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Introducing a Predictive Score for Successful Treatment Free Remission in Chronic Myeloid Leukemia (CML).

Claudiani S, Metelli S, Kamvar R, Szydlo R, Khan A, Byrne J, Gallipoli P, Bulley SJ, Horne GA, Rothwell K, Copland M, Clark RE, Khorashad JS, Foroni L, Milojkovic D, Apperley JF.

Blood. 2019 Nov 13;134(Supplement_1):26. doi: 10.1182/blood-2019-131500.


Molecular Characterisation of a Supergene Conditioning Super-High Vitamin C in Kiwifruit Hybrids.

McCallum J, Laing W, Bulley S, Thomson S, Catanach A, Shaw M, Knaebel M, Tahir J, Deroles S, Timmerman-Vaughan G, Crowhurst R, Hilario E, Chisnall M, Lee R, Macknight R, Seal A.

Plants (Basel). 2019 Jul 22;8(7). pii: E237. doi: 10.3390/plants8070237.


Enhanced ascorbate level improves multi-stress tolerance in a widely grown indica rice variety without compromising its agronomic characteristics.

Ali B, Pantha S, Acharya R, Ueda Y, Wu LB, Ashrafuzzaman M, Ishizaki T, Wissuwa M, Bulley S, Frei M.

J Plant Physiol. 2019 Sep;240:152998. doi: 10.1016/j.jplph.2019.152998. Epub 2019 Jun 13.


Ano1 mediates pressure-sensitive contraction frequency changes in mouse lymphatic collecting vessels.

Zawieja SD, Castorena JA, Gui P, Li M, Bulley SA, Jaggar JH, Rock JR, Davis MJ.

J Gen Physiol. 2019 Apr 1;151(4):532-554. doi: 10.1085/jgp.201812294. Epub 2019 Mar 12.


Arterial smooth muscle cell PKD2 (TRPP1) channels regulate systemic blood pressure.

Bulley S, Fernández-Peña C, Hasan R, Leo MD, Muralidharan P, Mackay CE, Evanson KW, Moreira-Junior L, Mata-Daboin A, Burris SK, Wang Q, Kuruvilla KP, Jaggar JH.

Elife. 2018 Dec 4;7. pii: e42628. doi: 10.7554/eLife.42628.


A manually annotated Actinidia chinensis var. chinensis (kiwifruit) genome highlights the challenges associated with draft genomes and gene prediction in plants.

Pilkington SM, Crowhurst R, Hilario E, Nardozza S, Fraser L, Peng Y, Gunaseelan K, Simpson R, Tahir J, Deroles SC, Templeton K, Luo Z, Davy M, Cheng C, McNeilage M, Scaglione D, Liu Y, Zhang Q, Datson P, De Silva N, Gardiner SE, Bassett H, Chagné D, McCallum J, Dzierzon H, Deng C, Wang YY, Barron L, Manako K, Bowen J, Foster TM, Erridge ZA, Tiffin H, Waite CN, Davies KM, Grierson EP, Laing WA, Kirk R, Chen X, Wood M, Montefiori M, Brummell DA, Schwinn KE, Catanach A, Fullerton C, Li D, Meiyalaghan S, Nieuwenhuizen N, Read N, Prakash R, Hunter D, Zhang H, McKenzie M, Knäbel M, Harris A, Allan AC, Gleave A, Chen A, Janssen BJ, Plunkett B, Ampomah-Dwamena C, Voogd C, Leif D, Lafferty D, Souleyre EJF, Varkonyi-Gasic E, Gambi F, Hanley J, Yao JL, Cheung J, David KM, Warren B, Marsh K, Snowden KC, Lin-Wang K, Brian L, Martinez-Sanchez M, Wang M, Ileperuma N, Macnee N, Campin R, McAtee P, Drummond RSM, Espley RV, Ireland HS, Wu R, Atkinson RG, Karunairetnam S, Bulley S, Chunkath S, Hanley Z, Storey R, Thrimawithana AH, Thomson S, David C, Testolin R, Huang H, Hellens RP, Schaffer RJ.

