hmg/ddy352.

13.

ABT-199 (Venetoclax), a BH3-mimetic Bcl-2 inhibitor, does not cause Ca2+ -signalling dysregulation or toxicity in pancreatic acinar cells.

Jakubowska MA, Kerkhofs M, Martines C, Efremov DG, Gerasimenko JV, Gerasimenko OV, Petersen OH, Bultynck G, Vervliet T, Ferdek PE.

Br J Pharmacol. 2018 Sep 28. doi: 10.1111/bph.14505. [Epub ahead of print]

PMID:
30266036
14.

Nonlinear relationship between ER Ca2+ depletion versus induction of the unfolded protein response, autophagy inhibition, and cell death.

Szalai P, Parys JB, Bultynck G, Christensen SB, Nissen P, Møller JV, Engedal N.

Cell Calcium. 2018 Dec;76:48-61. doi: 10.1016/j.ceca.2018.09.005. Epub 2018 Sep 17.

PMID:
30261424
15.

Carbohydrate Loading to Combat Acute Pancreatitis.

Vervliet T, Yule DI, Bultynck G.

Trends Biochem Sci. 2018 Oct;43(10):741-744. doi: 10.1016/j.tibs.2018.08.001. Epub 2018 Aug 28.

PMID:
30170888
16.

Superoxide Anion Production and Bioenergetic Profile in Young and Elderly Human Primary Myoblasts.

Marrone M, La Rovere RML, Guarnieri S, Di Filippo ES, Monaco G, Pietrangelo T, Bultynck G, Fulle S, Mancinelli R.

Oxid Med Cell Longev. 2018 Jul 24;2018:2615372. doi: 10.1155/2018/2615372. eCollection 2018.

17.

Pathophysiological consequences of isoform-specific IP3 receptor mutations.

Kerkhofs M, Seitaj B, Ivanova H, Monaco G, Bultynck G, Parys JB.

Biochim Biophys Acta Mol Cell Res. 2018 Nov;1865(11 Pt B):1707-1717. doi: 10.1016/j.bbamcr.2018.06.004. Epub 2018 Jun 12. Review.

PMID:
29906486
18.

Constitutive IP3 signaling underlies the sensitivity of B-cell cancers to the Bcl-2/IP3 receptor disruptor BIRD-2.

Bittremieux M, La Rovere RM, Akl H, Martines C, Welkenhuyzen K, Dubron K, Baes M, Janssens A, Vandenberghe P, Laurenti L, Rietdorf K, Morciano G, Pinton P, Mikoshiba K, Bootman MD, Efremov DG, De Smedt H, Parys JB, Bultynck G.

Cell Death Differ. 2019 Mar;26(3):531-547. doi: 10.1038/s41418-018-0142-3. Epub 2018 Jun 13.

19.

BH4 domain peptides derived from Bcl-2/Bcl-XL as novel tools against acute pancreatitis.

Vervliet T, Gerasimenko JV, Ferdek PE, Jakubowska MA, Petersen OH, Gerasimenko OV, Bultynck G.

Cell Death Discov. 2018 May 10;4:58. doi: 10.1038/s41420-018-0054-5. eCollection 2018.

20.

Deleterious effects of calcium indicators within cells; an inconvenient truth.

Bootman MD, Allman S, Rietdorf K, Bultynck G.

Cell Calcium. 2018 Jul;73:82-87. doi: 10.1016/j.ceca.2018.04.005. Epub 2018 Apr 15. Review.

PMID:
29689523
21.

Role of Mitochondria-Associated ER Membranes in Calcium Regulation in Cancer-Specific Settings.

Morciano G, Marchi S, Morganti C, Sbano L, Bittremieux M, Kerkhofs M, Corricelli M, Danese A, Karkucinska-Wieckowska A, Wieckowski MR, Bultynck G, Giorgi C, Pinton P.

Neoplasia. 2018 May;20(5):510-523. doi: 10.1016/j.neo.2018.03.005. Epub 2018 Apr 5. Review.

22.

A critical appraisal of the role of intracellular Ca2+-signaling pathways in Kawasaki disease.

Bijnens J, Missiaen L, Bultynck G, Parys JB.

Cell Calcium. 2018 May;71:95-103. doi: 10.1016/j.ceca.2018.01.002. Epub 2018 Feb 3. Review.

PMID:
29604968
23.

Emerging molecular mechanisms in chemotherapy: Ca2+ signaling at the mitochondria-associated endoplasmic reticulum membranes.

Kerkhofs M, Bittremieux M, Morciano G, Giorgi C, Pinton P, Parys JB, Bultynck G.

Cell Death Dis. 2018 Feb 28;9(3):334. doi: 10.1038/s41419-017-0179-0. Review.

24.

Editorial: Inter-Organelle Calcium Communication in Cancer.

Cardenas C, Pinton P, Bultynck G.

Front Oncol. 2018 Feb 6;8:14. doi: 10.3389/fonc.2018.00014. eCollection 2018. No abstract available.

25.

Reciprocal sensitivity of diffuse large B-cell lymphoma cells to Bcl-2 inhibitors BIRD-2 versus venetoclax.

