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Items: 1 to 50 of 113

1.

Human osteoarthritic synovial fluid increases excitability of mouse dorsal root ganglion sensory neurons: an in-vitro translational model to study arthritic pain.

Chakrabarti S, Jadon DR, Bulmer DC, Smith ESJ.

Rheumatology (Oxford). 2019 Aug 13. pii: kez331. doi: 10.1093/rheumatology/kez331. [Epub ahead of print]

PMID:
31410487
2.

Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons.

Lu VB, Rievaj J, O'Flaherty EA, Smith CA, Pais R, Pattison LA, Tolhurst G, Leiter AB, Bulmer DC, Gribble FM, Reimann F.

Nat Commun. 2019 Mar 4;10(1):1029. doi: 10.1038/s41467-019-09045-9.

3.

5-oxoETE triggers nociception in constipation-predominant irritable bowel syndrome through MAS-related G protein-coupled receptor D.

Bautzova T, Hockley JRF, Perez-Berezo T, Pujo J, Tranter MM, Desormeaux C, Barbaro MR, Basso L, Le Faouder P, Rolland C, Malapert P, Moqrich A, Eutamene H, Denadai-Souza A, Vergnolle N, Smith ESJ, Hughes DI, Barbara G, Dietrich G, Bulmer DC, Cenac N.

Sci Signal. 2018 Dec 18;11(561). pii: eaal2171. doi: 10.1126/scisignal.aal2171.

4.

The human gut microbe Bacteroides thetaiotaomicron encodes the founding member of a novel glycosaminoglycan-degrading polysaccharide lyase family PL29.

Ndeh D, Munoz Munoz J, Cartmell A, Bulmer D, Wills C, Henrissat B, Gray J.

J Biol Chem. 2018 Nov 16;293(46):17906-17916. doi: 10.1074/jbc.RA118.004510. Epub 2018 Sep 27.

PMID:
30262663
5.

The extracellular matrix glycoprotein tenascin-X regulates peripheral sensory and motor neurones.

Aktar R, Peiris M, Fikree A, Cibert-Goton V, Walmsley M, Tough IR, Watanabe P, Araujo EJA, Mohammed SD, Delalande JM, Bulmer DC, Scott SM, Cox HM, Voermans NC, Aziz Q, Blackshaw LA.

J Physiol. 2018 Sep;596(17):4237-4251. doi: 10.1113/JP276300. Epub 2018 Jul 18.

6.

Human visceral nociception: findings from translational studies in human tissue.

Hockley JRF, Smith ESJ, Bulmer DC.

Am J Physiol Gastrointest Liver Physiol. 2018 Oct 1;315(4):G464-G472. doi: 10.1152/ajpgi.00398.2017. Epub 2018 May 31. Review.

PMID:
29848022
7.

Single-cell RNAseq reveals seven classes of colonic sensory neuron.

Hockley JRF, Taylor TS, Callejo G, Wilbrey AL, Gutteridge A, Bach K, Winchester WJ, Bulmer DC, McMurray G, Smith ESJ.

Gut. 2019 Apr;68(4):633-644. doi: 10.1136/gutjnl-2017-315631. Epub 2018 Feb 26.

8.

Structure and function of a novel periplasmic chitooligosaccharide-binding protein from marine Vibrio bacteria.

Suginta W, Sritho N, Ranok A, Bulmer DM, Kitaoku Y, van den Berg B, Fukamizo T.

J Biol Chem. 2018 Apr 6;293(14):5150-5159. doi: 10.1074/jbc.RA117.001012. Epub 2018 Feb 14.

9.

Evidence for long-term sensitization of the bowel in patients with post-infectious-IBS.

Balemans D, Mondelaers SU, Cibert-Goton V, Stakenborg N, Aguilera-Lizarraga J, Dooley J, Liston A, Bulmer DC, Vanden Berghe P, Boeckxstaens GE, Wouters MM.

Sci Rep. 2017 Oct 19;7(1):13606. doi: 10.1038/s41598-017-12618-7.

10.