BMC Genomics. 2018 Apr 16;19(1):257. doi: 10.1186/s12864-018-4656-3.


Membrane depolarization activates BK channels through ROCK-mediated β1 subunit surface trafficking to limit vasoconstriction.

Leo MD, Zhai X, Muralidharan P, Kuruvilla KP, Bulley S, Boop FA, Jaggar JH.

Sci Signal. 2017 May 9;10(478). pii: eaah5417. doi: 10.1126/scisignal.aah5417.


Increasing ascorbate levels in crops to enhance human nutrition and plant abiotic stress tolerance.

Macknight RC, Laing WA, Bulley SM, Broad RC, Johnson AA, Hellens RP.

Curr Opin Biotechnol. 2017 Apr;44:153-160. doi: 10.1016/j.copbio.2017.01.011. Epub 2017 Feb 21. Review.


Angiotensin II reduces the surface abundance of KV 1.5 channels in arterial myocytes to stimulate vasoconstriction.

Kidd MW, Bulley S, Jaggar JH.

J Physiol. 2017 Mar 1;595(5):1607-1618. doi: 10.1113/JP272893. Epub 2017 Feb 5.


In B cells, phosphatidylinositol 5-phosphate 4-kinase-α synthesizes PI(4,5)P2 to impact mTORC2 and Akt signaling.

Bulley SJ, Droubi A, Clarke JH, Anderson KE, Stephens LR, Hawkins PT, Irvine RF.

Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):10571-6. doi: 10.1073/pnas.1522478113. Epub 2016 Sep 6.


Now you see it, now you don't: the changing face of endothelin-1 signalling during vascular ontogenesis.

Bulley S, Jaggar JH.

J Physiol. 2016 Sep 1;594(17):4703-4. doi: 10.1113/JP272564. No abstract available.


Nuclear localizations of phosphatidylinositol 5-phosphate 4-kinases α and β are dynamic and independently regulated during starvation-induced stress.

Droubi A, Bulley SJ, Clarke JH, Irvine RF.

Biochem J. 2016 Jul 15;473(14):2155-63. doi: 10.1042/BCJ20160380. Epub 2016 May 16.


The regulation of ascorbate biosynthesis.

Bulley S, Laing W.

Curr Opin Plant Biol. 2016 Oct;33:15-22. doi: 10.1016/j.pbi.2016.04.010. Epub 2016 May 11. Review.


Rab25 influences functional Cav1.2 channel surface expression in arterial smooth muscle cells.

Bannister JP, Bulley S, Leo MD, Kidd MW, Jaggar JH.

Am J Physiol Cell Physiol. 2016 Jun 1;310(11):C885-93. doi: 10.1152/ajpcell.00345.2015. Epub 2016 Apr 13.


There is no 'Conundrum' of InsP6.

Irvine RF, Bulley SJ, Wilson MS, Saiardi A.

Open Biol. 2015 Nov;5(11). pii: 150181. doi: 10.1098/rsob.150181.


Angiotensin II stimulates internalization and degradation of arterial myocyte plasma membrane BK channels to induce vasoconstriction.

Leo MD, Bulley S, Bannister JP, Kuruvilla KP, Narayanan D, Jaggar JH.

Am J Physiol Cell Physiol. 2015 Sep 15;309(6):C392-402. doi: 10.1152/ajpcell.00127.2015. Epub 2015 Jul 15.


A novel method for the purification of inositol phosphates from biological samples reveals that no phytate is present in human plasma or urine.

Wilson MS, Bulley SJ, Pisani F, Irvine RF, Saiardi A.

Open Biol. 2015 Mar;5(3):150014. doi: 10.1098/rsob.150014.


An upstream open reading frame is essential for feedback regulation of ascorbate biosynthesis in Arabidopsis.

Laing WA, Martínez-Sánchez M, Wright MA, Bulley SM, Brewster D, Dare AP, Rassam M, Wang D, Storey R, Macknight RC, Hellens RP.

