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Items: 16


Protein Kinase A Is Essential for Invasion of Plasmodium falciparum into Human Erythrocytes.

Wilde ML, Triglia T, Marapana D, Thompson JK, Kouzmitchev AA, Bullen HE, Gilson PR, Cowman AF, Tonkin CJ.

mBio. 2019 Oct 8;10(5). pii: e01972-19. doi: 10.1128/mBio.01972-19.


A 4-cyano-3-methylisoquinoline inhibitor of Plasmodium falciparum growth targets the sodium efflux pump PfATP4.

Gilson PR, Kumarasingha R, Thompson J, Zhang X, Penington JS, Kalhor R, Bullen HE, Lehane AM, Dans MG, de Koning-Ward TF, Holien JK, Soares da Costa TP, Hulett MD, Buskes MJ, Crabb BS, Kirk K, Papenfuss AT, Cowman AF, Abbott BM.

Sci Rep. 2019 Jul 16;9(1):10292. doi: 10.1038/s41598-019-46500-5.


The triumvirate of signaling molecules controlling Toxoplasma microneme exocytosis: Cyclic GMP, calcium, and phosphatidic acid.

Bullen HE, Bisio H, Soldati-Favre D.

PLoS Pathog. 2019 May 23;15(5):e1007670. doi: 10.1371/journal.ppat.1007670. eCollection 2019 May.


Knockdown of the translocon protein EXP2 in Plasmodium falciparum reduces growth and protein export.

Charnaud SC, Kumarasingha R, Bullen HE, Crabb BS, Gilson PR.

PLoS One. 2018 Nov 15;13(11):e0204785. doi: 10.1371/journal.pone.0204785. eCollection 2018.


Spatial organization of protein export in malaria parasite blood stages.

Charnaud SC, Jonsdottir TK, Sanders PR, Bullen HE, Dickerman BK, Kouskousis B, Palmer CS, Pietrzak HM, Laumaea AE, Erazo AB, McHugh E, Tilley L, Crabb BS, Gilson PR.

Traffic. 2018 Aug;19(8):605-623. doi: 10.1111/tra.12577. Epub 2018 May 23.


Plasmodium falciparum parasites deploy RhopH2 into the host erythrocyte to obtain nutrients, grow and replicate.

Counihan NA, Chisholm SA, Bullen HE, Srivastava A, Sanders PR, Jonsdottir TK, Weiss GE, Ghosh S, Crabb BS, Creek DJ, Gilson PR, de Koning-Ward TF.

Elife. 2017 Mar 2;6. pii: e23217. doi: 10.7554/eLife.23217.


Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity.

Gilson PR, Tan C, Jarman KE, Lowes KN, Curtis JM, Nguyen W, Di Rago AE, Bullen HE, Prinz B, Duffy S, Baell JB, Hutton CA, Jousset Subroux H, Crabb BS, Avery VM, Cowman AF, Sleebs BE.

J Med Chem. 2017 Feb 9;60(3):1171-1188. doi: 10.1021/acs.jmedchem.6b01673. Epub 2017 Jan 26.


Proteomic analysis reveals novel proteins associated with the Plasmodium protein exporter PTEX and a loss of complex stability upon truncation of the core PTEX component, PTEX150.

Elsworth B, Sanders PR, Nebl T, Batinovic S, Kalanon M, Nie CQ, Charnaud SC, Bullen HE, de Koning Ward TF, Tilley L, Crabb BS, Gilson PR.

Cell Microbiol. 2016 Nov;18(11):1551-1569. doi: 10.1111/cmi.12596. Epub 2016 May 3.


Disrupting the Allosteric Interaction between the Plasmodium falciparum cAMP-dependent Kinase and Its Regulatory Subunit.

Littler DR, Bullen HE, Harvey KL, Beddoe T, Crabb BS, Rossjohn J, Gilson PR.

J Biol Chem. 2016 Dec 2;291(49):25375-25386. Epub 2016 Oct 13.


A central role for phosphatidic acid as a lipid mediator of regulated exocytosis in apicomplexa.

Bullen HE, Soldati-Favre D.

FEBS Lett. 2016 Aug;590(15):2469-81. doi: 10.1002/1873-3468.12296. Epub 2016 Jul 26. Review.


Phosphatidic Acid-Mediated Signaling Regulates Microneme Secretion in Toxoplasma.

Bullen HE, Jia Y, Yamaryo-Botté Y, Bisio H, Zhang O, Jemelin NK, Marq JB, Carruthers V, Botté CY, Soldati-Favre D.

Cell Host Microbe. 2016 Mar 9;19(3):349-60. doi: 10.1016/j.chom.2016.02.006.


Characterization of a serine hydrolase targeted by acyl-protein thioesterase inhibitors in Toxoplasma gondii.

Kemp LE, Rusch M, Adibekian A, Bullen HE, Graindorge A, Freymond C, Rottmann M, Braun-Breton C, Baumeister S, Porfetye AT, Vetter IR, Hedberg C, Soldati-Favre D.

J Biol Chem. 2013 Sep 20;288(38):27002-18. doi: 10.1074/jbc.M113.460709. Epub 2013 Aug 2.


Spatial association with PTEX complexes defines regions for effector export into Plasmodium falciparum-infected erythrocytes.

Riglar DT, Rogers KL, Hanssen E, Turnbull L, Bullen HE, Charnaud SC, Przyborski J, Gilson PR, Whitchurch CB, Crabb BS, Baum J, Cowman AF.

Nat Commun. 2013;4:1415. doi: 10.1038/ncomms2449.


Recent insights into the export of PEXEL/HTS-motif containing proteins in Plasmodium parasites.

Bullen HE, Crabb BS, Gilson PR.

Curr Opin Microbiol. 2012 Dec;15(6):699-704. doi: 10.1016/j.mib.2012.09.008. Epub 2012 Oct 22. Review.


Biosynthesis, localization, and macromolecular arrangement of the Plasmodium falciparum translocon of exported proteins (PTEX).

Bullen HE, Charnaud SC, Kalanon M, Riglar DT, Dekiwadia C, Kangwanrangsan N, Torii M, Tsuboi T, Baum J, Ralph SA, Cowman AF, de Koning-Ward TF, Crabb BS, Gilson PR.

J Biol Chem. 2012 Mar 9;287(11):7871-84. doi: 10.1074/jbc.M111.328591. Epub 2012 Jan 17.


A novel family of Apicomplexan glideosome-associated proteins with an inner membrane-anchoring role.

Bullen HE, Tonkin CJ, O'Donnell RA, Tham WH, Papenfuss AT, Gould S, Cowman AF, Crabb BS, Gilson PR.

J Biol Chem. 2009 Sep 11;284(37):25353-63. doi: 10.1074/jbc.M109.036772. Epub 2009 Jun 26.

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