Peripheral KV7 channels regulate visceral sensory function in mouse and human colon.

Peiris M, Hockley JR, Reed DE, Smith ESJ, Bulmer DC, Blackshaw LA.

Mol Pain. 2017 Jan-Dec;13:1744806917709371. doi: 10.1177/1744806917709371.

11.

Visceral and somatic pain modalities reveal NaV 1.7-independent visceral nociceptive pathways.

Hockley JR, González-Cano R, McMurray S, Tejada-Giraldez MA, McGuire C, Torres A, Wilbrey AL, Cibert-Goton V, Nieto FR, Pitcher T, Knowles CH, Baeyens JM, Wood JN, Winchester WJ, Bulmer DC, Cendán CM, McMurray G.

J Physiol. 2017 Apr 15;595(8):2661-2679. doi: 10.1113/JP272837. Epub 2017 Mar 1.

12.

Ex vivo study of human visceral nociceptors.

McGuire C, Boundouki G, Hockley JRF, Reed D, Cibert-Goton V, Peiris M, Kung V, Broad J, Aziz Q, Chan C, Ahmed S, Thaha MA, Sanger GJ, Blackshaw LA, Knowles CH, Bulmer DC.

Gut. 2018 Jan;67(1):86-96. doi: 10.1136/gutjnl-2016-311629. Epub 2016 Sep 21.

13.

P2Y Receptors Sensitize Mouse and Human Colonic Nociceptors.

Hockley JR, Tranter MM, McGuire C, Boundouki G, Cibert-Goton V, Thaha MA, Blackshaw LA, Michael GJ, Baker MD, Knowles CH, Winchester WJ, Bulmer DC.

J Neurosci. 2016 Feb 24;36(8):2364-76. doi: 10.1523/JNEUROSCI.3369-15.2016.

14.

Histamine Receptor H1-Mediated Sensitization of TRPV1 Mediates Visceral Hypersensitivity and Symptoms in Patients With Irritable Bowel Syndrome.

Wouters MM, Balemans D, Van Wanrooy S, Dooley J, Cibert-Goton V, Alpizar YA, Valdez-Morales EE, Nasser Y, Van Veldhoven PP, Vanbrabant W, Van der Merwe S, Mols R, Ghesquière B, Cirillo C, Kortekaas I, Carmeliet P, Peetermans WE, Vermeire S, Rutgeerts P, Augustijns P, Hellings PW, Belmans A, Vanner S, Bulmer DC, Talavera K, Vanden Berghe P, Liston A, Boeckxstaens GE.

Gastroenterology. 2016 Apr;150(4):875-87.e9. doi: 10.1053/j.gastro.2015.12.034. Epub 2016 Jan 2.

PMID:
26752109
15.

Cultured enterocytes internalise bacteria across their basolateral surface for, pathogen-inhibitable, trafficking to the apical compartment.

Dean P, Quitard S, Bulmer DM, Roe AJ, Kenny B.

Sci Rep. 2015 Nov 27;5:17359. doi: 10.1038/srep17359.

16.

The voltage-gated sodium channel NaV 1.9 in visceral pain.

Hockley JR, Winchester WJ, Bulmer DC.

Neurogastroenterol Motil. 2016 Mar;28(3):316-26. doi: 10.1111/nmo.12698. Epub 2015 Oct 14. Review.

PMID:
26462871
17.

Evidence of a role for GTP cyclohydrolase-1 in visceral pain.

Bulmer DC, Botha CA, Wheeldon A, Grey K, Mein CA, Lee K, Knowles CH, Winchester WJ, Aziz Q.

Neurogastroenterol Motil. 2015 May;27(5):656-62. doi: 10.1111/nmo.12538. Epub 2015 Mar 17.

PMID:
25783971
18.

Mechanisms of activation of mouse and human enteroendocrine cells by nutrients.

Symonds EL, Peiris M, Page AJ, Chia B, Dogra H, Masding A, Galanakis V, Atiba M, Bulmer D, Young RL, Blackshaw LA.