Plant Cell. 2015 Mar;27(3):772-86. doi: 10.1105/tpc.114.133777. Epub 2015 Feb 27.


9-Phenanthrol inhibits recombinant and arterial myocyte TMEM16A channels.

Burris SK, Wang Q, Bulley S, Neeb ZP, Jaggar JH.

Br J Pharmacol. 2015 May;172(10):2459-68. doi: 10.1111/bph.13077. Epub 2015 Mar 24.


Exploring phosphatidylinositol 5-phosphate 4-kinase function.

Bulley SJ, Clarke JH, Droubi A, Giudici ML, Irvine RF.

Adv Biol Regul. 2015 Jan;57:193-202. doi: 10.1016/j.jbior.2014.09.007. Epub 2014 Oct 2. Review.


Cl⁻ channels in smooth muscle cells.

Bulley S, Jaggar JH.

Pflugers Arch. 2014 May;466(5):861-72. Review. Erratum in: Pflugers Arch. 2014 May;466(5):873.


Smooth muscle cell transient receptor potential polycystin-2 (TRPP2) channels contribute to the myogenic response in cerebral arteries.

Narayanan D, Bulley S, Leo MD, Burris SK, Gabrick KS, Boop FA, Jaggar JH.

J Physiol. 2013 Oct 15;591(20):5031-46. doi: 10.1113/jphysiol.2013.258319. Epub 2013 Jul 15.


Taurine regulation of voltage-gated channels in retinal neurons.

Rowan MJ, Bulley S, Purpura LA, Ripps H, Shen W.

Adv Exp Med Biol. 2013;775:85-99. doi: 10.1007/978-1-4614-6130-2_7.


The modulatory role of taurine in retinal ganglion cells.

Jiang Z, Bulley S, Guzzone J, Ripps H, Shen W.

Adv Exp Med Biol. 2013;775:53-68. doi: 10.1007/978-1-4614-6130-2_5.


Diversity and relative levels of actinidin, kiwellin, and thaumatin-like allergens in 15 varieties of kiwifruit (Actinidia).

Maddumage R, Nieuwenhuizen NJ, Bulley SM, Cooney JM, Green SA, Atkinson RG.

J Agric Food Chem. 2013 Jan 23;61(3):728-39. doi: 10.1021/jf304289f. Epub 2013 Jan 14.


Feasibility study of analgesia via epidural versus continuous wound infusion after laparoscopic colorectal resection.

Boulind CE, Ewings P, Bulley SH, Reid JM, Jenkins JT, Blazeby JM, Francis NK.

Br J Surg. 2013 Feb;100(3):395-402. doi: 10.1002/bjs.8999. Epub 2012 Dec 19.


First-line erlotinib in patients with advanced non-small-cell lung cancer unsuitable for chemotherapy (TOPICAL): a double-blind, placebo-controlled, phase 3 trial.

Lee SM, Khan I, Upadhyay S, Lewanski C, Falk S, Skailes G, Marshall E, Woll PJ, Hatton M, Lal R, Jones R, Toy E, Chao D, Middleton G, Bulley S, Ngai Y, Rudd R, Hackshaw A, Boshoff C.

Lancet Oncol. 2012 Nov;13(11):1161-70. doi: 10.1016/S1470-2045(12)70412-6. Epub 2012 Oct 16.


Taurine activates delayed rectifier Kv channels via a metabotropic pathway in retinal neurons.

Bulley S, Liu Y, Ripps H, Shen W.

J Physiol. 2013 Jan 1;591(1):123-32. doi: 10.1113/jphysiol.2012.243147. Epub 2012 Oct 8.


Transcriptional upregulation of α2δ-1 elevates arterial smooth muscle cell voltage-dependent Ca2+ channel surface expression and cerebrovascular constriction in genetic hypertension.

Bannister JP, Bulley S, Narayanan D, Thomas-Gatewood C, Luzny P, Pachuau J, Jaggar JH.