Vervloessem T, Akl H, Tousseyn T, De Smedt H, Parys JB, Bultynck G.

Oncotarget. 2017 Dec 4;8(67):111656-111671. doi: 10.18632/oncotarget.22898. eCollection 2017 Dec 19.

26.

The SH3-binding domain of Cx43 participates in loop/tail interactions critical for Cx43-hemichannel activity.

Iyyathurai J, Wang N, D'hondt C, Jiang JX, Leybaert L, Bultynck G.

Cell Mol Life Sci. 2018 Jun;75(11):2059-2073. doi: 10.1007/s00018-017-2722-7. Epub 2017 Dec 7.

27.

Ca2+ signaling and cell death: Focus on the role of Ca2+ signals in the regulation of cell death & survival processes in health, disease and therapy.

Parys JB, Bultynck G.

Cell Calcium. 2018 Mar;70:1-2. doi: 10.1016/j.ceca.2017.11.003. Epub 2017 Nov 22. No abstract available.

PMID:
29187297
28.

A double point mutation at residues Ile14 and Val15 of Bcl-2 uncovers a role for the BH4 domain in both protein stability and function.

Monaco G, La Rovere R, Karamanou S, Welkenhuyzen K, Ivanova H, Vandermarliere E, Di Martile M, Del Bufalo D, De Smedt H, Parys JB, Economou A, Bultynck G.

FEBS J. 2018 Jan;285(1):127-145. doi: 10.1111/febs.14324. Epub 2017 Dec 2.

29.

Tumor suppressive Ca2+ signaling is driven by IP3 receptor fitness.

Bultynck G, Campanella M.

Cell Stress. 2017 Nov 1;1(2):73-78. doi: 10.15698/cst2017.11.109. No abstract available.

PMID:
31225437
30.

Organelle membrane derived patches: reshaping classical methods for new targets.

Shapovalov G, Ritaine A, Bidaux G, Slomianny C, Borowiec AS, Gordienko D, Bultynck G, Skryma R, Prevarskaya N.

Sci Rep. 2017 Oct 26;7(1):14082. doi: 10.1038/s41598-017-13968-y.

31.

Ca2+ signaling and cell death: Focus on Ca2+-transport systems and their implication in cell death and survival.

Bultynck G, Parys JB.

Cell Calcium. 2018 Jan;69:1-3. doi: 10.1016/j.ceca.2017.09.001. Epub 2017 Sep 8. No abstract available.

PMID:
28965649
32.

The regulation of autophagy by calcium signals: Do we have a consensus?

Bootman MD, Chehab T, Bultynck G, Parys JB, Rietdorf K.

Cell Calcium. 2018 Mar;70:32-46. doi: 10.1016/j.ceca.2017.08.005. Epub 2017 Aug 19. Review.

PMID:
28847414
33.

Alterations in Ca2+ Signalling via ER-Mitochondria Contact Site Remodelling in Cancer.

Kerkhofs M, Giorgi C, Marchi S, Seitaj B, Parys JB, Pinton P, Bultynck G, Bittremieux M.

Adv Exp Med Biol. 2017;997:225-254. doi: 10.1007/978-981-10-4567-7_17. Review.

PMID:
28815534
34.

Endoplasmic Reticulum-Mitochondria Communication Through Ca2+ Signaling: The Importance of Mitochondria-Associated Membranes (MAMs).

Marchi S, Bittremieux M, Missiroli S, Morganti C, Patergnani S, Sbano L, Rimessi A, Kerkhofs M, Parys JB, Bultynck G, Giorgi C, Pinton P.

Adv Exp Med Biol. 2017;997:49-67. doi: 10.1007/978-981-10-4567-7_4. Review.

PMID:
28815521
35.

IP3 Receptor-Mediated Calcium Signaling and Its Role in Autophagy in Cancer.

Kania E, Roest G, Vervliet T, Parys JB, Bultynck G.

Front Oncol. 2017 Jul 5;7:140. doi: 10.3389/fonc.2017.00140. eCollection 2017. Review.

36.

Bcl-2 inhibitors as anti-cancer therapeutics: The impact of and on calcium signaling.

Vervloessem T, Kerkhofs M, La Rovere RM, Sneyers F, Parys JB, Bultynck G.

Cell Calcium. 2018 Mar;70:102-116. doi: 10.1016/j.ceca.2017.05.014. Epub 2017 Jun 4. Review.

PMID:
28705421
37.

DebULKing fat in the heart: a fascinating role for autophagy.

Vervliet T, Bultynck G.

Cardiovasc Res. 2017 Aug 1;113(10):1089-1092. doi: 10.1093/cvr/cvx127. No abstract available.

PMID:
28666348
38.

Modulation of Ca2+ Signaling by Anti-apoptotic B-Cell Lymphoma 2 Proteins at the Endoplasmic Reticulum-Mitochondrial Interface.

Vervliet T, Clerix E, Seitaj B, Ivanova H, Monaco G, Bultynck G.

Front Oncol. 2017 May 3;7:75. doi: 10.3389/fonc.2017.00075. eCollection 2017. Review.