Gut. 2015 Apr;64(4):618-26. doi: 10.1136/gutjnl-2014-306834. Epub 2014 Jul 11.

19.

Multiple roles for NaV1.9 in the activation of visceral afferents by noxious inflammatory, mechanical, and human disease-derived stimuli.

Hockley JR, Boundouki G, Cibert-Goton V, McGuire C, Yip PK, Chan C, Tranter M, Wood JN, Nassar MA, Blackshaw LA, Aziz Q, Michael GJ, Baker MD, Winchester WJ, Knowles CH, Bulmer DC.

Pain. 2014 Oct;155(10):1962-75. doi: 10.1016/j.pain.2014.06.015. Epub 2014 Jun 24.

20.

Mucin gene expression in reflux laryngeal mucosa: histological and in situ hybridization observations.

Ali Mel-S, Bulmer DM, Dettmar PW, Pearson JP.

Int J Otolaryngol. 2014;2014:264075. doi: 10.1155/2014/264075. Epub 2014 Mar 24.

21.

Anti-emetic and emetic effects of erythromycin in Suncus murinus: role of vagal nerve activation, gastric motility stimulation and motilin receptors.

Javid FA, Bulmer DC, Broad J, Aziz Q, Dukes GE, Sanger GJ.

Eur J Pharmacol. 2013 Jan 15;699(1-3):48-54. doi: 10.1016/j.ejphar.2012.11.035. Epub 2012 Nov 28.

PMID:
23201066
22.

The function of the bacterial cytoskeleton in Salmonella pathogenesis.

Doble AC, Bulmer DM, Kharraz L, Karavolos MH, Khan CM.

Virulence. 2012 Aug 15;3(5):446-9. doi: 10.4161/viru.20993. Epub 2012 Aug 15. No abstract available.

23.

The application of STEM and in situ controlled dehydration to bacterial systems using ESEM.

Staniewicz L, Donald AM, Stokes DJ, Thomson N, Sivaniah E, Grant A, Bulmer D, Khan A.

Scanning. 2012 Jul-Aug;34(4):237-46. doi: 10.1002/sca.21000. Epub 2012 Jun 11.

PMID:
22689513
24.

The bacterial cytoskeleton modulates motility, type 3 secretion, and colonization in Salmonella.

Bulmer DM, Kharraz L, Grant AJ, Dean P, Morgan FJ, Karavolos MH, Doble AC, McGhie EJ, Koronakis V, Daniel RA, Mastroeni P, Khan CM.

PLoS Pathog. 2012 Jan;8(1):e1002500. doi: 10.1371/journal.ppat.1002500. Epub 2012 Jan 26.

25.

Achieving translation in models of visceral pain.

Bulmer DC, Grundy D.

Curr Opin Pharmacol. 2011 Dec;11(6):575-81. doi: 10.1016/j.coph.2011.09.008. Epub 2011 Oct 13. Review.

PMID:
22000605
26.

Salmonella Typhi sense host neuroendocrine stress hormones and release the toxin haemolysin E.

Karavolos MH, Bulmer DM, Spencer H, Rampioni G, Schmalen I, Baker S, Pickard D, Gray J, Fookes M, Winzer K, Ivens A, Dougan G, Williams P, Khan CM.

EMBO Rep. 2011 Mar;12(3):252-8. doi: 10.1038/embor.2011.4. Epub 2011 Feb 18.

27.

Human visceral afferent recordings: preliminary report.

Peiris M, Bulmer DC, Baker MD, Boundouki G, Sinha S, Hobson A, Lee K, Aziz Q, Knowles CH.

Gut. 2011 Feb;60(2):204-8. doi: 10.1136/gut.2010.221820. Epub 2010 Oct 28.

PMID:
21030526
28.

Selective alpha7 nicotinic acetylcholine receptor agonists worsen disease in experimental colitis.

Snoek SA, Verstege MI, van der Zanden EP, Deeks N, Bulmer DC, Skynner M, Lee K, Te Velde AA, Boeckxstaens GE, de Jonge WJ.

Br J Pharmacol. 2010 May;160(2):322-33. doi: 10.1111/j.1476-5381.2010.00699.x.