Hypertension. 2012 Oct;60(4):1006-15. doi: 10.1161/HYPERTENSIONAHA.112.199661. Epub 2012 Sep 4.


TMEM16A/ANO1 channels contribute to the myogenic response in cerebral arteries.

Bulley S, Neeb ZP, Burris SK, Bannister JP, Thomas-Gatewood CM, Jangsangthong W, Jaggar JH.

Circ Res. 2012 Sep 28;111(8):1027-36. Epub 2012 Aug 7.


Investigation of ascorbate metabolism during inducement of storage disorders in pear.

Cascia G, Bulley SM, Punter M, Bowen J, Rassam M, Schotsmans WC, Larrigaudière C, Johnston JW.

Physiol Plant. 2013 Feb;147(2):121-34. doi: 10.1111/j.1399-3054.2012.01641.x. Epub 2012 Jun 18.


Direct Visualisation of Abnormal Dendritic Spine Morphology in the Hippocampus of the R6/2 Transgenic Mouse Model of Huntington's Disease.

Bulley SJ, Drew CJ, Morton AJ.

J Huntingtons Dis. 2012;1(2):267-73. doi: 10.3233/JHD-120024.


Enhancing ascorbate in fruits and tubers through over-expression of the L-galactose pathway gene GDP-L-galactose phosphorylase.

Bulley S, Wright M, Rommens C, Yan H, Rassam M, Lin-Wang K, Andre C, Brewster D, Karunairetnam S, Allan AC, Laing WA.

Plant Biotechnol J. 2012 May;10(4):390-7. doi: 10.1111/j.1467-7652.2011.00668.x. Epub 2011 Dec 1.


TMEM16A channels generate Ca²⁺-activated Cl⁻ currents in cerebral artery smooth muscle cells.

Thomas-Gatewood C, Neeb ZP, Bulley S, Adebiyi A, Bannister JP, Leo MD, Jaggar JH.

Am J Physiol Heart Circ Physiol. 2011 Nov;301(5):H1819-27. doi: 10.1152/ajpheart.00404.2011. Epub 2011 Aug 19.


Differences in the allergenicity of 6 different kiwifruit cultivars analyzed by prick-to-prick testing, open food challenges, and ELISA.

Le TM, Fritsche P, Bublin M, Oberhuber C, Bulley S, van Hoffen E, Ballmer-Weber BK, Knulst AC, Hoffmann-Sommergruber K.

J Allergy Clin Immunol. 2011 Mar;127(3):677-9.e1-2. doi: 10.1016/j.jaci.2010.10.003. Epub 2010 Nov 20. No abstract available.


Reciprocal regulation between taurine and glutamate response via Ca2+-dependent pathways in retinal third-order neurons.

Bulley S, Shen W.

J Biomed Sci. 2010 Aug 24;17 Suppl 1:S5. doi: 10.1186/1423-0127-17-S1-S5.


Component-resolved diagnosis of kiwifruit allergy with purified natural and recombinant kiwifruit allergens.

Bublin M, Pfister M, Radauer C, Oberhuber C, Bulley S, Dewitt AM, Lidholm J, Reese G, Vieths S, Breiteneder H, Hoffmann-Sommergruber K, Ballmer-Weber BK.

J Allergy Clin Immunol. 2010 Mar;125(3):687-94, 694.e1. doi: 10.1016/j.jaci.2009.10.017. Epub 2010 Jan 12.


A qualitative evaluation of patients' experiences of an enhanced recovery programme for colorectal cancer.

Blazeby JM, Soulsby M, Winstone K, King PM, Bulley S, Kennedy RH.

Colorectal Dis. 2010 Oct;12(10 Online):e236-42. doi: 10.1111/j.1463-1318.2009.02104.x.


Single dose oral rofecoxib for acute postoperative pain in adults.

Bulley S, Derry S, Moore RA, McQuay HJ.

Cochrane Database Syst Rev. 2009 Oct 7;(4):CD004604. doi: 10.1002/14651858.CD004604.pub3. Review.


