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Items: 25


HEPATOKIN1 is a biochemistry-based model of liver metabolism for applications in medicine and pharmacology.

Berndt N, Bulik S, Wallach I, Wünsch T, König M, Stockmann M, Meierhofer D, Holzhütter HG.

Nat Commun. 2018 Jun 19;9(1):2386. doi: 10.1038/s41467-018-04720-9.


A multiscale modelling approach to assess the impact of metabolic zonation and microperfusion on the hepatic carbohydrate metabolism.

Berndt N, Horger MS, Bulik S, Holzhütter HG.

PLoS Comput Biol. 2018 Feb 15;14(2):e1006005. doi: 10.1371/journal.pcbi.1006005. eCollection 2018 Feb.


Renal oncocytoma characterized by the defective complex I of the respiratory chain boosts the synthesis of the ROS scavenger glutathione.

Kürschner G, Zhang Q, Clima R, Xiao Y, Busch JF, Kilic E, Jung K, Berndt N, Bulik S, Holzhütter HG, Gasparre G, Attimonelli M, Babu M, Meierhofer D.

Oncotarget. 2017 Nov 11;8(62):105882-105904. doi: 10.18632/oncotarget.22413. eCollection 2017 Dec 1.


Local oxygen homeostasis during various neuronal network activity states in the mouse hippocampus.

Schneider J, Berndt N, Papageorgiou IE, Maurer J, Bulik S, Both M, Draguhn A, Holzhütter HG, Kann O.

J Cereb Blood Flow Metab. 2017 Jan 1:271678X17740091. doi: 10.1177/0271678X17740091. [Epub ahead of print]


Regulation of liver metabolism by the endosomal GTPase Rab5.

Zeigerer A, Bogorad RL, Sharma K, Gilleron J, Seifert S, Sales S, Berndt N, Bulik S, Marsico G, D'Souza RCJ, Lakshmanaperumal N, Meganathan K, Natarajan K, Sachinidis A, Dahl A, Holzhütter HG, Shevchenko A, Mann M, Koteliansky V, Zerial M.

Cell Rep. 2015 May 12;11(6):884-892. doi: 10.1016/j.celrep.2015.04.018. Epub 2015 Apr 30.


Sequential metabolic phases as a means to optimize cellular output in a constant environment.

Palinkas A, Bulik S, Bockmayr A, Holzhütter HG.

PLoS One. 2015 Mar 18;10(3):e0118347. doi: 10.1371/journal.pone.0118347. eCollection 2015.


Assessment of hepatic detoxification activity: proposal of an improved variant of the (13)c-methacetin breath test.

Holzhütter HG, Lock JF, Taheri P, Bulik S, Goede A, Stockmann M.

PLoS One. 2013 Aug 15;8(8):e70780. doi: 10.1371/journal.pone.0070780. eCollection 2013.


Quantifying the contribution of the liver to glucose homeostasis: a detailed kinetic model of human hepatic glucose metabolism.

König M, Bulik S, Holzhütter HG.

PLoS Comput Biol. 2012;8(6):e1002577. doi: 10.1371/journal.pcbi.1002577. Epub 2012 Jun 21.


Enzymatic features of the glucose metabolism in tumor cells.

Herling A, König M, Bulik S, Holzhütter HG.

FEBS J. 2011 Jul;278(14):2436-59. doi: 10.1111/j.1742-4658.2011.08174.x. Epub 2011 Jun 10. Review.


HepatoNet1: a comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiology.

Gille C, Bölling C, Hoppe A, Bulik S, Hoffmann S, Hübner K, Karlstädt A, Ganeshan R, König M, Rother K, Weidlich M, Behre J, Holzhütter HG.

Mol Syst Biol. 2010 Sep 7;6:411. doi: 10.1038/msb.2010.62.


Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis.

Huthmacher C, Hoppe A, Bulik S, Holzhütter HG.

BMC Syst Biol. 2010 Aug 31;4:120. doi: 10.1186/1752-0509-4-120.


IGERS: inferring Gibbs energy changes of biochemical reactions from reaction similarities.

Rother K, Hoffmann S, Bulik S, Hoppe A, Gasteiger J, Holzhütter HG.

Biophys J. 2010 Jun 2;98(11):2478-86. doi: 10.1016/j.bpj.2010.02.052.


Characterizing the N-terminal processing motif of MHC class I ligands.

Schatz MM, Peters B, Akkad N, Ullrich N, Martinez AN, Carroll O, Bulik S, Rammensee HG, van Endert P, Holzhütter HG, Tenzer S, Schild H.

J Immunol. 2008 Mar 1;180(5):3210-7.


The stability and robustness of metabolic states: identifying stabilizing sites in metabolic networks.

Grimbs S, Selbig J, Bulik S, Holzhütter HG, Steuer R.

Mol Syst Biol. 2007;3:146. Epub 2007 Nov 13.


Modeling the MHC class I pathway by combining predictions of proteasomal cleavage, TAP transport and MHC class I binding.

Tenzer S, Peters B, Bulik S, Schoor O, Lemmel C, Schatz MM, Kloetzel PM, Rammensee HG, Schild H, Holzhütter HG.

Cell Mol Life Sci. 2005 May;62(9):1025-37.


Cytosolic processing of proteasomal cleavage products can enhance the presentation efficiency of MHC-1 epitopes.

Bulik S, Peters B, Ebeling C, Holzhütter H.

Genome Inform. 2004;15(1):24-34.


A method for classifying metabolites in topological pathway analyses based on minimization of pathway number.

Dandekar T, Moldenhauer F, Bulik S, Bertram H, Schuster S.

Biosystems. 2003 Aug;70(3):255-70.


Identifying MHC class I epitopes by predicting the TAP transport efficiency of epitope precursors.

Peters B, Bulik S, Tampe R, Van Endert PM, Holzhütter HG.

J Immunol. 2003 Aug 15;171(4):1741-9.


The pharmacokinetics and metabolism of SC-53228, a specific leukotriene B4 receptor antagonist.

Paulson S, Readus Y, Bulik S, Schoenhard G, Stolzenbach J, Fretland D.

Inflamm Res. 1995 Aug;44 Suppl 2:S143-4. No abstract available.


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