29.

Laryngeal mucosa: its susceptibility to damage by acid and pepsin.

Bulmer DM, Ali MS, Brownlee IA, Dettmar PW, Pearson JP.

Laryngoscope. 2010 Apr;120(4):777-82. doi: 10.1002/lary.20665.

PMID:
20213655
30.

Salmonella pathogenicity island 1 (SPI-1) type III secretion of SopD involves N- and C-terminal signals and direct binding to the InvC ATPase.

Boonyom R, Karavolos MH, Bulmer DM, Khan CM.

Microbiology. 2010 Jun;156(Pt 6):1805-14. doi: 10.1099/mic.0.038117-0. Epub 2010 Feb 25.

PMID:
20185511
31.

5-HT(2B) receptors modulate visceral hypersensitivity in a stress-sensitive animal model of brain-gut axis dysfunction.

O'Mahony SM, Bulmer DC, Coelho AM, Fitzgerald P, Bongiovanni C, Lee K, Winchester W, Dinan TG, Cryan JF.

Neurogastroenterol Motil. 2010 May;22(5):573-8, e124. doi: 10.1111/j.1365-2982.2009.01432.x. Epub 2009 Dec 9.

PMID:
20003079
32.

Genome-wide transposon mutagenesis identifies a role for host neuroendocrine stress hormones in regulating the expression of virulence genes in Salmonella.

Spencer H, Karavolos MH, Bulmer DM, Aldridge P, Chhabra SR, Winzer K, Williams P, Khan CM.

J Bacteriol. 2010 Feb;192(3):714-24. doi: 10.1128/JB.01329-09. Epub 2009 Nov 20.

33.

LuxS-based quorum sensing does not affect the ability of Salmonella enterica serovar Typhimurium to express the SPI-1 type 3 secretion system, induce membrane ruffles, or invade epithelial cells.

Perrett CA, Karavolos MH, Humphrey S, Mastroeni P, Martinez-Argudo I, Spencer H, Bulmer D, Winzer K, McGhie E, Koronakis V, Williams P, Khan CM, Jepson MA.

J Bacteriol. 2009 Dec;191(23):7253-9. doi: 10.1128/JB.00727-09. Epub 2009 Sep 25.

34.

Essential role for TRPV1 in stress-induced (mast cell-dependent) colonic hypersensitivity in maternally separated rats.

van den Wijngaard RM, Klooker TK, Welting O, Stanisor OI, Wouters MM, van der Coelen D, Bulmer DC, Peeters PJ, Aerssens J, de Hoogt R, Lee K, de Jonge WJ, Boeckxstaens GE.

Neurogastroenterol Motil. 2009 Oct;21(10):1107-e94. doi: 10.1111/j.1365-2982.2009.01339.x. Epub 2009 Jun 11.

PMID:
19523146
35.

A distinct subset of submucosal mast cells undergoes hyperplasia following neonatal maternal separation: a role in visceral hypersensitivity?

Hyland NP, Julio-Pieper M, O'Mahony SM, Bulmer DC, Lee K, Quigley EM, Dinan TG, Cryan JF.

Gut. 2009 Jul;58(7):1029-30; author reply 1030-1. doi: 10.1136/gut.2008.167882. No abstract available.

PMID:
19520896
36.

Possible role for TRPV1 in neomycin-induced inhibition of visceral hypersensitivity in rat.

van den Wijngaard RM, Welting O, Bulmer DC, Wouters MM, Lee K, de Jonge WJ, Boeckxstaens GE.

Neurogastroenterol Motil. 2009 Aug;21(8):863-e60. doi: 10.1111/j.1365-2982.2009.01287.x. Epub 2009 Mar 9.

PMID:
19298229
37.

Impairment of rectal afferent mechanosensitivity in experimental diabetes in the rat.

Beyak MJ, Bulmer DC, Sellers D, Grundy D.

Neurogastroenterol Motil. 2009 Jun;21(6):678-81. doi: 10.1111/j.1365-2982.2009.01266.x. Epub 2009 Feb 23.