Medical staff at a London district hospital are not chronic vectors of MRSA or Clostridium difficile.

Wall EC, Ghazy A, Bulley S, Ahmad F, Aali A, Lynn W.

J Infect. 2009 Jun;58(6):469-71. doi: 10.1016/j.jinf.2009.03.009. Epub 2009 Mar 31. No abstract available.


Gene expression studies in kiwifruit and gene over-expression in Arabidopsis indicates that GDP-L-galactose guanyltransferase is a major control point of vitamin C biosynthesis.

Bulley SM, Rassam M, Hoser D, Otto W, Schünemann N, Wright M, MacRae E, Gleave A, Laing W.

J Exp Bot. 2009;60(3):765-78. doi: 10.1093/jxb/ern327. Epub 2009 Jan 6.


Characterization of Bet v 1-related allergens from kiwifruit relevant for patients with combined kiwifruit and birch pollen allergy.

Oberhuber C, Bulley SM, Ballmer-Weber BK, Bublin M, Gaier S, DeWitt AM, Briza P, Hofstetter G, Lidholm J, Vieths S, Hoffmann-Sommergruber K.

Mol Nutr Food Res. 2008 Nov;52 Suppl 2:S230-40. doi: 10.1002/mnfr.200800146.


Analysis of expressed sequence tags from Actinidia: applications of a cross species EST database for gene discovery in the areas of flavor, health, color and ripening.

Crowhurst RN, Gleave AP, MacRae EA, Ampomah-Dwamena C, Atkinson RG, Beuning LL, Bulley SM, Chagne D, Marsh KB, Matich AJ, Montefiori M, Newcomb RD, Schaffer RJ, Usadel B, Allan AC, Boldingh HL, Bowen JH, Davy MW, Eckloff R, Ferguson AR, Fraser LG, Gera E, Hellens RP, Janssen BJ, Klages K, Lo KR, MacDiarmid RM, Nain B, McNeilage MA, Rassam M, Richardson AC, Rikkerink EH, Ross GS, Schröder R, Snowden KC, Souleyre EJ, Templeton MD, Walton EF, Wang D, Wang MY, Wang YY, Wood M, Wu R, Yauk YK, Laing WA.

BMC Genomics. 2008 Jul 27;9:351. doi: 10.1186/1471-2164-9-351.


Setting up non-commercial clinical trials takes too long in the UK: findings from a prospective study.

Hackshaw A, Farrant H, Bulley S, Seckl MJ, Ledermann JA.

J R Soc Med. 2008 Jun;101(6):299-304. doi: 10.1258/jrsm.2008.070373.


Cardiac chamber hypertrophy following hematopoietic stem cell transplantation for primary immunodeficiency.

Bulley SR, Benson L, Grunebaum E, Roifman CM.

Biol Blood Marrow Transplant. 2008 Feb;14(2):229-35. doi: 10.1016/j.bbmt.2007.10.027.


Inferior outcomes for overweight children undergoing allogeneic stem cell transplantation.

Bulley S, Gassas A, Dupuis LL, Aplenc R, Beyene J, Greenberg ML, Doyle JJ, Sung L.

Br J Haematol. 2008 Jan;140(2):214-7. Epub 2007 Nov 19.


The missing step of the L-galactose pathway of ascorbate biosynthesis in plants, an L-galactose guanyltransferase, increases leaf ascorbate content.

Laing WA, Wright MA, Cooney J, Bulley SM.

Proc Natl Acad Sci U S A. 2007 May 29;104(22):9534-9. Epub 2007 May 7.


Modification of gibberellin biosynthesis in the grafted apple scion allows control of tree height independent of the rootstock.

Bulley SM, Wilson FM, Hedden P, Phillips AL, Croker SJ, James DJ.

Plant Biotechnol J. 2005 Mar;3(2):215-23.


Defibrotide for the treatment of hepatic veno-occlusive disease in children.

Bulley SR, Strahm B, Doyle J, Dupuis LL.

Pediatr Blood Cancer. 2007 Jun 15;48(7):700-4.


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