39.

Endoplasmic Reticulum-Mitochondrial Ca2+ Fluxes Underlying Cancer Cell Survival.

Ivanova H, Kerkhofs M, La Rovere RM, Bultynck G.

Front Oncol. 2017 May 3;7:70. doi: 10.3389/fonc.2017.00070. eCollection 2017. Review.

40.

Data on cytotoxicity in HeLa and SU-DHL-4 cells exposed to DPB162-AE compound.

Bittremieux M, Mikoshiba K, Bultynck G.

Data Brief. 2017 Mar 23;12:91-96. doi: 10.1016/j.dib.2017.03.034. eCollection 2017 Jun.

41.

Mitochondrial Cx43 hemichannels contribute to mitochondrial calcium entry and cell death in the heart.

Gadicherla AK, Wang N, Bulic M, Agullo-Pascual E, Lissoni A, De Smet M, Delmar M, Bultynck G, Krysko DV, Camara A, Schlüter KD, Schulz R, Kwok WM, Leybaert L.

Basic Res Cardiol. 2017 May;112(3):27. doi: 10.1007/s00395-017-0618-1. Epub 2017 Mar 31.

PMID:
28364353
42.

Basal ryanodine receptor activity suppresses autophagic flux.

Vervliet T, Pintelon I, Welkenhuyzen K, Bootman MD, Bannai H, Mikoshiba K, Martinet W, Nadif Kasri N, Parys JB, Bultynck G.

Biochem Pharmacol. 2017 May 15;132:133-142. doi: 10.1016/j.bcp.2017.03.011. Epub 2017 Mar 18.

PMID:
28322744
43.

Resveratrol-induced autophagy is dependent on IP3Rs and on cytosolic Ca2.

Luyten T, Welkenhuyzen K, Roest G, Kania E, Wang L, Bittremieux M, Yule DI, Parys JB, Bultynck G.

Biochim Biophys Acta Mol Cell Res. 2017 Jun;1864(6):947-956. doi: 10.1016/j.bbamcr.2017.02.013. Epub 2017 Feb 28.

44.

DPB162-AE, an inhibitor of store-operated Ca2+ entry, can deplete the endoplasmic reticulum Ca2+ store.

Bittremieux M, Gerasimenko JV, Schuermans M, Luyten T, Stapleton E, Alzayady KJ, De Smedt H, Yule DI, Mikoshiba K, Vangheluwe P, Gerasimenko OV, Parys JB, Bultynck G.

Cell Calcium. 2017 Mar;62:60-70. doi: 10.1016/j.ceca.2017.01.015. Epub 2017 Feb 1.

PMID:
28196740
45.

Calcium, oxidative stress and connexin channels, a harmonious orchestra directing the response to radiotherapy treatment?

Decrock E, Hoorelbeke D, Ramadan R, Delvaeye T, De Bock M, Wang N, Krysko DV, Baatout S, Bultynck G, Aerts A, Vinken M, Leybaert L.

Biochim Biophys Acta Mol Cell Res. 2017 Jun;1864(6):1099-1120. doi: 10.1016/j.bbamcr.2017.02.007. Epub 2017 Feb 11. Review.

46.

The BH4 domain of Bcl-2 orthologues from different classes of vertebrates can act as an evolutionary conserved inhibitor of IP3 receptor channels.

Ivanova H, Luyten T, Decrock E, Vervliet T, Leybaert L, Parys JB, Bultynck G.

Cell Calcium. 2017 Mar;62:41-46. doi: 10.1016/j.ceca.2017.01.010. Epub 2017 Jan 25.

PMID:
28179071
47.

IP3 Receptor Properties and Function at Membrane Contact Sites.

Roest G, La Rovere RM, Bultynck G, Parys JB.

Adv Exp Med Biol. 2017;981:149-178. doi: 10.1007/978-3-319-55858-5_7. Review.

PMID:
29594861
48.

The selective Bcl-2 inhibitor venetoclax, a BH3 mimetic, does not dysregulate intracellular Ca2+ signaling.

Vervloessem T, Ivanova H, Luyten T, Parys JB, Bultynck G.

Biochim Biophys Acta Mol Cell Res. 2017 Jun;1864(6):968-976. doi: 10.1016/j.bbamcr.2016.11.024. Epub 2016 Nov 30.

49.

At the cross-point of connexins, calcium, and ATP: blocking hemichannels inhibits vasoconstriction of rat small mesenteric arteries.

Bol M, Wang N, De Bock M, Wacquier B, Decrock E, Gadicherla A, Decaluwé K, Vanheel B, van Rijen HV, Krysko DV, Bultynck G, Dupont G, Van de Voorde J, Leybaert L.

Cardiovasc Res. 2017 Feb;113(2):195-206. doi: 10.1093/cvr/cvw215. Epub 2016 Sep 27.

PMID:
27677282
50.

ER-Mitochondria contact sites: A new regulator of cellular calcium flux comes into play.

Krols M, Bultynck G, Janssens S.

J Cell Biol. 2016 Aug 15;214(4):367-70. doi: 10.1083/jcb.201607124. Review.

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