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Items: 14


Protein kinase A-dependent phosphorylation stimulates the transcriptional activity of hypoxia-inducible factor 1.

Bullen JW, Tchernyshyov I, Holewinski RJ, DeVine L, Wu F, Venkatraman V, Kass DL, Cole RN, Van Eyk J, Semenza GL.

Sci Signal. 2016 May 31;9(430):ra56. doi: 10.1126/scisignal.aaf0583.


Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m⁶A-demethylation of NANOG mRNA.

Zhang C, Samanta D, Lu H, Bullen JW, Zhang H, Chen I, He X, Semenza GL.

Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):E2047-56. doi: 10.1073/pnas.1602883113. Epub 2016 Mar 21.


HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells.

Zhang H, Lu H, Xiang L, Bullen JW, Zhang C, Samanta D, Gilkes DM, He J, Semenza GL.

Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):E6215-23. doi: 10.1073/pnas.1520032112. Epub 2015 Oct 28.


Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype.

Lu H, Samanta D, Xiang L, Zhang H, Hu H, Chen I, Bullen JW, Semenza GL.

Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):E4600-9. doi: 10.1073/pnas.1513433112. Epub 2015 Jul 30.


HIF-1α and TAZ serve as reciprocal co-activators in human breast cancer cells.

Xiang L, Gilkes DM, Hu H, Luo W, Bullen JW, Liang H, Semenza GL.

Oncotarget. 2015 May 20;6(14):11768-78.


Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype.

Xiang L, Gilkes DM, Hu H, Takano N, Luo W, Lu H, Bullen JW, Samanta D, Liang H, Semenza GL.

Oncotarget. 2014 Dec 30;5(24):12509-27.


Cross-talk between two essential nutrient-sensitive enzymes: O-GlcNAc transferase (OGT) and AMP-activated protein kinase (AMPK).

Bullen JW, Balsbaugh JL, Chanda D, Shabanowitz J, Hunt DF, Neumann D, Hart GW.

J Biol Chem. 2014 Apr 11;289(15):10592-606. doi: 10.1074/jbc.M113.523068. Epub 2014 Feb 21.


Myelin-associated glycoprotein (MAG) protects neurons from acute toxicity using a ganglioside-dependent mechanism.

Mehta NR, Nguyen T, Bullen JW Jr, Griffin JW, Schnaar RL.

ACS Chem Neurosci. 2010 Mar 17;1(3):215-222.


Cross-talk between GlcNAcylation and phosphorylation: roles in insulin resistance and glucose toxicity.

Copeland RJ, Bullen JW, Hart GW.

Am J Physiol Endocrinol Metab. 2008 Jul;295(1):E17-28. doi: 10.1152/ajpendo.90281.2008. Epub 2008 Apr 29. Review.


Regulation of adiponectin and its receptors in response to development of diet-induced obesity in mice.

Bullen JW Jr, Bluher S, Kelesidis T, Mantzoros CS.

Am J Physiol Endocrinol Metab. 2007 Apr;292(4):E1079-86. Epub 2006 Dec 12.


Circulating adiponectin and expression of adiponectin receptors in human skeletal muscle: associations with metabolic parameters and insulin resistance and regulation by physical training.

Blüher M, Bullen JW Jr, Lee JH, Kralisch S, Fasshauer M, Klöting N, Niebauer J, Schön MR, Williams CJ, Mantzoros CS.

J Clin Endocrinol Metab. 2006 Jun;91(6):2310-6. Epub 2006 Mar 21.


Circulating resistin in lean, obese, and insulin-resistant mouse models: lack of association with insulinemia and glycemia.

Lee JH, Bullen JW Jr, Stoyneva VL, Mantzoros CS.

Am J Physiol Endocrinol Metab. 2005 Mar;288(3):E625-32. Epub 2004 Nov 2.


Short-term resistance to diet-induced obesity in A/J mice is not associated with regulation of hypothalamic neuropeptides.

Bullen JW Jr, Ziotopoulou M, Ungsunan L, Misra J, Alevizos I, Kokkotou E, Maratos-Flier E, Stephanopoulos G, Mantzoros CS.

Am J Physiol Endocrinol Metab. 2004 Oct;287(4):E662-70.


Responsiveness to peripherally administered melanocortins in lean and obese mice.

Blüher S, Ziotopoulou M, Bullen JW Jr, Moschos SJ, Ungsunan L, Kokkotou E, Maratos-Flier E, Mantzoros CS.

Diabetes. 2004 Jan;53(1):82-90.

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