PMID:
19239626
38.

Adrenaline modulates the global transcriptional profile of Salmonella revealing a role in the antimicrobial peptide and oxidative stress resistance responses.

Karavolos MH, Spencer H, Bulmer DM, Thompson A, Winzer K, Williams P, Hinton JC, Khan CM.

BMC Genomics. 2008 Oct 6;9:458. doi: 10.1186/1471-2164-9-458.

39.

Genetic detoxification of an aroA Salmonella enterica serovar Typhimurium vaccine strain does not compromise protection against virulent Salmonella and enhances the immune responses towards a protective malarial antigen.

McKelvie ND, Khan SA, Karavolos MH, Bulmer DM, Lee JJ, DeMarco R, Maskell DJ, Zavala F, Hormaeche CE, Khan CM.

FEMS Immunol Med Microbiol. 2008 Mar;52(2):237-46. doi: 10.1111/j.1574-695X.2007.00368.x. Epub 2008 Jan 3.

40.

LuxS affects flagellar phase variation independently of quorum sensing in Salmonella enterica serovar typhimurium.

Karavolos MH, Bulmer DM, Winzer K, Wilson M, Mastroeni P, Williams P, Khan CM.

J Bacteriol. 2008 Jan;190(2):769-71. Epub 2007 Nov 16.

41.

Ghrelin augments afferent response to distension in rat isolated jejunum.

Murray CD, Booth CE, Bulmer DC, Kamm MA, Emmanuel AV, Winchester WJ.

Neurogastroenterol Motil. 2006 Dec;18(12):1112-20.

PMID:
17109695
42.

Role of the universal stress protein UspA of Salmonella in growth arrest, stress and virulence.

Liu WT, Karavolos MH, Bulmer DM, Allaoui A, Hormaeche RD, Lee JJ, Khan CM.

Microb Pathog. 2007 Jan;42(1):2-10. Epub 2006 Nov 1.

PMID:
17081727
43.

Vagal selective effects of ruthenium red on the jejunal afferent fibre response to ischaemia in the rat.

Bulmer DC, Jiang W, Hicks GA, Davis JB, Winchester WJ, Grundy D.

Neurogastroenterol Motil. 2005 Feb;17(1):102-11.

PMID:
15670270
44.

Expression of mucin gene products in laryngeal squamous cancer.

Paleri V, Pearson JP, Bulmer D, Jeannon JP, Wight RG, Wilson JA.

Otolaryngol Head Neck Surg. 2004 Jul;131(1):84-8.

PMID:
15243562
45.

Cell biology of laryngeal epithelial defenses in health and disease: further studies.

Johnston N, Bulmer D, Gill GA, Panetti M, Ross PE, Pearson JP, Pignatelli M, Axford SE, Dettmar PW, Koufman JA.

Ann Otol Rhinol Laryngol. 2003 Jun;112(6):481-91.

PMID:
12834114
46.

Rapid adenosine release in the nucleus tractus solitarii during defence response in rats: real-time measurement in vivo.

Dale N, Gourine AV, Llaudet E, Bulmer D, Thomas T, Spyer KM.

J Physiol. 2002 Oct 1;544(Pt 1):149-60.

47.

Fos expression in the midbrain periaqueductal grey after trigeminovascular stimulation.

Hoskin KL, Bulmer DC, Lasalandra M, Jonkman A, Goadsby PJ.

J Anat. 2001 Jan;198(Pt 1):29-35.

48.
49.

Direct 5S rRNA Assay for Monitoring Mixed-Culture Bioprocesses.

Stoner DL, Browning CK, Bulmer DK, Ward TE, Macdonell MT.

Appl Environ Microbiol. 1996 Jun;62(6):1969-76.

50.

Characterization of a new bacteriophage which infects bacteria of the genus Acidiphilium.

Ward TE, Bruhn DF, Shean ML, Watkins CS, Bulmer D, Winston V.

J Gen Virol. 1993 Nov;74 ( Pt 11):2419-25.

PMID:
8245857

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